{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:50:49Z","timestamp":1786989049057,"version":"build-2736575974"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.exer.2021.108810","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T04:01:10Z","timestamp":1635480070000},"page":"108810","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Angiotensin II is a crucial factor in retinal aneurysm formation"],"prefix":"10.1016","volume":"213","author":[{"given":"He","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-yu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-ting","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2021.108810_bib1","first-page":"353","article-title":"Role of angiotensin II type 1 receptor in cerebral aneurysm formation in rats","volume":"24","author":"Aoki","year":"2009","journal-title":"International journal of molecular medicine"},{"key":"10.1016\/j.exer.2021.108810_bib2","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.2337\/db09-1606","article-title":"TNF-\u03b1 signals through PKC\u03b6\/NF-\u03baB to alter the tight junction complex and increase retinal endothelial cell permeability","volume":"59","author":"Aveleira","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.exer.2021.108810_bib3","first-page":"25","article-title":"Ultrastructural analysis of interleukin-1 beta-induced leukocyte recruitment to the rat retina","volume":"38","author":"Bamforth","year":"1997","journal-title":"Investigative ophthalmology & visual science"},{"key":"10.1016\/j.exer.2021.108810_bib4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/jhh.2011.37","article-title":"How does hypertension affect your eyes?","volume":"26","author":"Bhargava","year":"2012","journal-title":"Journal of Human Hypertension"},{"key":"10.1016\/j.exer.2021.108810_bib5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s00417-009-1175-6","article-title":"Imaging of macroaneurysms occurring during retinal vein occlusion and diabetic retinopathy by indocyanine green angiography and high resolution optical coherence tomography","volume":"248","author":"Bourhis","year":"2010","journal-title":"Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie"},{"key":"10.1016\/j.exer.2021.108810_bib6","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1159\/000087451","article-title":"Angiotensin II stimulates matrix metalloproteinase secretion in human vascular smooth muscle cells via nuclear factor-kappaB and activator protein 1 in a redox-sensitive manner","volume":"42","author":"Browatzki","year":"2005","journal-title":"Journal of vascular research"},{"key":"10.1016\/j.exer.2021.108810_bib7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1161\/HYPERTENSIONAHA.111.182154","article-title":"Angiotensin II-induced hypertension is modulated by nuclear factor-\u03baBin the paraventricular nucleus","volume":"59","author":"Cardinale","year":"2012","journal-title":"Hypertension (Dallas, Tex. : 1979)"},{"key":"10.1016\/j.exer.2021.108810_bib8","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0140-6736(97)06209-0","article-title":"Effect of lisinopril on progression of retinopathy in normotensive people with type 1 diabetes. The EUCLID study group. EURODIAB controlled trial of lisinopril in insulin-dependent diabetes mellitus","volume":"351","author":"Chaturvedi","year":"1998","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.exer.2021.108810_bib9","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0002-9394(14)70687-7","article-title":"Macroaneurysms associated with retinal branch vein occlusion","volume":"109","author":"Cousins","year":"1990","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.exer.2021.108810_bib10","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1172\/JCI7818","article-title":"Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice","volume":"105","author":"Daugherty","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.exer.2021.108810_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116799","article-title":"Azilsartan reduced TNF-\u03b1 and IL-1\u03b2 levels, increased IL-10 levels and upregulated VEGF, FGF, KGF, and TGF-\u03b1 in an oral mucositis model","volume":"10","author":"de Ara\u00fajo","year":"2015","journal-title":"PloS one"},{"key":"10.1016\/j.exer.2021.108810_bib12","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3109\/08830189809043005","article-title":"Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist","volume":"16","author":"Dinarello","year":"1998","journal-title":"International Reviews of Immunology"},{"key":"10.1016\/j.exer.2021.108810_bib13","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jss.2006.03.026","article-title":"Early increased MT1-MMP expression and late MMP-2 and MMP-9 activity during Angiotensin II induced aneurysm