{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T01:12:01Z","timestamp":1784941921210,"version":"3.55.0"},"reference-count":159,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.exer.2022.109003","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T20:58:28Z","timestamp":1645649908000},"page":"109003","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["The eye lens as an aging paradigm par excellence"],"prefix":"10.1016","volume":"218","author":[{"given":"Roy A.","family":"Quinlan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Giblin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2022.109003_bib1","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s00439-015-1554-5","article-title":"Compound mouse mutants of bZIP transcription factors Mafg and Mafk reveal a regulatory network of non-crystallin genes associated with cataract","volume":"134","author":"Agrawal","year":"2015","journal-title":"Hum. Genet."},{"key":"10.1016\/j.exer.2022.109003_bib2","doi-asserted-by":"crossref","first-page":"e4473","DOI":"10.1002\/jms.4473","article-title":"MALDI imaging mass spectrometry of \u03b2- and \u03b3-crystallins in the ocular lens","volume":"55","author":"Anderson","year":"2020","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.exer.2022.109003_bib3","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1080\/09553002.2018.1532609","article-title":"Dotting the eyes: mouse strain dependency of the lens epithelium to low dose radiation-induced DNA damage","volume":"94","author":"Barnard","year":"2018","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.exer.2022.109003_bib4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.exer.2016.03.024","article-title":"Small molecules, both dietary and endogenous, influence the onset of lens cataracts","volume":"156","author":"Barnes","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109003_bib5","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1093\/hmg\/ddaa096","article-title":"The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology","volume":"29","author":"Barnum","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2022.109003_bib6","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1364\/BOE.4.002585","article-title":"Variational analysis of the mouse and rat eye optical parameters","volume":"4","author":"Bawa","year":"2013","journal-title":"Biomed. Opt Express"},{"key":"10.1016\/j.exer.2022.109003_bib7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.exer.2015.03.010","article-title":"A test of lens opacity as an indicator of preclinical Alzheimer Disease","volume":"140","author":"Bei","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109003_bib8","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1167\/iovs.15-17897","article-title":"Environmental and genetic factors explain differences in intraocular scattering","volume":"57","author":"Benito","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109003_bib9","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1136\/bjophthalmol-2019-315282","article-title":"Inherited cataracts: molecular genetics, clinical features, disease mechanisms and novel therapeutic approaches","volume":"104","author":"Berry","year":"2020","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109003_bib10","first-page":"1","article-title":"Pathogenic variants in the CYP21A2 gene cause isolated autosomal dominant congenital posterior polar cataracts","author":"Berry","year":"2021","journal-title":"Ophthalmic Genet."},{"key":"10.1016\/j.exer.2022.109003_bib11","first-page":"129","article-title":"Zur Wirkung der R\u00f6ntgen-strahlen auf das menschliche Auge","volume":"46","author":"Birch-Hirschfeld","year":"1908","journal-title":"Klin. Monatsbl\u00e4tter Augenheilkd."},{"key":"10.1016\/j.exer.2022.109003_bib12","doi-asserted-by":"crossref","DOI":"10.1194\/jlr.TR120000874","article-title":"Lipid conformational order and the etiology of cataract and dry eye","volume":"62","author":"Borchman","year":"2021","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.exer.2022.109003_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/nu11051186","article-title":"Nutritional strategies to prevent lens cataract: current status and future strategies","volume":"11","author":"Braakhuis","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.exer.2022.109003_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108682","article-title":"Mechanisms of organelle elimination for lens development and differentiation","volume":"209","author":"Brennan","year":"2021","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109003_bib15","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/s41577-020-00421-x","article-title":"After 62 years of regulating immunity, dexamethasone meets COVID- 19","volume":"20","author":"Cain","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.exer.2022.109003_bib16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jcp.25048","article-title":"Mechanisms and consequences of double-strand DNA break formation in chromatin","volume":"231","author":"Cannan","year":"2016","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.exer.2022.109003_bib17","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1021\/jasms.1c00193","article-title":"Data-independent acquisition mass spectrometry of the human lens enhances spatiotemporal measurement of fiber cell aging","volume":"32","author":"Cantrell","year":"2021","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.exer.2022.109003_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/children8080646","article-title":"Juvenile idiopathic arthritis associated uveitis","volume":"8","author":"Carlsson","year":"2021","journal-title":"Children"},{"key":"10.1016\/j.exer.2022.109003_bib19","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1136\/bjo.82.2.186","article-title":"Effect of cigarette smoking on copper, lead, and cadmium accumulation in human