{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T22:48:59Z","timestamp":1793659739239,"version":"4.5.1"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770962"],"award-info":[{"award-number":["81770962"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101089"],"award-info":[{"award-number":["82101089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171014"],"award-info":[{"award-number":["82171014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["212300410169"],"award-info":[{"award-number":["212300410169"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["21JCQN004"],"award-info":[{"award-number":["21JCQN004"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["232300421317"],"award-info":[{"award-number":["232300421317"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["LHGJ20220085"],"award-info":[{"award-number":["LHGJ20220085"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.exer.2023.109573","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T20:54:10Z","timestamp":1689108850000},"page":"109573","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Long-term high fructose intake promotes lacrimal gland dysfunction by inducing gut dysbiosis in mice"],"prefix":"10.1016","volume":"234","author":[{"given":"Di","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingli","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenzhen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du-Liurui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangman","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2023.109573_bib1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00018-018-2943-4","article-title":"An insight into gut microbiota and its functionalities","volume":"76","author":"Adak","year":"2019","journal-title":"Cell. Mol. Life Sci. : CMLS"},{"key":"10.1016\/j.exer.2023.109573_bib2","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1093\/annonc\/mds076","article-title":"Dietary fructose, carbohydrates, glycemic indices and pancreatic cancer risk: a systematic review and meta-analysis of cohort studies","volume":"23","author":"Aune","year":"2012","journal-title":"Ann. Oncol. : official journal of the European Society for Medical Oncology"},{"key":"10.1016\/j.exer.2023.109573_bib3","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1440-1681.2007.04815.x","article-title":"Changes in redox ratio and protein glycation in precataractous lens from fructose-fed rats: effects of exogenous L-carnitine","volume":"35","author":"Balasaraswathi","year":"2008","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.exer.2023.109573_bib4","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41598-017-18896-5","article-title":"Combination of high-fat\/high-fructose diet and low-dose streptozotocin to model long-term type-2 diabetes complications","volume":"8","author":"Barri\u00e8re","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2023.109573_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/nu13082795","article-title":"Effect of diet and dietary components on the composition of the gut microbiota","volume":"13","author":"Beam","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.exer.2023.109573_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/nu12113444","article-title":"Fructose-induced intestinal microbiota shift following two types of short-term high-fructose dietary phases","volume":"12","author":"Beisner","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.exer.2023.109573_bib7","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1017\/S0007114500001896","article-title":"High-fructose feeding of streptozotocin-diabetic rats is associated with increased cataract formation and increased oxidative stress in the kidney","volume":"84","author":"Bell","year":"2000","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.exer.2023.109573_bib8","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","article-title":"TFOS DEWS II pathophysiology report","volume":"15","author":"Bron","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2023.109573_bib9","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.chom.2014.11.010","article-title":"Diet dominates host genotype in shaping the murine gut microbiota","volume":"17","author":"Carmody","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.exer.2023.109573_bib10","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1590\/1414-431x20144217","article-title":"Exercise training prevents increased intraocular pressure and sympathetic vascular modulation in an experimental model of metabolic syndrome","volume":"48","author":"Castro","year":"2015","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.exer.2023.109573_bib11","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.exer.2023.109573_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9070728","article-title":"Sugar fructose triggers gut dysbiosis and metabolic inflammation with cardiac arrhythmogenesis","volume":"9","author":"Cheng","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.exer.2023.109573_bib13","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The microbiota-gut-brain Axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.exer.2023.109573_bib14","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature12820","article-title":"Diet rapidly and reproducibly alters the human gut microbiome","volume":"505","author":"David","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.exer.2023.109573_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/nu10060761","article-title":"High-glucose or -fructose diet cause changes of the gut microbiota and metabolic disorders in mice without body weight change","volume":"10","author":"Do","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.exer.2023.109573_bib80","article-title":"Epitranscriptome Analysis of Oxidative Stressed Retinal Epithelial Cells Depicted a Possible RNA Editing Landscape of Retinal Degeneration","volume":"11","author":"Donato","year":"2022","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"10.1016\/j.exer.2023.109573_bib16","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/nmeth.2604","article-title":"UPARSE: highly accurate OTU sequences from microbial amplicon reads","volume":"10","author":"Edgar","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.exer.2023.109573_bib17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","article-title":"Gut