formation","volume":"135","author":"Eagleton","year":"2006","journal-title":"The Journal of surgical research"},{"key":"10.1016\/j.exer.2021.108810_bib14","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0002-9394(14)75249-3","article-title":"A histopathologic study of retinal arterial aneurysms","volume":"85","author":"Fichte","year":"1978","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.exer.2021.108810_bib15","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1152\/physiolgenomics.00041.2019","article-title":"Effect of MMP-9 gene knockout on retinal vascular form and function","volume":"51","author":"George","year":"2019","journal-title":"Physiological genomics"},{"key":"10.1016\/j.exer.2021.108810_bib16","doi-asserted-by":"crossref","first-page":"e292","DOI":"10.1111\/aos.14273","article-title":"Ganglion cell layer thickening in well-controlled patients with type 1 diabetes: an early sign for diabetic retinopathy?","volume":"98","author":"Gerendas","year":"2020","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.exer.2021.108810_bib17","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1007\/s001250051539","article-title":"Angiotensin converting enzyme inhibition reduces retinal overexpression of vascular endothelial growth factor and hyperpermeability in experimental diabetes","volume":"43","author":"Gilbert","year":"2000","journal-title":"Diabetologia"},{"key":"10.1016\/j.exer.2021.108810_bib18","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/labinvest.3700486","article-title":"Expression and localization of PDGF-B, PDGF-D, and PDGF receptor in the kidney of angiotensin II-infused rat","volume":"86","author":"Ishizaka","year":"2006","journal-title":"Laboratory investigation; a journal of technical methods and pathology"},{"key":"10.1016\/j.exer.2021.108810_bib19","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ijcard.2018.05.072","article-title":"Inhibition of interleukin-1 suppresses angiotensin II-induced aortic inflammation and aneurysm formation","volume":"270","author":"Isoda","year":"2018","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.exer.2021.108810_bib20","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1113\/jphysiol.2004.073098","article-title":"Effects of angiotensin II on the pericyte-containing microvasculature of the rat retina","volume":"561","author":"Kawamura","year":"2004","journal-title":"Journal of Physiology"},{"key":"10.1016\/j.exer.2021.108810_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2017.03.003","article-title":"PDGFs and their receptors","volume":"614","author":"Kazlauskas","year":"2017","journal-title":"Gene"},{"key":"10.1016\/j.exer.2021.108810_bib22","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1136\/jmg.37.7.498","article-title":"The ACE I allele is associated with increased risk for ruptured intracranial aneurysms","volume":"37","author":"Keramatipour","year":"2000","journal-title":"Journal of medical genetics"},{"key":"10.1016\/j.exer.2021.108810_bib23","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/jcbfm.2008.154","article-title":"Blockade of angiotensin II attenuates VEGF-mediated blood-retinal barrier breakdown in diabetic retinopathy","volume":"29","author":"Kim","year":"2009","journal-title":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism"},{"key":"10.1016\/j.exer.2021.108810_bib24","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1161\/HYPERTENSIONAHA.118.11184","article-title":"PARP-1 (Poly[ADP-Ribose] Polymerase 1) inhibition Protects from Ang II (angiotensin II)-Induced abdominal aortic aneurysm in mice","volume":"72","author":"Liang","year":"2018","journal-title":"Hypertension (Dallas, Tex. : 1979)"},{"key":"10.1016\/j.exer.2021.108810_bib25","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.277.5323.242","article-title":"Pericyte loss and microaneurysm formation in PDGF-B-deficient mice","volume":"277","author":"Lindahl","year":"1997","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.exer.2021.108810_bib26","doi-asserted-by":"crossref","first-page":"12563","DOI":"10.1074\/jbc.270.21.12563","article-title":"Convergence of angiotensin II and platelet-derived growth factor receptor signaling cascades in vascular smooth muscle cells","volume":"270","author":"Linseman","year":"1995","journal-title":"The Journal of biological chemistry"},{"key":"10.1016\/j.exer.2021.108810_bib27","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1172\/JCI0215334","article-title":"Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms","volume":"110","author":"Longo","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.exer.2021.108810_bib28","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1167\/iovs.16-19998","article-title":"Blood vessel basement membrane alterations in human retinal microaneurysms during