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Sci."},{"key":"10.1016\/j.exer.2023.109537_bib71","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.845129","article-title":"'NLRP3 inflammasome-mediated pyroptosis pathway contributes to the pathogenesis of Candida albicans keratitis'","volume":"9","author":"Lian","year":"2022","journal-title":"Front. Med."},{"key":"10.1016\/j.exer.2023.109537_bib72","doi-asserted-by":"crossref","first-page":"16836","DOI":"10.1073\/pnas.1415518111","article-title":"'Synchronized renal tubular cell death involves ferroptosis'","volume":"111","author":"Linkermann","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2023.109537_bib73","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1707531114","article-title":"'MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis'","volume":"114","author":"Liu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2023.109537_bib74","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature18629","article-title":"'Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores'","volume":"535","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.exer.2023.109537_bib75","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.visres.2017.03.002","article-title":"'Diabetic complications in the cornea'","volume":"139","author":"Ljubimov","year":"2017","journal-title":"Vis. Res."},{"key":"10.1016\/j.exer.2023.109537_bib76","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.cell.2014.02.008","article-title":"Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes","volume":"156","author":"Lu","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.exer.2023.109537_bib77","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00417-014-2853-6","article-title":"'Evaluation of oxidative stress levels in the conjunctival epithelium of patients with or without dry eye, and dry eye patients treated with preservative-free hyaluronic acid 0.15 % and vitamin B12 eye drops'","volume":"253","author":"Macri","year":"2015","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2023.109537_bib78","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/imr.12296","article-title":"'Regulation of inflammasome activation'","volume":"265","author":"Man","year":"2015","journal-title":"Immunol. 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Biol. Chem."},{"key":"10.1016\/j.exer.2023.109537_bib83","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.bbagen.2019.06.010","article-title":"'Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases'","volume":"1863","author":"Nakamura","year":"2019","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.exer.2023.109537_bib84","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.redox.2017.03.007","article-title":"'BID links ferroptosis to mitochondrial cell death pathways'","volume":"12","author":"Neitemeier","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.exer.2023.109537_bib85","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133283","article-title":"The impact of iron overload and ferroptosis on reproductive disorders in humans: implications for preeclampsia","volume":"20","author":"Ng","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2023.109537_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111306","article-title":"'Airborne particulate matter (PM(2.5)) triggers cornea inflammation and pyroptosis via NLRP3 activation'","volume":"207","author":"Niu","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.exer.2023.109537_bib87","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1126\/science.aau2818","article-title":"'Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death'","volume":"362","author":"Orning","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.exer.2023.109537_bib88","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-97956-3","article-title":"'Cigarette smoke extract and heated tobacco products promote ferritin cleavage and iron accumulation in human corneal epithelial cells'","volume":"11","author":"Otsu","year":"2021","journal-title":"Sci. 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Diabetes Res."},{"key":"10.1016\/j.exer.2023.109537_bib94","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.cyto.2008.05.011","article-title":"'Tear cytokine and ocular surface alterations following brief passive cigarette smoke exposure'","volume":"43","author":"Rummenie","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.exer.2023.109537_bib95","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1002\/2211-5463.12141","article-title":"'Glutathione peroxidase 4 plays an important role in oxidative homeostasis and wound repair in corneal epithelial cells'","volume":"6","author":"Sakai","year":"2016","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.exer.2023.109537_bib96","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1152\/physrev.00041.2016","article-title":"'Origin and consequences of necroinflammation'","volume":"98","author":"Sarhan","year":"2018","journal-title":"Physiol. 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Eye Res."},{"key":"10.1016\/j.exer.2023.109537_bib106","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"'Ferroptosis: molecular mechanisms and health implications'","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.exer.2023.109537_bib107","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1167\/iovs.04-0041","article-title":"'Caspase-1 inhibitor reduces severity of pseudomonas aeruginosa keratitis in mice'","volume":"45","author":"Thakur","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109537_bib108","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/02713680490516710","article-title":"'Regulation of Pseudomonas aeruginosa corneal infection in IL-1 beta converting enzyme (ICE, caspase-1) deficient mice'","volume":"29","author":"Thakur","year":"2004","journal-title":"Curr. 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Autoimmun."