{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:40:43Z","timestamp":1786653643822,"version":"build-2736575974"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016220","name":"Georgia Clinical and Translational Science Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016220","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","award":["P30 CA91842"],"award-info":[{"award-number":["P30 CA91842"]}],"id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA91842"],"award-info":[{"award-number":["P30 CA91842"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EY029130"],"award-info":[{"award-number":["R01 EY029130"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 EY002687"],"award-info":[{"award-number":["P30 EY002687"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EY009852"],"award-info":[{"award-number":["R01 EY009852"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010258","name":"Marfan Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010258","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007930","name":"Institute of Clinical and Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007930","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.exer.2021.108811","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T12:57:41Z","timestamp":1635425861000},"page":"108811","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Single-cell RNA-sequencing analysis of the ciliary epithelium and contiguous tissues in the mouse eye"],"prefix":"10.1016","volume":"213","author":[{"given":"J.C.","family":"Youkilis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bassnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2021.108811_bib1","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1167\/iovs.07-1338","article-title":"Bestrophin-2 is involved in the generation of intraocular pressure","volume":"49","author":"Bakall","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108811_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100902","article-title":"Zinn's zonule","volume":"82","author":"Bassnett","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2021.108811_bib3","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/sj.eye.6700199","article-title":"The role of the posterior ciliary body in the biosynthesis of vitreous humour","volume":"16","author":"Bishop","year":"2002","journal-title":"Eye"},{"key":"10.1016\/j.exer.2021.108811_bib4","doi-asserted-by":"crossref","first-page":"F920","DOI":"10.1152\/ajprenal.2001.281.5.F920","article-title":"Immunolocalization of electrogenic sodium-bicarbonate cotransporters pNBC1 and kNBC1 in the rat eye","volume":"281","author":"Bok","year":"2001","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.exer.2021.108811_bib5","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.exer.2003.09.021","article-title":"The ins and outs of aqueous humour secretion","volume":"78","author":"Civan","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2021.108811_bib6","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jtos.2021.03.010","article-title":"A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells","volume":"21","author":"Collin","year":"2021","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2021.108811_bib7","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1021\/mp300429e","article-title":"Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures","volume":"10","author":"Dahlin","year":"2013","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.exer.2021.108811_bib8","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1167\/iovs.16-20866","article-title":"Proteomic analysis of the bovine and human ciliary zonule","volume":"58","author":"De Maria","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108811_bib9","doi-asserted-by":"crossref","DOI":"10.1167\/iovs.62.15.27","article-title":"Compositional analysis of extracellular aggregates in the eyes of patients with exfoliation syndrome and exfoliation glaucoma","author":"De Maria","year":"2021","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108811_bib10","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/978-981-10-7311-3_10","article-title":"Overview of rodent zic genes","volume":"1046","author":"Diamand","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2021.108811_bib11","doi-asserted-by":"crossref","first-page":"R74","DOI":"10.1186\/gb-2005-6-9-r74","article-title":"Differential gene expression in anatomical compartments of the human eye","volume":"6","author":"Diehn","year":"2005","journal-title":"Genome Biol."},{"key":"10.1016\/j.exer.2021.108811_bib12","first-page":"343","article-title":"Immunolocalization of the Na-K-Cl cotransporter in bovine ciliary epithelium","volume":"42","author":"Dunn","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108811_bib13","doi-asserted-by":"crossref","first-page":"5117","DOI":"10.1074\/jbc.RA117.001483","article-title":"Structural and compositional diversity of fibrillin microfibrils in human tissues","volume":"293","author":"Eckersley","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2021.108811_bib14","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.exer.2021.108811_bib15","first-page":"315","article-title":"Bioinformatics and reanalysis of subtracted expressed sequence tags from the human ciliary body: identification of novel biological functions","volume":"8","author":"Escribano","year":"2002","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2021.108811_bib16","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.preteyeres.2018.09.001","article-title":"The peripheral eye: a neurogenic area with potential to treat retinal