{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T22:08:31Z","timestamp":1766182111883,"version":"build-2065373602"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["145BHQ09000300X05","81770936","82101135"],"award-info":[{"award-number":["145BHQ09000300X05","81770936","82101135"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.exer.2023.109547","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T02:01:40Z","timestamp":1687226500000},"page":"109547","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["SIRT2 inhibition attenuates the vasculopathy and vision impairment via Akt signaling in retinopathy of prematurity"],"prefix":"10.1016","volume":"233","author":[{"given":"Zhicha","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinji","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueyue","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Hei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zifeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9774-7837","authenticated-orcid":false,"given":"Yusheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2023.109547_bib1","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1001\/archophthalmol.2009.244","article-title":"Incidence of retinopathy of prematurity in infants born before 27 weeks' gestation in Sweden","volume":"127","author":"Austeng","year":"2009","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2023.109547_bib2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/sj.jp.7211878","article-title":"Systemic fungal infection is associated with the development of retinopathy of prematurity in very low birth weight infants: a meta-review","volume":"28","author":"Bharwani","year":"2008","journal-title":"J. Perinatol."},{"issue":"Suppl. 1","key":"10.1016\/j.exer.2023.109547_bib3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/pr.2013.205","article-title":"Preterm-associated visual impairment and estimates of retinopathy of prematurity at regional and global levels for 2010","volume":"74","author":"Blencowe","year":"2013","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.exer.2023.109547_bib4","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.140363","article-title":"IGF1, serum glucose, and retinopathy of prematurity in extremely preterm infants","volume":"5","author":"Cakir","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.exer.2023.109547_bib5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/cvr\/cvs352","article-title":"SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence","volume":"97","author":"Cardus","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.exer.2023.109547_bib6","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s10456-013-9374-5","article-title":"Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy","volume":"16","author":"Chen","year":"2013","journal-title":"Angiogenesis"},{"key":"10.1016\/j.exer.2023.109547_bib7","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1096\/fj.201801086RR","article-title":"Role of TLR4\u2010MAP4K4 signaling pathway in models of oxygen\u2010induced retinopathy","volume":"33","author":"Chen","year":"2018","journal-title":"Faseb. J."},{"key":"10.1016\/j.exer.2023.109547_bib8","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/dmcn.15468","article-title":"Retinopathy of prematurity","volume":"65","author":"Dammann","year":"2023","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.exer.2023.109547_bib9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1742-2094-7-3","article-title":"Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype","volume":"7","author":"Dirscherl","year":"2010","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.exer.2023.109547_bib10","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.7150\/thno.39320","article-title":"Smooth muscle SIRT1 reprograms endothelial cells to suppress angiogenesis after ischemia","volume":"10","author":"Dou","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.exer.2023.109547_bib11","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.3389\/fonc.2019.01516","article-title":"Role of sirtuins in tumor angiogenesis","volume":"9","author":"Edatt","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.exer.2023.109547_bib12","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1038\/ng.2361","article-title":"NMNAT1 mutations cause Leber congenital amaurosis","volume":"44","author":"Falk","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exer.2023.109547_bib13","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s00441-015-2353-y","article-title":"Macrophages promote vasculogenesis of retinal neovascularization in an oxygen-induced retinopathy model in mice","volume":"364","author":"Gao","year":"2016","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.exer.2023.109547_bib14","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0002-9440(10)62284-5","article-title":"Inhibition of tumor necrosis factor-alpha improves physiological angiogenesis and reduces pathological neovascularization in ischemic retinopathy","volume":"166","author":"Gardiner","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2023.109547_bib15","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev.pathol.4.110807.092250","article-title":"Mammalian sirtuins: biological insights and disease