{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T02:48:19Z","timestamp":1777344499843,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002911","name":"Universidad Complutense de Madrid","doi-asserted-by":"publisher","award":["AEC44\/20\u201323116"],"award-info":[{"award-number":["AEC44\/20\u201323116"]}],"id":[{"id":"10.13039\/501100002911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003751","name":"Ministerio de Sanidad, Servicios Sociales e Igualdad","doi-asserted-by":"publisher","award":["RD16\/0008\/0017"],"award-info":[{"award-number":["RD16\/0008\/0017"]}],"id":[{"id":"10.13039\/501100003751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","award":["PEJ-2019-TL \/ BMD-12441"],"award-info":[{"award-number":["PEJ-2019-TL \/ BMD-12441"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.exer.2022.109245","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T11:13:39Z","timestamp":1662549219000},"page":"109245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Effects of hyperosmolarity on annexin A1 on ocular surface epithelium in vitro"],"prefix":"10.1016","volume":"224","author":[{"given":"Miguel Angel","family":"Fernandez \u2013Torres","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria Eugenia","family":"Lled\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria J","family":"Perez de Lara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6722-2044","authenticated-orcid":false,"given":"Ana","family":"Guzman-Aranguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2022.109245_bib1","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1186\/1471-2407-14-961","article-title":"Role of intracellular and extracellular annexin A1 in migration and invasion of human pancreatic carcinoma cells","volume":"14","author":"Belvedere","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.exer.2022.109245_bib2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.gene.2017.02.032","article-title":"ANXA1Ac2-26 peptide, a possible therapeutic approach in inflammatory ocular diseases","volume":"614","author":"Cardin","year":"2017","journal-title":"Gene"},{"key":"10.1016\/j.exer.2022.109245_bib3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0014-5793(03)00570-2","article-title":"Annexin A1 processing is associated with caspase-dependent apoptosis in BZR cells","volume":"546","author":"Debret","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.exer.2022.109245_bib4","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/imm.13184","article-title":"The role of annexin A1 in the modulation of the NLRP3 inflammasome","volume":"160","author":"Galvao","year":"2020","journal-title":"Immunology"},{"key":"10.1016\/j.exer.2022.109245_bib5","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1167\/tvst.6.5.10","article-title":"Augmenting endogenous levels of retinal annexin A1 suppresses uveitis in mice","volume":"6","author":"Gardner","year":"2017","journal-title":"Transl. Vis Sci. Technol."},{"key":"10.1016\/j.exer.2022.109245_bib6","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.exer.2015.03.013","article-title":"Beneficial effect of annexin A1 in a model of experimental allergic conjunctivitis","volume":"134","author":"Gimenes","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109245_bib7","doi-asserted-by":"crossref","first-page":"5689","DOI":"10.4049\/jimmunol.1202030","article-title":"Anti-inflammatory mechanisms of the annexin A1 protein and its mimetic peptide Ac2-26 in models of ocular inflammation in vivo and in vitro","volume":"190","author":"Girol","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.exer.2022.109245_bib8","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/jcb.20293","article-title":"Differentiation of human colon adenocarcinoma cells alters the expression and intracellular localization of annexins A1, A2, and A5","volume":"94","author":"Guzman-Aranguez","year":"2005","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.exer.2022.109245_bib9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s11302-017-9556-5","article-title":"Hyperosmotic stress induces ATP release and changes in P2X7 receptor levels in human corneal and conjunctival epithelial cells","volume":"13","author":"Guzman-Aranguez","year":"2017","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.exer.2022.109245_bib10","doi-asserted-by":"crossref","first-page":"5665","DOI":"10.4049\/jimmunol.1102306","article-title":"Regulation of cytosolic phospholipase A2 phosphorylation by proteolytic cleavage of annexin A1 in activated mast cells","volume":"188","author":"Kwon","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.exer.2022.109245_bib11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1167\/iovs.13-12080","article-title":"Tear proteomic analysis of patients with type 2 diabetes and dry eye syndrome by two-dimensional nano-liquid chromatography coupled with tandem mass spectrometry","volume":"55","author":"Li","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109245_bib12","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.exer.2005.08.019","article-title":"JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cells","volume":"82","author":"Li","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2022.109245_bib13","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1096\/fj.06-7464rev","article-title":"Annexin 1: the new face of an old molecule","volume":"21","author":"Lim","year":"2007","journal-title":"Faseb. J."},{"key":"10.1016\/j.exer.2022.109245_bib14","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/ICO.0b013e318030d259","article-title":"Hyperosmolarity-induced apoptosis in human corneal epithelial cells is mediated by cytochrome c and MAPK pathways","volume":"26","author":"Luo","year":"2007","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2022.109245_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.618653","article-title":"Pro-resolving mediator annexin A1 regulates intracellular Ca(2+) and mucin secretion in cultured goblet cells suggesting a new use in inflammatory conjunctival diseases","volume":"12","author":"Lyngstadaas","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exer.2022.109245_bib16","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ejphar.2018.11.008","article-title":"Involvement of the annexin A1-Fpr anti-inflammatory system in the ocular allergy","volume":"842","author":"Marmorato","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.exer.2022.109245_bib17","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1242\/jcs.111.20.3007","article-title":"Polarized localizations of annexins I, II, VI and XIII in epithelial cells of intestinal, hepatic and pancreatic tissues","volume":"111","author":"Massey-Harroche","year":"1998","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.exer.2022.109245_bib18","first-page":"3141","article-title":"Molecular