},{"key":"10.1016\/j.exer.2023.109537_bib111","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nrm3737","article-title":"'Regulated necrosis: the expanding network of non-apoptotic cell death pathways'","volume":"15","author":"Vanden Berghe","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.exer.2023.109537_bib112","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/cdd.2010.138","article-title":"'cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1\/RIP3-dependent reactive oxygen species production'","volume":"18","author":"Vanlangenakker","year":"2011","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.exer.2023.109537_bib113","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1167\/iovs.12-10325","article-title":"'Evaluation of lipid oxidative stress status in Sj\u00f6gren syndrome patients'","volume":"54","author":"Wakamatsu","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109537_bib114","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nri3561","article-title":"'Concepts of tissue injury and cell death in inflammation: a historical perspective'","volume":"14","author":"Wallach","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.exer.2023.109537_bib115","doi-asserted-by":"crossref","first-page":"809","DOI":"10.7150\/ijbs.63219","article-title":"'The advanced glycation end-products (AGEs)\/ROS\/NLRP3 inflammasome axis contributes to delayed diabetic corneal wound healing and nerve regeneration'","volume":"18","author":"Wan","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.exer.2023.109537_bib116","doi-asserted-by":"crossref","first-page":"10168","DOI":"10.1096\/fj.201902814RRR","article-title":"'Inhibition of EZH2 alleviates angiogenesis in a model of corneal neovascularization by blocking FoxO3a-mediated oxidative stress'","volume":"34","author":"Wan","year":"2020","journal-title":"Faseb. J."},{"key":"10.1016\/j.exer.2023.109537_bib117","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.molcel.2014.03.003","article-title":"'Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3'","volume":"54","author":"Wang","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.exer.2023.109537_bib118","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10276","article-title":"'Ferrostatin-1-loaded liposome for treatment of corneal alkali burn via targeting ferroptosis'","volume":"7","author":"Wang","year":"2022","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.exer.2023.109537_bib119","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.celrep.2013.08.045","article-title":"'Protective roles for caspase-8 and cFLIP in adult homeostasis'","volume":"5","author":"Weinlich","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.exer.2023.109537_bib120","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature10273","article-title":"FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation","volume":"477","author":"Welz","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.exer.2023.109537_bib121","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/ni.1714","article-title":"'Death receptor signal transducers: nodes of coordination in immune signaling networks'","volume":"10","author":"Wilson","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.exer.2023.109537_bib122","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.cell.2016.05.076","article-title":"'Hexokinase is an innate immune receptor for the detection of bacterial peptidoglycan'","volume":"166","author":"Wolf","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.exer.2023.109537_bib123","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10495-019-01589-x","article-title":"'Necroptosis and its role in infectious diseases'","volume":"25","author":"Xia","year":"2020","journal-title":"Apoptosis"},{"key":"10.1016\/j.exer.2023.109537_bib124","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"'Ferroptosis: process and function'","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.exer.2023.109537_bib125","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108750","article-title":"'Wedelolactone ameliorates Pseudomonas aeruginosa-induced inflammation and corneal injury by suppressing caspase-4\/5\/11\/GSDMD-mediated non-canonical pyroptosis'","volume":"211","author":"Xu","year":"2021","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2023.109537_bib126","doi-asserted-by":"crossref","first-page":"20699","DOI":"10.1073\/pnas.1320808110","article-title":"'Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection'","volume":"110","author":"Yanai","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2023.109537_bib127","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.immuni.2015.10.009","article-title":"'Caspase-11 requires the pannexin-1 channel and the purinergic P2X7 pore to mediate pyroptosis and endotoxic shock'","volume":"43","author":"Yang","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.exer.2023.109537_bib128","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/s41419-018-1029-4","article-title":"'Silencing long non-coding RNA Kcnq1ot1 alleviates pyroptosis and fibrosis in diabetic cardiomyopathy'","volume":"9","author":"Yang","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2023.109537_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2020.104868","article-title":"'Norfloxacin induces apoptosis and necroptosis in human corneal epithelial cells'","volume":"66","author":"Yang","year":"2020","journal-title":"Toxicol. 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Commun."},{"key":"10.1016\/j.exer.2023.109537_bib133","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41419-022-05027-w","article-title":"'TFRC upregulation promotes ferroptosis in CVB3 infection via nucleus recruitment of Sp1'","volume":"13","author":"Yi","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2023.109537_bib134","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.it.2011.02.002","article-title":"The Nlrp3 inflammasome: contributions to intestinal homeostasis","volume":"32","author":"Zaki","year":"2011","journal-title":"Trends Immunol."},{"key":"10.1016\/j.exer.2023.109537_bib135","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1126\/science.aaf3036","article-title":"'An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells'","volume":"352","author":"Zanoni","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.exer.2023.109537_bib136","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.immuni.2017.09.010","article-title":"'By capturing inflammatory lipids released from dying cells, the receptor CD14 induces inflammasome-dependent phagocyte hyperactivation'","volume":"47","author":"Zanoni","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.exer.2023.109537_bib137","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.2147\/JIR.S310116","article-title":"'Calcitriol alleviates hyperosmotic stress-induced corneal epithelial cell damage via inhibiting the NLRP3-ASC-caspase-1-GSDMD pyroptosis pathway in dry eye disease'","volume":"14","author":"Zhang","year":"2021","journal-title":"J. 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