{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:06:06Z","timestamp":1791489966756,"version":"4.3.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"am","delay-in-days":314,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY029870"],"award-info":[{"award-number":["EY029870"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.exer.2023.109526","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T12:37:57Z","timestamp":1686141477000},"page":"109526","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Role of the adenylate cyclase\/cyclic AMP pathway in oxytocin-induced lacrimal gland myoepithelial cells contraction"],"prefix":"10.1016","volume":"233","author":[{"given":"Angela","family":"G\u00e1rriz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Morokuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Toribio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1622-4431","authenticated-orcid":false,"given":"Driss","family":"Zoukhri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2023.109526_bib1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1124\/mol.112.080689","article-title":"A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion","volume":"83","author":"Almahariq","year":"2013","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.exer.2023.109526_bib2","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1016\/S0021-9258(18)32814-X","article-title":"Interactions of forskolin and adenylate cyclase. Effects on substrate kinetics and protection against inactivation by heat and N-ethylmaleimide","volume":"258","author":"Awad","year":"1983","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2023.109526_bib3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1146\/annurev.physiol.61.1.85","article-title":"Excitation-contraction coupling in gastrointestinal and other smooth muscles","volume":"61","author":"Bolton","year":"1999","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.exer.2023.109526_bib4","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1074\/jbc.M111.277178","article-title":"Functional selective oxytocin-derived agonists discriminate between individual G protein family subtypes","volume":"287","author":"Busnelli","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2023.109526_bib5","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/360684a0","article-title":"Isozyme-selective stimulation of phospholipase C-beta 2 by G protein beta gamma-subunits","volume":"360","author":"Camps","year":"1992","journal-title":"Nature"},{"issue":"Pt 1","key":"10.1016\/j.exer.2023.109526_bib6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1469-7793.1998.235bi.x","article-title":"Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells","volume":"511","author":"Carranza","year":"1998","journal-title":"J. Physiol."},{"key":"10.1016\/j.exer.2023.109526_bib7","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.bbrc.2013.09.107","article-title":"The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1)","volume":"440","author":"Courilleau","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2023.109526_bib8","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1113\/jphysiol.1968.sp008513","article-title":"Neural control of salivary myoepithelial cells","volume":"196","author":"Emmelin","year":"1968","journal-title":"J. Physiol."},{"key":"10.1016\/j.exer.2023.109526_bib9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0014-2999(98)00439-7","article-title":"Phosphodiesterase inhibitors suppress alpha2-adrenoceptor-mediated 5-hydroxytryptamine release from tracheae of newborn rabbits","volume":"354","author":"Freitag","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.exer.2023.109526_bib10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1167\/iovs.62.14.25","article-title":"Role of the phospholipase C pathway and calcium mobilization in oxytocin-induced contraction of lacrimal gland myoepithelial cells","volume":"62","author":"Garriz","year":"2021","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109526_bib11","doi-asserted-by":"crossref","first-page":"8802","DOI":"10.1016\/S0021-9258(18)81864-6","article-title":"Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein","volume":"264","author":"Glass","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2023.109526_bib12","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1111\/j.1471-4159.2010.06861.x","article-title":"Dual modulation of inward rectifier potassium currents in olfactory neuronal cells by promiscuous G protein coupling of the oxytocin receptor","volume":"114","author":"Gravati","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.exer.2023.109526_bib13","doi-asserted-by":"crossref","first-page":"9919","DOI":"10.1038\/s41598-018-28227-x","article-title":"Myoepithelial cell-driven acini contraction in response to oxytocin receptor stimulation is impaired in lacrimal glands of Sjogren's syndrome animal models","volume":"8","author":"Hawley","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2023.109526_bib14","first-page":"610","article-title":"Identification of vasoactive intestinal peptide receptor subtypes