{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T04:22:22Z","timestamp":1781929342896,"version":"3.54.5"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.exer.2023.109387","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T20:33:51Z","timestamp":1673642031000},"page":"109387","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Efficacy and safety of microbial transglutaminase-induced scleral stiffening in vivo"],"prefix":"10.1016","volume":"227","author":[{"given":"Xiaona","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2023.109387_bib1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ophtha.2003.05.010","article-title":"Prevalence and causes of visual impairment and blindness among 9980 Scandinavian adults - the Copenhagen City Eye Study","volume":"111","author":"Buch","year":"2004","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2023.109387_bib2","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0161-6420(02)01898-5","article-title":"Incidence of blindness and low vision in a sample population: the Priverno Eye Study","volume":"110","author":"Cedrone","year":"2003","journal-title":"Italy. Ophthalmol."},{"key":"10.1016\/j.exer.2023.109387_bib3","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/jbm.b.30439","article-title":"Gelatin-based biomimetic tissue adhesive. Potential for retinal reattachment","volume":"77","author":"Chen","year":"2006","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.exer.2023.109387_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14050900","article-title":"The role of atropine in preventing myopia progression: an update","volume":"14","author":"Chierigo","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.exer.2023.109387_bib5","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1089\/ten.2006.12.1467","article-title":"Characterization of a microbial transglutaminase cross-linked type II collagen scaffold","volume":"12","author":"Dm","year":"2006","journal-title":"Tissue Eng."},{"key":"10.1016\/j.exer.2023.109387_bib6","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/519276a","article-title":"The myopia boom","volume":"519","author":"Dolgin","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.exer.2023.109387_bib7","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.exer.2014.07.019","article-title":"Scleral cross-linking using riboflavin and ultraviolet-a radiation for prevention of progressive myopia in a rabbit model","volume":"127","author":"Dotan","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2023.109387_bib8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11274-019-2791-x","article-title":"Transglutaminases: part I-origins, sources, and biotechnological characteristics","volume":"36","author":"Duarte","year":"2020","journal-title":"World J. Microbiol. Biotechnol."},{"key":"10.1016\/j.exer.2023.109387_bib9","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/BF02764314","article-title":"Scleral change in experimentally myopic monkeys","volume":"228","author":"Funata","year":"1990","journal-title":"Graef Arch. Clin. Exp."},{"key":"10.1016\/j.exer.2023.109387_bib10","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1042\/bj20021234","article-title":"Transglutaminases: nature's biological glues","volume":"368","author":"Griffin","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.exer.2023.109387_bib11","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00253-012-4569-z","article-title":"Enzyme-catalyzed protein crosslinking","volume":"97","author":"Heck","year":"2013","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.exer.2023.109387_bib12","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.ophtha.2016.01.006","article-title":"Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050","volume":"123","author":"Holden","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2023.109387_bib13","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.ophtha.2006.04.022","article-title":"Prevalence and causes of low vision and blindness in a Japanese adult population: the Tajimi Study","volume":"113","author":"Iwase","year":"2006","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2023.109387_bib14","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.ophtha.2021.11.023","article-title":"Effect of repeated low-level red-light therapy for myopia control in children: a multicenter randomized controlled trial","volume":"129","author":"Jiang","year":"2022","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2023.109387_bib15","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s12223-013-0287-x","article-title":"Microbial transglutaminase and its application in the food industry. A review","volume":"59","author":"Kieliszek","year":"2014","journal-title":"Folia Microbiol."},{"key":"10.1016\/j.exer.2023.109387_bib16","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1186\/s12886-020-01751-z","article-title":"Various cross-linking methods inhibit the collagenase I degradation of rabbit scleral tissue","volume":"20","author":"Krasselt","year":"2020","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.exer.2023.109387_bib17","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1080\/02713683.2018.1522647","article-title":"Scleral cross-linking using glyceraldehyde for the prevention of axial elongation in the rabbit: blocked axial elongation and altered scleral microstructure","volume":"44","author":"Lin","year":"2019","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2023.109387_bib18","first-page":"354","article-title":"Scleral ultrastructure and biomechanical changes in rabbits after negative lens