{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T22:48:20Z","timestamp":1778021300322,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009330","name":"Medical Science and Technology Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["A202136911"],"award-info":[{"award-number":["A202136911"]}],"id":[{"id":"10.13039\/501100009330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.exer.2021.108716","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T01:23:29Z","timestamp":1627867409000},"page":"108716","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["TLR2 signaling contributes to the angiogenesis of oxygen-induced retinopathy"],"prefix":"10.1016","volume":"210","author":[{"given":"Yuying","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"23","key":"10.1016\/j.exer.2021.108716_bib1","doi-asserted-by":"crossref","first-page":"10457","DOI":"10.1073\/pnas.92.23.10457","article-title":"Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins","volume":"92","author":"Aiello","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.exer.2021.108716_bib2","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1167\/iovs.05-1096","article-title":"T2-TrpRS inhibits preretinal neovascularization and enhances physiological vascular regrowth in OIR as assessed by a new method of quantification","volume":"47","author":"Banin","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.exer.2021.108716_bib3","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1590\/S0001-37652007000300004","article-title":"The effects of the subconjunctival injection of bevacizumab (Avastin) on angiogenesis in the rat cornea","volume":"79","author":"Barros","year":"2007","journal-title":"An. Acad. Bras. Cienc."},{"issue":"1","key":"10.1016\/j.exer.2021.108716_bib4","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1172\/JCI22869","article-title":"SDF-1 is both necessary and sufficient to promote proliferative retinopathy","volume":"115","author":"Butler","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.exer.2021.108716_bib5","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/74651","article-title":"Mechanisms of angiogenesis and arteriogenesis","volume":"6","author":"Carmeliet","year":"2000","journal-title":"Nat. Med."},{"issue":"10","key":"10.1016\/j.exer.2021.108716_bib6","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s00011-010-0208-2","article-title":"Important aspects of Toll-like receptors, ligands and their signaling pathways","volume":"59","author":"Chang","year":"2010","journal-title":"Inflamm. Res."},{"issue":"1","key":"10.1016\/j.exer.2021.108716_bib7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1136\/bjo.2005.072686","article-title":"Toll-like receptors in ocular immunity and the immunopathogenesis of inflammatory eye disease","volume":"90","author":"Chang","year":"2006","journal-title":"Br. J. Ophthalmol."},{"issue":"2","key":"10.1016\/j.exer.2021.108716_bib8","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1161\/ATVBAHA.112.300679","article-title":"Angiogenesis mediated by toll-like receptor 4 in ischemic neural tissue","volume":"33","author":"Chang","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"3","key":"10.1016\/j.exer.2021.108716_bib9","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.exer.2006.11.007","article-title":"New quantitative analysis, using high-resolution images, of oxygen-induced retinal neovascularization in mice","volume":"84","author":"Chikaraishi","year":"2007","journal-title":"Exp. Eye Res."},{"issue":"4","key":"10.1016\/j.exer.2021.108716_bib10","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1167\/iovs.06-0923","article-title":"Hepatocyte growth factor\/scatter factor promotes retinal angiogenesis through increased urokinase expression","volume":"48","author":"Colombo","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.exer.2021.108716_bib11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.yjmcc.2010.08.006","article-title":"Arteriogenesis requires toll-like receptor 2 and 4 expression in bone-marrow derived cells","volume":"50","author":"de Groot","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"3","key":"10.1016\/j.exer.2021.108716_bib12","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1046\/j.1471-4159.2003.02202.x","article-title":"Toll-like receptor 2 (TLR2) mediates astrocyte activation in response to the Gram-positive bacterium Staphylococcus aureus","volume":"88","author":"Esen","year":"2004","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.exer.2021.108716_bib14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/01.RES.0000153188.68898.ac","article-title":"Innate immunity and angiogenesis","volume":"96","author":"Frantz","year":"2005","journal-title":"Circ. Res."