pathologies?","volume":"68","author":"Fernandez-Nogales","year":"2019","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2021.108811_bib17","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/s41586-021-03620-1","article-title":"A roadmap for the human developmental cell atlas","volume":"597","author":"Haniffa","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.exer.2021.108811_bib18","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.exer.2021.108811_bib19","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/15440","article-title":"Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities","volume":"23","author":"Igarashi","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exer.2021.108811_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0044973","article-title":"Gene expression and functional annotation of the human ciliary body epithelia","volume":"7","author":"Janssen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2021.108811_bib21","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.037283","article-title":"Targeted deletion of fibrillin-1 in the mouse eye results in ectopia lentis and other ocular phenotypes associated with Marfan syndrome","volume":"12","author":"Jones","year":"2019","journal-title":"Dis. Model Mech."},{"key":"10.1016\/j.exer.2021.108811_bib22","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.1167\/iovs.19-27656","article-title":"Single-cell RNA transcriptome helps define the limbal\/corneal epithelial stem\/early transit amplifying cells and how autophagy affects this population","volume":"60","author":"Kaplan","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108811_bib23","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1080\/10253890.2017.1322575","article-title":"Corticotropin-releasing hormone-binding protein and stress: from invertebrates to humans","volume":"20","author":"Ketchesin","year":"2017","journal-title":"Stress"},{"key":"10.1016\/j.exer.2021.108811_bib24","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002123R","article-title":"Single-cell RNA sequencing redefines the mesenchymal cell landscape of mouse endometrium","volume":"35","author":"Kirkwood","year":"2021","journal-title":"Faseb. J."},{"key":"10.1016\/j.exer.2021.108811_bib25","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1128\/MCB.23.15.5245-5255.2003","article-title":"The actin-binding domain of Slac2-a\/melanophilin is required for melanosome distribution in melanocytes","volume":"23","author":"Kuroda","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.exer.2021.108811_bib26","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.cell.2015.05.002","article-title":"Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets","volume":"161","author":"Macosko","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.exer.2021.108811_bib27","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/bs.ctdb.2018.12.008","article-title":"Eye organogenesis: a hierarchical view of ocular development","volume":"132","author":"Miesfeld","year":"2019","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.exer.2021.108811_bib28","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1006\/dbio.1996.8449","article-title":"The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation","volume":"182","author":"Nagai","year":"1997","journal-title":"Dev. Biol."},{"key":"10.1016\/j.exer.2021.108811_bib29","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0925-4773(98)00073-2","article-title":"Xenopus Zic family and its role in neural and neural crest development","volume":"75","author":"Nakata","year":"1998","journal-title":"Mech. Dev."},{"key":"10.1016\/j.exer.2021.108811_bib30","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.exer.2004.10.011","article-title":"DNA microarray analysis of gene expression in iris and ciliary body of rat eyes with endotoxin-induced uveitis","volume":"80","author":"Ohta","year":"2005","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2021.108811_bib31","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0167-0115(95)00007-X","article-title":"G protein-coupled corticotropin-releasing hormone receptors in rat retina","volume":"56","author":"Olianas","year":"1995","journal-title":"Regul. Pept."},{"key":"10.1016\/j.exer.2021.108811_bib32","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1523\/JNEUROSCI.2518-17.2018","article-title":"Convergence and divergence of CRH amacrine cells in mouse retinal circuitry","volume":"38","author":"Park","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2021.108811_bib33","doi-asserted-by":"crossref","first-page":"12856","DOI":"10.1073\/pnas.2001896117","article-title":"Molecular taxonomy of human ocular outflow tissues defined by single-cell transcriptomics","volume":"117","author":"Patel","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2021.108811_bib34","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/(SICI)1097-4695(199808)36:2<206::AID-NEU8>3.0.CO;2-5","article-title":"Multipotential stem cells and progenitors in the vertebrate retina","volume":"36","author":"Reh","year":"1998","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.exer.2021.108811_bib35","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/550451a","article-title":"The human cell atlas: from vision to reality","volume":"550","author":"Rozenblatt-Rosen","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.exer.2021.108811_bib36","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.3192","article-title":"Spatial reconstruction of single-cell gene expression data","volume":"33","author":"Satija","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.exer.2021.108811_bib37","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/j.cell.2016.07.054","article-title":"Comprehensive classification of retinal bipolar neurons by single-cell transcriptomics","volume":"166","author":"Shekhar","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.exer.2021.108811_bib38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.matbio.2020.10.002","article-title":"Latent-transforming growth factor beta-binding protein-2 (LTBP-2) is required for longevity but not for development of zonular fibers","volume":"95","author":"Shi","year":"2021","journal-title":"Matrix Biol."