{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T03:11:44Z","timestamp":1768014704473,"version":"3.49.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"am","delay-in-days":335,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30-EY008098"],"award-info":[{"award-number":["P30-EY008098"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01-EY023966"],"award-info":[{"award-number":["R01-EY023966"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01-EY031708"],"award-info":[{"award-number":["R01-EY031708"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["T32-EY017271"],"award-info":[{"award-number":["T32-EY017271"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001607","name":"Eye and Ear Foundation of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.exer.2023.109701","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T20:04:16Z","timestamp":1698350656000},"page":"109701","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["2D or not 2D? Mapping the in-depth inclination of the collagen fibers of the corneoscleral shell"],"prefix":"10.1016","volume":"237","author":[{"given":"Fengting","family":"Ji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marissa","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Yi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0790-7911","authenticated-orcid":false,"given":"Ian A.","family":"Sigal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2023.109701_bib1","doi-asserted-by":"crossref","first-page":"5159","DOI":"10.1167\/iovs.09-3669","article-title":"3D collagen orientation study of the human cornea using X-ray diffraction and femtosecond laser technology","volume":"50","author":"Abahussin","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109701_bib2","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2014.0717","article-title":"Transverse depth-dependent changes in corneal collagen lamellar orientation and distribution","volume":"12","author":"Abass","year":"2015","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.exer.2023.109701_bib3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000309678","article-title":"Mechanical behavior of the sclera","volume":"193","author":"Arciniegas","year":"1986","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.exer.2023.109701_bib4","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.actbio.2017.11.015","article-title":"The hierarchical response of human corneal collagen to load","volume":"65","author":"Bell","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.exer.2023.109701_bib5","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1167\/iovs.05-0893","article-title":"Mapping collagen organization in the human cornea: left and right eyes are structurally distinct","volume":"47","author":"Boote","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109701_bib6","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.exer.2014.10.004","article-title":"Tissue plasminogen activator reduces the elevated intraocular pressure induced by prednisolone in sheep","volume":"128","author":"Candia","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2023.109701_bib7","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s10237-012-0455-y","article-title":"Scleral anisotropy and its effects on the mechanical response of the optic nerve head","volume":"12","author":"Coudrillier","year":"2013","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.exer.2023.109701_bib8","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1167\/iovs.15-18193","article-title":"Effects of peripapillary scleral stiffening on the deformation of the lamina cribrosa","volume":"57","author":"Coudrillier","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109701_bib9","doi-asserted-by":"crossref","DOI":"10.1115\/1.4029430","article-title":"Collagen structure and mechanical properties of the human sclera: analysis for the effects of age","volume":"137","author":"Coudrillier","year":"2015","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.exer.2023.109701_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131396","article-title":"Glaucoma-related changes in the mechanical properties and collagen micro-architecture of the human sclera","volume":"10","author":"Coudrillier","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2023.109701_bib11","doi-asserted-by":"crossref","first-page":"7922","DOI":"10.1167\/iovs.13-12262","article-title":"Differences in the region- and depth-dependent microstructural organization in normal versus glaucomatous human posterior sclerae","volume":"54","author":"Danford","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109701_bib12","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1740-8261.1995.tb00236.x","article-title":"Ultrasonographic and biometric evaluation of sheep and cattle eyes","volume":"36","author":"El\u2010Maghraby","year":"1995","journal-title":"Vet. Radiol. Ultrasound"},{"key":"10.1016\/j.exer.2023.109701_bib13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1146\/annurev.bioeng.6.040803.140055","article-title":"Ocular biomechanics and biotransport","volume":"6","author":"Ethier","year":"2004","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"10.1016\/j.exer.2023.109701_bib14","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1167\/iovs.15-17573","article-title":"Finite element modeling of factors influencing optic nerve head deformation due to intracranial pressure","volume":"57","author":"Feola","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109701_bib15","series-title":"Biomechanics: Mechanical Properties of Living Tissues","author":"Fung","year":"2013"},{"key":"10.1016\/j.exer.2023.109701_bib16","series-title":"Linear Mixed-Effects Model, Linear Mixed-Effects Models Using R","first-page":"245","author":"Ga\u0142ecki","year":"2013"},{"key":"10.1016\/j.exer.2023.109701_bib17","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1167\/iovs.09-4920","article-title":"Treatment