{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:55:41Z","timestamp":1792644941704,"version":"4.5.0"},"reference-count":399,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.exer.2022.109101","type":"journal-article","created":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T09:37:25Z","timestamp":1651397845000},"page":"109101","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":100,"special_numbering":"C","title":["Biochemistry of human tear film: A review"],"prefix":"10.1016","volume":"220","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9875-3849","authenticated-orcid":false,"given":"Simin","family":"Masoudi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2022.109101_bib1","first-page":"529","article-title":"Concentrations of MUC16 and MUC5AC using three tear collection methods","volume":"23","author":"Ablamowicz","year":"2017","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2022.109101_bib2","doi-asserted-by":"crossref","first-page":"8285","DOI":"10.1167\/iovs.13-12235","article-title":"Tear MMP-9 levels as a marker of ocular surface inflammation in conjunctivochalasis","volume":"54","author":"Acera","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00417-002-0607-3","article-title":"Diurnal variation in group IIa phospholipase A2 content in tears of contact lens wearers and normal controls","volume":"241","author":"Aho","year":"2003","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib4","series-title":"Albert & Jakobiec's Principles and Practice of Ophthalmology","author":"Albert","year":"2008"},{"key":"10.1016\/j.exer.2022.109101_bib5","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.clae.2019.07.007","article-title":"The relationship between tear film MMP-9 and meibomian gland changes during soft contact lens wear","volume":"43","author":"Alghamdi","year":"2020","journal-title":"Contact Lens Anterior Eye"},{"key":"10.1016\/j.exer.2022.109101_bib6","first-page":"1","article-title":"Bio-chemical markers of chronic, non-infectious disease in the human tear film","author":"Alotaibi","year":"2021","journal-title":"Clin. Exp. Optom. : J. Aust. Optometrical Assoc."},{"key":"10.1016\/j.exer.2022.109101_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051979","article-title":"Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome","volume":"7","author":"Aluru","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2022.109101_bib8","volume":"vol. 10","author":"\u00c1lvarez-Barrios","year":"2021"},{"key":"10.1016\/j.exer.2022.109101_bib9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.5935\/0004-2749.20140050","article-title":"Is dry eye an environmental disease?","volume":"77","author":"Alves","year":"2014","journal-title":"Arq. Bras. Oftalmol."},{"key":"10.1016\/j.exer.2022.109101_bib10","doi-asserted-by":"crossref","first-page":"11296","DOI":"10.1038\/s41598-018-29568-3","article-title":"Tear eicosanoids in healthy people and ocular surface disease","volume":"8","author":"Ambaw","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2022.109101_bib11","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0021-5155(00)00161-1","article-title":"The eye and nutrition","volume":"44","author":"Amemiya","year":"2000","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib12","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/978-94-009-9609-0_38","article-title":"Enzymatic activities found in human tears","volume":"18","author":"Anderson","year":"1979","journal-title":"Progr. Anterior Eye Segment Res. Practi, SpringerLink"},{"key":"10.1016\/j.exer.2022.109101_bib13","first-page":"173","volume":"vol. 123","author":"Andriantsitohaina","year":"2012"},{"key":"10.1016\/j.exer.2022.109101_bib14","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1373\/49.7.1041","article-title":"Ion suppression in mass spectrometry","volume":"49","author":"Annesley","year":"2003","journal-title":"Clin. Chem."},{"key":"10.1016\/j.exer.2022.109101_bib15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2174\/157489110791233559","article-title":"Surfactant protein (SP)-A and SP-D as antimicrobial and immunotherapeutic agents","volume":"5","author":"Awasthi","year":"2010","journal-title":"Recent Pat. Anti-Infect. Drug Discov."},{"key":"10.1016\/j.exer.2022.109101_bib16","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jprot.2016.05.006","article-title":"Human tear proteomics and peptidomics in ophthalmology: toward the translation of proteomic biomarkers into clinical practice","volume":"150","author":"Azkargorta","year":"2017","journal-title":"J. Proteonomics"},{"key":"10.1016\/j.exer.2022.109101_bib17","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1373\/clinchem.2006.078543","article-title":"Mass spectral determination of fasting tear glucose concentrations in nondiabetic volunteers","volume":"53","author":"Baca","year":"2007","journal-title":"Clin. Chem."},{"key":"10.1016\/j.exer.2022.109101_bib18","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.exer.2011.12.010","article-title":"Levels of lactoferrin, secretory IgA and serum albumin in the tear film of people with keratoconus","volume":"96","author":"Balasubramanian","year":"2012","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib19","series-title":"Stress Biomarkers in the Tear Film","author":"Banbury","year":"2009"},{"key":"10.1016\/j.exer.2022.109101_bib20","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1167\/iovs.17-23198","article-title":"Substance P modulation of human and murine corneal neovascularization","volume":"59","author":"Barbariga","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s10753-010-9210-7","article-title":"Calgranulin B (S100A9\/MRP14): a key molecule in idiopathic pulmonary fibrosis?","volume":"34","author":"Bargagli","year":"2011","journal-title":"Inflammation"},{"key":"10.1016\/j.exer.2022.109101_bib22","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jtos.2013.07.003","article-title":"Role of hyperosmolarity in the pathogenesis and management of dry eye disease: proceedings of the OCEAN group meeting","volume":"11","author":"Baudouin","year":"2013","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2022.109101_bib23","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1097\/00003226-200108000-00011","article-title":"Characterization of ocular surface symptoms from optometric practices in north America","volume":"20","author":"Begley","year":"2001","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2022.109101_bib24","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.oftal.2016.12.009","article-title":"Determination of inmune response and inflammation mediators in tears: changes in dry eye and glaucoma as compared to healthy controls","volume":"92","author":"Benitez-Del-Castillo S\u00e1nchez","year":"2017","journal-title":"Arch. Soc. Esp. Oftalmol."},{"key":"10.1016\/j.exer.2022.109101_bib25","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1159\/000510211","article-title":"Tear 1H nuclear magnetic resonance-based metabolomics application to the molecular diagnosis of aqueous tear deficiency and meibomian gland dysfunction","volume":"64","author":"Ben\u00edtez Del Castillo","year":"2021","journal-title":"Ophthalmic Res."},{"key":"10.1016\/j.exer.2022.109101_bib26","doi-asserted-by":"crossref","first-page":"S203","DOI":"10.1016\/S1542-0124(12)70256-2","article-title":"Neurogenic inflammation: a first line of defense for the ocular surface","volume":"3","author":"Beuerman","year":"2005","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2022.109101_bib27","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/BF00186580","article-title":"Collectionand concentration of tear proteins studied by SDS gel electrophoresis. Presentation of a new method with special reference to dry eye patients","volume":"232","author":"Bjerrum","year":"1994","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib28","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1167\/iovs.07-1081","article-title":"Release of membrane-associated mucins from ocular surface epithelia","volume":"49","author":"Blalock","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib29","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1021\/acs.langmuir.8b04182","article-title":"Investigating the role of specific tear film lipids connected to dry eye syndrome: a study on O-Acyl-\u03c9-hydroxy fatty acids and diesters","volume":"35","author":"Bland","year":"2019","journal-title":"Langmuir"},{"key":"10.1016\/j.exer.2022.109101_bib30","first-page":"20","article-title":"Meibum lipid composition and conformation in parkinsonism","volume":"12","author":"Blinchevsky","year":"2021","journal-title":"EC Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib31","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3892\/or.2012.1849","article-title":"Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach","volume":"28","author":"B\u00f6hm","year":"2012","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.exer.2022.109101_bib32","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.jtos.2019.02.005","article-title":"The optimum temperature for the heat therapy for meibomian gland dysfunction","volume":"17","author":"Borchman","year":"2019","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2022.109101_bib33","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1167\/iovs.10-6514","article-title":"Human meibum lipid conformation and thermodynamic changes with meibomian-gland dysfunction","volume":"52","author":"Borchman","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib34","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.chemphyslip.2007.04.001","article-title":"Spectroscopic evaluation of human tear lipids","volume":"147","author":"Borchman","year":"2007","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.exer.2022.109101_bib35","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/ICO.0000000000002095","article-title":"Differences in meibum and tear lipid composition and conformation","volume":"39","author":"Borchman","year":"2020","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2022.109101_bib36","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.exer.2010.05.014","article-title":"Changes in human meibum lipid with meibomian gland dysfunction using principal component analysis","volume":"91","author":"Borchman","year":"2010","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib37","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.1167\/iovs.07-0201","article-title":"Detection of surfactant proteins A and D in human tear fluid and the human lacrimal system","volume":"48","author":"Br\u00e4uer","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib38","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev-fluid-120710-101042","article-title":"Dynamics of the tear film","volume":"44","author":"Braun","year":"2012","journal-title":"Annu. Rev. Fluid Mech."},{"key":"10.1016\/j.exer.2022.109101_bib39","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1515\/bmc-2012-0001","article-title":"The role of hyperosmotic stress in inflammation and disease","volume":"3","author":"Brocker","year":"2012","journal-title":"Biomol. Concepts"},{"key":"10.1016\/j.exer.2022.109101_bib40","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.exer.2003.09.019","article-title":"Functional aspects of the tear film lipid layer","volume":"78","author":"Bron","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib41","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.exer.2003.09.019","article-title":"Functional aspects of the tear film lipid layer","volume":"78","author":"Bron","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib42","doi-asserted-by":"crossref","first-page":"7417","DOI":"10.1167\/iovs.13-12916","article-title":"A comparison of patient matched meibum and tear lipidomes","volume":"54","author":"Brown","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib43","first-page":"1681","article-title":"Ascorbic acid content of human corneal epithelium","volume":"41","author":"Brubaker","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib44","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1194\/jlr.R900004-JLR200","article-title":"Thematic Review Series: proteomics. An integrated omics analysis of eicosanoid biology","volume":"50","author":"Buczynski","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.exer.2022.109101_bib45","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/head.13459","article-title":"Migraine progression: a systematic review","volume":"59","author":"Buse","year":"2019","journal-title":"Headache"},{"key":"10.1016\/j.exer.2022.109101_bib46","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1167\/iovs.08-1889","article-title":"On the lipid composition of human meibum and tears: comparative analysis of nonpolar lipids","volume":"49","author":"Butovich","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib47","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1194\/jlr.M800426-JLR200","article-title":"Cholesteryl esters as a depot for very long chain fatty acids in human meibum","volume":"50","author":"Butovich","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.exer.2022.109101_bib48","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.preteyeres.2009.07.002","article-title":"The Meibomian puzzle: combining pieces together","volume":"28","author":"Butovich","year":"2009","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib49","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.steroids.2010.04.011","article-title":"Fatty acid composition of cholesteryl esters of human meibomian gland secretions","volume":"75","author":"Butovich","year":"2010","journal-title":"Steroids"},{"key":"10.1016\/j.exer.2022.109101_bib50","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.exer.2013.05.010","article-title":"Tear film lipids","volume":"117","author":"Butovich","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib51","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1167\/iovs.13-13355","article-title":"Biophysical and morphological evaluation of human normal and dry eye meibum using hot