basis for MMP9 induction and disruption of epithelial cell-cell contacts by galectin-3","volume":"127","author":"Mauris","year":"2014","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.exer.2022.109245_bib19","first-page":"1583","article-title":"The involvement of anti-inflammatory protein, annexin A1, in ocular toxoplasmosis","volume":"18","author":"Mimura","year":"2012","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2022.109245_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0126277","article-title":"Upregulation of NLRP3 inflammasome in the tears and ocular surface of dry eye patients","volume":"10","author":"Niu","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2022.109245_bib21","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00011-003-1235-z","article-title":"Annexin 1: more than an anti-phospholipase protein","volume":"53","author":"Parente","year":"2004","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.exer.2022.109245_bib22","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1080\/14728222.2017.1364363","article-title":"Annexin A1 and specialized proresolving lipid mediators: promoting resolution as a therapeutic strategy in human inflammatory diseases","volume":"21","author":"Perucci","year":"2017","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.exer.2022.109245_bib23","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.ajo.2011.08.023","article-title":"Tear dysfunction and the cornea: LXVIII edward Jackson memorial lecture","volume":"152","author":"Pflugfelder","year":"2011","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2022.109245_bib24","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.bbamcr.2006.08.041","article-title":"Proteolytic cleavage of annexin 1 by human leukocyte elastase","volume":"1763","author":"Rescher","year":"2006","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.exer.2022.109245_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/cells9040926","article-title":"Annexin A1 regulates NLRP3 inflammasome activation and modifies lipid release profile in isolated peritoneal macrophages","author":"Sanches","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.exer.2022.109245_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/cells10010121","article-title":"Role of annexin A1 in NLRP3 inflammasome activation in murine neutrophils","volume":"10","author":"Sanches","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.exer.2022.109245_bib27","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s004030000172","article-title":"Membrane expression of annexin I is enhanced by calcium and TPA in cultured human keratinocytes","volume":"292","author":"Sato-Matsumura","year":"2000","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.exer.2022.109245_bib28","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jprot.2012.11.017","article-title":"Tear proteome and protein network analyses reveal a novel pentamarker panel for tear film characterization in dry eye and meibomian gland dysfunction","volume":"78","author":"Soria","year":"2013","journal-title":"J. Proteonomics"},{"key":"10.1016\/j.exer.2022.109245_bib29","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","article-title":"TFOS DEWS II epidemiology report","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2022.109245_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8239258","article-title":"Annexin A1 and the resolution of inflammation: modulation of neutrophil recruitment, apoptosis, and clearance","author":"Sugimoto","year":"2016","journal-title":"J Immunol Res"},{"key":"10.1016\/j.exer.2022.109245_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21239271","article-title":"Defining dry eye from a clinical perspective","volume":"21","author":"Tsubota","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2022.109245_bib32","first-page":"2559","article-title":"Annexin I degradation in bronchoalveolar lavage fluids from healthy smokers: a possible mechanism of inflammation","volume":"4","author":"Vishwanatha","year":"1998","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.exer.2022.109245_bib33","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1021\/bi00167a036","article-title":"Role of the amino-terminal domain in regulating interactions of annexin-I with membranes - effects of amino-terminal truncation and mutagenesis of the phosphorylation sites","volume":"33","author":"Wang","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.exer.2022.109245_bib34","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.4049\/jimmunol.1000119","article-title":"A proinflammatory role for proteolytically cleaved annexin A1 in neutrophil transendothelial migration","volume":"185","author":"Williams","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.exer.2022.109245_bib35","first-page":"S7","article-title":"Identification of the 37 kda Annexin-A1 protein in tears of normal subjects and association of its 33 kda inactive form with active vernal keratoconjunctivitis Patients","author":"Yazid","year":"2012","journal-title":"J. Allergy Ther."},{"key":"10.1016\/j.exer.2022.109245_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2014.12.004","article-title":"Annexin-A1 restricts Th17 cells and attenuates the severity of autoimmune disease","volume":"58","author":"Yazid","year":"2015","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.exer.2022.109245_bib37","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1167\/iovs.18-23965","article-title":"Hyperosmotic stress-induced TRPM2 channel activation stimulates NLRP3 inflammasome activity in primary human corneal epithelial cells","volume":"59","author":"Zheng","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2022.109245_bib38","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s10753-021-01555-3","article-title":"Crosstalk between RPE cells and choroidal endothelial cells via the ANXA1\/FPR2\/SHP2\/NLRP3 inflammasome\/pyroptosis Axis promotes choroidal neovascularization","volume":"45","author":"Zhu","year":"2022","journal-title":"Inflammation"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483522003256?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483522003256?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:33:52Z","timestamp":1762148032000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483522003256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":38,"alternative-id":["S0014483522003256"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2022.109245","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of hyperosmolarity on annexin A1 on ocular surface epithelium in vitro","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2022.109245","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109245"}}