of sheep steroid\u2013induced ocular hypertension with a glucocorticoid-inducible MMP1 gene therapy virus","volume":"51","author":"Gerometta","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109701_bib18","doi-asserted-by":"crossref","first-page":"9684","DOI":"10.1167\/iovs.11-7894","article-title":"Quantitative mapping of scleral fiber orientation in normal rat eyes","volume":"52","author":"Girard","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109701_bib19","doi-asserted-by":"crossref","DOI":"10.1115\/1.3113682","article-title":"Peripapillary and posterior scleral mechanics\u2014part I: development of an anisotropic hyperelastic constitutive model","volume":"131","author":"Girard","year":"2009","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.exer.2023.109701_bib20","doi-asserted-by":"crossref","first-page":"4763","DOI":"10.1167\/iovs.18-25025","article-title":"Radial and circumferential collagen fibers are a feature of the peripapillary sclera of human, monkey, pig, cow, goat, and sheep","volume":"59","author":"Gogola","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109701_bib21","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s10237-011-0326-y","article-title":"A constrained von Mises distribution to describe fiber organization in thin soft tissues","volume":"11","author":"Gouget","year":"2012","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.exer.2023.109701_bib22","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.jmbbm.2013.03.027","article-title":"Material properties of the posterior human sclera","volume":"29","author":"Grytz","year":"2014","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.exer.2023.109701_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.cma.2019.112654","article-title":"A mesh-free approach to incorporate complex anisotropic and heterogeneous material properties into eye-specific finite element models","volume":"358","author":"Grytz","year":"2020","journal-title":"Comput. Methods Appl. Mech. Eng."},{"key":"10.1016\/j.exer.2023.109701_bib24","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s10237-010-0240-8","article-title":"The collagen fibril architecture in the lamina cribrosa and peripapillary sclera predicted by a computational remodeling approach","volume":"10","author":"Grytz","year":"2011","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.exer.2023.109701_bib25","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1001\/archopthalmol.2011.1467","article-title":"Depth profile study of abnormal collagen orientation in keratoconus corneas","volume":"130","author":"Hayes","year":"2012","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2023.109701_bib26","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.exer.2018.04.003","article-title":"Crimp around the globe; patterns of collagen crimp across the corneoscleral shell","volume":"172","author":"Jan","year":"2018","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2023.109701_bib27","first-page":"3378","article-title":"Microstructural crimp of the lamina cribrosa and peripapillary sclera collagen fibers","volume":"58","author":"Jan","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109701_bib28","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1364\/BOE.6.004705","article-title":"Polarization microscopy for characterizing fiber orientation of ocular tissues","volume":"6","author":"Jan","year":"2015","journal-title":"Biomed. Opt Express"},{"key":"10.1016\/j.exer.2023.109701_bib29","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1167\/iovs.16-20772","article-title":"Collagen architecture of the posterior pole: high-resolution wide field of view visualization and analysis using polarized light microscopy","volume":"58","author":"Jan","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109701_bib30","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.actbio.2018.03.026","article-title":"Collagen fiber recruitment: a microstructural basis for the nonlinear response of the posterior pole of the eye to increases in intraocular pressure","volume":"72","author":"Jan","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.exer.2023.109701_bib31","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s10659-020-09812-6","article-title":"A morphoelastic shell model of the eye","volume":"145","author":"Kimpton","year":"2021","journal-title":"J. Elasticity"},{"key":"10.1016\/j.exer.2023.109701_bib32","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1001\/archopthalmol.2011.1309","article-title":"In vivo evaluation of focal lamina cribrosa defects in glaucoma","volume":"130","author":"Kiumehr","year":"2012","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2023.109701_bib33","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3389\/fbioe.2019.00129","article-title":"A subdomain method for mapping the heterogeneous mechanical properties of the human posterior sclera","volume":"7","author":"Kollech","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.exer.2023.109701_bib34","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.preteyeres.2018.01.002","article-title":"Evolution of the vertebrate corneal stroma","volume":"64","author":"Koudouna","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2023.109701_bib35","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1137\/S1052623496303470","article-title":"Convergence properties of the Nelder--Mead simplex method in low dimensions","volume":"9","author":"Lagarias","year":"1998","journal-title":"SIAM J. Optim."