stage polarized light microscopy","volume":"55","author":"Butovich","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib52","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1006\/abbi.2000.1816","article-title":"Oxidation of linoleyl alcohol by potato tuber lipoxygenase: kinetics and positional, stereo, and geometrical (cis, trans) specificity of the reaction","volume":"378","author":"Butovich","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.exer.2022.109101_bib53","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1080\/02713680802018419","article-title":"Understanding and analyzing meibomian lipids-a review","volume":"33","author":"Butovich","year":"2008","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib54","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0167-4838(01)00162-5","article-title":"Enzyme-catalyzed and enzyme-triggered pathways in dioxygenation of 1-monolinoleoyl-rac-glycerol by potato tuber lipoxygenase","volume":"1546","author":"Butovich","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exer.2022.109101_bib55","doi-asserted-by":"crossref","first-page":"108189","DOI":"10.1016\/j.exer.2020.108189","article-title":"Delineating a novel metabolic high triglycerides-low waxes syndrome that affects lipid homeostasis in meibomian and sebaceous glands","volume":"199","author":"Butovich","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib56","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1194\/jlr.M700237-JLR200","article-title":"Lipids of human meibum: mass-spectrometric analysis and structural elucidation","volume":"48","author":"Butovich","year":"2007","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.exer.2022.109101_bib57","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1194\/jlr.M900252-JLR200","article-title":"Human tear film and meibum. Very long chain wax esters and (O-acyl)-omega-hydroxy fatty acids of meibum","volume":"50","author":"Butovich","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.exer.2022.109101_bib58","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/OPX.0b013e318181ae4f","article-title":"Tear lipocalin and lysozyme in Sjogren and non-Sjogren dry eye","volume":"85","author":"Caffery","year":"2008","journal-title":"Optom. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib59","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1379\/CSC-270.1","article-title":"Oxidative stress and cellular stress response in diabetic nephropathy","volume":"12","author":"Calabrese","year":"2007","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.exer.2022.109101_bib60","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1615\/CritRevBiomedEng.2019026109","article-title":"Toward a label-free electrochemical impedance immunosensor design for quantifying cortisol in tears","volume":"47","author":"Cardinell","year":"2019","journal-title":"Crit. Rev. Biomed. Eng."},{"key":"10.1016\/j.exer.2022.109101_bib61","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.fct.2012.09.021","article-title":"A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives","volume":"51","author":"Carocho","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.exer.2022.109101_bib62","doi-asserted-by":"crossref","first-page":"e250","DOI":"10.1111\/j.1755-3768.2010.01978.x","article-title":"Cytokine and chemokine levels in tears from healthy subjects","volume":"88","author":"Carre\u00f1o","year":"2010","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib63","doi-asserted-by":"crossref","DOI":"10.1167\/iovs.13-12993","article-title":"Preface: the aging eye: normal changes, age-related diseases, and sight-saving approaches","volume":"54","author":"Chader","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib64","series-title":"Biochemistry, Tear Film, StatPearls","author":"Chang","year":"2021"},{"key":"10.1016\/j.exer.2022.109101_bib66","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jtos.2019.02.004","article-title":"Untargeted lipidomic analysis of human tears: a new approach for quantification of O-acyl-omega hydroxy fatty acids","volume":"17","author":"Chen","year":"2019","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2022.109101_bib67","doi-asserted-by":"crossref","first-page":"4876","DOI":"10.1021\/pr2004874","article-title":"Characterization of the human tear metabolome by LC-MS\/MS","volume":"10","author":"Chen","year":"2011","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.exer.2022.109101_bib68","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S1542-0124(12)70185-4","article-title":"Antioxidant defenses in the ocular surface","volume":"7","author":"Chen","year":"2009","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2022.109101_bib69","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jtos.2013.10.004","article-title":"Ocular surface concepts: development and citation","volume":"12","author":"Cher","year":"2014","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2022.109101_bib70","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.4155\/bio-2018-0173","article-title":"Quantification of eicosanoids and their metabolites in biological matrices: a review","volume":"10","author":"Chhonker","year":"2018","journal-title":"Bioanalysis"},{"key":"10.1016\/j.exer.2022.109101_bib71","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/nn.3144","article-title":"Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology","volume":"15","author":"Chiu","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.exer.2022.109101_bib72","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1167\/iovs.08-2476","article-title":"Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome","volume":"50","author":"Chotikavanich","year":"2009","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib73","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1076\/ceyr.27.2.55.15458","article-title":"Antioxidants in tears and plasma: inter-relationships and effect of vitamin C supplementation","volume":"27","author":"Choy","year":"2003","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib74","first-page":"3293","article-title":"Ascorbic acid concentration and total antioxidant activity of human tear fluid measured using the FRASC assay","volume":"41","author":"Choy","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib75","first-page":"3130","article-title":"Water-soluble antioxidants in human tears: effect of the collection method","volume":"42","author":"Choy","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib76","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1097\/01.jom.0000171056.22917.ad","article-title":"Associations between dimensions of job stress and biomarkers of inflammation and infection","volume":"47","author":"Clays","year":"2005","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.exer.2022.109101_bib77","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1046\/j.1365-2249.2001.01408.x","article-title":"Tears contain the complement regulator CD59 as well as decay-accelerating factor (DAF)","volume":"123","author":"Cocuzzi","year":"2001","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.exer.2022.109101_bib78","doi-asserted-by":"crossref","first-page":"945","DOI":"10.4049\/jimmunol.0900921","article-title":"Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells","volume":"183","author":"Costantino","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.exer.2022.109101_bib79","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II definition and classification report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2022.109101_bib80","doi-asserted-by":"crossref","first-page":"Tfos123","DOI":"10.1167\/iovs.13-13235","article-title":"The TFOS International Workshop on Contact Lens Discomfort: report of the contact lens interactions with the tear film subcommittee","volume":"54","author":"Craig","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib81","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1089\/jop.1991.7.253","article-title":"Antioxidant enzymes in human tears","volume":"7","author":"Crouch","year":"1991","journal-title":"J. Ocul. Pharmacol."},{"key":"10.1016\/j.exer.2022.109101_bib82","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.jcrs.2008.02.024","article-title":"Plasminogen activator inhibitor in human tears after laser refractive surgery","volume":"34","author":"Csutak","year":"2008","journal-title":"J. Cataract Refract. Surg."},{"key":"10.1016\/j.exer.2022.109101_bib83","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1016\/j.bbamem.2016.02.020","article-title":"Tear film lipid layer: a molecular level view","volume":"1858","author":"Cwiklik","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exer.2022.109101_bib84","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40662-014-0006-y","article-title":"Practical issues concerning tear protein assays in dry eye","volume":"1","author":"D'Souza","year":"2014","journal-title":"Eye and vision (London, England)"},{"key":"10.1016\/j.exer.2022.109101_bib85","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1006\/exer.2001.1076","article-title":"Regulation of lacrimal gland secretion by neurotransmitters and the EGF family of growth factors","volume":"73","author":"Dartt","year":"2001","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib86","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S1542-0124(11)70022-2","article-title":"Tear lipocalin: structure and function","volume":"9","author":"Dartt","year":"2011","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2022.109101_bib87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exer.2013.10.008","article-title":"Complexity of the tear film: importance in homeostasis and dysfunction during disease","volume":"117","author":"Dartt","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib88","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1463-5224.2004.00325.x","article-title":"The tear film and ocular mucins","volume":"7","author":"Davidson","year":"2004","journal-title":"Vet. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib89","doi-asserted-by":"crossref","first-page":"R72","DOI":"10.1186\/gb-2006-7-8-r72","article-title":"Identification of 491 proteins in the tear fluid proteome reveals a large number of proteases and protease inhibitors","volume":"7","author":"de Souza","year":"2006","journal-title":"Genome Biol."},{"key":"10.1016\/j.exer.2022.109101_bib90","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1167\/iovs.11-9419","article-title":"Mass spectrometric identification of phospholipids in human tears and tear lipocalin","volume":"53","author":"Dean","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib91","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1167\/iovs.11-9419","article-title":"Mass spectrometric identification of phospholipids in human tears and tear lipocalin","volume":"53","author":"Dean","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib92","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.jcrs.2010.12.037","article-title":"Anatomy and physiology of the cornea","volume":"37","author":"DelMonte","year":"2011","journal-title":"J. Cataract Refract. Surg."},{"key":"10.1016\/j.exer.2022.109101_bib93","doi-asserted-by":"crossref","first-page":"5088","DOI":"10.1039\/c2an35821b","article-title":"Post-collection processing of Schirmer strip-collected human tear fluid impacts protein content","volume":"137","author":"Denisin","year":"2012","journal-title":"Analyst"},{"key":"10.1016\/j.exer.2022.109101_bib94","first-page":"177","article-title":"Analysis of tear inflammatory mediators: a comparison between the microarray and Luminex methods","volume":"22","author":"Dionne","year":"2016","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2022.109101_bib95","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.clae.2010.12.001","article-title":"The effects of 2 week senofilcon-A silicone hydrogel contact lens daily wear on tear functions and ocular surface health status","volume":"34","author":"Dogru","year":"2011","journal-title":"Contact Lens Anterior Eye"},{"key":"10.1016\/j.exer.2022.109101_bib96","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/jemt.10296","article-title":"Intracellular and extracellular roles of S100 proteins","volume":"60","author":"Donato","year":"2003","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.exer.2022.109101_bib97","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2174\/156652413804486214","article-title":"Functions of S100 proteins","volume":"13","author":"Donato","year":"2013","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.exer.2022.109101_bib98","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3181\/00379727-202-43529","article-title":"Lacrimal gland uptake and metabolism of ascorbic acid","volume":"202","author":"Dreyer","year":"1993","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.exer.2022.109101_bib99","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.0022-202X.2004.22719.x","article-title":"S100 proteins in the epidermis","volume":"123","author":"Eckert","year":"2004","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.exer.2022.109101_bib100","doi-asserted-by":"crossref","first-page":"11044","DOI":"10.1038\/s41598-018-29411-9","article-title":"Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sj\u00f6gren's Syndrome patients","volume":"8","author":"Edman","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2022.109101_bib101","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1139\/o04-052","article-title":"S100 proteins and their influence on pro-survival pathways in cancer","volume":"82","author":"Emberley","year":"2004","journal-title":"Biochem. Cell Biol. = Biochimie et biologie cellulaire"},{"key":"10.1016\/j.exer.2022.109101_bib102","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1475-1313.2008.00603.x","article-title":"Tear sample collection using cellulose acetate absorbent filters","volume":"28","author":"Esmaeelpour","year":"2008","journal-title":"Ophthalmic Physiol. Opt."