microbiota in human metabolic health and disease","volume":"19","author":"Fan","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.exer.2023.109573_bib18","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s40123-020-00278-2","article-title":"The gut-eye Axis: lessons learned from murine models","volume":"9","author":"Floyd","year":"2020","journal-title":"Ophthalmol. Therapy"},{"key":"10.1016\/j.exer.2023.109573_bib19","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.80550","article-title":"Retinopathy of prematurity: metabolic risk factors","volume":"11","author":"Fu","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.exer.2023.109573_bib20","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/s41586-022-04567-7","article-title":"Environmental factors shaping the gut microbiome in a Dutch population","volume":"604","author":"Gacesa","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.exer.2023.109573_bib21","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1038\/s41591-018-0210-8","article-title":"The influence of ethnicity and geography on human gut microbiome composition","volume":"24","author":"Gaulke","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.exer.2023.109573_bib22","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jhep.2021.02.027","article-title":"Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: a randomized controlled trial","volume":"75","author":"Geidl-Flueck","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.exer.2023.109573_bib23","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.cell.2014.09.053","article-title":"Human genetics shape the gut microbiome","volume":"159","author":"Goodrich","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.exer.2023.109573_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101196","article-title":"Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction","volume":"48","author":"Gutierrez","year":"2021","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.exer.2023.109573_bib25","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1167\/iovs.62.10.22","article-title":"Short-term high fructose intake impairs diurnal oscillations in the murine cornea","volume":"62","author":"He","year":"2021","journal-title":"Invest. Opthamol. Visual Sci."},{"key":"10.1016\/j.exer.2023.109573_bib26","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1016\/j.ajpath.2020.09.002","article-title":"High-fat diet-induced functional and pathologic changes in lacrimal gland","volume":"190","author":"He","year":"2020","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2023.109573_bib27","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/j.cmet.2021.09.010","article-title":"Molecular aspects of fructose metabolism and metabolic disease","volume":"33","author":"Herman","year":"2021","journal-title":"Cell Metabol."},{"key":"10.1016\/j.exer.2023.109573_bib28","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.tem.2016.06.005","article-title":"The sweet path to metabolic demise: fructose and lipid synthesis","volume":"27","author":"Herman","year":"2016","journal-title":"Trends Endocrinol. Metabol.: TEM (Trends Endocrinol. Metab.)"},{"key":"10.1016\/j.exer.2023.109573_bib29","doi-asserted-by":"crossref","first-page":"E1173","DOI":"10.1152\/ajpendo.00001.2021","article-title":"Maternal high-fructose diet induced early-onset retinopathy via the suppression of synaptic plasticity mediated by mitochondrial dysfunction","volume":"320","author":"Huang","year":"2021","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.exer.2023.109573_bib30","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jtos.2021.02.001","article-title":"Light cycle phase advance as a model for jet lag reprograms the circadian rhythms of murine extraorbital lacrimal glands","volume":"20","author":"Huang","year":"2021","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2023.109573_bib31","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1080\/10408398.2020.1747046","article-title":"High-fat or high-sugar diets as trigger inflammation in the microbiota-gut-brain axis","volume":"61","author":"Jamar","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.exer.2023.109573_bib32","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.jhep.2018.01.019","article-title":"Fructose and sugar: a major mediator of non-alcoholic fatty liver disease","volume":"68","author":"Jensen","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.exer.2023.109573_bib33","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jtos.2020.04.013","article-title":"Type 1 diabetes mellitus impairs diurnal oscillations in murine extraorbital lacrimal glands","volume":"18","author":"Jiao","year":"2020","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2023.109573_bib34","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1016\/j.ajpath.2021.08.006","article-title":"Microbial reconstitution improves aging-driven lacrimal gland circadian dysfunction","volume":"191","author":"Jiao","year":"2021","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2023.109573_bib35","doi-asserted-by":"crossref","first-page":"5436","DOI":"10.1038\/s41467-020-19263-1","article-title":"Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer","volume":"11","author":"Jiyoung Kim","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2023.109573_bib36","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/s41467-021-21461-4","article-title":"Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation","volume":"12","author":"Jones","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2023.109573_bib37","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1136\/bjophthalmol-2013-303953","article-title":"Decreased tear volume in patients with metabolic syndrome: the Osaka study","volume":"98","author":"Kawashima","year":"2014","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2023.109573_bib38","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/ceo.12290","article-title":"Review of the role of refined dietary sugars (fructose and glucose) in the genesis of retinal disease","volume":"42","author":"Kearney","year":"2014","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2023.109573_bib39","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.10224","article-title":"Current intake and demographic disparities in the association of fructose-rich foods and metabolic