relevance","volume":"5","author":"Haigis","year":"2010","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.exer.2023.109547_bib16","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ajo.2020.05.025","article-title":"Retinopathy of prematurity: evolving treatment with anti-vascular endothelial growth factor","volume":"218","author":"Hartnett","year":"2020","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2023.109547_bib17","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0092-8674(00)81768-7","article-title":"Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins","volume":"95","author":"Hiraoka","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.exer.2023.109547_bib18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1742-2094-11-87","article-title":"Neonatal systemic inflammation in rats alters retinal vessel development and simulates pathologic features of retinopathy of prematurity","volume":"11","author":"Hong","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.exer.2023.109547_bib19","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41419-018-1260-z","article-title":"Inhibition of SIRT2 limits tumour angiogenesis via inactivation of the STAT3\/VEGFA signalling pathway","volume":"10","author":"Hu","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2023.109547_bib20","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1167\/iovs.14-15842","article-title":"Pharmacokinetics of bevacizumab and its effects on serum VEGF and IGF-1 in infants with retinopathy of prematurity","volume":"56","author":"Kong","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109547_bib21","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.bbrc.2014.06.135","article-title":"SIRT2 ameliorates lipopolysaccharide-induced inflammation in macrophages","volume":"450","author":"Lee","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2023.109547_bib22","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.canlet.2016.01.031","article-title":"AK-1, a SIRT2 inhibitor, destabilizes HIF-1\u03b1 and diminishes its transcriptional activity during hypoxia","volume":"373","author":"Lee","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.exer.2023.109547_bib23","doi-asserted-by":"crossref","first-page":"24","DOI":"10.5483\/BMBRep.2019.52.1.290","article-title":"Sirtuin signaling in cellular senescence and aging","volume":"52","author":"Lee","year":"2019","journal-title":"BMB Rep."},{"key":"10.1016\/j.exer.2023.109547_bib24","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.preteyeres.2018.06.002","article-title":"NAD+ and sirtuins in retinal degenerative diseases: a look at future therapies","volume":"67","author":"Lin","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2023.109547_bib25","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12390","article-title":"IGF-1 promotes angiogenesis in endothelial cells\/adipose-derived stem cells co-culture system with activation of PI3K\/Akt signal pathway","volume":"50","author":"Lin","year":"2017","journal-title":"Cell Prolif."},{"key":"10.1016\/j.exer.2023.109547_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2017.00366","article-title":"Expression of sirtuins in the retinal neurons of mice, rats, and humans","volume":"9","author":"Luo","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.exer.2023.109547_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085031","article-title":"Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy","volume":"9","author":"Michan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2023.109547_bib28","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S1097-2765(03)00038-8","article-title":"The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase","volume":"11","author":"North","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.exer.2023.109547_bib29","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1126\/science.1143780","article-title":"Sirtuin 2 inhibitors rescue \u03b1-synuclein-mediated toxicity in models of Parkinson's disease","volume":"317","author":"Outeiro","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.exer.2023.109547_bib30","doi-asserted-by":"crossref","first-page":"6054","DOI":"10.1074\/jbc.M113.537266","article-title":"Sirt2 deacetylase is a novel AKT binding partner critical for AKT activation by insulin","volume":"289","author":"Ramakrishnan","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2023.109547_bib31","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1161\/ATVBAHA.113.301331","article-title":"Microglia and interleukin-1beta in ischemic retinopathy elicit microvascular degeneration through neuronal semaphorin-3A","volume":"33","author":"Rivera","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.exer.2023.109547_bib32","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-017-0943-1","article-title":"Retinopathy of prematurity: inflammation, choroidal degeneration, and novel promising therapeutic strategies","volume":"14","author":"Rivera","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.exer.2023.109547_bib33","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1002\/jcp.24334","article-title":"SIRT1 silencing confers neuroprotection through IGF-1 pathway activation","volume":"228","author":"Sansone","year":"2013","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.exer.2023.109547_bib34","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1167\/iovs.09-4137","article-title":"Paracrine modulation of CXCR4 by IGF-1 and VEGF: implications for choroidal neovascularization","volume":"51","author":"Sengupta","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"Suppl. l","key":"10.1016\/j.exer.2023.109547_bib35","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1507\/endocrj.46.Suppl_S59","article-title":"IGF-1 regulates migration and angiogenesis of human endothelial cells","volume":"46","author":"Shigematsu","year":"1999","journal-title":"Endocr. J."