},{"key":"10.1016\/j.exer.2022.109101_bib103","doi-asserted-by":"crossref","first-page":"108137","DOI":"10.1016\/j.exer.2020.108137","article-title":"Composition, structure and function of the corneal stroma","volume":"198","author":"Espana","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib104","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.ajo.2013.03.001","article-title":"Why does the healthy cornea resist Pseudomonas aeruginosa infection?","volume":"155","author":"Evans","year":"2013","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib105","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1046\/j.1442-9071.2001.00408.x","article-title":"Lacryglobin in human tears, a potential marker for cancer","volume":"29","author":"Evans","year":"2001","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib106","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0014-4835(02)00276-2","article-title":"Utilization of lacrimal urea assay in the monitoring of hemodialysis: conditions, limitations and lacrimal arginase characterization","volume":"76","author":"Farkas","year":"2003","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib395","doi-asserted-by":"crossref","first-page":"8997","DOI":"10.3390\/ijms22168997","article-title":"Characterization of lipids in saliva, tears and minor salivary glands of Sj\u00f6gren\u2019s syndrome patients using an HPLC\/MS-based approach","volume":"22","author":"Fineide","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib107","first-page":"1779","article-title":"Expression of collagenolytic\/gelatinolytic metalloproteinases by normal cornea","volume":"31","author":"Fini","year":"1990","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib108","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1743-7075-7-30","article-title":"Role of carnitine in disease","volume":"7","author":"Flanagan","year":"2010","journal-title":"Nutr. Metabol."},{"key":"10.1016\/j.exer.2022.109101_bib109","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0167-4838(00)00169-2","article-title":"Beyond the superfamily: the lipocalin receptors","volume":"1482","author":"Flower","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exer.2022.109101_bib110","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1128\/AAC.48.9.3367-3372.2004","article-title":"Human tear lipocalin exhibits antimicrobial activity by scavenging microbial siderophores","volume":"48","author":"Fluckinger","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.exer.2022.109101_bib111","doi-asserted-by":"crossref","DOI":"10.3390\/nu13061998","article-title":"A review of topical and systemic vitamin supplementation in ocular surface diseases","volume":"13","author":"Fogagnolo","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.exer.2022.109101_bib112","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1016\/j.bbagen.2014.03.017","article-title":"Cysteine cathepsins and extracellular matrix degradation","volume":"1840","author":"Fonovi\u0107","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exer.2022.109101_bib113","doi-asserted-by":"crossref","first-page":"1113s","DOI":"10.1093\/ajcn\/54.6.1113s","article-title":"Ascorbic acid protects lipids in human plasma and low-density lipoprotein against oxidative damage","volume":"54","author":"Frei","year":"1991","journal-title":"Am. J. Clin. Nutr."},{"issue":"Suppl. 2","key":"10.1016\/j.exer.2022.109101_bib114","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1097\/ICL.0000000000000641","article-title":"Tear proteases and protease inhibitors: potential biomarkers and disease drivers in ocular surface disease","volume":"46","author":"Fu","year":"2020","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.exer.2022.109101_bib115","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jaci.2015.11.039","article-title":"The usefulness of measuring tear periostin for the diagnosis and management of ocular allergic diseases","volume":"138","author":"Fujishima","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.exer.2022.109101_bib116","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.1002\/pmic.200300849","article-title":"Characterization of the in vivo forms of lacrimal-specific proline-rich proteins in human tear fluid","volume":"4","author":"Fung","year":"2004","journal-title":"Proteomics"},{"key":"10.1016\/j.exer.2022.109101_bib117","doi-asserted-by":"crossref","first-page":"542549","DOI":"10.1155\/2014\/542549","article-title":"Differential effects of dry eye disorders on metabolomic profile by 1H nuclear magnetic resonance spectroscopy","volume":"2014","author":"Galbis-Estrada","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.exer.2022.109101_bib400","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5662550","article-title":"High level of inflammatory cytokines in the tears: a bridge of patients with concomitant exotropia and dry eye","volume":"2021","author":"Gao","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.exer.2022.109101_bib118","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00418-010-0713-y","article-title":"Roles of human beta-defensins in innate immune defense at the ocular surface: arming and alarming corneal and conjunctival epithelial cells","volume":"134","author":"Garreis","year":"2010","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.exer.2022.109101_bib119","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1136\/bjo.2004.044347","article-title":"Autologous serum eye drops for ocular surface disorders","volume":"88","author":"Geerling","year":"2004","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib120","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1167\/iovs.62.4.20","article-title":"Tear film cytokine profile of patients with the boston keratoprosthesis type 1: comparing patients with and without glaucoma","volume":"62","author":"Geoffrion","year":"2021","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib121","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20143431","article-title":"Lipid saturation and the rheology of human tear lipids","volume":"20","author":"Georgiev","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib122","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.exer.2017.03.013","article-title":"Structure-function relationship of tear film lipid layer: a contemporary perspective","volume":"163","author":"Georgiev","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib123","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.colsurfb.2010.03.024","article-title":"Interactions of Meibomian gland secretion with polar lipids in Langmuir monolayers","volume":"78","author":"Georgiev","year":"2010","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"4390","key":"10.1016\/j.exer.2022.109101_bib124","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.1167\/iovs.07-0770","article-title":"The ocular surface: the challenge to enable and protect vision: the Friedenwald lecture","volume":"48","author":"Gipson","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7696(03)31001-0","article-title":"Role of mucins in the function of the corneal and conjunctival epithelia","volume":"231","author":"Gipson","year":"2003","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.exer.2022.109101_bib126","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S1542-0124(12)70149-0","article-title":"Character of ocular surface mucins and their alteration in dry eye disease","volume":"2","author":"Gipson","year":"2004","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2022.109101_bib127","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1167\/iovs.61.14.19","article-title":"Evidence for phospholipids on the surface of human tears","volume":"61","author":"Glasgow","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib128","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.bbalip.2018.01.004","article-title":"Interaction of ceramides and tear lipocalin","volume":"1863","author":"Glasgow","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.exer.2022.109101_bib398","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1076\/ceyr.25.4.227.13482","article-title":"Lipid, lipase and lipocalin differences between tolerant and intolerant contact lens wearers","volume":"25","author":"Glasson","year":"2002","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib129","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1076\/ceyr.17.3.257.5213","article-title":"Tear fluid content of electrochemically active components including water soluble antioxidants","volume":"17","author":"Gogia","year":"1998","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib130","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1136\/bjophthalmol-2012-301527","article-title":"Tear film inflammatory mediators during continuous wear of contact lenses and corneal refractive therapy","volume":"96","author":"Gonz\u00e1lez-P\u00e9rez","year":"2012","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib131","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/jcp.21869","article-title":"Cytokines and signaling pathways regulating matrix metalloproteinase-9 (MMP-9) expression in corneal epithelial cells","volume":"221","author":"Gordon","year":"2009","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.exer.2022.109101_bib132","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1167\/iovs.02-0170","article-title":"Tear evaporation dynamics in normal subjects and subjects with obstructive meibomian gland dysfunction","volume":"44","author":"Goto","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib133","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1001\/archopht.121.2.173","article-title":"Differentiation of lipid tear deficiency dry eye by kinetic analysis of tear interference images","volume":"121","author":"Goto","year":"2003","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib134","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bbapap.2005.08.023","article-title":"Human tear viscosity: an interactive role for proteins and lipids","volume":"1753","author":"Gouveia","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exer.2022.109101_bib135","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.exer.2010.02.014","article-title":"Membrane-tethered mucins have multiple functions on the ocular surface","volume":"90","author":"Govindarajan","year":"2010","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib136","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1007\/s00018-013-1539-2","article-title":"Regulation of pyruvate metabolism and human disease","volume":"71","author":"Gray","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.exer.2022.109101_bib137","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1167\/iovs.10-6997d","article-title":"The international workshop on meibomian gland dysfunction: report of the subcommittee on tear film lipids and lipid-protein interactions in health and disease","volume":"52","author":"Green-Church","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib138","series-title":"Innate Immune System and the Eye. Encyclopedia of the Eye","first-page":"439","author":"Gregory","year":"2010"},{"key":"10.1016\/j.exer.2022.109101_bib139","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1159\/000050903","article-title":"Analysis of the antibody repertoire in tears of dry-eye patients","volume":"215","author":"Grus","year":"2001","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.exer.2022.109101_bib140","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1002\/1522-2683(200105)22:9<1845::AID-ELPS1845>3.0.CO;2-N","article-title":"Analysis of tear protein patterns of dry-eye patients using fluorescent staining dyes and two-dimensional quantification algorithms","volume":"22","author":"Grus","year":"2001","journal-title":"Electrophoresis"},{"key":"10.1016\/j.exer.2022.109101_bib141","doi-asserted-by":"crossref","first-page":"10964","DOI":"10.1021\/acscatal.8b03401","article-title":"Mechanisms of cytochrome P450-catalyzed oxidations","volume":"8","author":"Guengerich","year":"2018","journal-title":"ACS Catal."},{"key":"10.1016\/j.exer.2022.109101_bib142","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1089\/jop.2018.0047","article-title":"Suppression of Th1-mediated keratoconjunctivitis sicca by lifitegrast","volume":"34","author":"Guimaraes de Souza","year":"2018","journal-title":"J. Ocul. Pharmacol. Therapeut."},{"key":"10.1016\/j.exer.2022.109101_bib143","doi-asserted-by":"crossref","first-page":"6948","DOI":"10.1007\/s11356-019-04134-0","article-title":"Comparative study of tear lipid composition in two human populations with different exposure to particulate matter in La Plata, Argentina","volume":"26","author":"Gutierrez","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.exer.2022.109101_bib144","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13167-016-0065-3","article-title":"Tear fluid biomarkers in ocular and systemic disease: potential use for predictive, preventive and personalised medicine","volume":"7","author":"Hagan","year":"2016","journal-title":"EPMA J."},{"key":"10.1016\/j.exer.2022.109101_bib145","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1074\/mcp.M110.003665","article-title":"Comprehensive analysis of phosphorylation sites in Tensin1 reveals regulation by p38MAPK","volume":"9","author":"Hall","year":"2010","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.exer.2022.109101_bib146","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1002\/art.38633","article-title":"Tear cathepsin S as a candidate biomarker for Sj\u00f6gren's syndrome","volume":"66","author":"Hamm-Alvarez","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.exer.2022.109101_bib147","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.exer.2014.09.005","article-title":"Oxidative photodegradation of ocular tissues: beneficial effects of filtering and exogenous antioxidants","volume":"129","author":"Hammond","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib148","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/mas.20023","article-title":"Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples","volume":"24","author":"Han","year":"2005","journal-title":"Mass Spectrom. Rev."