{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:48:44Z","timestamp":1780598924649,"version":"3.54.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2022206287"],"award-info":[{"award-number":["H2022206287"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.exer.2023.109576","type":"journal-article","created":{"date-parts":[[2023,7,23]],"date-time":"2023-07-23T09:39:35Z","timestamp":1690105175000},"page":"109576","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Analysis of long noncoding RNAs in the aqueous humor of wet age-related macular degeneration"],"prefix":"10.1016","volume":"234","author":[{"given":"Hanying","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialiang","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7276-286X","authenticated-orcid":false,"given":"Qingli","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2023.109576_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22179178","article-title":"Potential of long non-coding RNAs in age-related macular degeneration","volume":"22","author":"Blasiak","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2023.109576_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21144994","article-title":"Zinc and autophagy in age-related macular degeneration","volume":"21","author":"Blasiak","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2023.109576_bib3","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1001\/jama.2020.5576","article-title":"Current perspective on age-related macular degeneration","volume":"324","author":"Chakravarthy","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.exer.2023.109576_bib35","doi-asserted-by":"crossref","first-page":"697962","DOI":"10.3389\/fmolb.2021.697962","article-title":"LncRNA LINC00944 Promotes Tumorigenesis but Suppresses Akt Phosphorylation in Renal Cell Carcinoma","volume":"8","author":"Chen","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.exer.2023.109576_bib4","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1093\/nar\/gkp1137","article-title":"The Sanger FASTQ file format for sequences with quality scores, and the Solexa\/Illumina FASTQ variants","volume":"38","author":"Cock","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.exer.2023.109576_bib5","doi-asserted-by":"crossref","first-page":"13781","DOI":"10.1073\/pnas.1206494109","article-title":"ERK1\/2 activation is a therapeutic target in age-related macular degeneration","volume":"109","author":"Dridi","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.exer.2023.109576_bib6","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1073\/pnas.1221729110","article-title":"JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration","volume":"110","author":"Du","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.exer.2023.109576_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031400","article-title":"The multifunctional faces of T-cell intracellular antigen 1 in health and disease","volume":"23","author":"Fern\u00e1ndez-G\u00f3mez","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2023.109576_bib8","doi-asserted-by":"crossref","first-page":"P1","DOI":"10.1016\/j.ophtha.2019.09.024","article-title":"Age-related macular degeneration preferred Practice pattern","volume":"127","author":"Flaxel","year":"2020","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2023.109576_bib9","doi-asserted-by":"crossref","first-page":"4614","DOI":"10.1167\/iovs.06-0297","article-title":"Sustained versus transient ERK1\/2 signaling underlies the anti- and proapoptotic effects of oxidative stress in human RPE cells","volume":"47","author":"Glotin","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109576_bib10","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.omto.2021.01.008","article-title":"LINC00461 facilitates HNSCC development and reduces chemosensitivity by impairing miR-195-mediated inhibition of HOXA10","volume":"21","author":"Guan","year":"2021","journal-title":"Mol Ther Oncolytics"},{"key":"10.1016\/j.exer.2023.109576_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110072","article-title":"Long noncoding RNA PITPNA-AS1 promotes cervical cancer progression through regulating the cell cycle and apoptosis by targeting the miR-876-5p\/c-MET axis","volume":"128","author":"Guo","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.exer.2023.109576_bib12","first-page":"1","article-title":"Autophagy in age-related macular degeneration","author":"Kaarniranta","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.exer.2023.109576_bib13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10565-016-9371-8","article-title":"Autophagy regulates death of retinal pigment epithelium cells in age-related macular degeneration","volume":"33","author":"Kaarniranta","year":"2017","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.exer.2023.109576_bib14","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.exer.2023.109576_bib15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4137\/OED.S32200","article-title":"Targeting MAPK signaling in age-related macular degeneration","volume":"8","author":"Kyosseva","year":"2016","journal-title":"Ophthalmol. Eye Dis."