{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:46:17Z","timestamp":1777549577765,"version":"3.51.4"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["C14\/18\/088"],"award-info":[{"award-number":["C14\/18\/088"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G0A8619N"],"award-info":[{"award-number":["G0A8619N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.exer.2023.109406","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T20:26:11Z","timestamp":1675455971000},"page":"109406","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Unexpected failure of rod bipolar cell targeting using L7Cre-2 mice"],"prefix":"10.1016","volume":"228","author":[{"given":"Kaat","family":"Peperstraete","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2525-2269","authenticated-orcid":false,"given":"Myriam","family":"Baes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4872-7546","authenticated-orcid":false,"given":"Dani\u00eblle","family":"Swinkels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.exer.2023.109406_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/bmjopen-2020-037648","article-title":"Eye health and quality of life: an umbrella review protocol","volume":"10","author":"Assi","year":"2020","journal-title":"BMJ Open"},{"issue":"3\u20134","key":"10.1016\/j.exer.2023.109406_bib2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/1526-968X(200011\/12)28:3\/4<93::AID-GENE10>3.0.CO;2-W","article-title":"Cre recombinase expression in cerebellar Purkinje cells","volume":"28","author":"Barski","year":"2000","journal-title":"Genesis"},{"issue":"4","key":"10.1016\/j.exer.2023.109406_bib3","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/cne.903080409","article-title":"Cerebellar Purkinje cell markers are expressed in retinal bipolar neurons","volume":"308","author":"Berrebi","year":"1991","journal-title":"J. Comp. Neurol."},{"issue":"5","key":"10.1016\/j.exer.2023.109406_bib4","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s11103-005-7705-7","article-title":"Size does matter: Cre-mediated somatic deletion efficiency depends on the distance between the target lox-sites","volume":"58","author":"Coppoolse","year":"2005","journal-title":"Plant Mol. Biol."},{"issue":"1","key":"10.1016\/j.exer.2023.109406_bib5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11010-018-3489-3","article-title":"Differential distribution of peroxisomal proteins points to specific roles of peroxisomes in the murine retina","volume":"456","author":"Das","year":"2019","journal-title":"Mol. Cell. Biochem."},{"issue":"8","key":"10.1016\/j.exer.2023.109406_bib6","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.3390\/ijms22084101","article-title":"Peroxisomal disorders and their mouse models point to essential roles of peroxisomes for retinal integrity","volume":"22","author":"Das","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2023.109406_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.632930","article-title":"Peroxisomal multifunctional protein 2 deficiency perturbs lipid homeostasis in the retina and causes visual dysfunction in mice","volume":"9","author":"Das","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"5","key":"10.1016\/j.exer.2023.109406_bib8","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/bpa.12586","article-title":"Autonomous Purkinje cell axonal dystrophy causes ataxia in peroxisomal multifunctional protein-2 deficiency","volume":"28","author":"De Munter","year":"2018","journal-title":"Brain Pathol."},{"issue":"1","key":"10.1016\/j.exer.2023.109406_bib9","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/ana.20702","article-title":"Clinical and biochemical spectrum of D-bifunctional protein deficiency","volume":"59","author":"Ferdinandusse","year":"2006","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.exer.2023.109406_bib10","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.neuroscience.2009.10.021","article-title":"Characterization of transgenic mouse lines expressing Cre recombinase in the retina","volume":"165","author":"Ivanova","year":"2010","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.exer.2023.109406_bib11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuron.2020.01.008","article-title":"Optimizing nervous system-specific gene targeting with Cre driver lines: prevalence of germline recombination and influencing factors","volume":"106","author":"Luo","year":"2020","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.exer.2023.109406_bib12","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"Madisen","year":"2010","journal-title":"Nat. Neurosci."},{"issue":"9","key":"10.1016\/j.exer.2023.109406_bib13","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A global double-fluorescent Cre reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genesis"},{"issue":"4952","key":"10.1016\/j.exer.2023.109406_bib14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1126\/science.2109351","article-title":"A promoter that drives transgene expression in cerebellar Purkinje and retinal bipolar neurons","volume":"248","author":"Oberdick","year":"1990","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.exer.2023.109406_bib15","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.bbrc.2005.04.043","article-title":"L7\/Pcp-2 -specific expression of Cre recombinase using knock-in approach","volume":"331","author":"Saito","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.exer.2023.109406_bib16","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1006\/mcne.1995.1019","article-title":"Local control of granule cell generation by cerebellar Purkinje cells","volume":"6","author":"Smeyne","year":"1995","journal-title":"Mol. Cell. Neurosci."},{"issue":"5","key":"10.1016\/j.exer.2023.109406_bib17","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.tig.2017.12.008","article-title":"Detecting and avoiding problems when using the cre\u2013lox system","volume":"34","author":"Song","year":"2018","journal-title":"Trends Genet."},{"issue":"1","key":"10.1016\/j.exer.2023.109406_bib18","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3390\/cells11010161","article-title":"Cell type-selective loss of peroxisomal \u03b2-oxidation impairs bipolar cell but not photoreceptor survival in the retina","volume":"11","author":"Swinkels","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.exer.2023.109406_bib19","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.nbd.2013.06.006","article-title":"Peroxisomal multifunctional protein-2 deficiency causes neuroinflammation and degeneration of Purkinje cells independent of very long chain fatty acid accumulation","volume":"58","author":"Verheijden","year":"2013","journal-title":"Neurobiol. Dis."},{"issue":"5","key":"10.1016\/j.exer.2023.109406_bib20","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.bbamcr.2015.11.015","article-title":"Human disorders of peroxisome metabolism and biogenesis","volume":"1863","author":"Waterham","year":"2016","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"issue":"3","key":"10.1016\/j.exer.2023.109406_bib21","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/jnc.14643","article-title":"Tmem30a deficiency leads to retinal rod bipolar cell degeneration","volume":"148","author":"Yang","year":"2019","journal-title":"J. Neurochem."},{"issue":"10","key":"10.1016\/j.exer.2023.109406_bib22","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1167\/iovs.04-1201","article-title":"Transgenic mice expressing Cre-recombinase specifically in retinal rod bipolar neurons","volume":"46","author":"Zhang","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.exer.2023.109406_bib23","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0114-19.2019","article-title":"Targeting microglia using Cx3cr1-Cre lines: revisiting the specificity","volume":"6","author":"Zhao","year":"2019","journal-title":"eNeuro"},{"issue":"9","key":"10.1016\/j.exer.2023.109406_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0238435","article-title":"Loss of the ER membrane protein complex subunit Emc3 leads to retinal bipolar cell degeneration in aged mice","volume":"15","author":"Zhu","year":"2020","journal-title":"PLoS One"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483523000271?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483523000271?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:48:53Z","timestamp":1777398533000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483523000271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":24,"alternative-id":["S0014483523000271"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2023.109406","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unexpected failure of rod bipolar cell targeting using L7Cre-2 mice","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2023.109406","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109406"}}