lens","volume":"82","author":"Cekic","year":"1998","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109003_bib20","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.redox.2017.10.014","article-title":"Oxidative stress and the amyloid beta peptide in Alzheimer's disease","volume":"14","author":"Cheignon","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.exer.2022.109003_bib21","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1167\/iovs.17-21469","article-title":"Molecular genetic analysis of Pakistani families with autosomal recessive congenital cataracts by homozygosity screening","volume":"58","author":"Chen","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109003_bib22","doi-asserted-by":"crossref","first-page":"12497","DOI":"10.18632\/aging.102584","article-title":"Age-related changes in eye lens biomechanics, morphology, refractive index and transparency","volume":"11","author":"Cheng","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.exer.2022.109003_bib23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1076\/opep.5.3.133.8368","article-title":"Low-dose aspirin and risk of cataract and subtypes in a randomized trial of U.S. physicians","volume":"5","author":"Christen","year":"1998","journal-title":"Ophthalmic Epidemiol."},{"key":"10.1016\/j.exer.2022.109003_bib24","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/ICU.0000000000000438","article-title":"Management of cataract in uveitis patients","volume":"29","author":"Conway","year":"2018","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109003_bib25","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/GME.0000000000001477","article-title":"Interaction between postmenopausal hormone therapy and diabetes on cataract","volume":"27","author":"Costanian","year":"2020","journal-title":"Menopause"},{"key":"10.1016\/j.exer.2022.109003_bib26","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1001\/archopht.121.12.1753","article-title":"Hereditary hyperferritinemia-cataract syndrome: prevalence, lens morphology, spectrum of mutations, and clinical presentations","volume":"121","author":"Craig","year":"2003","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109003_bib27","doi-asserted-by":"crossref","first-page":"13929","DOI":"10.1038\/ncomms13929","article-title":"A cell-based computational model of early embryogenesis coupling mechanical behaviour and gene regulation","volume":"8","author":"Delile","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2022.109003_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/science.abc6506","article-title":"A DNA repair pathway can regulate transcriptional noise to promote cell fate transitions","volume":"373","author":"Desai","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.exer.2022.109003_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108317","article-title":"A simplified method for producing human lens epithelial cells and light-focusing micro-lenses from pluripotent stem cells","volume":"202","author":"Dewi","year":"2021","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109003_bib30","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0002-9394(14)73929-7","article-title":"Transient posterior subcapsular lens opacities in diabetes mellitus","volume":"115","author":"Dickey","year":"1993","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109003_bib31","doi-asserted-by":"crossref","first-page":"e144","DOI":"10.1016\/S2214-109X(20)30489-7","article-title":"Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study","volume":"9","author":"Disease","year":"2021","journal-title":"Lancet Global Health"},{"key":"10.1016\/j.exer.2022.109003_bib32","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.preteyeres.2016.09.002","article-title":"The physiological optics of the lens","volume":"56","author":"Donaldson","year":"2017","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2022.109003_bib33","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1016\/j.bpj.2017.04.046","article-title":"Influence of cholesterol on the oxygen permeability of membranes: insight from atomistic simulations","volume":"112","author":"Dotson","year":"2017","journal-title":"Biophys. J."},{"key":"10.1016\/j.exer.2022.109003_bib34","article-title":"N-acetylcarnosine (NAC) drops for age-related cataract","volume":"2","author":"Dubois","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.exer.2022.109003_bib35","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1093\/gerona\/58.3.M232","article-title":"Morbidity profiles of centenarians: survivors, delayers, and escapers","volume":"58","author":"Evert","year":"2003","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.exer.2022.109003_bib36","doi-asserted-by":"crossref","first-page":"34618","DOI":"10.1074\/jbc.M109.032094","article-title":"Mechanism of lysine oxidation in human lens crystallins during aging and in diabetes","volume":"284","author":"Fan","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2022.109003_bib37","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1167\/iovs.09-3989","article-title":"Natural course of Elschnig pearl formation and disappearance","volume":"51","author":"Findl","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109003_bib38","first-page":"970","article-title":"Expression of the type VI intermediate filament proteins CP49 and filensin in the mouse lens epithelium","volume":"22","author":"FitzGerald","year":"2016","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2022.109003_bib39","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.exer.2010.12.006","article-title":"Genistein and genistein-containing dietary supplements accelerate the early stages of cataractogenesis in the male ICR\/f rat","volume":"92","author":"Floyd","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109003_bib40","doi-asserted-by":"crossref","first-page":"10169","DOI":"10.1074\/jbc.271.17.10169","article-title":"Oxidative