},{"key":"10.1016\/j.exer.2023.109547_bib36","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000087587","article-title":"IGF-1 and retinopathy of prematurity in the preterm infant","volume":"88","author":"Smith","year":"2005","journal-title":"Neonatology"},{"key":"10.1016\/j.exer.2023.109547_bib37","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1159\/000365132","article-title":"Insulin-like growth factor-1 and anti-vascular endothelial growth factor in retinopathy of prematurity: has the time come?","volume":"106","author":"Stahl","year":"2014","journal-title":"Neonatology"},{"key":"10.1016\/j.exer.2023.109547_bib38","doi-asserted-by":"crossref","first-page":"8125","DOI":"10.1167\/iovs.13-12496","article-title":"Systemic inflammation perturbs developmental retinal angiogenesis and neuroretinal function","volume":"54","author":"Tremblay","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109547_bib39","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1042\/BJ20140213","article-title":"SIRT3 interactions with FOXO3 acetylation, phosphorylation and ubiquitinylation mediate endothelial cell responses to hypoxia","volume":"464","author":"Tseng","year":"2014","journal-title":"Biochem. J."},{"key":"10.1016\/j.exer.2023.109547_bib40","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1203\/PDR.0b013e3181973dc8","article-title":"Oxygen-induced retinopathy in mice: amplification by neonatal IGF-I deficit and attenuation by IGF-I administration","volume":"65","author":"Vanhaesebrouck","year":"2009","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.exer.2023.109547_bib41","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1007\/s11064-016-1981-2","article-title":"SIRT2 plays significant roles in lipopolysaccharides-induced neuroinflammation and brain injury in mice","volume":"41","author":"Wang","year":"2016","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.exer.2023.109547_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2019.100961","article-title":"SIRT2: controversy and multiple roles in disease and physiology","volume":"55","author":"Wang","year":"2019","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.exer.2023.109547_bib43","doi-asserted-by":"crossref","first-page":"7251","DOI":"10.1007\/s12035-016-0173-z","article-title":"Downregulation of NAD-dependent deacetylase SIRT2 protects mouse brain against ischemic stroke","volume":"54","author":"Xie","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.exer.2023.109547_bib44","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00441-018-2847-5","article-title":"Microglial density determines the appearance of pathological neovascular tufts in oxygen-induced retinopathy","volume":"374","author":"Xu","year":"2018","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.exer.2023.109547_bib45","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1242\/jcs.000679","article-title":"Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells","volume":"120","author":"Yana","year":"2007","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.exer.2023.109547_bib46","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1111\/jcmm.13256","article-title":"Up-regulated basigin-2 in microglia induced by hypoxia promotes retinal angiogenesis","volume":"21","author":"Yin","year":"2017","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.exer.2023.109547_bib47","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ebiom.2019.03.031","article-title":"Mitochondrial dysfunction-mediated decline in angiogenic capacity of endothelial progenitor cells is associated with capillary rarefaction in patients with hypertension via downregulation of CXCR4\/JAK2\/SIRT5 signaling","volume":"42","author":"Yu","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.exer.2023.109547_bib48","doi-asserted-by":"crossref","first-page":"8236","DOI":"10.1111\/jcmm.15499","article-title":"lncRNA NR2F1\u2010AS1 promotes breast cancer angiogenesis through activating IGF\u20101\/IGF\u20101R\/ERK pathway","volume":"24","author":"Zhang","year":"2020","journal-title":"J. Cell Mol. Med."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483523001689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483523001689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:35:20Z","timestamp":1762148120000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483523001689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":48,"alternative-id":["S0014483523001689"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2023.109547","relation":{},"ISSN":["0014-4835"],"issn-type":[{"type":"print","value":"0014-4835"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SIRT2 inhibition attenuates the vasculopathy and vision impairment via Akt signaling in retinopathy of prematurity","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2023.109547","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109547"}}