{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:18:38Z","timestamp":1790734718198,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"am","delay-in-days":332,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY029395"],"award-info":[{"award-number":["EY029395"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY034114"],"award-info":[{"award-number":["EY034114"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.exer.2023.109456","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T19:54:07Z","timestamp":1679687647000},"page":"109456","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Collagen XII regulates stromal wound closure"],"prefix":"10.1016","volume":"230","author":[{"given":"Christopher","family":"Donovan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devon","family":"Cogswell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel Y.","family":"Avila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis E.","family":"Margo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8377-5212","authenticated-orcid":false,"given":"Edgar M.","family":"Espana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2023.109456_bib1","doi-asserted-by":"crossref","first-page":"22549","DOI":"10.1074\/jbc.M111.335935","article-title":"Collagen XII and XIV, new partners of cartilage oligomeric matrix protein in the skin extracellular matrix suprastructure","volume":"287","author":"Agarwal","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2023.109456_bib2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/ICL.0000000000000908","article-title":"Clinical characteristics and severity distribution of tertiary eye center attendance by ocular chemical injury patients","volume":"48","author":"Akgun","year":"2022","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.exer.2023.109456_bib3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1242\/jcs.00229","article-title":"Making sense of latent TGFbeta activation","volume":"116","author":"Annes","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.exer.2023.109456_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2017.04.003","article-title":"The provisional matrix: setting the stage for tissue repair outcomes","volume":"60\u201361","author":"Barker","year":"2017","journal-title":"Matrix Biol."},{"key":"10.1016\/j.exer.2023.109456_bib5","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.matbio.2017.07.005","article-title":"Identification of a myofibroblast-specific expression signature in skin wounds","volume":"65","author":"Bergmeier","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.exer.2023.109456_bib6","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nrm3904","article-title":"Remodelling the extracellular matrix in development and disease","volume":"15","author":"Bonnans","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.exer.2023.109456_bib7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jtos.2020.11.008","article-title":"Creation and grading of experimental corneal scars in mice models","volume":"19","author":"Cogswell","year":"2021","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2023.109456_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108137","article-title":"Composition, structure and function of the corneal stroma","author":"Espana","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2023.109456_bib9","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1167\/iovs.14-16030","article-title":"Existence of corneal endothelial slow-cycling cells","volume":"56","author":"Espana","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109456_bib10","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1001\/archopht.1990.01070070051034","article-title":"Wound healing after excimer laser keratomileusis (photorefractive keratectomy) in monkeys","volume":"108","author":"Fantes","year":"1990","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2023.109456_bib11","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0945-053X(96)90137-7","article-title":"Characterization of the interactions of type XII collagen with two small proteoglycans from fetal bovine tendon, decorin and fibromodulin","volume":"15","author":"Font","year":"1996","journal-title":"Matrix Biol."},{"key":"10.1016\/j.exer.2023.109456_bib12","doi-asserted-by":"crossref","first-page":"6040","DOI":"10.1073\/pnas.84.17.6040","article-title":"Type XII collagen: distinct extracellular matrix component discovered by cDNA cloning","volume":"84","author":"Gordon","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2023.109456_bib13","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1167\/iovs.12-11456","article-title":"Abnormal corneal endothelial maturation in collagen XII and XIV null mice","volume":"54","author":"Hemmavanh","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109456_bib14","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1093\/hmg\/ddt637","article-title":"Mutations in the collagen XII gene define a new form of extracellular matrix-related myopathy","volume":"23","author":"Hicks","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2023.109456_bib15","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1126\/science.1192149","article-title":"Noncanonical TGFbeta signaling contributes to aortic aneurysm progression in Marfan syndrome mice","volume":"332","author":"Holm","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.exer.2023.109456_bib16","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1126\/science.1176009","article-title":"The extracellular matrix: not just pretty fibrils","volume":"326","author":"Hynes","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.exer.2023.109456_bib17","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1083\/jcb.201010010","article-title":"Type XII collagen regulates osteoblast polarity and communication during bone formation","volume":"193","author":"Izu","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.exer.2023.109456_bib18","doi-asserted-by":"crossref","first-page":"4989","DOI":"10.1167\/iovs.07-0654","article-title":"Compositional differences between infant and adult human corneal basement membranes","volume":"48","author":"Kabosova","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109456_bib19","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1083\/jcb.113.4.971","article-title":"Two type XII-like collagens localize to the surface of banded collagen fibrils","volume":"113","author":"Keene","year":"1991","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.exer.2023.109456_bib20","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1083\/jcb.130.4.1005","article-title":"Large