stress increases production of beta-amyloid precursor protein and beta-amyloid (Abeta) in mammalian lenses, and Abeta has toxic effects on lens epithelial cells","volume":"271","author":"Frederikse","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2022.109003_bib41","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0378-1119(93)90575-N","article-title":"Structure and organisation of a murine gene encoding small heat-shock protein Hsp25","volume":"128","author":"Gaestel","year":"1993","journal-title":"Gene"},{"key":"10.1016\/j.exer.2022.109003_bib42","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1006\/exer.2000.0912","article-title":"Distribution of ferritin and redox- active transition metals in normal and cataractous human lenses","volume":"71","author":"Garner","year":"2000","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109003_bib43","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1167\/iovs.15-18413","article-title":"Protein disulfide levels and lens elasticity modulation: applications for presbyopia","volume":"57","author":"Garner","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109003_bib44","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41467-021-27778-4","article-title":"Streamlined single-cell proteomics by an integrated microfluidic chip and data- independent acquisition mass spectrometry","volume":"13","author":"Gebreyesus","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2022.109003_bib45","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1021\/bi200091q","article-title":"Binding of \u03b3-crystallin substrate prevents the binding of copper and zinc ions to the molecular chaperone \u03b1-crystallin","volume":"50","author":"Ghosh","year":"2011","journal-title":"Biochemistry"},{"key":"10.1016\/j.exer.2022.109003_bib46","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1089\/jop.2000.16.121","article-title":"Glutathione: a vital lens antioxidant","volume":"16","author":"Giblin","year":"2000","journal-title":"J. Ocul. Pharmacol. Therapeut."},{"key":"10.1016\/j.exer.2022.109003_bib47","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1167\/iovs.10-6885","article-title":"A class I (Senofilcon A) soft contact lens prevents UVB-induced ocular effects, including cataract, in the rabbit in vivo","volume":"52","author":"Giblin","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109003_bib48","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0014-4835(84)90142-8","article-title":"A direct correlation between the levels of ascorbic acid and H2O2 in aqueous humor","volume":"38","author":"Giblin","year":"1984","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109003_bib49","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0014-4835(85)80033-6","article-title":"Response of cultured human lenses to H2O2","volume":"41","author":"Giblin","year":"1985","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109003_bib50","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0014-4835(87)80080-5","article-title":"Peroxide-induced effects on lens cation transport following inhibition of glutathione reductase activity in vitro","volume":"45","author":"Giblin","year":"1987","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109003_bib1a","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0014-4835(05)80105-8","article-title":"Nuclear light scattering, disulfide formation and membrane damage in lenses of older guinea pigs treated with hyperbaric oxygen","volume":"60","author":"Giblin","year":"1995","journal-title":"Exp Eye Res."},{"key":"10.1016\/j.exer.2022.109003_bib51","first-page":"1312","article-title":"Exposure of rabbit lens to hyperbaric oxygen in vitro: regional effects on GSH level","volume":"29","author":"Giblin","year":"1988","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109003_bib52","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.ajpath.2018.03.008","article-title":"Understanding liver regeneration: from mechanisms to regenerative medicine","volume":"188","author":"Gilgenkrantz","year":"2018","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2022.109003_bib53","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1364\/BOE.8.004827","article-title":"Lens internal curvature effects on age-related eye model and lens paradox","volume":"8","author":"Giovanzana","year":"2017","journal-title":"Biomed. Opt Express"},{"key":"10.1016\/j.exer.2022.109003_bib54","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.exer.2015.11.006","article-title":"From eyeless to neurological diseases","volume":"156","author":"Graw","year":"2017","journal-title":"Exp. Eye Res."},{"issue":"2","key":"10.1016\/j.exer.2022.109003_bib55","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cell.2021.12.018","article-title":"Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches","volume":"185","author":"Guilliams","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.exer.2022.109003_bib56","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1038\/s41467-021-23461-w","article-title":"Automated annotation and visualisation of high-resolution spatial proteomic mass spectrometry imaging data using HIT-MAP","volume":"12","author":"Guo","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2022.109003_bib57","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.exer.2008.04.003","article-title":"Search for a functional glucocorticoid receptor in the mammalian lens","volume":"88","author":"Gupta","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109003_bib58","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1136\/bjo.79.3.199","article-title":"Cigarettes and cataract: cadmium or a lack of vitamin C?","volume":"79","author":"Harding","year":"1995","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109003_bib59","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1074\/jbc.REV118.002809","article-title":"Small heat shock proteins: simplicity meets