},{"key":"10.1016\/j.exer.2022.109101_bib149","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrm2329","article-title":"Principles of bioactive lipid signalling: lessons from sphingolipids","volume":"9","author":"Hannun","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.exer.2022.109101_bib150","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrm.2017.107","article-title":"Sphingolipids and their metabolism in physiology and disease","volume":"19","author":"Hannun","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.exer.2022.109101_bib151","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.3389\/fimmu.2019.01178","article-title":"Tear lactoferrin and lysozyme as clinically relevant biomarkers of mucosal immune competence","volume":"10","author":"Hanstock","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exer.2022.109101_bib152","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0014-4835(88)80071-X","article-title":"Fibrinolytic activity and species of plasminogen activator in human tears","volume":"46","author":"Hayashi","year":"1988","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib153","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1136\/bjo.83.6.737","article-title":"Antimicrobial defensin peptides of the human ocular surface","volume":"83","author":"Haynes","year":"1999","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib154","first-page":"d1356","article-title":"S100 proteins: structure, functions and pathology","volume":"7","author":"Heizmann","year":"2002","journal-title":"Front. Biosci. : J. Vis. Literacy"},{"key":"10.1016\/j.exer.2022.109101_bib155","doi-asserted-by":"crossref","first-page":"5146","DOI":"10.1158\/1078-0432.CCR-05-0352","article-title":"Calcium-binding proteins S100A8 and S100A9 as novel diagnostic markers in human prostate cancer","volume":"11","author":"Hermani","year":"2005","journal-title":"Clin. Cancer Res. : Off. J. Am. Assoc. Canc. Res."},{"key":"10.1016\/j.exer.2022.109101_bib156","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ophtha.2011.07.041","article-title":"How normal is the transparent cornea? Effects of aging on corneal morphology","volume":"119","author":"Hillenaar","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2022.109101_bib157","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.exer.2013.07.027","article-title":"Tear film mucins: front line defenders of the ocular surface; comparison with airway and gastrointestinal tract mucins","volume":"117","author":"Hodges","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib158","first-page":"117","article-title":"[Evaluation of chemokines in tears of patients with infectious keratitis]","volume":"117","author":"Hori","year":"2013","journal-title":"Nippon. Ganka Gakkai Zasshi"},{"key":"10.1016\/j.exer.2022.109101_bib159","doi-asserted-by":"crossref","first-page":"Des151","DOI":"10.1167\/iovs.17-23623","article-title":"Secreted mucins on the ocular surface","volume":"59","author":"Hori","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib160","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1002\/pmic.201000206","article-title":"Identification of autoantibody biomarkers for primary Sj\u00f6gren's syndrome using protein microarrays","volume":"11","author":"Hu","year":"2011","journal-title":"Proteomics"},{"key":"10.1016\/j.exer.2022.109101_bib161","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.breast.2005.01.008","article-title":"SELDI-TOF-MS: the proteomics and bioinformatics approaches in the diagnosis of breast cancer","volume":"14","author":"Hu","year":"2005","journal-title":"Breast (Edinburgh, Scotland)"},{"key":"10.1016\/j.exer.2022.109101_bib162","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00417-011-1863-x","article-title":"Inflammatory cytokine profiles in the tears of thyroid-associated ophthalmopathy","volume":"250","author":"Huang","year":"2012","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib163","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.1167\/iovs.11-9054","article-title":"Evaluations of tear protein markers in dry eye disease: repeatability of measurement and correlation with disease","volume":"53","author":"Huang","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib164","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10184248","article-title":"The role of neuropeptides in pathogenesis of dry dye","volume":"10","author":"Hwang","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.exer.2022.109101_bib165","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s11886-019-1208-7","article-title":"Cardiovascular disease and hair cortisol: a novel biomarker of chronic stress","volume":"21","author":"Iob","year":"2019","journal-title":"Curr. Cardiol. Rep."},{"key":"10.1016\/j.exer.2022.109101_bib166","doi-asserted-by":"crossref","first-page":"21813","DOI":"10.3390\/ijms160921813","article-title":"Surface properties of squalene\/meibum films and NMR confirmation of squalene in tears","volume":"16","author":"Ivanova","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib167","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1097\/ICO.0b013e31821de383","article-title":"Tear film osmolarity measurements in dry eye disease using electrical impedance technology","volume":"30","author":"Jacobi","year":"2011","journal-title":"Cornea"},{"issue":"Suppl. 2","key":"10.1016\/j.exer.2022.109101_bib168","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1097\/ICL.0000000000000668","article-title":"Role of matrix metalloproteinase 9 in ocular surface disorders","volume":"46","author":"Jamerson","year":"2020","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.exer.2022.109101_bib169","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.biochi.2008.05.015","article-title":"Antimicrobial properties of lactoferrin","volume":"91","author":"Jenssen","year":"2009","journal-title":"Biochimie"},{"key":"10.1016\/j.exer.2022.109101_bib170","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1097\/00003226-199707000-00013","article-title":"A novel method of tear collection: comparison of glass capillary micropipettes with porous polyester rods","volume":"16","author":"Jones","year":"1997","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2022.109101_bib171","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/00003226-200301000-00010","article-title":"MUC7 expression in the human lacrimal gland and conjunctiva","volume":"22","author":"Jumblatt","year":"2003","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2022.109101_bib401","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1016\/j.bbmt.2015.08.020","article-title":"Tear cytokines as biomarkers for chronic graft-versus-host disease","volume":"21","author":"Jung","year":"2015","journal-title":"Biol. Blood Marrow Transplant.: J. Am. Soc. Blood Marrow Transplant."},{"key":"10.1016\/j.exer.2022.109101_bib397","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.ico.0000167877.11687.7e","article-title":"Assessment of stromal keratocytes and tear film inflammatory mediators during extended wear of contact lenses","volume":"25","author":"Kallinikos","year":"2006","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2022.109101_bib172","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158000","article-title":"Changes in the chemical barrier composition of tears in alzheimer's disease reveal potential tear diagnostic biomarkers","volume":"11","author":"Kall\u00f3","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2022.109101_bib173","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1177\/0333102419856640","article-title":"Calcitonin gene-related peptide levels in tear fluid are elevated in migraine patients compared to healthy controls","volume":"39","author":"Kamm","year":"2019","journal-title":"Cephalalgia : Int. J. Headache"},{"key":"10.1016\/j.exer.2022.109101_bib174","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1080\/08820538.2021.1890793","article-title":"Nerve growth factor as an ocular therapy: applications, challenges, and future directions","volume":"36","author":"Kanu","year":"2021","journal-title":"Semin. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exer.2015.01.007","article-title":"Tear metabolite changes in keratoconus","volume":"132","author":"Karamichos","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib176","doi-asserted-by":"crossref","first-page":"8115","DOI":"10.1021\/ac202061v","article-title":"Human tear protein analysis enabled by an alkaline microfluidic homogeneous immunoassay","volume":"83","author":"Karns","year":"2011","journal-title":"Anal. Chem."},{"key":"10.1016\/j.exer.2022.109101_bib177","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.exer.2016.12.007","article-title":"Determination of water-soluble and fat-soluble vitamins in tears and blood serum of infants and parents by liquid chromatography\/mass spectrometry","volume":"155","author":"Khaksari","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib178","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.clinbiochem.2011.10.006","article-title":"Comparison of tear proteins between healthy and early diabetic retinopathy patients","volume":"45","author":"Kim","year":"2012","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.exer.2022.109101_bib179","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.exer.2004.05.003","article-title":"TGF-beta1 stimulates production of gelatinase (MMP-9), collagenases (MMP-1, -13) and stromelysins (MMP-3, -10, -11) by human corneal epithelial cells","volume":"79","author":"Kim","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib180","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/jid.2011.404","article-title":"Overexpression of cathepsin S induces chronic atopic dermatitis in mice","volume":"132","author":"Kim","year":"2012","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.exer.2022.109101_bib181","doi-asserted-by":"crossref","first-page":"7897","DOI":"10.1021\/acsami.9b19421","article-title":"Label-free surface-enhanced Raman spectroscopy biosensor for on-site breast cancer detection using human tears","volume":"12","author":"Kim","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.exer.2022.109101_bib182","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s11894-010-0131-2","article-title":"Intestinal goblet cells and mucins in health and disease: recent insights and progress","volume":"12","author":"Kim","year":"2010","journal-title":"Curr. Gastroenterol. Rep."},{"key":"10.1016\/j.exer.2022.109101_bib183","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/02713680490516099","article-title":"The thickness of the tear film","volume":"29","author":"King-Smith","year":"2004","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib184","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1469-7580.2005.00394.x","article-title":"The role of eye-associated lymphoid tissue in corneal immune protection","volume":"206","author":"Knop","year":"2005","journal-title":"J. Anat."},{"key":"10.1016\/j.exer.2022.109101_bib185","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3341\/kjo.2019.0145","article-title":"Tear osmolarity and matrix metallopeptidase-9 in dry eye associated with sj\u00f6gren's syndrome","volume":"34","author":"Kook","year":"2020","journal-title":"Kor. J. Ophthalmol. : Kor. J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib186","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20081932","article-title":"Tear proteomics approach to monitoring sj\u00f6gren syndrome or dry eye disease","volume":"20","author":"Kuo","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib187","article-title":"Tear secretion-A short review","volume":"6","author":"Lakshmi Prabha","year":"2014","journal-title":"J. Pharmacol. Sci. Res."},{"key":"10.1016\/j.exer.2022.109101_bib188","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1194\/jlr.M044826","article-title":"Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles","volume":"55","author":"Lam","year":"2014","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.exer.2022.109101_bib189","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1194\/jlr.P041780","article-title":"Lipidomic analysis of human tear fluid reveals structure-specific lipid alterations in dry eye syndrome","volume":"55","author":"Lam","year":"2014","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.exer.2022.109101_bib190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024339","article-title":"Meibum lipid composition in Asians with dry eye disease","volume":"6","author":"Lam","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2022.109101_bib191","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1358\/dnp.2010.23.6.1472299","article-title":"Nerve growth factor eye drops to treat glaucoma","volume":"23","author":"Lambiase","year":"2010","journal-title":"Drug News Perspect."