syndrome","volume":"3","author":"Lancaster","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.exer.2023.109573_bib40","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s40168-014-0050-9","article-title":"Microbial shifts in the aging mouse gut","volume":"2","author":"Langille","year":"2014","journal-title":"Microbiome"},{"key":"10.1016\/j.exer.2023.109573_bib41","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.exer.2023.109573_bib42","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s40168-019-0713-7","article-title":"Dietary fructose-induced gut dysbiosis promotes mouse hippocampal neuroinflammation: a benefit of short-chain fatty acids","volume":"7","author":"Li","year":"2019","journal-title":"Microbiome"},{"key":"10.1016\/j.exer.2023.109573_bib43","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/bioinformatics\/btn025","article-title":"SOAP: short oligonucleotide alignment program","volume":"24","author":"Li","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1016\/j.exer.2023.109573_bib44","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1016\/j.ajpath.2018.08.009","article-title":"Antibiotic-induced dysbiosis of gut microbiota impairs corneal nerve regeneration by affecting CCR2-negative macrophage distribution","volume":"188","author":"Liu","year":"2018","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2023.109573_bib45","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1167\/iovs.18-26030","article-title":"Short-term high fructose intake reprograms the transcriptional clock rhythm of the murine extraorbital lacrimal gland","volume":"60","author":"Lu","year":"2019","journal-title":"Invest. Opthamol. Visual Sci."},{"key":"10.1016\/j.exer.2023.109573_bib46","doi-asserted-by":"crossref","first-page":"6509","DOI":"10.1073\/pnas.1503358112","article-title":"Differential effects of fructose versus glucose on brain and appetitive responses to food cues and decisions for food rewards","volume":"112","author":"Luo","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2023.109573_bib47","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/482027a","article-title":"Public health: the toxic truth about sugar","volume":"482","author":"Lustig","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.exer.2023.109573_bib48","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/502181a","article-title":"Metabolic syndrome: F stands for fructose and fat","volume":"502","author":"Lyssiotis","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.exer.2023.109573_bib49","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/bioinformatics\/btr507","article-title":"FLASH: fast length adjustment of short reads to improve genome assemblies","volume":"27","author":"Mago\u010d","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.exer.2023.109573_bib50","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1126\/science.aat8515","article-title":"High-fructose corn syrup enhances intestinal tumor growth in mice","volume":"363","author":"Marcus D Goncalves","year":"2019","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.exer.2023.109573_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/nu13051738","article-title":"Gut microbiota induced by pterostilbene and resveratrol in high-fat-high-fructose fed rats: putative role in steatohepatitis onset","volume":"13","author":"Milton-Laskibar","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.exer.2023.109573_bib52","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/s41579-020-00460-0","article-title":"The gut microbiota-brain axis in behaviour and brain disorders","volume":"19","author":"Morais","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.exer.2023.109573_bib53","article-title":"Carbohydrate intake and risk of glaucoma in the sun cohort","author":"Moreno-Monta\u00f1\u00e9s","year":"2021","journal-title":"Eur. J. Ophthalmol."},{"key":"10.1016\/j.exer.2023.109573_bib54","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1080\/07853890.2021.1925150","article-title":"Influence of gut microbiota on eye diseases: an overview","volume":"53","author":"Napolitano","year":"2021","journal-title":"Ann. Med."},{"key":"10.1016\/j.exer.2023.109573_bib55","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1126\/science.aac8469","article-title":"Gut microbiota and aging","volume":"350","author":"O'Toole","year":"2015","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.exer.2023.109573_bib56","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1093\/bioinformatics\/btu494","article-title":"STAMP: statistical analysis of taxonomic and functional profiles","volume":"30","author":"Parks","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.exer.2023.109573_bib57","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.ophtha.2017.07.010","article-title":"The pathophysiology of dry eye disease: what we know and future directions for research","volume":"124","author":"Pflugfelder","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2023.109573_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108115","article-title":"Biological functions of tear film","volume":"197","author":"Pflugfelder","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2023.109573_bib59","article-title":"Lack of NLRP3-inflammasome leads to gut-liver axis derangement, gut dysbiosis and a worsened phenotype in a mouse model of NAFLD","volume":"7","author":"Pierantonelli","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2023.109573_bib60","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201809872","article-title":"Gut microbes, ageing & organ function: a chameleon in modern biology?","volume":"11","author":"Reza","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.exer.2023.109573_bib61","doi-asserted-by":"crossref","DOI":"10.3390\/nu10111677","article-title":"The role of diet, micronutrients and the gut microbiota in age-related macular degeneration: new perspectives from the Gut\u207bRetina Axis","volume":"10","author":"Rinninella","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.exer.2023.109573_bib62","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1080\/02713683.2019.1694156","article-title":"Diet mimicking \"fast food\" causes structural changes to the retina relevant to age-related macular degeneration","volume":"45","author":"Roddy","year":"2020","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2023.109573_bib63","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1017\/S1368980016000057","article-title":"Added sugar intake and metabolic syndrome in US adolescents: cross-sectional analysis of the National Health and Nutrition Examination Survey 2005-2012","volume":"19","author":"Rodr\u00edguez","year":"2016","journal-title":"Publ. Health Nutr."