complexity","volume":"294","author":"Haslbeck","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2022.109003_bib60","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ydbio.2006.10.046","article-title":"Tudor- related proteins TDRD1\/MTR-1, TDRD6 and TDRD7\/TRAP: domain composition, intracellular localization, and function in male germ cells in mice","volume":"301","author":"Hosokawa","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.exer.2022.109003_bib61","article-title":"The association between near work activities and myopia in children-A systematic review and meta-analysis","volume":"10","author":"Huang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2022.109003_bib62","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1080\/03009734.2020.1802375","article-title":"Prevalence and risk factors for age-related cataract in Sweden","volume":"125","author":"Hugosson","year":"2020","journal-title":"Ups. J. Med. Sci."},{"key":"10.1016\/j.exer.2022.109003_bib63","doi-asserted-by":"crossref","DOI":"10.3390\/nu13072222","article-title":"The role of micronutrients in ageing Asia: what can Be implemented with the existing insights","volume":"13","author":"Inui","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.exer.2022.109003_bib64","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.preteyeres.2015.02.002","article-title":"Crystalline lens and refractive development","volume":"47","author":"Iribarren","year":"2015","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2022.109003_bib65","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1016\/j.bbamem.2016.06.026","article-title":"The lipidation profile of aquaporin-0 correlates with the acyl composition of phosphoethanolamine lipids in lens membranes","volume":"1858","author":"Ismail","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exer.2022.109003_bib66","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/s41433-020-0962-5","article-title":"Associations between cataract and multimorbidity: a cross-sectional study of 23,089 adults from Spain","volume":"35","author":"Jacob","year":"2021","journal-title":"Eye"},{"key":"10.1016\/j.exer.2022.109003_bib67","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1080\/07853890.2021.1928275","article-title":"Effects of hormone replacement therapy on lens opacity, serum inflammatory cytokines, and antioxidant levels","volume":"53","author":"Jee","year":"2021","journal-title":"Ann. Med."},{"key":"10.1016\/j.exer.2022.109003_bib68","doi-asserted-by":"crossref","first-page":"4986","DOI":"10.1167\/iovs.18-25067","article-title":"Lens epithelial cells initiate an inflammatory response following cataract surgery","volume":"59","author":"Jiang","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109003_bib69","doi-asserted-by":"crossref","first-page":"7029","DOI":"10.1167\/iovs.15-18047","article-title":"Distribution of the crystalline lens power in vivo as a function of age","volume":"56","author":"Jongenelen","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109003_bib70","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1089\/jop.2014.0016","article-title":"Topical nutraceutical Optixcare EH ameliorates experimental ocular oxidative stress in rats","volume":"30","author":"Kador","year":"2014","journal-title":"J. Ocul. Pharmacol. Therapeut."},{"key":"10.1016\/j.exer.2022.109003_bib71","doi-asserted-by":"crossref","first-page":"16898","DOI":"10.1038\/s41598-020-73625-9","article-title":"Three-dimensional data capture and analysis of intact eye lenses evidences emmetropia-associated changes in epithelial cell organization","volume":"10","author":"Kalligeraki","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2022.109003_bib72","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2174\/0929866525666171229230611","article-title":"Interaction of Cu+2 with \u03b1-crystallin: a biophysical and mass spectrometric study","volume":"25","author":"Karmakar","year":"2018","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.exer.2022.109003_bib73","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.cell.2019.08.033","article-title":"Long-distance cooperative and antagonistic RNA polymerase dynamics via DNA supercoiling","volume":"179","author":"Kim","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.exer.2022.109003_bib74","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0022-4731(87)90342-6","article-title":"Characterization and biological relevance of a 29-kDa, oestrogen receptor-related protein","volume":"27","author":"King","year":"1987","journal-title":"J. Steroid Biochem."},{"key":"10.1016\/j.exer.2022.109003_bib75","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1001\/archopht.1994.01090130095025","article-title":"Is there evidence of an estrogen effect on age-related lens opacities? The Beaver Dam Eye Study","volume":"112","author":"Klein","year":"1994","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109003_bib76","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19103093","article-title":"Roles of TGF \u03b2 and FGF signals in the lens: tropomyosin regulation for posterior capsule opacity","volume":"19","author":"Kubo","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2022.109003_bib77","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1463-5224.2006.00506.x","article-title":"Quantitative analysis of animal model lens anatomy: accommodative range is related to fiber structure and organization","volume":"9","author":"Kuszak","year":"2006","journal-title":"Vet. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109003_bib78","first-page":"251","article-title":"Computer modeling of secondary fiber development and growth: I. Nonprimate lenses","volume":"12","author":"Kuszak","year":"2006","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2022.109003_bib79","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.exer.2003.09.016","article-title":"Fibre cell organization in crystalline lenses","volume":"78","author":"Kuszak","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109003_bib80","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147576","article-title":"Age and smoking related changes in metal ion levels in human lens: implications for cataract formation","volume":"11","author":"Langford-Smith","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2022.109003_bib81","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1600-0420.1997.tb00398.x","article-title":"Inflammatory response after endocapsular phacoemulsification or conventional extracapsular lens extraction in the rabbit eye","volume":"75","author":"Laurell","year":"1997","journal-title":"Acta Ophthalmol. Scand."},{"key":"10.1016\/j.exer.2022.109003_bib82","doi-asserted-by":"crossref","first-page":"12719","DOI":"10.1074\/jbc.RA118.003075","article-title":"Membrane-associated androgen receptor (AR) potentiates its transcriptional activities by activating heat shock protein 27 (HSP27)","volume":"293","author":"Li","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2022.109003_bib83","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.18632\/oncotarget.12275","article-title":"Immune cells in liver regeneration","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.exer.2022.109003_bib84","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2021.767696","article-title":"Protein and water distribution across visual Axis in mouse lens: a confocal Raman MicroSpectroscopic study for cold cataract","volume":"9","author":"Li","year":"2021","journal-title":"Front. Chem."},{"key":"10.1016\/j.exer.2022.109003_bib85","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/cm.970090104","article-title":"Actin filament patterns in mouse lens epithelium: a study of the effects of aging, injury, and genetics","volume":"9","author":"Liou","year":"1988","journal-title":"Cell Motil Cytoskeleton"},{"key":"10.1016\/j.exer.2022.109003_bib86","doi-asserted-by":"crossref","first-page":"10031","DOI":"10.1038\/s41598-020-66642-1","article-title":"In- vivo anterior segment OCT imaging provides unique insight into cerulean blue-dot opacities and cataracts in Down syndrome","volume":"10","author":"Little","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2022.109003_bib87","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202002154","article-title":"Mechanosensitive collaboration between integrins and connexins allows nutrient and antioxidant transport into the lens","volume":"219","author":"Liu","year":"2020","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.exer.2022.109003_bib88","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.21037\/atm-2019-rcs-03","article-title":"Lens regeneration in humans: using regenerative potential for tissue repairing","volume":"8","author":"Liu","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.exer.2022.109003_bib89","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.exer.2016.05.026","article-title":"Solar ultraviolet radiation cataract","volume":"156","author":"L\u00f6fgren","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109003_bib90","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1177\/1535370219867296","article-title":"Microtubules: evolving roles and critical cellular interactions","volume":"244","author":"Logan","year":"2019","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.exer.2022.109003_bib91","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/s41576-021-00370-8","article-title":"Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics","volume":"22","author":"Longo","year":"2021","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.exer.2022.109003_bib92","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ydbio.2011.06.036","article-title":"Periaxin is required for hexagonal geometry and membrane organization of mature lens fibers","volume":"357","author":"Maddala","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.exer.2022.109003_bib93","doi-asserted-by":"crossref","first-page":"C115","DOI":"10.1152\/ajpcell.00111.2015","article-title":"Ankyrin-B directs membrane tethering of periaxin and is required for maintenance of lens fiber cell hexagonal shape and mechanics","volume":"310","author":"Maddala","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.exer.2022.109003_bib94","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12886-017-0443-1","article-title":"Prevention and reversal of selenite-induced cataracts by N-acetylcysteine amide in Wistar rats","volume":"17","author":"Maddirala","year":"2017","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.exer.2022.109003_bib95","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1074\/jbc.M111.309047","article-title":"Structural and mechanistic implications of metal binding in the small heat-shock protein \u03b1B-crystallin","volume":"287","author":"Mainz","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2022.109003_bib96","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1167\/iovs.61.4.11","article-title":"Age-related changes to the three-dimensional full shape of the isolated human crystalline lens","volume":"61","author":"Martinez-Enriquez","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109003_bib97","doi-asserted-by":"crossref","DOI":"10.1007\/s00232-007-9019-y","article-title":"The lens circulation","author":"Mathias","year":"2007","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.exer.2022.109003_bib98","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.200322","article-title":"Brain and testis: more alike than previously thought?","volume":"11","author":"Matos","year":"2021","journal-title":"Open Biol."