{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:10:57Z","timestamp":1792188657782,"version":"4.4.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870642"],"award-info":[{"award-number":["81870642"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271069"],"award-info":[{"award-number":["82271069"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82122017"],"award-info":[{"award-number":["82122017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970780"],"award-info":[{"award-number":["81970780"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470613"],"award-info":[{"award-number":["81470613"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670835"],"award-info":[{"award-number":["81670835"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101100"],"award-info":[{"award-number":["82101100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018625","name":"Science and Technology Innovation Plan Of Shanghai Science and Technology Commission","doi-asserted-by":"publisher","award":["21S31904900"],"award-info":[{"award-number":["21S31904900"]}],"id":[{"id":"10.13039\/501100018625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018625","name":"Science and Technology Innovation Plan Of Shanghai Science and Technology Commission","doi-asserted-by":"publisher","award":["19441900700"],"award-info":[{"award-number":["19441900700"]}],"id":[{"id":"10.13039\/501100018625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003347","name":"Fudan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2502800"],"award-info":[{"award-number":["2022YFC2502800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.exer.2023.109648","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T11:37:45Z","timestamp":1694432265000},"page":"109648","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Tear inflammatory cytokines as potential biomarkers for myopic macular degeneration"],"prefix":"10.1016","volume":"235","author":[{"given":"Dongling","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2023.109648_bib1","first-page":"18","article-title":"Looking into aqueous humor through metabolomics spectacles \u2212 exploring its metabolic characteristics in relation to myopia","volume":"127","author":"Barbas-Bernardos","year":"2016","journal-title":"J. Pharmaceut. Biomed. Anal., Curr. Trends in bioanal. Honour Prof. Roman Kaliszan"},{"key":"10.1016\/j.exer.2023.109648_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2019.107737","article-title":"Serum metabolomics profiling and potential biomarkers of myopia using LC-QTOF\/MS","volume":"186","author":"Dai","year":"2019","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2023.109648_bib3","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.exer.2006.02.004","article-title":"Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye","volume":"83","author":"De Paiva","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2023.109648_bib4","article-title":"Early changes in ocular surface and tear inflammatory mediators after small-incision lenticule extraction and femtosecond laser-assisted laser in situ keratomileusis","volume":"9","author":"Gao","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2023.109648_bib5","first-page":"270","article-title":"Myopia and inflammation","volume":"6","author":"Herbort","year":"2011","journal-title":"J. Ophthalmic Vis. Res."},{"key":"10.1016\/j.exer.2023.109648_bib6","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.ophtha.2016.01.006","article-title":"Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050","volume":"123","author":"Holden","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2023.109648_bib7","doi-asserted-by":"crossref","first-page":"E3744","DOI":"10.3390\/nu12123744","article-title":"Oral bovine milk lactoferrin administration suppressed myopia development through matrix metalloproteinase 2 in a mouse model","volume":"12","author":"Ikeda","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.exer.2023.109648_bib8","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.ophtha.2006.04.022","article-title":"Prevalence and causes of low vision and blindness in a Japanese adult population: the Tajimi Study","volume":"113","author":"Iwase","year":"2006","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2023.109648_bib9","doi-asserted-by":"crossref","first-page":"4824","DOI":"10.1167\/iovs.16-19757","article-title":"Tear interferon-gamma as a biomarker for evaporative dry eye disease","volume":"57","author":"Jackson","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109648_bib10","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41433-020-0968-z","article-title":"Serum metabolic signatures of high myopia among older Chinese adults","volume":"35","author":"Ke","year":"2021","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.exer.2023.109648_bib11","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1442-9071.2011.02747.x","article-title":"Monocyte chemoattractant protein-1 in the aqueous humour of patients with age-related macular degeneration","volume":"40","author":"Kramer","year":"2012","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2023.109648_bib12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ebiom.2016.07.021","article-title":"Role of chronic inflammation in myopia progression: clinical evidence and experimental validation","volume":"10","author":"Lin","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.exer.2023.109648_bib13","first-page":"2931","article-title":"Changes to tear cytokines of type 2 diabetic patients with or without retinopathy","volume":"16","author":"Liu","year":"2010","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2023.109648_bib14","doi-asserted-by":"crossref","DOI":"10.1159\/000524502","article-title":"Effect of interleukin 6 on scleral fibroblast proliferation, differentiation, and apoptosis involved in myopic scleral remodeling","author":"Liu","year":"2022","journal-title":"Ophthalmic Res."