},{"issue":"46","key":"10.1016\/j.exer.2021.108716_bib15","doi-asserted-by":"crossref","first-page":"30336","DOI":"10.1074\/jbc.273.46.30336","article-title":"Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase\/Akt signal transduction pathway. Requirement for Flk-1\/KDR activation","volume":"273","author":"Gerber","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.exer.2021.108716_bib16","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1167\/iovs.09-4203","article-title":"Stimulation of axon regeneration in the mature optic nerve by intravitreal application of the toll-like receptor 2 agonist Pam3Cys","volume":"51","author":"Hauk","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"10","key":"10.1016\/j.exer.2021.108716_bib17","first-page":"3327","article-title":"Platelet-activating factor in vasoobliteration of oxygen-induced retinopathy","volume":"43","author":"Hou","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.exer.2021.108716_bib18","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1517\/14728220902794939","article-title":"Toll-like receptors in liver ischemia-reperfusion injury: a novel target for therapeutic modulation?","volume":"13","author":"Katsargyris","year":"2009","journal-title":"Expert Opin. Ther. Targets"},{"issue":"11","key":"10.1016\/j.exer.2021.108716_bib19","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molmed.2007.09.002","article-title":"Signaling to NF-kappaB by toll-like receptors","volume":"13","author":"Kawai","year":"2007","journal-title":"Trends Mol. Med."},{"issue":"3","key":"10.1016\/j.exer.2021.108716_bib20","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2174\/156652406776894572","article-title":"Toll-like receptors and corneal innate immunity","volume":"6","author":"Kumar","year":"2006","journal-title":"Curr. Mol. Med."},{"issue":"5","key":"10.1016\/j.exer.2021.108716_bib21","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1161\/ATVBAHA.111.224048","article-title":"High-mobility group box-1 mediates toll-like receptor 4-dependent angiogenesis","volume":"31","author":"Lin","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"7","key":"10.1016\/j.exer.2021.108716_bib22","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1167\/iovs.09-4226","article-title":"Neuronal-driven angiogenesis: role of NGF in retinal neovascularization in an oxygen-induced retinopathy model","volume":"51","author":"Liu","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"11","key":"10.1016\/j.exer.2021.108716_bib23","doi-asserted-by":"crossref","first-page":"5697","DOI":"10.1167\/iovs.10-5407","article-title":"Glaucomatous tissue stress and the regulation of immune response through glial Toll-like receptor signaling","volume":"51","author":"Luo","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.exer.2021.108716_bib24","doi-asserted-by":"crossref","first-page":"208","DOI":"10.15252\/emmm.201505613","article-title":"Increased VEGF-A promotes multiple distinct aging diseases of the eye through shared pathomechanisms","volume":"8","author":"Marneros","year":"2016","journal-title":"EMBO Mol. Med."},{"issue":"14","key":"10.1016\/j.exer.2021.108716_bib25","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.1126\/scisignal.abc5371","article-title":"TLR2 promotes proangiogenic immune cell recruitment and tumor angiogenesis","volume":"666","author":"McCoy","year":"2021","journal-title":"Sci. Signal."},{"issue":"5","key":"10.1016\/j.exer.2021.108716_bib26","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/01.all.0000182537.55650.99","article-title":"Toll-like receptors and the eye","volume":"5","author":"Micera","year":"2005","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.exer.2021.108716_bib27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2006.12.002","article-title":"Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors","volume":"19","author":"Miyake","year":"2007","journal-title":"Semin. Immunol."},{"issue":"1","key":"10.1016\/j.exer.2021.108716_bib28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1096\/fasebj.13.1.9","article-title":"Vascular endothelial growth factor (VEGF) and its receptors","volume":"13","author":"Neufeld","year":"1999","journal-title":"Faseb. J."},{"issue":"6","key":"10.1016\/j.exer.2021.108716_bib29","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.4049\/jimmunol.181.6.3841","article-title":"TLR2 expression in astrocytes is induced by TNF-alpha- and NF-kappa B-dependent pathways","volume":"181","author":"Nirmal","year":"2008","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.exer.2021.108716_bib30","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1073\/pnas.92.3.905","article-title":"Vascular endothelial growth factor\/vascular permeability factor expression in a mouse model of retinal neovascularization","volume":"92","author":"Pierce","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2021.108716_bib31","doi-asserted-by":"crossref","unstructured":"Grace Pinhal-Enfield, Madhuri Ramanathan, Gyorgy Hasko, Stefanie N Vogel, Andrew L Salzman, Geert-Jan Boons, et al. An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors. Am. J. Pathol.. 