},{"key":"10.1016\/j.exer.2022.109003_bib99","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2021.100138","article-title":"Trapped ion mobility spectrometry and parallel accumulation- serial fragmentation in proteomics","volume":"20","author":"Meier","year":"2021","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.exer.2022.109003_bib100","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.exer.2013.11.016","article-title":"Absence of amyloid-beta in lenses of Alzheimer patients: a confocal Raman microspectroscopic study","volume":"119","author":"Michael","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109003_bib159","first-page":"169","article-title":"Reorganisation of the microtubule cytoskeleton and centrosomal loss during lens fibre cell differentiation","volume":"299","author":"Millar","year":"1997","journal-title":"Nova Acta Leopoldiana"},{"key":"10.1016\/j.exer.2022.109003_bib101","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/S0042-6989(02)00078-0","article-title":"Age-related changes in refractive index distribution and power of the human lens as measured by magnetic resonance micro-imaging in vitro","volume":"42","author":"Moffat","year":"2002","journal-title":"Vis. Res."},{"key":"10.1016\/j.exer.2022.109003_bib102","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/00006324-200203000-00008","article-title":"Explanation of the lens paradox","volume":"79","author":"Moffat","year":"2002","journal-title":"Optom. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109003_bib103","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1080\/02713683.2017.1343852","article-title":"Natural course of posterior subcapsular cataract over a short time period","volume":"42","author":"Neumayer","year":"2017","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2022.109003_bib104","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/ggi.14051","article-title":"Multimorbidity patterns, all-cause mortality and healthy aging in older English adults: results from the English Longitudinal Study of Aging","volume":"20","author":"Nguyen","year":"2020","journal-title":"Geriatr. Gerontol. Int."},{"key":"10.1016\/j.exer.2022.109003_bib105","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1007\/BF03401759","article-title":"Increased levels of advanced glycation endproducts in the lenses and blood vessels of cigarette smokers","volume":"4","author":"Nicholl","year":"1998","journal-title":"Mol. Med."},{"key":"10.1016\/j.exer.2022.109003_bib106","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.2169\/internalmedicine.56.8231","article-title":"Werner syndrome and diabetes mellitus accompanied by adrenal cortex cancer","volume":"56","author":"Nishioka","year":"2017","journal-title":"Intern. Med."},{"key":"10.1016\/j.exer.2022.109003_bib107","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1006\/bbrc.1999.0841","article-title":"Lens proteins block the copper-mediated formation of reactive oxygen species during glycation reactions in vitro","volume":"259","author":"Ortwerth","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2022.109003_bib108","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1038\/s42255-021-00466-9","article-title":"Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice","volume":"3","author":"Pak","year":"2021","journal-title":"Nat. Metabol."},{"key":"10.1016\/j.exer.2022.109003_bib109","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1136\/bjo.68.2.113","article-title":"Nuclear cataract and myopia during hyperbaric oxygen therapy","volume":"68","author":"Palmquist","year":"1984","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109003_bib110","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1097\/GME.0000000000000887","article-title":"Timing of first childbirth and age-related cataract","volume":"24","author":"Park","year":"2017","journal-title":"Menopause"},{"key":"10.1016\/j.exer.2022.109003_bib111","first-page":"22","article-title":"Iron homeostasis disorder and Alzheimer's disease","author":"Peng","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2022.109003_bib112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yexcr.2004.11.021","article-title":"Seeing is believing! the optical properties of the eye lens are dependent upon a functional intermediate filament cytoskeleton","volume":"305","author":"Perng","year":"2005","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.exer.2022.109003_bib113","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1016\/j.yexcr.2007.04.005","article-title":"Insights into the beaded filament of the eye lens","volume":"313","author":"Perng","year":"2007","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.exer.2022.109003_bib114","article-title":"Shaping an optical dome: the size and shape of the insect compound eye","author":"Pichaud","year":"2021","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.exer.2022.109003_bib115","first-page":"634","article-title":"Color and solubility of the proteins of human cataracts","volume":"7","author":"Pirie","year":"1968","journal-title":"Invest. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109003_bib116","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.bbamem.2017.10.020","article-title":"Is the cholesterol bilayer domain a barrier to oxygen transport into the eye lens?","volume":"1860","author":"Plesnar","year":"2018","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.exer.2022.109003_bib118","first-page":"65","article-title":"Metabolism and function of glutathione in the lens","volume":"106","author":"Reddy","year":"1984","journal-title":"Ciba Found. Symp."