},{"key":"10.1016\/j.exer.2023.109648_bib15","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.ajo.2015.01.022","article-title":"International photographic classification and grading system for myopic maculopathy","volume":"159","author":"Ohno-Matsui","year":"2015","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2023.109648_bib16","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3109\/02713683.2013.836542","article-title":"Cytokine profiles in tears accompanying the secondary conjunctival responses induced by nasal allergy","volume":"39","author":"Pelikan","year":"2014","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2023.109648_bib17","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s12026-015-8763-9","article-title":"Membrane array and multiplex bead analysis of tear cytokines in systemic sclerosis","volume":"64","author":"Rentka","year":"2016","journal-title":"Immunol. Res."},{"key":"10.1016\/j.exer.2023.109648_bib18","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1475-1313.2005.00298.x","article-title":"Myopia and associated pathological complications","volume":"25","author":"Saw","year":"2005","journal-title":"Ophthalmic Physiol. Opt."},{"key":"10.1016\/j.exer.2023.109648_bib19","doi-asserted-by":"crossref","first-page":"375","DOI":"10.4103\/0301-4738.67042","article-title":"Increased levels of vascular endothelial growth factor in the aqueous humor of patients with diabetic retinopathy","volume":"58","author":"Selim","year":"2010","journal-title":"Indian J. Ophthalmol."},{"key":"10.1016\/j.exer.2023.109648_bib20","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1159\/000339893","article-title":"Myopic maculopathy: a review","volume":"228","author":"Silva","year":"2012","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.exer.2023.109648_bib21","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1080\/02713683.2020.1774065","article-title":"The human lacrimal gland: historical perspectives, current understanding, and recent advances","volume":"45","author":"Singh","year":"2020","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2023.109648_bib22","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2174\/1871530319666190618142215","article-title":"Proteomics screening of differentially expressed cytokines in tears of patients with Graves' ophthalmopathy","volume":"20","author":"Song","year":"2020","journal-title":"Endocr. Metab. Immune Disord. - Drug Targets"},{"key":"10.1016\/j.exer.2023.109648_bib23","doi-asserted-by":"crossref","first-page":"222","DOI":"10.31083\/j.fbl2707222","article-title":"Aqueous humor cytokine response in the contralateral eye after first-eye cataract surgery in patients with primary angle-closure glaucoma, high myopia or type 2 diabetes mellitus","volume":"27","author":"Tang","year":"2022","journal-title":"Front. Biosci."},{"key":"10.1016\/j.exer.2023.109648_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2020.155308","article-title":"Proinflammatory and angiogenesis-related cytokines in vitreous samples of highly myopic patients","volume":"137","author":"Wei","year":"2021","journal-title":"Cytokine"},{"key":"10.1016\/j.exer.2023.109648_bib25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ajo.2013.08.010","article-title":"Epidemiology and disease burden of pathologic myopia and myopic choroidal neovascularization: an evidence-based systematic review","volume":"157","author":"Wong","year":"2014","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2023.109648_bib26","doi-asserted-by":"crossref","first-page":"e682","DOI":"10.1016\/S2468-2667(20)30254-1","article-title":"Prevalence and causes of vision loss in China from 1990 to 2019: findings from the global burden of disease study 2019","volume":"5","author":"Xu","year":"2020","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.exer.2023.109648_bib27","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jhep.2006.09.007","article-title":"Prevention of severe toxic liver injury and oxidative stress in MCP-1-deficient mice","volume":"46","author":"Zamara","year":"2007","journal-title":"J. Hepatol."},{"key":"10.1016\/j.exer.2023.109648_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.1029425","article-title":"Difference in aqueous concentration and vitreous mass of cytokines in high myopias with and without choroidal neovascularization","volume":"9","author":"Zhang","year":"2022","journal-title":"Front. Med."},{"key":"10.1016\/j.exer.2023.109648_bib29","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1038\/s41467-021-22041-2","article-title":"Aberrant TGF-\u03b21 signaling activation by MAF underlies pathological lens growth in high myopia","volume":"12","author":"Zhu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2023.109648_bib30","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.exer.2015.03.017","article-title":"Proinflammatory status in the aqueous humor of high myopic cataract eyes","volume":"142","author":"Zhu","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2023.109648_bib31","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1136\/bjophthalmol-2019-315298","article-title":"Prevalence of myopic macular degeneration worldwide: a systematic review and meta-analysis","volume":"104","author":"Zou","year":"2020","journal-title":"Br. J. Ophthalmol."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483523002695?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483523002695?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:24:40Z","timestamp":1777404280000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483523002695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":31,"alternative-id":["S0014483523002695"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2023.109648","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tear inflammatory cytokines as potential biomarkers for myopic macular degeneration","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2023.109648","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109648"}}