},{"key":"10.1016\/j.exer.2023.109576_bib16","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.exer.2023.109576_bib17","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.exer.2023.109576_bib18","article-title":"Long non-coding RNA LINC00847 induced by E2F1 accelerates non-small cell lung cancer progression through targeting miR-147a\/IFITM1 Axis","volume":"8","author":"Li","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.exer.2023.109576_bib19","doi-asserted-by":"crossref","first-page":"9987","DOI":"10.1080\/21655979.2022.2062531","article-title":"Long intergenic non-protein coding RNA 847 promotes laryngeal squamous cell carcinoma progression through the microRNA-181a-5p\/zinc finger E-box binding homeobox 2 axis","volume":"13","author":"Li","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.exer.2023.109576_bib20","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.14336\/AD.2019.1126","article-title":"An updated review of the epigenetic mechanism underlying the pathogenesis of age-related macular degeneration","volume":"11","author":"Li","year":"2020","journal-title":"Aging Dis"},{"key":"10.1016\/j.exer.2023.109576_bib21","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.exer.2023.109576_bib22","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0140-6736(18)31550-2","article-title":"Age-related macular degeneration","volume":"392","author":"Mitchell","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.exer.2023.109576_bib23","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.4161\/auto.36184","article-title":"Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD","volume":"10","author":"Mitter","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.exer.2023.109576_bib24","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1186\/s12935-021-02131-3","article-title":"Iron-sulphur cluster biogenesis factor LYRM4 is a novel prognostic biomarker associated with immune infiltrates in hepatocellular carcinoma","volume":"21","author":"Pang","year":"2021","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.exer.2023.109576_bib25","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.mam.2012.06.003","article-title":"Animal models of age related macular degeneration","volume":"33","author":"Pennesi","year":"2012","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.exer.2023.109576_bib26","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1159\/000492886","article-title":"Oxidative stress is the principal contributor to inflammasome activation in retinal pigment epithelium cells with defunct proteasomes and autophagy","volume":"49","author":"Piippo","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.exer.2023.109576_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109740","article-title":"Long noncoding RNA LINC00461 mediates cisplatin resistance of rectal cancer via miR-593-5p\/CCND1 axis","volume":"124","author":"Qu","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.exer.2023.109576_bib28","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1167\/iovs.62.10.18","article-title":"Analysis of the aqueous humor proteome in patients with age-related macular degeneration","volume":"62","author":"Rinsky","year":"2021","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109576_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.743611","article-title":"Development and validation of an autophagy-related LncRNA prognostic signature in head and neck squamous cell carcinoma","volume":"11","author":"Shen","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.exer.2023.109576_bib30","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/s41419-019-2067-2","article-title":"PITPNA-AS1 abrogates the inhibition of miR-876-5p on WNT5A to facilitate hepatocellular carcinoma progression","volume":"10","author":"Sun","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2023.109576_bib31","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1016\/j.sjbs.2020.06.037","article-title":"APOE2 promotes the development and progression of subretinal neovascularization in age-related macular degeneration via MAPKs signaling pathway","volume":"27","author":"Sun","year":"2020","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.exer.2023.109576_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105489","article-title":"Recent theranostic paradigms for the management of Age-related macular degeneration","volume":"153","author":"Suri","year":"2020","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.exer.2023.109576_bib33","doi-asserted-by":"crossref","first-page":"292","DOI":"10.7150\/ijms.37804","article-title":"Altered long non-coding RNAs involved in immunological regulation and associated with choroidal neovascularization in mice","volume":"17","author":"Zhang","year":"2020","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.exer.2023.109576_bib34","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1080\/02713683.2020.1748659","article-title":"Analysis of long noncoding RNAs in choroid neovascularization","volume":"45","author":"Zhang","year":"2020","journal-title":"Curr. Eye Res."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483523001975?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483523001975?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:25:44Z","timestamp":1758000344000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483523001975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":35,"alternative-id":["S0014483523001975"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2023.109576","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of long noncoding RNAs in the aqueous humor of wet age-related macular degeneration","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2023.109576","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109576"}}