},{"key":"10.1016\/j.exer.2022.109003_bib119","doi-asserted-by":"crossref","first-page":"6778","DOI":"10.1038\/s41467-021-26842-3","article-title":"An atlas of protein turnover rates in mouse tissues","volume":"12","author":"Rolfs","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2022.109003_bib120","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1021\/acs.biochem.0c00293","article-title":"Human \u03b3s-crystallin-copper binding helps buffer against aggregation caused by oxidative damage","volume":"59","author":"Roskamp","year":"2020","journal-title":"Biochemistry"},{"key":"10.1016\/j.exer.2022.109003_bib121","doi-asserted-by":"crossref","first-page":"4505","DOI":"10.1021\/acs.biochem.9b00507","article-title":"Divalent cations and the divergence of \u03b2\u03b3-crystallin function","volume":"58","author":"Roskamp","year":"2019","journal-title":"Biochemistry"},{"key":"10.1016\/j.exer.2022.109003_bib122","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0014-4835(02)00330-5","article-title":"Knockout of the intermediate filament protein CP49 destabilises the lens fibre cell cytoskeleton and decreases lens optical quality, but does not induce cataract","volume":"76","author":"Sandilands","year":"2003","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109003_bib123","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.exer.2003.09.028","article-title":"Bfsp2 mutation found in mouse 129 strains causes the loss of CP49' and induces vimentin-dependent changes in the lens fibre cell cytoskeleton","volume":"78","author":"Sandilands","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109003_bib124","first-page":"544","article-title":"TEMPOL protects against lens DNA strand breaks and cataract in the x-rayed rabbit","volume":"39","author":"Sasaki","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109003_bib125","first-page":"1473","article-title":"Transition metal- catalyzed oxidation of ascorbate in human cataract extracts: possible role of advanced glycation end products","volume":"41","author":"Saxena","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109003_bib126","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.1364\/BOE.8.004172","article-title":"Crystalline lens paradoxes revisited: significance of age-related restructuring of the GRIN","volume":"8","author":"Sheil","year":"2017","journal-title":"Biomed. Opt Express"},{"key":"10.1016\/j.exer.2022.109003_bib127","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1242\/jcs.045203","article-title":"The stratified syncytium of the vertebrate lens","volume":"122","author":"Shi","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.exer.2022.109003_bib128","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1080\/03007995.2019.1647012","article-title":"Cataract surgeon viewpoints on the need for novel preventative anti-inflammatory and anti-posterior capsular opacification therapies","volume":"35","author":"Shihan","year":"2019","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.exer.2022.109003_bib129","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10384-019-00700-8","article-title":"Association between axial length and in vivo human crystalline lens biometry during accommodation: a swept-source optical coherence tomography study","volume":"64","author":"Shoji","year":"2020","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109003_bib130","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.survophthal.2019.03.003","article-title":"The potential role of nutrition on lens pathology: a systematic review and meta-analysis","volume":"64","author":"Sideri","year":"2019","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109003_bib158","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.exer.2022.109003_bib131","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s12886-016-0392-0","article-title":"Oestradiol levels and superoxide dismutase activity in age-related cataract: a case-control study","volume":"16","author":"\u0160kilji\u0107","year":"2016","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.exer.2022.109003_bib132","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/pro.2229","article-title":"Evolution of crystallins for a role in the vertebrate eye lens","volume":"22","author":"Slingsby","year":"2013","journal-title":"Protein Sci."},{"key":"10.1016\/j.exer.2022.109003_bib133","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1172\/JCI38277","article-title":"Functions of the intermediate filament cytoskeleton in the eye lens","volume":"119","author":"Song","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exer.2022.109003_bib134","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4161\/org.7.3.18421","article-title":"Planar cell polarity in the mammalian eye lens","volume":"7","author":"Sugiyama","year":"2011","journal-title":"Organogenesis"},{"key":"10.1016\/j.exer.2022.109003_bib135","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mod.2016.01.003","article-title":"Non-essential role for cilia in coordinating precise alignment of lens fibres","volume":"139","author":"Sugiyama","year":"2016","journal-title":"Mech. Dev."},{"key":"10.1016\/j.exer.2022.109003_bib136","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1093\/gerona\/62.7.774","article-title":"Morbidity of Tokyo-area centenarians and its relationship to functional status","volume":"62","author":"Takayama","year":"2007","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.exer.2022.109003_bib137","first-page":"22","article-title":"miRNA-signature of irradiated Ptch1+\/- mouse lens is dependent on genetic background","volume":"197","author":"Tanno","year":"2022","journal-title":"Radiat. Res."},{"key":"10.1016\/j.exer.2022.109003_bib138","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1021\/jasms.0c00439","article-title":"Spatially resolved mass spectrometry at the single cell: recent innovations in proteomics and metabolomics","volume":"32","author":"Taylor","year":"2021","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.exer.2022.109003_bib139","first-page":"1396","article-title":"Morphology of the normal human lens","volume":"37","author":"Taylor","year":"1996","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109003_bib140","doi-asserted-by":"crossref","first-page":"M89","DOI":"10.1167\/iovs.18-25965","article-title":"IMI - myopia genetics report","volume":"60","author":"Tedja","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109003_bib141","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s12920-019-0560-1","article-title":"Analysis of genetic networks regulating refractive eye development in collaborative cross progenitor strain mice reveals new genes and pathways underlying human myopia","volume":"12","author":"Tkatchenko","year":"2019","journal-title":"BMC Med. Genom."