{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:06:07Z","timestamp":1791489967970,"version":"4.3.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["117S264"],"award-info":[{"award-number":["117S264"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.exer.2022.109138","type":"journal-article","created":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T17:07:37Z","timestamp":1654448857000},"page":"109138","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Current methodology and cell sources for lacrimal gland tissue engineering"],"prefix":"10.1016","volume":"221","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5206-7894","authenticated-orcid":false,"given":"K\u0131van\u00e7","family":"Kasal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5212-5516","authenticated-orcid":false,"given":"Sinan","family":"G\u00fcven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4131-2532","authenticated-orcid":false,"given":"Canan Asli","family":"Utine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.exer.2022.109138_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169346","article-title":"Human lacrimal gland gene expression","volume":"12","author":"Aakalu","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2022.109138_bib2","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.46188","article-title":"Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform","volume":"8","author":"Achberger","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.exer.2022.109138_bib3","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1167\/iovs.15-16475","article-title":"Isolation and investigation of presumptive murine lacrimal gland stem cells","volume":"56","author":"Ackermann","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109138_bib4","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.stem.2021.02.024","article-title":"Exploring the human lacrimal gland using organoids and single-cell sequencing","volume":"28","author":"Bannier-H\u00e9laou\u00ebt","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.exer.2022.109138_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4615-2417-5_1","article-title":"Regulation of tear secretion","volume":"350","author":"Dartt","year":"1994","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2022.109138_bib6","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1242\/dev.01285","article-title":"Bmp7 regulates branching morphogenesis of the lacrimal gland by promoting mesenchymal proliferation and condensation","volume":"131","author":"Dean","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.exer.2022.109138_bib7","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.3109\/02713683.2016.1148741","article-title":"Development of causative treatment strategies for lacrimal gland insufficiency by tissue engineering and cell therapy. Part 1: regeneration of lacrimal gland tissue: can we stimulate lacrimal gland renewal in vivo?","volume":"41","author":"Dietrich","year":"2016","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2022.109138_bib8","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1080\/02713683.2019.1637438","article-title":"Towards lacrimal gland regeneration: current concepts and experimental approaches","volume":"45","author":"Dietrich","year":"2020","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2022.109138_bib9","doi-asserted-by":"crossref","first-page":"70","DOI":"10.5336\/medsci.2017-57770","article-title":"Tissue engineering and its application areas","volume":"38","author":"Ergin","year":"2018","journal-title":"Turkiye Klinikleri J. Med. Sci."},{"key":"10.1016\/j.exer.2022.109138_bib10","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/dvdy.24551","article-title":"Lacrimal gland development: from signaling interactions to regenerative medicine","volume":"246","author":"Garg","year":"2017","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.exer.2022.109138_bib11","doi-asserted-by":"crossref","first-page":"855","DOI":"10.5966\/sctm.2012-0093","article-title":"A practical and efficient cellular substrate for the generation of \u0131nduced pluripotent stem cells from adults: blood\u2010derived endothelial progenitor cells","volume":"1","author":"Geti","year":"2012","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.exer.2022.109138_bib12","doi-asserted-by":"crossref","first-page":"88","DOI":"10.5966\/sctm.2016-0191","article-title":"Lacrimal gland repair using progenitor cells","volume":"6","author":"Gromova","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.exer.2022.109138_bib13","first-page":"99","article-title":"Differentiation of rabbit bone marrow mesenchymal stem cells into corneal epithelial cells in vivo and ex vivo","volume":"15","author":"Gu","year":"2009","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2022.109138_bib14","first-page":"240","article-title":"Dry eye: an inflammatory ocular disease","volume":"9","author":"Hessen","year":"2014","journal-title":"J. Ophthalmic Vis. Res."},{"key":"10.1016\/j.exer.2022.109138_bib15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jtos.2015.11.005","article-title":"Challenges and strategies for regenerating the lacrimal gland","volume":"14","author":"Hirayama","year":"2016","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2022.109138_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41514-016-0001-8","article-title":"Identification of transcription factors that promote the differentiation of human pluripotent stem cells into lacrimal gland epithelium-like cells","volume":"3","author":"Hirayama","year":"2017","journal-title":"NPJ Aging Mech. Dis."},{"key":"10.1016\/j.exer.2022.109138_bib17","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.exer.2015.11.020","article-title":"Cytokeratin expression in mouse lacrimal gland germ epithelium","volume":"146","author":"Hirayama","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109138_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms3497","article-title":"Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ","volume":"4","author":"Hirayama","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2022.109138_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/s41576-022-00466-9","article-title":"Human organs-on-chips for disease modelling, drug development and personalized medicine","author":"Ingber","year":"2022","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.exer.2022.109138_bib20","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3390\/cells10020240","article-title":"The future of regenerative medicine: cell therapy using pluripotent stem cells and acellular therapies based on extracellular vesicles","volume":"10","author":"Jarrige","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.exer.2022.109138_bib21","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/emm.2013.121","article-title":"Human salivary gland stem cells ameliorate hyposalivation of radiation-damaged rat salivary glands","volume":"45","author":"Jeong","year":"2013","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.exer.2022.109138_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-021-02133-y","article-title":"Establishment of functional epithelial organoids from human lacrimal