in the lacrimal gland and their signal-transducing components","volume":"38","author":"Hodges","year":"1997","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109526_bib15","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.bone.2008.04.023","article-title":"Use of an alpha-smooth muscle actin GFP reporter to identify an osteoprogenitor population","volume":"43","author":"Kalajzic","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.exer.2023.109526_bib16","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1124\/pr.111.005603","article-title":"The expanding roles of G<em>\u03b2\u03b3<\/em> subunits in G protein\u2013coupled receptor signaling and drug action","volume":"65","author":"Khan","year":"2013","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.exer.2023.109526_bib17","article-title":"Effects of dibutyryl cyclic-AMP on survival and neuronal differentiation of neural stem\/progenitor cells transplanted into spinal cord injured rats","volume":"6","author":"Kim","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2023.109526_bib18","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/jss.400040206","article-title":"The cytochemical localization of adenylate cyclase activity in mucous and serous cells of the salivary gland","volume":"4","author":"Kim","year":"1976","journal-title":"J. Supramol. Struct."},{"key":"10.1016\/j.exer.2023.109526_bib19","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0960-894X(97)00136-4","article-title":"Bioactivatable derivatives of 8-substituted cAMP-analogues","volume":"7","author":"Kruppa","year":"1997","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.exer.2023.109526_bib20","doi-asserted-by":"crossref","first-page":"a006023","DOI":"10.1101\/cshperspect.a006023","article-title":"Signaling in muscle contraction","volume":"7","author":"Kuo","year":"2015","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.exer.2023.109526_bib21","doi-asserted-by":"crossref","first-page":"149","DOI":"10.5483\/BMBRep.2021.54.3.233","article-title":"Epac: new emerging cAMP-binding protein","volume":"54","author":"Lee","year":"2021","journal-title":"BMB Rep."},{"key":"10.1016\/j.exer.2023.109526_bib22","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/aja.1001320202","article-title":"Myoepithelial cells in the exorbital lacrimal and parotid glands of the rat in frozen-etched replicas","volume":"132","author":"Leeson","year":"1971","journal-title":"Am. J. Anat."},{"key":"10.1016\/j.exer.2023.109526_bib23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0248-4900(96)84782-4","article-title":"Immunolocalization of myoepithelial cells in isolated acini of rat exorbital lacrimal gland: cellular distribution of muscarinic receptors","volume":"86","author":"Lemullois","year":"1996","journal-title":"Biol. Cell."},{"key":"10.1016\/j.exer.2023.109526_bib24","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3389\/fncel.2013.00155","article-title":"cAMP promotes the differentiation of neural progenitor cells in vitro via modulation of voltage-gated calcium channels","volume":"7","author":"Lepski","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.exer.2023.109526_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.574030","article-title":"Protein kinase inhibitor peptide as a tool to specifically inhibit protein kinase A","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.exer.2023.109526_bib26","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1527-3466.2006.00261.x","article-title":"The many faces of H89: a review","volume":"24","author":"Lochner","year":"2006","journal-title":"Cardiovasc. Drug Rev."},{"key":"10.1016\/j.exer.2023.109526_bib27","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s40610-015-0020-4","article-title":"Myoepithelial cells: their origin and function in lacrimal gland morphogenesis, homeostasis, and repair","volume":"1","author":"Makarenkova","year":"2015","journal-title":"Curr. Mol. Biol. Rep."},{"key":"10.1016\/j.exer.2023.109526_bib28","first-page":"1173","article-title":"Identification of G proteins in lacrimal gland","volume":"36","author":"Meneray","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109526_bib29","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s004240100521","article-title":"Synergistic effects of ATP on oxytocin-induced intracellular Ca2+ response in mouse mammary myoepithelial cells","volume":"442","author":"Nakano","year":"2001","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.exer.2023.109526_bib30","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.1074\/jbc.M608495200","article-title":"Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes","volume":"282","author":"Oestreich","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2023.109526_bib31","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1432-1033.1985.tb09010.x","article-title":"Activation of protein kinase isozymes by cyclic nucleotide analogs used singly or in combination. Principles for optimizing the isozyme specificity of analog