aging","volume":"58","author":"L\u00f3pez-Luppo","year":"2017","journal-title":"Investigative ophthalmology & visual science"},{"key":"10.1016\/j.exer.2021.108810_bib29","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1111\/eci.12173","article-title":"Role of the renin-angiotensin system on abdominal aortic aneurysms","volume":"43","author":"Malekzadeh","year":"2013","journal-title":"European journal of clinical investigation"},{"key":"10.1016\/j.exer.2021.108810_bib30","first-page":"1133","volume":"vol. 39","author":"Mansour","year":"2019"},{"key":"10.1016\/j.exer.2021.108810_bib31","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/sj.eye.6702068","article-title":"Retinal artery macroaneurysms: clinical and fluorescein angiographic features in 34 patients","volume":"20","author":"Moosavi","year":"2006","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.exer.2021.108810_bib32","doi-asserted-by":"crossref","first-page":"H739","DOI":"10.1152\/ajpheart.00656.2001","article-title":"Angiotensin II stimulates migration of retinal microvascular pericytes: involvement of TGF-beta and PDGF-BB","volume":"282","author":"Nadal","year":"2002","journal-title":"American journal of physiology. Heart and circulatory physiology"},{"key":"10.1016\/j.exer.2021.108810_bib33","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1167\/iovs.04-1476","article-title":"Suppression of ocular inflammation in endotoxin-induced uveitis by blocking the angiotensin II type 1 receptor","volume":"46","author":"Nagai","year":"2005","journal-title":"Investigative ophthalmology & visual science"},{"key":"10.1016\/j.exer.2021.108810_bib34","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1016\/S0024-3205(02)01998-7","article-title":"Increased local angiotensin II formation in aneurysmal aorta","volume":"71","author":"Nishimoto","year":"2002","journal-title":"Life sciences"},{"key":"10.1016\/j.exer.2021.108810_bib35","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1161\/01.CIR.0000087339.31094.3C","article-title":"Role of a decreased expression of the local renin-angiotensin system in the etiology of cerebral aneurysms","volume":"108","author":"Ohkuma","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.exer.2021.108810_bib36","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1742-2094-9-102","article-title":"Telmisartan directly ameliorates the neuronal inflammatory response to IL-1\u03b2 partly through the JNK\/c-Jun and NADPH oxidase pathways","volume":"9","author":"Pang","year":"2012","journal-title":"Journal of neuroinflammation"},{"key":"10.1016\/j.exer.2021.108810_bib37","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1161\/HYPERTENSIONAHA.108.117663","article-title":"Plasma kallikrein mediates angiotensin II type 1 receptor-stimulated retinal vascular permeability","volume":"53","author":"Phipps","year":"2009","journal-title":"Hypertension (Dallas, Tex. : 1979)"},{"key":"10.1016\/j.exer.2021.108810_bib38","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1016\/j.ajpath.2011.02.006","article-title":"Angiotensin II-induced MMP-2 activity and MMP-14 and basigin protein expression are mediated via the angiotensin II receptor type 1-mitogen-activated protein kinase 1 pathway in retinal pigment epithelium: implications for age-related macular degeneration","volume":"178","author":"Pons","year":"2011","journal-title":"The American journal of pathology"},{"key":"10.1016\/j.exer.2021.108810_bib39","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1172\/JCI8931","article-title":"Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms","volume":"105","author":"Pyo","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.exer.2021.108810_bib40","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1136\/bjo.2010.198937","article-title":"In vivo identification of alteration of inner neurosensory layers in branch retinal artery occlusion","volume":"96","author":"Ritter","year":"2012","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.exer.2021.108810_bib41","first-page":"676","article-title":"The response of retinal vasculature to angiotensin","volume":"28","author":"Rockwood","year":"1987","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"10.1016\/j.exer.2021.108810_bib42","first-page":"1939","article-title":"PDGF-induced coupling of function with metabolism in microvascular pericytes of the retina","volume":"42","author":"Sakagami","year":"2001","journal-title":"Investigative ophthalmology & visual science"},{"key":"10.1016\/j.exer.2021.108810_bib43","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1161\/01.STR.0000131655.45227.f7","article-title":"II genotype of the angiotensin-converting enzyme gene increases the risk for subarachnoid hemorrhage from ruptured