glands","volume":"12","author":"Jeong","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.exer.2022.109138_bib23","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1167\/iovs.17-23576","article-title":"Regeneration of lacrimal gland function to maintain the health of the ocular surface","volume":"59","author":"Kawakita","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109138_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.survophthal.2022.01.010","article-title":"Metabolomics and lipidomics approaches in human tears: a systematic review","author":"Khanna","year":"2022","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109138_bib25","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1542-0124(12)70081-2","article-title":"The definition and classification of dry eye disease","volume":"5","author":"Lemp","year":"2007","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2022.109138_bib26","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1089\/scd.2018.0176","article-title":"Rapid differentiation of multi-zone ocular cells from human \u0131nduced pluripotent stem cells and generation of corneal epithelial and endothelial cells","volume":"28","author":"Li","year":"2019","journal-title":"Stem Cell. Dev."},{"key":"10.1016\/j.exer.2022.109138_bib27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1089\/ten.tea.2015.0286","article-title":"Three-dimensional culture of functional adult rabbit lacrimal gland epithelial cells on decellularized scaffold","volume":"22","author":"Lin","year":"2016","journal-title":"Tissue Eng."},{"key":"10.1016\/j.exer.2022.109138_bib28","doi-asserted-by":"crossref","first-page":"982","DOI":"10.3390\/ijms17060982","article-title":"Strategies to optimize adult stem cell therapy for tissue regeneration","volume":"17","author":"Liu","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2022.109138_bib29","first-page":"1","article-title":"A ligation of the lacrimal excretory duct in mouse induces lacrimal gland inflammation with proliferative cells","volume":"1","author":"Liu","year":"2017","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.exer.2022.109138_bib30","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1242\/dev.127.12.2563","article-title":"FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development","volume":"127","author":"Makarenkova","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.exer.2022.109138_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jtos.2020.11.004","article-title":"Organoids and organ chips in ophthalmology","volume":"19","author":"Manafi","year":"2021","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2022.109138_bib32","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1002\/term.2631","article-title":"Development of lacrimal gland spheroids for lacrimal gland tissue regeneration","volume":"12","author":"Massie","year":"2018","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.exer.2022.109138_bib33","article-title":"Organ-on-chip in development: towards a roadmap for organs-on-chip","author":"Mastrangeli","year":"2019","journal-title":"Preprints"},{"key":"10.1016\/j.exer.2022.109138_bib34","series-title":"Development of High-Throughput Lacrimal Gland Organoid Platforms for Drug Discovery in Dry Eye Disease","author":"Rodboon","year":"2021"},{"key":"10.1016\/j.exer.2022.109138_bib35","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000315019","article-title":"Generation of two-and three-dimensional lacrimal gland constructs","volume":"45","author":"Schrader","year":"2010","journal-title":"Res. Proj. Dry Eye Syndr."},{"key":"10.1016\/j.exer.2022.109138_bib36","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1007\/s00417-007-0612-7","article-title":"Amniotic membrane as a carrier for lacrimal gland acinar cells","volume":"245","author":"Schrader","year":"2007","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109138_bib37","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1136\/bjo.2008.137927","article-title":"Cultivation of lacrimal gland acinar cells in a microgravity environment","volume":"293","author":"Schrader","year":"2009","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109138_bib38","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1002\/sctm.20-0007","article-title":"Precision installation of a highly efficient suicide gene safety switch in human induced pluripotent stem cells","volume":"9","author":"Shi","year":"2020","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.exer.2022.109138_bib39","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s00417-018-3926-8","article-title":"Establishing and characterizing lacrispheres from human lacrimal gland for potential clinical application","volume":"256","author":"Tiwari","year":"2018","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109138_bib40","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1167\/iovs.08-2503","article-title":"Purification and characterization of mouse lacrimal gland epithelial cells and reconstruction of an acinarlike structure in three-dimensional culture","volume":"50","author":"Ueda","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109138_bib41","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1167\/iovs.11-7893","article-title":"Role of epithelial-mesenchymal transition in repair of the lacrimal gland after experimentally induced injury","volume":"53","author":"You","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109138_bib42","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1167\/iovs.10-5686","article-title":"Isolation and propagation of mesenchymal stem cells from the lacrimal gland","volume":"52","author":"You","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109138_bib43","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00441-011-1271-x","article-title":"Detection of brdu-label retaining cells in the lacrimal gland: \u0131mplications for tissue repair","volume":"346","author":"You","year":"2011","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.exer.2022.109138_bib44","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.3748\/wjg.v11.i19.2906","article-title":"Nestin-positive progenitor cells isolated from human fetal pancreas have phenotypic markers identical to mesenchymal stem cells","volume":"11","author":"Zhang","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.exer.2022.109138_bib45","doi-asserted-by":"crossref","first-page":"4399","DOI":"10.1167\/iovs.08-1730","article-title":"Mechanisms of murine lacrimal gland repair after experimentally induced inflammation","volume":"49","author":"Zoukhri","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483522002184?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483522002184?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:18:23Z","timestamp":1757999903000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483522002184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":45,"alternative-id":["S0014483522002184"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2022.109138","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Current methodology and cell sources for lacrimal gland tissue engineering","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2022.109138","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109138"}}