},{"key":"10.1016\/j.exer.2022.109101_bib192","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1167\/iovs.08-2716","article-title":"In vitro evidence of nerve growth factor effects on human conjunctival epithelial cell differentiation and mucin gene expression","volume":"50","author":"Lambiase","year":"2009","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib193","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-1-4419-9194-2_10","article-title":"Cytochrome P450-derived eicosanoids mediators of ocular surface inflammation. are","volume":"525","author":"Laniado-Schwartzman","year":"2003","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2022.109101_bib194","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jtos.2015.10.004","article-title":"The matrix metalloproteinase 9 point-of-care test in dry eye","volume":"14","author":"Lanza","year":"2016","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2022.109101_bib195","first-page":"100974","article-title":"The two-faced effects of nerves and neuropeptides in corneal diseases","author":"Lasagni Vitar","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib196","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.jacc.2013.05.070","article-title":"The association between cortisol response to mental stress and high-sensitivity cardiac troponin T plasma concentration in healthy adults","volume":"62","author":"Lazzarino","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.exer.2022.109101_bib197","first-page":"75","article-title":"Surface-enhanced laser desorption\/ionisation time-of-flight mass spectrometry to detect breast cancer markers in tears and serum","volume":"6","author":"Lebrecht","year":"2009","journal-title":"Cancer Genom. Proteonomics"},{"key":"10.1016\/j.exer.2022.109101_bib198","first-page":"177","article-title":"Diagnosis of breast cancer by tear proteomic pattern","volume":"6","author":"Lebrecht","year":"2009","journal-title":"Cancer Genom. Proteonomics"},{"key":"10.1016\/j.exer.2022.109101_bib199","article-title":"Biosynthesized multivalent lacritin peptides stimulate exosome production in human corneal epithelium","volume":"21","author":"Lee","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib200","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.ajo.2004.12.051","article-title":"Nerve growth factor concentration and implications in photorefractive keratectomy vs laser in situ keratomileusis","volume":"139","author":"Lee","year":"2005","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib201","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1542-0124(12)70081-2","article-title":"The definition and classification of dry eye disease: report of the definition and classification subcommittee of the international dry eye WorkShop","volume":"5","author":"Lemp","year":"2007","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2022.109101_bib202","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1167\/iovs.02-0766","article-title":"Tear levels and activity of matrix metalloproteinase (MMP)-1 and MMP-9 in vernal keratoconjunctivitis","volume":"44","author":"Leonardi","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib203","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/IJG.0b013e31815c5f4f","article-title":"Prevalence of ocular surface disease in glaucoma patients","volume":"17","author":"Leung","year":"2008","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.exer.2022.109101_bib204","doi-asserted-by":"crossref","first-page":"5772","DOI":"10.1038\/srep05772","article-title":"Tear proteomic analysis of Sj\u00f6gren syndrome patients with dry eye syndrome by two-dimensional-nano-liquid chromatography coupled with tandem mass spectrometry","volume":"4","author":"Li","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2022.109101_bib205","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1167\/iovs.13-12080","article-title":"Tear proteomic analysis of patients with type 2 diabetes and dry eye syndrome by two-dimensional nano-liquid chromatography coupled with tandem mass spectrometry","volume":"55","author":"Li","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib206","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.molmed.2015.10.001","article-title":"Lipid-based therapy for ocular surface inflammation and disease","volume":"21","author":"Lim","year":"2015","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.exer.2022.109101_bib207","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1189\/jlb.1008608","article-title":"Oxidative modifications of S100 proteins: functional regulation by redox","volume":"86","author":"Lim","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.exer.2022.109101_bib208","series-title":"The Handbook of Metabolic Phenotyping","author":"Lindon","year":"2018"},{"key":"10.1016\/j.exer.2022.109101_bib209","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/13547500410001668379","article-title":"Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis","volume":"9","author":"Lindon","year":"2004","journal-title":"Biomarkers : Biochem. Indicat. Exposure, Response Susceptibility Chem."},{"key":"10.1016\/j.exer.2022.109101_bib210","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0167-4838(00)00164-3","article-title":"Immunocalins: a lipocalin subfamily that modulates immune and inflammatory responses","volume":"1482","author":"L\u00f6gdberg","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exer.2022.109101_bib211","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.breast.2020.07.009","article-title":"Prevalence of symptomatic dry eye in breast cancer patients undergoing systemic adjuvant treatment: a cross-sectional study","volume":"53","author":"Ma","year":"2020","journal-title":"Breast (Edinburgh, Scotland)"},{"key":"10.1016\/j.exer.2022.109101_bib212","series-title":"Cornea. Pivotal Trials in Ophthalmology","first-page":"25","author":"Ma","year":"2021"},{"key":"10.1016\/j.exer.2022.109101_bib213","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.exer.2007.01.025","article-title":"Focus on molecules: lacritin","volume":"86","author":"Ma","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib214","doi-asserted-by":"crossref","first-page":"45","DOI":"10.7150\/jca.5044","article-title":"Cystatins in immune system","volume":"4","author":"Magister","year":"2013","journal-title":"J. Cancer"},{"key":"10.1016\/j.exer.2022.109101_bib215","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.exer.2013.07.013","article-title":"Contact lens interactions with the tear film","volume":"117","author":"Mann","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib216","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/ACI.0b013e32830e6b04","article-title":"Functions of ocular surface mucins in health and disease","volume":"8","author":"Mantelli","year":"2008","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"10.1016\/j.exer.2022.109101_bib217","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1097\/ACI.0b013e32833e16cc","article-title":"Neurogenic inflammation of the ocular surface","volume":"10","author":"Mantelli","year":"2010","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"10.1016\/j.exer.2022.109101_bib218","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/mi.2011.41","article-title":"Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut","volume":"4","author":"Mantis","year":"2011","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.exer.2022.109101_bib219","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/OPX.0000000000001040","article-title":"Substance P in flush tears and schirmer strips of healthy participants","volume":"94","author":"Markoulli","year":"2017","journal-title":"Optom. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib220","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3109\/02713683.2010.542867","article-title":"Validation of the flush method as an alternative to basal or reflex tear collection","volume":"36","author":"Markoulli","year":"2011","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib221","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1097\/OPX.0000000000001096","article-title":"Corneal nerve morphology and tear film substance P in diabetes","volume":"94","author":"Markoulli","year":"2017","journal-title":"Optom. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib222","doi-asserted-by":"crossref","first-page":"108567","DOI":"10.1016\/j.exer.2021.108567","article-title":"Profiling of non-polar lipids in tears of contact lens wearers during the day","volume":"207","author":"Masoudi","year":"2021","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib223","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1097\/OPX.0000000000001110","article-title":"Differences in tear film biochemistry of symptomatic and asymptomatic lens wearers","volume":"94","author":"Masoudi","year":"2017","journal-title":"Optom. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib224","article-title":"Contact lens-induced discomfort and inflammatory mediator changes in tears","author":"Masoudi","year":"2016","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.exer.2022.109101_bib225","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1080\/02713683.2016.1255338","article-title":"Relation between ocular comfort, arachidonic acid mediators, and histamine","volume":"42","author":"Masoudi","year":"2017","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib226","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1167\/iovs.13-12777","article-title":"Method development for quantification of five tear proteins using selected reaction monitoring (SRM) mass spectrometry","volume":"55","author":"Masoudi","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib227","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1097\/ICO.0b013e3181a16578","article-title":"Analysis of inflammatory cytokines in the tears of dry eye patients","volume":"28","author":"Massingale","year":"2009","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2022.109101_bib228","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.2174\/0929867325666181009153212","article-title":"Structural and molecular tear film changes in glaucoma","volume":"26","author":"Mastropasqua","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.exer.2022.109101_bib229","first-page":"159","article-title":"Why the eye becomes dry: a cornea and lacrimal gland feedback model","volume":"26","author":"Mathers","year":"2000","journal-title":"CLAO J. : Off. Publ. Contact Lens Assoc. Ophthalmol, Inc"},{"key":"10.1016\/j.exer.2022.109101_bib230","first-page":"79","article-title":"A compositional based model for the tear film lipid layer","volume":"95","author":"McCulley","year":"1997","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"10.1016\/j.exer.2022.109101_bib231","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0014-4835(03)00203-3","article-title":"The lipid layer of tears: dependent on meibomian gland function","volume":"78","author":"McCulley","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib232","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.exer.2013.07.014","article-title":"Antimicrobial compounds in tears","volume":"117","author":"McDermott","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib233","first-page":"703","article-title":"Quantification of MUC2 and MUC5AC transcripts in human conjunctiva","volume":"41","author":"McKenzie","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib234","doi-asserted-by":"crossref","first-page":"22172","DOI":"10.1074\/jbc.M114.570143","article-title":"A cleavage-potentiated fragment of tear lacritin is bactericidal","volume":"289","author":"McKown","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2022.109101_bib235","first-page":"258","article-title":"Retinal pathology and skin barrier defect in mice carrying a Stargardt disease-3 mutation in elongase of very long chain fatty acids-4","volume":"13","author":"McMahon","year":"2007","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2022.109101_bib236","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s11745-013-3755-9","article-title":"The spectrophotometric sulfo-phospho-vanillin assessment of total lipids in human meibomian gland secretions","volume":"48","author":"McMahon","year":"2013","journal-title":"Lipids"},{"key":"10.1016\/j.exer.2022.109101_bib237","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0014-4835(05)80007-7","article-title":"Increased release of immunoreactive calcitonin gene-related peptide (CGRP) in tears after excimer laser keratectomy","volume":"60","author":"Mertaniemi","year":"1995","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib238","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1038\/ncomms4125","article-title":"TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins","volume":"5","author":"Meseguer","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2022.109101_bib239","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.colsurfb.2005.05.011","article-title":"Insertion of tear proteins into a meibomian lipids film","volume":"44","author":"Miano","year":"2005","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.exer.2022.109101_bib240","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1167\/iovs.17-23358","article-title":"Age-related changes to human tear composition","volume":"59","author":"Micera","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib241","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.exer.2015.05.002","article-title":"The real reason for having a meibomian lipid layer covering the outer surface of the tear film - a review","volume":"137","author":"Millar","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib242","doi-asserted-by":"crossref","first-page":"4945","DOI":"10.1111\/j.1742-4658.2008.06653.x","article-title":"S100-annexin complexes--biology of conditional association","volume":"275","author":"Miwa","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.exer.2022.109101_bib243","doi-asserted-by":"crossref","first-page":"D1192","DOI":"10.2741\/Moniaux","article-title":"Structural organization and classification of the human mucin genes","volume":"6","author":"Moniaux","year":"2001","journal-title":"Front. Biosci. : J. Vis. Literacy"},{"key":"10.1016\/j.exer.2022.109101_bib244","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s12192-013-0435-x","article-title":"Heat shock protein 70 and albuminuria in patients with type 2 diabetes: a matched case control study","volume":"18","author":"Morteza","year":"2013","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.exer.2022.109101_bib245","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/01.ico.0000133987.34274.c0","article-title":"Increased eotaxin in tears of patients wearing contact lenses","volume":"23","author":"Moschos","year":"2004","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2022.109101_bib246","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1089\/jir.2006.26.71","article-title":"IL-8 and IFN-gamma in tear fluid of patients with cystic fibrosis","volume":"26","author":"Mrugacz","year":"2006","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.exer.2022.109101_bib247","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1167\/iovs.10-5445","article-title":"Surfactant properties of human meibomian