aneurysm","volume":"35","author":"Slowik","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.exer.2021.108810_bib44","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jchemneu.2018.06.001","article-title":"Markers for human brain pericytes and smooth muscle cells","volume":"92","author":"Smyth","year":"2018","journal-title":"Journal of chemical neuroanatomy"},{"key":"10.1016\/j.exer.2021.108810_bib45","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.optom.2013.08.002","article-title":"Ruptured retinal arterial macroaneurysm: diagnosis and management","volume":"7","author":"Speilburg","year":"2014","journal-title":"J Optom"},{"key":"10.1016\/j.exer.2021.108810_bib46","doi-asserted-by":"crossref","first-page":"C1633","DOI":"10.1152\/ajpcell.00092.2008","article-title":"Regulation of angiotensin II receptors and extracellular matrix turnover in human retinal pigment epithelium: role of angiotensin II","volume":"295","author":"Striker","year":"2008","journal-title":"American journal of physiology. Cell physiology"},{"key":"10.1016\/j.exer.2021.108810_bib47","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s10384-006-0347-0","article-title":"Serous macular detachment associated with retinal arterial macroaneurysm","volume":"50","author":"Takahashi","year":"2006","journal-title":"Jpn J Ophthalmol"},{"key":"10.1016\/j.exer.2021.108810_bib48","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1080\/01616412.1998.11740571","article-title":"Angiotensin I-converting enzyme gene polymorphism in intracranial saccular aneurysm individuals","volume":"20","author":"Takenaka","year":"1998","journal-title":"Neurological research"},{"key":"10.1016\/j.exer.2021.108810_bib49","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/jhh.2009.27","article-title":"Angiotensin-converting enzyme gene and retinal arteriolar narrowing: the Funagata Study","volume":"23","author":"Tanabe","year":"2009","journal-title":"J Hum Hypertens"},{"key":"10.1016\/j.exer.2021.108810_bib50","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1291\/hypres.25.817","article-title":"Possible roles of angiotensin II-forming enzymes, angiotensin converting enzyme and chymase-like enzyme, in the human aneurysmal aorta","volume":"25","author":"Tsunemi","year":"2002","journal-title":"Hypertension research : official journal of the Japanese Society of Hypertension"},{"key":"10.1016\/j.exer.2021.108810_bib51","first-page":"263","article-title":"Effects of RAS inhibitors on diabetic retinopathy: a systematic review and meta-analysis. The lancet","volume":"3","author":"Wang","year":"2015","journal-title":"Diabetes & endocrinology"},{"key":"10.1016\/j.exer.2021.108810_bib52","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.redox.2018.02.022","article-title":"The immunoproteasome subunit LMP10 mediates angiotensin II-induced retinopathy in mice","volume":"16","author":"Wang","year":"2018","journal-title":"Redox biology"},{"key":"10.1016\/j.exer.2021.108810_bib53","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/s41422-019-0216-x","article-title":"Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression","volume":"29","author":"Wang","year":"2019","journal-title":"Cell research"},{"key":"10.1016\/j.exer.2021.108810_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399404008129","article-title":"Diabetes and retinal vascular disorders: role of the renin-angiotensin system","volume":"6","author":"Wilkinson-Berka","year":"2004","journal-title":"Expert reviews in molecular medicine"},{"key":"10.1016\/j.exer.2021.108810_bib55","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.lfs.2018.11.036","article-title":"Genistein inhibits Ang II-induced CRP and MMP-9 generations via the ER-p38\/ERK1\/2-PPAR\u03b3-NF-\u03baB signaling pathway in rat vascular smooth muscle cells","volume":"216","author":"Xu","year":"2019","journal-title":"Life sciences"},{"key":"10.1016\/j.exer.2021.108810_bib56","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1136\/bjo.2003.035923","article-title":"Features of retinal arterial macroaneurysms in patients with uveitis","volume":"88","author":"Yamanaka","year":"2004","journal-title":"Br J Ophthalmol"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483521003766?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483521003766?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:14:31Z","timestamp":1757999671000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483521003766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":56,"alternative-id":["S0014483521003766"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2021.108810","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Angiotensin II is a crucial factor in retinal aneurysm formation","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2021.108810","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108810"}}