combinations","volume":"150","author":"Ogreid","year":"1985","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.exer.2023.109526_bib32","doi-asserted-by":"crossref","first-page":"9503","DOI":"10.1167\/iovs.11-7809","article-title":"Increase of intracellular Ca2+ by purinergic receptors in cultured rat lacrimal gland myoepithelial cells","volume":"52","author":"Ohtomo","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109526_bib33","first-page":"L279","article-title":"Interactions between Ca2+ and cAMP messenger system in regulation of airway smooth muscle contraction","volume":"258","author":"Rasmussen","year":"1990","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.exer.2023.109526_bib34","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10911-005-9583-7","article-title":"Oxytocin receptor signaling in myoepithelial and cancer cells","volume":"10","author":"Reversi","year":"2005","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"10.1016\/j.exer.2023.109526_bib35","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1113\/eph8602179","article-title":"Hormones and calcium: mechanisms controlling uterine smooth muscle contractile activity. The Litchfield Lecture","volume":"86","author":"Sanborn","year":"2001","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.exer.2023.109526_bib36","doi-asserted-by":"crossref","first-page":"L991","DOI":"10.1152\/ajplung.00273.2021","article-title":"Melatonin MT2 receptor is expressed and potentiates contraction in human airway smooth muscle","volume":"321","author":"Sasaki","year":"2021","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.exer.2023.109526_bib37","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a011148","article-title":"The cyclic AMP pathway","volume":"4","author":"Sassone-Corsi","year":"2012","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.exer.2023.109526_bib38","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1073\/pnas.78.6.3363","article-title":"Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells","volume":"78","author":"Seamon","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2023.109526_bib39","first-page":"E870","article-title":"Coupling of oxytocin receptor to G proteins in rat myometrium during labor: gi receptor interaction","volume":"272","author":"Strakova","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.exer.2023.109526_bib40","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1126\/science.1962211","article-title":"Type-specific regulation of adenylyl cyclase by G protein \u03b2\u03b3 subunits","volume":"254","author":"Tang","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.exer.2023.109526_bib41","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S1040-7952(97)80019-5","article-title":"Structure, function, and regulation of human cAMP-dependent protein kinases","volume":"31","author":"Tasken","year":"1997","journal-title":"Adv. Sec. Messenger Phosphoprotein. Res."},{"key":"10.1016\/j.exer.2023.109526_bib42","first-page":"821","article-title":"Morphological changes of myoepithelial cells of mouse lacrimal glands during postnatal development","volume":"10","author":"Wang","year":"1995","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.exer.2023.109526_bib43","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.3892\/mmr.2016.5005","article-title":"The cyclic AMP signaling pathway: exploring targets for successful drug discovery (Review)","volume":"13","author":"Yan","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.exer.2023.109526_bib44","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1634\/stemcells.2004-0346","article-title":"Bone marrow lacks a transplantable progenitor for smooth muscle type alpha-actin-expressing cells","volume":"24","author":"Yokota","year":"2006","journal-title":"Stem Cell."},{"key":"10.1016\/j.exer.2023.109526_bib45","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1210\/me.2006-0220","article-title":"Oxytocin receptors differentially signal via Gq and Gi proteins in pregnant and nonpregnant rat uterine myocytes: implications for myometrial contractility","volume":"21","author":"Zhou","year":"2007","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.exer.2023.109526_bib46","doi-asserted-by":"crossref","first-page":"C263","DOI":"10.1152\/ajpcell.1997.272.1.C263","article-title":"Lacrimal gland PKC isoforms are differentially involved in agonist-induced protein secretion","volume":"272","author":"Zoukhri","year":"1997","journal-title":"Am. J. Physiol."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483523001471?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483523001471?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:36:27Z","timestamp":1762148187000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483523001471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":46,"alternative-id":["S0014483523001471"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2023.109526","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of the adenylate cyclase\/cyclic AMP pathway in oxytocin-induced lacrimal gland myoepithelial cells contraction","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2023.109526","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109526"}}