lipids","volume":"52","author":"Mudgil","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib248","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S1542-0124(12)70028-9","article-title":"Tear osmolarity","volume":"4","author":"Murube","year":"2006","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2022.109101_bib249","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jtos.2012.08.001","article-title":"The origin of tears. III. The lipid component in the XIX and XX centuries","volume":"10","author":"Murube","year":"2012","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2022.109101_bib250","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/112067219900900201","article-title":"Origin and types of emotional tearing","volume":"9","author":"Murube","year":"1999","journal-title":"Eur. J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib251","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1136\/bjophthalmol-2019-314234","article-title":"Tear neuromediators in eyes on chronic topical antiglaucoma therapy with and without BAK preservatives","volume":"105","author":"Murugesan","year":"2021","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib252","volume":"vol. 26","author":"Mustapha","year":"2021"},{"key":"10.1016\/j.exer.2022.109101_bib253","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.ajo.2010.11.003","article-title":"Amino Acid profiles in human tear fluids analyzed by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry","volume":"151","author":"Nakatsukasa","year":"2011","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib254","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19082209","article-title":"Effects of lipid saturation on the surface properties of human meibum films","volume":"19","author":"Nencheva","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib255","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1080\/02713683.2018.1501803","article-title":"Comparison of collection methods for the measure of human meibum and tear film-derived lipids using mass spectrometry","volume":"43","author":"Ngo","year":"2018","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib256","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1128\/IAI.73.4.2147-2156.2005","article-title":"Surfactant protein D is present in human tear fluid and the cornea and inhibits epithelial cell invasion by Pseudomonas aeruginosa","volume":"73","author":"Ni","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.exer.2022.109101_bib257","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1681\/ASN.2015101162","article-title":"Cathepsin S-dependent protease-activated receptor-2 activation: a new mechanism of endothelial dysfunction","volume":"27","author":"Nikolic-Paterson","year":"2016","journal-title":"J. Am. Soc. Nephrol. : JASN (J. Am. Soc. Nephrol.)"},{"key":"10.1016\/j.exer.2022.109101_bib258","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1126\/science.1411571","article-title":"Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C","volume":"258","author":"Nishizuka","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.exer.2022.109101_bib259","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s11481-009-9156-4","article-title":"Metabolomics: moving to the clinic","volume":"5","author":"Nordstr\u00f6m","year":"2010","journal-title":"J. Neuroimmune Pharmacol. : Off. J. Soc. NeuroImmune Pharmacol."},{"key":"10.1016\/j.exer.2022.109101_bib260","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1289\/ehp.10363","article-title":"Ambient levels of air pollution induce goblet-cell hyperplasia in human conjunctival epithelium","volume":"115","author":"Novaes","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.exer.2022.109101_bib261","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1463-5224.2007.00546.x","article-title":"Proteinases of the cornea and preocular tear film","volume":"10","author":"Ollivier","year":"2007","journal-title":"Vet. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib262","doi-asserted-by":"crossref","first-page":"183300","DOI":"10.1016\/j.bbamem.2020.183300","article-title":"Mixed polar-nonpolar lipid films as minimalistic models of Tear Film Lipid Layer: a Langmuir trough and fluorescence microscopy study","volume":"1862","author":"Ol\u017cy\u0144ska","year":"2020","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.exer.2022.109101_bib263","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nri1418","article-title":"Matrix metalloproteinases as modulators of inflammation and innate immunity","volume":"4","author":"Parks","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.exer.2022.109101_bib264","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.proghi.2006.03.001","article-title":"Mucins and TFF peptides of the tear film and lacrimal apparatus","volume":"41","author":"Paulsen","year":"2006","journal-title":"Prog. Histochem. Cytochem."},{"key":"10.1016\/j.exer.2022.109101_bib265","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/cvr\/cvp030","article-title":"Sphingomyelinases: their regulation and roles in cardiovascular pathophysiology","volume":"82","author":"Pavoine","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.exer.2022.109101_bib266","article-title":"Comparative study on variations in selected tear electrolytes compositions among HIV infected patients. nt","volume":"6","author":"Peggy","year":"2020","journal-title":"J. Forensic Med. Invest."},{"key":"10.1016\/j.exer.2022.109101_bib267","doi-asserted-by":"crossref","DOI":"10.3390\/nu12040952","article-title":"The role of nutrition and nutritional supplements in ocular surface diseases","volume":"12","author":"Pellegrini","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.exer.2022.109101_bib268","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.1167\/iovs.05-0980","article-title":"Increased levels of diadenosine polyphosphates in dry eye","volume":"47","author":"Peral","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib269","doi-asserted-by":"crossref","first-page":"E132","DOI":"10.1097\/OPX.0b013e318194e767","article-title":"L-carnitine and short chain ester in tears from patients with dry eye","volume":"86","author":"Pescosolido","year":"2009","journal-title":"Optom. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib270","doi-asserted-by":"crossref","first-page":"e75","DOI":"10.1111\/j.1755-3768.2010.02082.x","article-title":"A comparison of basal and eye-flush tears for the analysis of cat tear proteins","volume":"89","author":"Petznick","year":"2011","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib271","first-page":"1316","article-title":"Detection of sialomucin complex (MUC4) in human ocular surface epithelium and tear fluid","volume":"41","author":"Pflugfelder","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib272","doi-asserted-by":"crossref","first-page":"108115","DOI":"10.1016\/j.exer.2020.108115","article-title":"Biological functions of tear film","volume":"197","author":"Pflugfelder","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib273","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18071349","article-title":"Tear film steroid profiling in dry eye disease by liquid chromatography tandem mass spectrometry","volume":"18","author":"Pieragostino","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib274","first-page":"361","article-title":"[Lactoferrin: a multifunctional protein]","volume":"25","author":"Pierce","year":"2009","journal-title":"M-S (Med. Sci.) : M\u00e9d.\/Sci."},{"key":"10.1016\/j.exer.2022.109101_bib275","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.2147\/OPTH.S95242","article-title":"Tear film osmolarity and dry eye disease: a review of the literature","volume":"9","author":"Potvin","year":"2015","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib276","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/ICL.0b013e3182482910","article-title":"Elevated tear interleukin-6 and interleukin-8 levels associated with silicone hydrogel and conventional hydrogel contact lens wear","volume":"38","author":"Poyraz","year":"2012","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.exer.2022.109101_bib277","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jtos.2014.06.002","article-title":"The presence and significance of polar meibum and tear lipids","volume":"13","author":"Pucker","year":"2015","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2022.109101_bib278","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.clae.2012.12.005","article-title":"Comparison of IgA, TNF-\u03b1 and surface tension of the tear film in two different times of the day","volume":"36","author":"Puinhas","year":"2013","journal-title":"Contact Lens Anterior Eye"},{"key":"10.1016\/j.exer.2022.109101_bib279","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/OPX.0000000000000188","article-title":"Patient acceptability of tear collection in the primary healthcare setting","volume":"91","author":"Quah","year":"2014","journal-title":"Optom. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib280","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006512","article-title":"From bacterial killing to immune modulation: recent insights into the functions of lysozyme","volume":"13","author":"Ragland","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.exer.2022.109101_bib281","series-title":"Inflammatory Proteins Associated with Contact Lens-Related Dry Eye","first-page":"101442","author":"Ramamoorthy","year":"2021"},{"key":"10.1016\/j.exer.2022.109101_bib282","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1097\/ICO.0000000000001935","article-title":"Structural differences in meibum from donors after hematopoietic stem cell transplantations","volume":"38","author":"Ramasubramanian","year":"2019","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2022.109101_bib283","doi-asserted-by":"crossref","first-page":"6442","DOI":"10.1167\/iovs.12-10487","article-title":"Do lipids retard the evaporation of the tear fluid?","volume":"53","author":"Rantam\u00e4ki","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib284","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.preteyeres.2011.02.002","article-title":"Lessons from the biophysics of interfaces: lung surfactant and tear fluid","volume":"30","author":"Rantamaki","year":"2011","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib285","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.fertnstert.2005.02.058","article-title":"Difference in expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in patients with persistent ovarian cysts","volume":"84","author":"Raspollini","year":"2005","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.exer.2022.109101_bib286","series-title":"Handbook of Proteolytic Enzymes","author":"Rawlings","year":"2013"},{"key":"10.1016\/j.exer.2022.109101_bib287","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1007\/978-1-4615-0717-8_183","article-title":"The effect of punctal occlusion on tear lactoferrin in aqueous deficient dry eye patients","volume":"506","author":"Reese","year":"2002","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2022.109101_bib288","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exer.2017.05.006","article-title":"Degradation of proteoglycan 4\/lubricin by cathepsin S: potential mechanism for diminished ocular surface lubrication in Sj\u00f6gren's syndrome","volume":"161","author":"Regmi","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib289","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s12026-015-8763-9","article-title":"Membrane array and multiplex bead analysis of tear cytokines in systemic sclerosis","volume":"64","author":"Rentka","year":"2016","journal-title":"Immunol. Res."},{"key":"10.1016\/j.exer.2022.109101_bib290","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1177\/0004563217695843","article-title":"Evaluation of commonly used tear sampling methods and their relevance in subsequent biochemical analysis","volume":"54","author":"Rentka","year":"2017","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.exer.2022.109101_bib291","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1074-7613(00)80249-6","article-title":"Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading","volume":"4","author":"Riese","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/j.exer.2022.109101_bib292","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1194\/jlr.M026732","article-title":"Hyperosmolarity-induced lipid droplet formation depends on ceramide production by neutral sphingomyelinase 2","volume":"53","author":"Robciuc","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.exer.2022.109101_bib293","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1167\/iovs.13-12577","article-title":"Lipid-modifying enzymes in human tear fluid and corneal epithelial stress response","volume":"55","author":"Robciuc","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib294","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1097\/ICO.0000000000000893","article-title":"Tear matrix metalloproteinases and myeloperoxidase levels in patients with boston keratoprosthesis type I","volume":"35","author":"Robert","year":"2016","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2022.109101_bib295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bse0590001","article-title":"Enzymes: principles and biotechnological applications","volume":"59","author":"Robinson","year":"2015","journal-title":"Essays Biochem."},{"key":"10.1016\/j.exer.2022.109101_bib296","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1194\/jlr.D700035-JLR200","article-title":"Quantitative evaluation of sebum lipid components with nuclear magnetic resonance","volume":"49","author":"Robosky","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.exer.2022.109101_bib297","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1542-0124(12)70177-5","article-title":"The aging lacrimal gland: changes in structure and function","volume":"6","author":"Rocha","year":"2008","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2022.109101_bib298","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1097\/OPX.0000000000000411","article-title":"Comparison of tear lipid profile among basal, reflex, and flush tear samples","volume":"91","author":"Rohit","year":"2014","journal-title":"Optom. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib299","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1097\/OPX.0000000000000420","article-title":"Clinical and biochemical tear lipid parameters in contact lens wearers","volume":"91","author":"Rohit","year":"2014","journal-title":"Optom. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib300","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.4155\/bio.12.100","article-title":"LC-MS metabolomics of polar compounds","volume":"4","author":"Rojo","year":"2012","journal-title":"Bioanalysis"},{"key":"10.1016\/j.exer.2022.109101_bib301","first-page":"2131","article-title":"Preservative toxicity in glaucoma medication: clinical evaluation of benzalkonium chloride-free 0.5% timolol eye drops","volume":"7","author":"Rosin","year":"2013","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib302","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1177\/112067210901900409","article-title":"Dry eye syndrome-related quality of life in glaucoma patients","volume":"19","author":"Rossi","year":"2009","journal-title":"Eur. J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib303","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1471-4906(03)00062-0","article-title":"Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules","volume":"24","author":"Roth","year":"2003","journal-title":"Trends Immunol."},{"key":"10.1016\/j.exer.2022.109101_bib304","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jtos.2013.03.001","article-title":"The fall and rise of tear albumin levels: a multifactorial phenomenon","volume":"11","author":"Runstr\u00f6m","year":"2013","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2022.109101_bib305","first-page":"47","article-title":"Tear levels of neuropeptides increase after specific allergen challenge in allergic conjunctivitis","volume":"17","author":"Sacchetti","year":"2011","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2022.109101_bib306","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1023\/A:1017943826684","article-title":"Host-defense mechanism of the ocular surfaces","volume":"21","author":"Sack","year":"2001","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.exer.2022.109101_bib307","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/978-1-4615-0717-8_76","article-title":"Changes in the diurnal pattern of the distribution of gelatinases and associated proteins in normal and pathological tear fluids: evidence that the PMN cell is a major source of MMP activity in tear fluid","volume":"506","author":"Sack","year":"2002","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2022.109101_bib308","first-page":"626","article-title":"Diurnal tear cycle: evidence for a nocturnal inflammatory constitutive tear fluid","volume":"33","author":"Sack","year":"1992","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib309","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1165\/rcmb.2010-0095RT","article-title":"Secretory leukocyte protease inhibitor and elafin\/trappin-2: versatile mucosal antimicrobials and regulators of immunity","volume":"42","author":"Sallenave","year":"2010","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.exer.2022.109101_bib310","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/ICU.0b013e32834787bb","article-title":"MMP-9 and the perioperative management of LASIK surgery","volume":"22","author":"Sambursky","year":"2011","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib311","doi-asserted-by":"crossref","first-page":"6265","DOI":"10.1167\/iovs.10-6220","article-title":"Lacritin, a novel human tear glycoprotein, promotes sustained basal tearing and is well tolerated","volume":"52","author":"Samudre","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib312","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1167\/iovs.09-4609","article-title":"Detection and quantification of tear phospholipids and cholesterol in contact lens deposits: the effect of contact lens material and lens care solution","volume":"51","author":"Saville","year":"2010","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib313","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1007\/s00417-002-0537-0","article-title":"The effect of sample treatment on separation profiles of tear fluid proteins: qualitative and semi-quantitative protein determination by an automated analysis system","volume":"240","author":"Schmut","year":"2002","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib314","doi-asserted-by":"crossref","DOI":"10.4102\/aveh.v71i3.79","article-title":"Immunological and antimicrobial molecules in human tears: a review and preliminary report","volume":"71","author":"Schnetler","year":"2012","journal-title":"African Vision Eye Health"},{"key":"10.1016\/j.exer.2022.109101_bib315","first-page":"123","article-title":"Mmunological and antimicrobial molecules in human tears: a review and preliminary report","volume":"71","author":"Schnetlera","year":"2012","journal-title":"South Afr. Optom."},{"key":"10.1016\/j.exer.2022.109101_bib316","first-page":"86","article-title":"Lipid composition of human meibum: a review","volume":"72","author":"Schnetlera","year":"2013","journal-title":"South Afr. Optom."},{"key":"10.1016\/j.exer.2022.109101_bib317","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1042\/bj20011876","article-title":"Identification of two highly sialylated human tear-fluid DMBT1 isoforms: the major high-molecular-mass glycoproteins in human tears","volume":"366","author":"Schulz","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.exer.2022.109101_bib318","doi-asserted-by":"crossref","first-page":"e412","DOI":"10.1111\/aos.13526","article-title":"Dry eye disease and oxidative stress","volume":"96","author":"Seen","year":"2018","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib319","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ecoenv.2012.02.021","article-title":"Defining reference values of trace elements in the tear film: diagnostic methods and possible applications","volume":"80","author":"Semeraro","year":"2012","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.exer.2022.109101_bib320","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1136\/bjo.64.9.693","article-title":"Tear glucose levels in normal people and in diabetic patients","volume":"64","author":"Sen","year":"1980","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib321","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1016\/j.ophtha.2012.05.038","article-title":"Change in prostaglandin expression levels and synthesizing activities in dry eye disease","volume":"119","author":"Shim","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2022.109101_bib322","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1076\/ceyr.26.2.89.14515","article-title":"Polar lipids in human meibomian gland secretions","volume":"26","author":"Shine","year":"2003","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib323","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/aps.2013.200","article-title":"Immunomodulatory effects of lactoferrin","volume":"35","author":"Siqueiros-Cend\u00f3n","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.exer.2022.109101_bib324","first-page":"41","article-title":"American Cancer Society guidelines for the early detection of cancer, 2004","volume":"54","author":"Smith","year":"2004","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.exer.2022.109101_bib325","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1136\/bjo.85.2.147","article-title":"Tear film MMP accumulation and corneal disease","volume":"85","author":"Smith","year":"2001","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib326","doi-asserted-by":"crossref","first-page":"152","DOI":"10.5114\/reum.2015.53137","article-title":"Metabolomics and its potential in diagnosis, prognosis and treatment of rheumatic diseases","volume":"53","author":"Smole\u0144ska","year":"2015","journal-title":"Reumatologia"},{"key":"10.1016\/j.exer.2022.109101_bib327","first-page":"1703","article-title":"Regulation of MMP-9 activity in human tear fluid and corneal epithelial culture supernatant","volume":"41","author":"Sobrin","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib328","first-page":"2154","article-title":"Regulation of collagenase, stromelysin, and urokinase-type plasminogen activator in primary pterygium body fibroblasts by inflammatory cytokines","volume":"41","author":"Solomon","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib329","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4103\/ijo.IJO_646_17","article-title":"Anatomy of cornea and ocular surface","volume":"66","author":"Sridhar","year":"2018","journal-title":"Indian J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib330","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.1167\/iovs.11-9022","article-title":"iTRAQ quantitative proteomics in the analysis of tears in dry eye patients","volume":"53","author":"Srinivasan","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib331","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1444-0938.2011.00634.x","article-title":"Osmolality and tear film dynamics","volume":"95","author":"Stahl","year":"2012","journal-title":"Clin. Exp. Optom. : J. Aust. Optometrical Assoc."},{"key":"10.1016\/j.exer.2022.109101_bib332","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1177\/002215540205000506","article-title":"Immunolocalization of surfactant protein-D (SP-D) in human fetal, newborn, and adult tissues","volume":"50","author":"Stahlman","year":"2002","journal-title":"J. Histochem. Cytochem. : Off. J. Histochem. Soc."},{"key":"10.1016\/j.exer.2022.109101_bib333","doi-asserted-by":"crossref","first-page":"6125","DOI":"10.1167\/iovs.10-5390","article-title":"An objective approach to dry eye disease severity","volume":"51","author":"Sullivan","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib334","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0094913","article-title":"Cortisol biosynthesis in the human ocular surface innate immune response","volume":"9","author":"Susarla","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2022.109101_bib335","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1097\/00006324-200011000-00008","article-title":"Decay-accelerating factor in tears of contact lens wearers and patients with contact lens-associated complications","volume":"77","author":"Szczotka","year":"2000","journal-title":"Optom. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib336","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1620\/tjem.192.61","article-title":"Distribution of acid sphingomyelinase in human various body fluids","volume":"192","author":"Takahashi","year":"2000","journal-title":"Tohoku J. Exp. Med."},{"issue":"Suppl. 1","key":"10.1016\/j.exer.2022.109101_bib337","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1111\/j.1442-9071.1997.tb01749.x","article-title":"Presence of inflammatory mediators in the tears of contact lens wearers and non-contact lens wearers","volume":"25","author":"Tan","year":"1997","journal-title":"Aust. N. Z. J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib338","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000131066","article-title":"The normal tear film","volume":"41","author":"Tiffany","year":"2008","journal-title":"Dev. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib339","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.semcdb.2004.05.002","article-title":"Physiological and pathological actions of sphingosine 1-phosphate","volume":"15","author":"Timothy","year":"2004","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.exer.2022.109101_bib340","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.1167\/iovs.05-1504","article-title":"Tear film osmolarity: determination of a referent for dry eye diagnosis","volume":"47","author":"Tomlinson","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib341","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jtos.2013.10.001","article-title":"S100A proteins as molecular targets in the ocular surface inflammatory diseases","volume":"12","author":"Tong","year":"2014","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2022.109101_bib342","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1097\/ICO.0b013e31825e845d","article-title":"Correlation between signs and symptoms of ocular surface dysfunction and tear osmolarity with ambient levels of air pollution in a large metropolitan area","volume":"32","author":"Torricelli","year":"2013","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2022.109101_bib343","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3389\/fendo.2020.00377","article-title":"Protective effects of PACAP in peripheral organs","volume":"11","author":"Toth","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.exer.2022.109101_bib344","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/01.ico.0000138837.52694.37","article-title":"Surface pressure measurements of human tears and individual tear film components indicate that proteins are major contributors to the surface pressure","volume":"24","author":"Tragoulias","year":"2005","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2022.109101_bib345","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/1097-4652(200009)184:3<385::AID-JCP14>3.0.CO;2-7","article-title":"Calcium signaling induced by adhesion mediates protein tyrosine phosphorylation and is independent of pHi","volume":"184","author":"Trinkaus-Randall","year":"2000","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.exer.2022.109101_bib346","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1136\/bjo.2005.080846","article-title":"Proteomic analysis of human meibomian gland secretions","volume":"90","author":"Tsai","year":"2006","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib347","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.jtos.2019.08.010","article-title":"Tear film substance P: a potential biomarker for diabetic peripheral neuropathy","volume":"17","author":"Tummanapalli","year":"2019","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2022.109101_bib348","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtos.2019.08.010","article-title":"Tear film substance P: a potential biomarker for diabetic peripheral neuropathy","author":"Tummanapalli","year":"2019","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2022.109101_bib349","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cyto.2005.11.013","article-title":"Alteration pattern of tear cytokines during the course of a day: diurnal rhythm analyzed by multicytokine assay","volume":"33","author":"Uchino","year":"2006","journal-title":"Cytokine"},{"key":"10.1016\/j.exer.2022.109101_bib350","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00496763","article-title":"Collection method dependent concentrations of some metabolites in human tear fluid, with special reference to glucose in hyperglycaemic conditions","volume":"202","author":"van Haeringen","year":"1977","journal-title":"Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib351","first-page":"1056","article-title":"A method to extract cytokines and matrix metalloproteinases from Schirmer strips and analyze using Luminex","volume":"17","author":"VanDerMeid","year":"2011","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2022.109101_bib352","article-title":"Evaluation of tear film urea level as a diagnostic marker of dry eye disease: a pilot study","author":"Velamakanni","year":"2021","journal-title":"J. Lab Phys."