},{"key":"10.1016\/j.exer.2021.108811_bib39","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1167\/iovs.13-11619","article-title":"Development, composition, and structural arrangements of the ciliary zonule of the mouse","volume":"54","author":"Shi","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108811_bib40","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ydbio.2021.06.005","article-title":"A single-cell guide to retinal development: cell fate decisions of multipotent retinal progenitors in scRNA-seq","volume":"478","author":"Shiau","year":"2021","journal-title":"Dev. Biol."},{"key":"10.1016\/j.exer.2021.108811_bib41","doi-asserted-by":"crossref","first-page":"12298","DOI":"10.1073\/pnas.93.22.12298","article-title":"msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation","volume":"93","author":"Shioda","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2021.108811_bib42","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/0361-9230(84)90169-2","article-title":"Corticotropin releasing factor-like immunoreactive neurons in the rat retina","volume":"12","author":"Skofitsch","year":"1984","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.exer.2021.108811_bib43","series-title":"Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods","author":"Smith","year":"2002"},{"key":"10.1016\/j.exer.2021.108811_bib44","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.neuron.2019.11.006","article-title":"Single-cell profiles of retinal ganglion cells differing in resilience to injury reveal neuroprotective genes","volume":"104","author":"Tran","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.exer.2021.108811_bib45","doi-asserted-by":"crossref","first-page":"10339","DOI":"10.1073\/pnas.2001250117","article-title":"Cell atlas of aqueous humor outflow pathways in eyes of humans and four model species provides insight into glaucoma pathogenesis","volume":"117","author":"van Zyl","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2021.108811_bib46","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.exer.2013.03.004","article-title":"Exon-level expression profiling of ocular tissues","volume":"111","author":"Wagner","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2021.108811_bib47","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1152\/physrev.00011.2019","article-title":"The renal physiology of pendrin-positive intercalated cells","volume":"100","author":"Wall","year":"2020","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.exer.2021.108811_bib48","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jmoldx.2011.08.002","article-title":"RNAscope: a novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues","volume":"14","author":"Wang","year":"2012","journal-title":"J. Mol. Diagn."},{"key":"10.1016\/j.exer.2021.108811_bib49","doi-asserted-by":"crossref","first-page":"C798","DOI":"10.1152\/ajpcell.00406.2009","article-title":"Regulation of gap junction coupling in bovine ciliary epithelium","volume":"298","author":"Wang","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.exer.2021.108811_bib50","first-page":"763","article-title":"Immunocytochemical localization of NaK-ATPase isoforms in the rat and mouse ocular ciliary epithelium","volume":"42","author":"Wetzel","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2021.108811_bib51","first-page":"1327","article-title":"NEIBank: genomics and bioinformatics resources for vision research","volume":"14","author":"Wistow","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2021.108811_bib52","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1016\/j.celrep.2018.03.010","article-title":"Single-cell deconvolution of fibroblast heterogeneity in mouse pulmonary fibrosis","volume":"22","author":"Xie","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.exer.2021.108811_bib53","doi-asserted-by":"crossref","first-page":"5177","DOI":"10.1523\/JNEUROSCI.0471-20.2020","article-title":"Mouse retinal cell atlas: molecular identification of over sixty amacrine cell types","volume":"40","author":"Yan","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2021.108811_bib54","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14049","article-title":"Massively parallel digital transcriptional profiling of single cells","volume":"8","author":"Zheng","year":"2017","journal-title":"Nat. Commun."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483521003778?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483521003778?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T21:34:55Z","timestamp":1777412095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483521003778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":54,"alternative-id":["S0014483521003778"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2021.108811","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single-cell RNA-sequencing analysis of the ciliary epithelium and contiguous tissues in the mouse eye","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2021.108811","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108811"}}