},{"key":"10.1016\/j.exer.2022.109003_bib142","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1016\/j.ygeno.2021.06.021","article-title":"Genetic network regulating visual acuity makes limited contribution to visually guided eye emmetropization","volume":"113","author":"Tkatchenko","year":"2021","journal-title":"Genomics"},{"key":"10.1016\/j.exer.2022.109003_bib143","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s12920-021-01005-x","article-title":"Genome-wide analysis of retinal transcriptome reveals common genetic network underlying perception of contrast and optical defocus detection","volume":"14","author":"Tkatchenko","year":"2021","journal-title":"BMC Med. Genom."},{"key":"10.1016\/j.exer.2022.109003_bib144","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2006021","article-title":"Gene expression in response to optical defocus of opposite signs reveals bidirectional mechanism of visually guided eye growth","volume":"16","author":"Tkatchenko","year":"2018","journal-title":"PLoS Biol."},{"key":"10.1016\/j.exer.2022.109003_bib145","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1080\/15548627.2021.1894058","article-title":"TDRD7 participates in lens development and spermiogenesis by mediating autophagosome maturation","volume":"17","author":"Tu","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.exer.2022.109003_bib146","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.mrrev.2019.02.004","article-title":"Cataractogenic load - a concept to study the contribution of ionizing radiation to accelerated aging in the eye lens","volume":"779","author":"Uwineza","year":"2019","journal-title":"Mutat. Res."},{"key":"10.1016\/j.exer.2022.109003_bib147","doi-asserted-by":"crossref","first-page":"R994","DOI":"10.1152\/ajpregu.00180.2018","article-title":"The lens internal microcirculation system delivers solutes to the lens core faster than would be predicted by passive diffusion","volume":"315","author":"Vaghefi","year":"2018","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.exer.2022.109003_bib148","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1001\/archopht.1952.01700030313005","article-title":"Experimental studies on early lens changes after roentgen irradiation. III. Effect of x-radiation on mitotic activity and nuclear fragmentation of lens epithelium in normal and cysteine-treated rabbits","volume":"47","author":"Von Sallmann","year":"1952","journal-title":"A.M.A. Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109003_bib149","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.tcb.2021.02.008","article-title":"Mechanical regulation of transcription: recent advances","volume":"31","author":"Wagh","year":"2021","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.exer.2022.109003_bib150","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2021.145893","article-title":"Effect of glycolysis and heat shock proteins on hypoxia adaptation of Tibetan sheep at different altitude","volume":"803","author":"Wen","year":"2021","journal-title":"Gene"},{"key":"10.1016\/j.exer.2022.109003_bib151","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.56344","article-title":"A 10-year follow-up study of sex inclusion in the biological sciences","volume":"9","author":"Woitowich","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.exer.2022.109003_bib152","first-page":"559","article-title":"Cortical cataract development--an expression of primary damage to the lens epithelium","volume":"6","author":"Worgul","year":"1989","journal-title":"Lens Eye Toxic. Res."},{"key":"10.1016\/j.exer.2022.109003_bib153","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1001\/archinte.161.11.1448","article-title":"Postmenopausal estrogen use, type of menopause, and lens opacities: the Framingham studies","volume":"161","author":"Worzala","year":"2001","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.exer.2022.109003_bib154","article-title":"Association of OGG1 and MTHFR polymorphisms with age-related cataract: a systematic review and meta-analysis","volume":"12","author":"Wu","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2022.109003_bib155","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s12192-013-0420-4","article-title":"Genetic polymorphisms of HSP70 in age- related cataract","volume":"18","author":"Zhang","year":"2013","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.exer.2022.109003_bib156","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.ophtha.2011.11.004","article-title":"Genetic polymorphisms in DNA repair genes OGG1, APE1, XRCC1, and XPD and the risk of age-related cataract","volume":"119","author":"Zhang","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2022.109003_bib157","first-page":"2325","article-title":"Genetic polymorphisms of superoxide dismutases, catalase, and glutathione peroxidase in age-related cataract","volume":"17","author":"Zhang","year":"2011","journal-title":"Mol. Vis."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483522000847?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483522000847?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:21:01Z","timestamp":1758000061000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483522000847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":159,"alternative-id":["S0014483522000847"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2022.109003","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The eye lens as an aging paradigm par excellence","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2022.109003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109003"}}