application","volume":"11","author":"Lin","year":"2018","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.exer.2023.109387_bib19","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/j.ophtha.2010.01.020","article-title":"Prevalence and progression of myopic retinopathy in Chinese adults: the Beijing Eye Study","volume":"117","author":"Liu","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2023.109387_bib20","doi-asserted-by":"crossref","first-page":"e253","DOI":"10.1111\/aos.12172","article-title":"Collagen crosslinking of porcine sclera using genipin","volume":"91","author":"Liu","year":"2013","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.exer.2023.109387_bib21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/jbm.b.31368","article-title":"Biomimetic sealant based on gelatin and microbial transglutaminase: an initial in vivo investigation","volume":"91","author":"Liu","year":"2009","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.exer.2023.109387_bib22","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.3665","article-title":"Preparation and characteristics of gelatin sponges crosslinked by microbial transglutaminase","volume":"5","author":"Long","year":"2017","journal-title":"PeerJ"},{"key":"10.1016\/j.exer.2023.109387_bib23","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/nrm1014","article-title":"Transglutaminases: crosslinking enzymes with pleiotropic functions","volume":"4","author":"Lorand","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.exer.2023.109387_bib24","first-page":"2179","article-title":"Structural and ultrastructural changes to the sclera in a mammalian model of high myopia","volume":"42","author":"McBrien","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109387_bib25","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.preteyeres.2017.09.004","article-title":"The epidemics of myopia: aetiology and prevention","volume":"62","author":"Morgan","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2023.109387_bib26","first-page":"133","article-title":"Effects of 7-methylxanthine on form-deprivation myopia in pigmented rabbits","volume":"5","author":"Nie","year":"2012","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.exer.2023.109387_bib27","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/0002-9394(71)91095-6","article-title":"The fine structure of human scleral collagen","volume":"71","author":"Spitznas","year":"1971","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2023.109387_bib28","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.bbrc.2020.05.078","article-title":"Effect of enzyme-induced collagen crosslinking on porcine sclera","volume":"528","author":"Sun","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2023.109387_bib29","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1021\/acs.bioconjchem.7b00594","article-title":"Primary amine-clustered DNA aptamer for DNA-protein conjugation catalyzed by microbial transglutaminase","volume":"28","author":"Takahara","year":"2017","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.exer.2023.109387_bib30","doi-asserted-by":"crossref","first-page":"M31","DOI":"10.1167\/iovs.18-25967","article-title":"IMI - report on experimental models of emmetropization and myopia","volume":"60","author":"Troilo","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109387_bib31","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12886-015-0086-z","article-title":"Effects of scleral cross-linking using genipin on the process of form-deprivation myopia in the Guinea pig: a randomized controlled experimental study","volume":"15","author":"Wang","year":"2015","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.exer.2023.109387_bib32","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.jcrs.2007.12.030","article-title":"Crosslinking of scleral collagen in the rabbit using glyceraldehyde","volume":"34","author":"Wollensak","year":"2008","journal-title":"J. Cataract Refract. Surg."},{"key":"10.1016\/j.exer.2023.109387_bib33","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1600-0420.2005.00447.x","article-title":"Cross-linking of scleral collagen in the rabbit using riboflavin and UVA","volume":"83","author":"Wollensak","year":"2005","journal-title":"Acta Ophthalmol. Scand."},{"key":"10.1016\/j.exer.2023.109387_bib34","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.jcrs.2003.11.032","article-title":"Collagen crosslinking of human and porcine sclera","volume":"30","author":"Wollensak","year":"2004","journal-title":"J. Cataract Refract. Surg."},{"key":"10.1016\/j.exer.2023.109387_bib35","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1167\/tvst.8.6.27","article-title":"Efficacy and safety of transglutaminase-induced corneal stiffening in rabbits","volume":"8","author":"Wu","year":"2019","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.exer.2023.109387_bib36","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/02713683.2017.1390770","article-title":"Crosslinking enzyme lysyl oxidase modulates scleral remodeling in form-deprivation myopia","volume":"43","author":"Yuan","year":"2018","journal-title":"Curr. Eye Res."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483523000088?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483523000088?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:24:13Z","timestamp":1758000253000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483523000088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":36,"alternative-id":["S0014483523000088"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2023.109387","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of microbial transglutaminase-induced scleral stiffening in vivo","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2023.109387","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109387"}}