2003;163(2):711-721.","DOI":"10.1016\/S0002-9440(10)63698-X"},{"issue":"5","key":"10.1016\/j.exer.2021.108716_bib32","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00424-005-1436-0","article-title":"Nerve growth factor activates aorta endothelial cells causing PI3K\/Akt- and ERK-dependent migration","volume":"450","author":"Rahbek","year":"2005","journal-title":"Pfl\u00fcgers Archiv"},{"issue":"6","key":"10.1016\/j.exer.2021.108716_bib33","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.exer.2010.03.012","article-title":"Toll-like receptors in ocular surface disease","volume":"90","author":"Redfern","year":"2010","journal-title":"Exp. Eye Res."},{"issue":"12","key":"10.1016\/j.exer.2021.108716_bib34","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1172\/JCI29683","article-title":"Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy","volume":"116","author":"Ritter","year":"2006","journal-title":"J. Clin. Invest."},{"issue":"Pt 5","key":"10.1016\/j.exer.2021.108716_bib35","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1242\/jcs.114.5.853","article-title":"The splice variants of vascular endothelial growth factor (VEGF) and their receptors","volume":"114","author":"Robinson","year":"2001","journal-title":"J. Cell Sci."},{"issue":"4","key":"10.1016\/j.exer.2021.108716_bib37","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.bbrc.2006.05.056","article-title":"Central role of endogenous Toll-like receptor-2 activation in regulating inflammation, reactive oxygen species production, and subsequent neointimal formation after vascular injury","volume":"345","author":"Shishido","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.exer.2021.108716_bib38","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2174\/157339906775473671","article-title":"Angiogenic and antiangiogenic factors in proliferative diabetic retinopathy","volume":"2","author":"Sim\u00f3","year":"2006","journal-title":"Curr. Diabetes Rev."},{"issue":"1","key":"10.1016\/j.exer.2021.108716_bib39","first-page":"101","article-title":"Oxygen-induced retinopathy in the mouse","volume":"35","author":"Smith","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.exer.2021.108716_bib40","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1462-5822.2008.01264.x","article-title":"Staphylococcus epidermidis polysaccharide intercellular adhesin induces IL-8 expression in human astrocytes via a mechanism involving TLR2","volume":"11","author":"Stevens","year":"2009","journal-title":"Cell Microbiol."},{"issue":"9","key":"10.1016\/j.exer.2021.108716_bib41","article-title":"Choroidal neovascularization enhanced by Chlamydia pneumoniae via Toll-like receptor 2 in the retinal pigment epithelium","volume":"51","author":"Takeshi","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.exer.2021.108716_bib42","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/path.2059","article-title":"TLR-2-mediated induction of vascular endothelial growth factor (VEGF) in cartilage in septic joint disease","volume":"210","author":"Varoga","year":"2006","journal-title":"J. Pathol."},{"issue":"8","key":"10.1016\/j.exer.2021.108716_bib43","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1056\/NEJMoa041773","article-title":"Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy","volume":"353","author":"Watanabe","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"7318","key":"10.1016\/j.exer.2021.108716_bib44","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/nature09421","article-title":"Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands","volume":"467","author":"West","year":"2010","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.exer.2021.108716_bib45","doi-asserted-by":"crossref","first-page":"4780","DOI":"10.1167\/iovs.05-0376","article-title":"Riluzole inhibits VEGF-induced endothelial cell proliferation in vitro and hyperoxia-induced abnormal vessel formation in vivo","volume":"46","author":"Yoo","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483521002827?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483521002827?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:31:25Z","timestamp":1762147885000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483521002827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":43,"alternative-id":["S0014483521002827"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2021.108716","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TLR2 signaling contributes to the angiogenesis of oxygen-induced retinopathy","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2021.108716","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108716"}}