},{"key":"10.1016\/j.exer.2022.109101_bib353","doi-asserted-by":"crossref","first-page":"289","DOI":"10.4103\/0301-4738.53054","article-title":"Tear ascorbic acid levels and the total antioxidant status in contact lens wearers: a pilot study","volume":"57","author":"Venkata","year":"2009","journal-title":"Indian J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib354","doi-asserted-by":"crossref","first-page":"6255","DOI":"10.1021\/jm040086x","article-title":"Synthesis and structure-activity relationships of 4-alkynyloxy phenyl sulfanyl, sulfinyl, and sulfonyl alkyl hydroxamates as tumor necrosis factor-alpha converting enzyme and matrix metalloproteinase inhibitors","volume":"47","author":"Venkatesan","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.exer.2022.109101_bib355","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1016\/j.bmc.2007.01.011","article-title":"Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs","volume":"15","author":"Verma","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.exer.2022.109101_bib356","first-page":"567","article-title":"A proposal of new ocular items in Sj\u00f6gren's syndrome classification criteria","volume":"24","author":"Versura","year":"2006","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.exer.2022.109101_bib357","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.pharmthera.2009.09.003","article-title":"The role of CGRP in the pathophysiology of migraine and efficacy of CGRP receptor antagonists as acute antimigraine drugs","volume":"124","author":"Villal\u00f3n","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.exer.2022.109101_bib358","first-page":"244","article-title":"Mastocytosis and adverse reactions to biogenic amines and histamine-releasing foods: what is the evidence?","volume":"63","author":"Vlieg-Boerstra","year":"2005","journal-title":"Neth. J. Med."},{"key":"10.1016\/j.exer.2022.109101_bib359","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.exer.2013.07.015","article-title":"Tears as a source of biomarkers for ocular and systemic diseases","volume":"117","author":"von Thun Und Hohenstein-Blaul","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib360","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1167\/iovs.12-10325","article-title":"Evaluation of lipid oxidative stress status in Sj\u00f6gren syndrome patients","volume":"54","author":"Wakamatsu","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib361","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1083\/jcb.200605140","article-title":"Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways","volume":"174","author":"Wang","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.exer.2022.109101_bib362","doi-asserted-by":"crossref","first-page":"18146","DOI":"10.1074\/jbc.M112.436584","article-title":"Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism","volume":"288","author":"Wang","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2022.109101_bib363","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1194\/jlr.R600003-JLR200","article-title":"The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function","volume":"47","author":"Wattenberg","year":"2006","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.exer.2022.109101_bib364","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1167\/iovs.12-9558","article-title":"Divalent cations in tears, and their influence on tear film stability in humans and rabbits","volume":"53","author":"Wei","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib365","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1084\/jem.20051971","article-title":"A fundamental bimodal role for neuropeptide Y1 receptor in the immune system","volume":"202","author":"Wheway","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.exer.2022.109101_bib366","first-page":"1","article-title":"Complement and complement regulatory proteins in human tears","volume":"38","author":"Willcox","year":"1997","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib367","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jtos.2017.03.006","article-title":"TFOS DEWS II tear film report","volume":"15","author":"Willcox","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2022.109101_bib368","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s00417-018-3984-y","article-title":"Tear film proteome in age-related macular degeneration","volume":"256","author":"Winiarczyk","year":"2018","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib369","volume":"vol. 19","author":"Wishart","year":"2008"},{"key":"10.1016\/j.exer.2022.109101_bib370","doi-asserted-by":"crossref","first-page":"D608","DOI":"10.1093\/nar\/gkx1089","article-title":"HMDB 4.0: the human metabolome database for 2018","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.exer.2022.109101_bib371","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1016\/j.bbamem.2017.08.015","article-title":"Interaction of lysozyme with a tear film lipid layer model: a molecular dynamics simulation study","volume":"1859","author":"Wizert","year":"2017","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.exer.2022.109101_bib372","doi-asserted-by":"crossref","first-page":"6132","DOI":"10.1167\/iovs.14-15269","article-title":"Expression analysis of the transmembrane mucin MUC20 in human corneal and conjunctival epithelia","volume":"55","author":"Woodward","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib373","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1097\/01.ico.0000247217.16510.f2","article-title":"Phospholipids and their degrading enzyme in the tears of soft contact lens wearers","volume":"25","author":"Yamada","year":"2006","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2022.109101_bib374","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0002-9394(00)00415-3","article-title":"Decreased substance P concentrations in tears from patients with corneal hypesthesia","volume":"129","author":"Yamada","year":"2000","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib375","first-page":"637","article-title":"Role of substance P in experimental allergic conjunctivitis in Guinea pigs","volume":"19","author":"Yamaji","year":"1997","journal-title":"Methods Find Exp. Clin. Pharmacol."},{"key":"10.1016\/j.exer.2022.109101_bib376","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1242\/jeb.01730","article-title":"Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses","volume":"208","author":"Yancey","year":"2005","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.exer.2022.109101_bib377","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.4103\/1673-5374.308666","article-title":"Corneal neuromediator profiles following laser refractive surgery","volume":"16","author":"Yang","year":"2021","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.exer.2022.109101_bib378","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1016\/j.bios.2010.12.042","article-title":"A contact lens with embedded sensor for monitoring tear glucose level","volume":"26","author":"Yao","year":"2011","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.exer.2022.109101_bib379","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20153755","article-title":"Tear metabolomics in dry eye disease: a review","volume":"20","author":"Yazdani","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2022.109101_bib380","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1046\/j.1475-1313.2002.00066.x","article-title":"A multi-centre study of lapsed contact lens wearers","volume":"22","author":"Young","year":"2002","journal-title":"Ophthalmic Physiol. Opt."},{"key":"10.1016\/j.exer.2022.109101_bib381","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.exer.2007.11.013","article-title":"MUC19 expression in human ocular surface and lacrimal gland and its alteration in Sj\u00f6gren syndrome patients","volume":"86","author":"Yu","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib399","first-page":"441","article-title":"Comparative Analysis of Tear Film Levels of Inflammatory Mediators in Contact Lens Users","volume":"41","author":"Y\u00fcksel Elgin","year":"2016","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib382","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF00161161","article-title":"Proteins in tears from healthy and diseased eyes","volume":"50","author":"Zavaro","year":"1980","journal-title":"Doc. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109101_bib383","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1097\/00003226-200111000-00019","article-title":"Quantification of MUC5AC protein in human tears","volume":"20","author":"Zhao","year":"2001","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2022.109101_bib384","doi-asserted-by":"crossref","first-page":"27215","DOI":"10.1074\/jbc.M114.599712","article-title":"Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4","volume":"289","author":"Zhao","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2022.109101_bib385","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph15102269","article-title":"Association between dry eye disease, air pollution and weather changes in Taiwan","volume":"15","author":"Zhong","year":"2018","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.exer.2022.109101_bib386","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.preteyeres.2012.06.002","article-title":"Tear analysis in ocular surface diseases","volume":"31","author":"Zhou","year":"2012","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2022.109101_bib387","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/14789450.2017.1285703","article-title":"The power of tears: how tear proteomics research could revolutionize the clinic","volume":"14","author":"Zhou","year":"2017","journal-title":"Expet Rev. Proteonomics"},{"key":"10.1016\/j.exer.2022.109101_bib388","first-page":"2077","article-title":"Elevation of human \u03b1-defensins and S100 calcium-binding proteins A8 and A9","volume":"50","author":"Zhou","year":"2009","journal-title":"Tear Fluid of Patients with Pterygium"},{"key":"10.1016\/j.exer.2022.109101_bib389","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.1021\/pr900686s","article-title":"Identification of tear fluid biomarkers in dry eye syndrome using iTRAQ quantitative proteomics","volume":"8","author":"Zhou","year":"2009","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.exer.2022.109101_bib390","doi-asserted-by":"crossref","first-page":"400","DOI":"10.47102\/annals-acadmedsg.V35N6p400","article-title":"Characterisation of human tear proteins using high-resolution mass spectrometry","volume":"35","author":"Zhou","year":"2006","journal-title":"Ann. Acad. Med. Singapore"},{"key":"10.1016\/j.exer.2022.109101_bib391","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1016\/j.jprot.2012.04.053","article-title":"In-depth analysis of the human tear proteome","volume":"75","author":"Zhou","year":"2012","journal-title":"J. Proteonomics"},{"key":"10.1016\/j.exer.2022.109101_bib392","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S1471-4906(02)02228-7","article-title":"Immunology of the lacrimal gland and ocular tear film","volume":"23","author":"Zierhut","year":"2002","journal-title":"Trends Immunol."},{"key":"10.1016\/j.exer.2022.109101_bib393","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0143-4160(93)90053-9","article-title":"Identification of an S100 target protein: glycogen phosphorylase","volume":"14","author":"Zimmer","year":"1993","journal-title":"Cell Calcium"},{"key":"10.1016\/j.exer.2022.109101_bib394","doi-asserted-by":"crossref","first-page":"104351","DOI":"10.1016\/j.jprot.2021.104351","article-title":"Tear dynamics testing and quantitative proteomics analysis in patients with chronic renal failure","volume":"248","author":"Zong","year":"2021","journal-title":"J. Proteonomics"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483522001816?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483522001816?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:18:23Z","timestamp":1757999903000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483522001816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":399,"alternative-id":["S0014483522001816"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2022.109101","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biochemistry of human tear film: A review","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2022.109101","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109101"}}