and small splice variants of collagen XII: differential expression and ligand binding","volume":"130","author":"Koch","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.exer.2023.109456_bib21","first-page":"997","article-title":"Extracellular matrix alterations in human corneas with bullous keratopathy","volume":"37","author":"Ljubimov","year":"1996","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109456_bib22","doi-asserted-by":"crossref","first-page":"7246","DOI":"10.1167\/iovs.11-8592","article-title":"NC1 long and NC3 short splice variants of type XII collagen are overexpressed during corneal scarring","volume":"53","author":"Massoudi","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109456_bib23","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1002\/acn3.50882","article-title":"Dominant collagen XII mutations cause a distal myopathy","volume":"6","author":"Mohassel","year":"2019","journal-title":"Ann Clin Transl Neurol"},{"key":"10.1016\/j.exer.2023.109456_bib24","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1167\/iovs.63.12.24","article-title":"Multiple optical elastography techniques reveal the regulation of corneal stiffness by collagen XII","volume":"63","author":"Nair","year":"2022","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109456_bib25","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.227900","article-title":"The myofibroblast at a glance","volume":"133","author":"Pakshir","year":"2020","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.exer.2023.109456_bib26","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/dvdy.331","article-title":"The role of LTBPs in TGF beta signaling","volume":"251","author":"Rifkin","year":"2022","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.exer.2023.109456_bib27","doi-asserted-by":"crossref","first-page":"7409","DOI":"10.1074\/jbc.R400029200","article-title":"Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability","volume":"280","author":"Rifkin","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2023.109456_bib28","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.matbio.2017.11.014","article-title":"LTBPs in biology and medicine: LTBP diseases","volume":"71\u201372","author":"Rifkin","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.exer.2023.109456_bib29","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.matbio.2015.05.005","article-title":"Latent TGF-beta-binding proteins","volume":"47","author":"Robertson","year":"2015","journal-title":"Matrix Biol."},{"key":"10.1016\/j.exer.2023.109456_bib30","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a021907","article-title":"Regulation of the bioavailability of TGF-beta and TGF-beta-related proteins","volume":"8","author":"Robertson","year":"2016","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.exer.2023.109456_bib31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.matbio.2020.08.002","article-title":"Role of collagen XII in skin homeostasis and repair","volume":"94","author":"Schonborn","year":"2020","journal-title":"Matrix Biol."},{"key":"10.1016\/j.exer.2023.109456_bib32","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.ajpath.2021.10.014","article-title":"Collagen XII regulates corneal stromal structure by modulating transforming growth factor-beta activity","volume":"192","author":"Sun","year":"2022","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2023.109456_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajpath.2021.08.016","article-title":"Collagen XIV is an intrinsic regulator of corneal stromal structure and function","author":"Sun","year":"2021","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2023.109456_bib34","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1167\/iovs.61.5.61","article-title":"Collagen XII is a regulator of corneal stroma structure and function","volume":"61","author":"Sun","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109456_bib35","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/ar.a.10120","article-title":"Expression of FACIT collagens XII and XIV during bleomycin-induced pulmonary fibrosis in mice","volume":"275","author":"Tzortzaki","year":"2003","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"},{"key":"10.1016\/j.exer.2023.109456_bib36","doi-asserted-by":"crossref","first-page":"27461","DOI":"10.1074\/jbc.M603147200","article-title":"Collagen XII interacts with avian tenascin-X through its NC3 domain","volume":"281","author":"Veit","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2023.109456_bib37","doi-asserted-by":"crossref","first-page":"114","DOI":"10.7205\/MILMED-D-16-00041","article-title":"Corneal and corneoscleral injury in combat ocular trauma from operations Iraqi freedom and enduring freedom","volume":"182","author":"Vlasov","year":"2017","journal-title":"Mil. Med."},{"key":"10.1016\/j.exer.2023.109456_bib38","first-page":"2408","article-title":"Type XII collagen contributes to diversities in human corneal and limbal extracellular matrices","volume":"38","author":"Wessel","year":"1997","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109456_bib39","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in tissue repair, regeneration, and fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.exer.2023.109456_bib40","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1089\/jop.2021.0116","article-title":"Effects of regular\/dilute proparacaine anesthetic eye drops in combination with ophthalmic antibiotics on corneal wound healing","volume":"38","author":"Zhang","year":"2022","journal-title":"J. Ocul. Pharmacol. Therapeut."},{"key":"10.1016\/j.exer.2023.109456_bib41","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1093\/hmg\/ddt627","article-title":"Recessive and dominant mutations in COL12A1 cause a novel EDS\/myopathy overlap syndrome in humans and mice","volume":"23","author":"Zou","year":"2014","journal-title":"Hum. Mol. Genet."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483523000775?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483523000775?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:22:56Z","timestamp":1758000176000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483523000775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":41,"alternative-id":["S0014483523000775"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2023.109456","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Collagen XII regulates stromal wound closure","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2023.109456","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109456"}}