},{"key":"10.1016\/j.exer.2023.109573_bib81","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3389\/fgene.2020.00146","article-title":"High-Throughput Sequencing to Detect Novel Likely Gene-Disrupting Variants in Pathogenesis of Sporadic Brain Arteriovenous Malformations","volume":"11","author":"Scimone","year":"2020","journal-title":"Front. Genet"},{"key":"10.1016\/j.exer.2023.109573_bib82","doi-asserted-by":"crossref","first-page":"165956","DOI":"10.1016\/j.bbadis.2020.165956","article-title":"Transcriptome analysis provides new molecular signatures in sporadic Cerebral Cavernous Malformation endothelial cells","volume":"1866","author":"Scimone","year":"2020","journal-title":"Biochimica et biophysica acta. Mol. Basis Dis"},{"key":"10.1016\/j.exer.2023.109573_bib64","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.15537\/smj.2016.12.15623","article-title":"Dry eye disease in patients with metabolic syndrome","volume":"37","author":"Serefoglu Cabuk","year":"2016","journal-title":"Saudi Med. J."},{"key":"10.1016\/j.exer.2023.109573_bib65","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/gerona\/glq079","article-title":"Increased fructose intake as a risk factor for dementia","volume":"65","author":"Stephan","year":"2010","journal-title":"J. Gerontol. Series A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.exer.2023.109573_bib66","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.cell.2018.08.047","article-title":"Post-antibiotic gut mucosal microbiome reconstitution is impaired by probiotics and improved by autologous FMT","volume":"174","author":"Suez","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.exer.2023.109573_bib67","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.654074","article-title":"Intestinal microbiota mediates high-fructose and high-fat diets to induce chronic intestinal inflammation","volume":"11","author":"Tan","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.exer.2023.109573_bib68","first-page":"1038","article-title":"Metabolic syndrome risk factors and dry eye syndrome: a Meta-analysis","volume":"9","author":"Tang","year":"2016","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.exer.2023.109573_bib69","doi-asserted-by":"crossref","DOI":"10.3390\/nu11091987","article-title":"Dietary fructose and the metabolic syndrome","volume":"11","author":"Taskinen","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.exer.2023.109573_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112450","article-title":"Metabolic syndrome triggered by high-fructose diet favors choroidal neovascularization and impairs retinal light sensitivity in the rat","volume":"9","author":"Thierry","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2023.109573_bib71","first-page":"1034","article-title":"Fructose stimulated de novo lipogenesis is promoted by inflammation","volume":"2","author":"Todoric","year":"2020","journal-title":"Nat. Meybol."},{"key":"10.1016\/j.exer.2023.109573_bib72","article-title":"Sj\u00f6gren-like lacrimal keratoconjunctivitis in germ-free mice","volume":"19","author":"Wang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2023.109573_bib73","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1128\/AEM.00062-07","article-title":"Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy","volume":"73","author":"Wang","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.exer.2023.109573_bib83","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/s41593-020-0586-x","article-title":"Spatiotemporal single-cell analysis of gene expression in the mouse suprachiasmatic nucleus","volume":"23","author":"Wen","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.exer.2023.109573_bib74","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41385-019-0193-x","article-title":"Antibiotic-induced dysbiosis of gut microbiota impairs corneal development in postnatal mice by affecting CCR2 negative macrophage distribution","volume":"13","author":"Wu","year":"2020","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.exer.2023.109573_bib75","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jaut.2018.06.004","article-title":"Protective role of commensal bacteria in Sj\u00f6gren Syndrome","volume":"93","author":"Zaheer","year":"2018","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.exer.2023.109573_bib76","article-title":"Recent advances in fructose intake and risk of hyperuricemia","volume":"131","author":"Zhang","year":"2020","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.exer.2023.109573_bib77","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.redox.2018.07.002","article-title":"Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1\/Nrf2 pathway","volume":"18","author":"Zhao","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.exer.2023.109573_bib78","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41575-018-0061-2","article-title":"You are what you eat: diet, health and the gut microbiota","volume":"16","author":"Zmora","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.exer.2023.109573_bib79","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1167\/iovs.63.5.23","article-title":"High-fat nutritional challenge reshapes circadian signatures in murine extraorbital lacrimal glands","volume":"63","author":"Zou","year":"2022","journal-title":"Invest. Opthamol. Visual Sci."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448352300194X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448352300194X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:36:14Z","timestamp":1762148174000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001448352300194X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":83,"alternative-id":["S001448352300194X"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2023.109573","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term high fructose intake promotes lacrimal gland dysfunction by inducing gut dysbiosis in mice","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2023.109573","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109573"}}