},{"key":"10.1016\/j.exer.2023.109701_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1364\/BOE.3.000001","article-title":"In vivo structural imaging of the cornea by polarization-resolved second harmonic microscopy","volume":"3","author":"Latour","year":"2012","journal-title":"Biomed. Opt Express"},{"key":"10.1016\/j.exer.2023.109701_bib37","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1016\/j.ophtha.2012.06.009","article-title":"Diagnosing preperimetric glaucoma with spectral domain optical coherence tomography","volume":"119","author":"Lisboa","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2023.109701_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.07.001","article-title":"Corneal structure and transparency","volume":"49","author":"Meek","year":"2015","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2023.109701_bib39","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1167\/iovs.06-1177","article-title":"Second-harmonic imaging microscopy of normal human and keratoconus cornea","volume":"48","author":"Morishige","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109701_bib40","first-page":"1125","article-title":"Circumcorneal annulus of collagen fibrils in the human limbus","volume":"39","author":"Newton","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109701_bib41","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1167\/iovs.11-8611","article-title":"Depth-dependent transverse shear properties of the human corneal stroma","volume":"53","author":"Petsche","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109701_bib42","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s10237-012-0466-8","article-title":"The role of 3-D collagen organization in stromal elasticity: a model based on X-ray diffraction data and second harmonic-generated images","volume":"12","author":"Petsche","year":"2013","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.exer.2023.109701_bib43","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1107\/S0021889813022358","article-title":"A wide-angle X-ray fibre diffraction method for quantifying collagen orientation across large tissue areas: application to the human eyeball coat","volume":"46","author":"Pijanka","year":"2013","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.exer.2023.109701_bib44","doi-asserted-by":"crossref","first-page":"5258","DOI":"10.1167\/iovs.12-9705","article-title":"Quantitative mapping of collagen fiber orientation in non-glaucoma and glaucoma posterior human sclerae","volume":"53","author":"Pijanka","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109701_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0118648","article-title":"Depth-dependent changes in collagen organization in the human peripapillary sclera","volume":"10","author":"Pijanka","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2023.109701_bib46","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.exer.2023.109701_bib47","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1007\/s10237-020-01333-4","article-title":"Biomechanical properties of the rat sclera obtained with inverse finite element modeling","volume":"19","author":"Schwaner","year":"2020","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.exer.2023.109701_bib48","article-title":"Individual-specific modeling of rat optic nerve head biomechanics in glaucoma","volume":"143","author":"Schwaner","year":"2020","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.exer.2023.109701_bib49","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1167\/iovs.04-0978","article-title":"The influence of various substances on the biomechanical behavior of lamina cribrosa and peripapillary sclera","volume":"46","author":"Spoerl","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109701_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-12006-1","article-title":"Formalin fixation and cryosectioning cause only minimal changes in shape or size of ocular tissues","volume":"7","author":"Tran","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2023.109701_bib51","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1365-2818.2008.02086.x","article-title":"Second-harmonic microscopy of ex vivo porcine corneas","volume":"232","author":"Vohnsen","year":"2008","journal-title":"J. Microsc."},{"key":"10.1016\/j.exer.2023.109701_bib52","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.exer.2017.05.004","article-title":"Whole-globe biomechanics using high-field MRI","volume":"160","author":"Voorhees","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2023.109701_bib53","doi-asserted-by":"crossref","first-page":"5336","DOI":"10.1167\/iovs.17-22015","article-title":"Lamina cribrosa pore shape and size as predictors of neural tissue mechanical insult","volume":"58","author":"Voorhees","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109701_bib54","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.actbio.2018.08.020","article-title":"Peripapillary sclera architecture revisited: a tangential fiber model and its biomechanical implications","volume":"79","author":"Voorhees","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.exer.2023.109701_bib55","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.actbio.2017.05.042","article-title":"Effects of collagen microstructure and material properties on the deformation of the neural tissues of the lamina cribrosa","volume":"58","author":"Voorhees","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.exer.2023.109701_bib56","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.actbio.2020.06.026","article-title":"Collagen fiber interweaving is central to sclera stiffness","volume":"113","author":"Wang","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.exer.2023.109701_bib57","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0014-4835(03)00212-4","article-title":"Scleral structure, organisation and disease. A review","volume":"78","author":"Watson","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2023.109701_bib58","doi-asserted-by":"crossref","first-page":"8818","DOI":"10.1167\/iovs.11-8070","article-title":"Nonlinear optical macroscopic assessment of 3-D corneal collagen organization and axial biomechanics","volume":"52","author":"Winkler","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109701_bib59","doi-asserted-by":"crossref","first-page":"7293","DOI":"10.1167\/iovs.13-13150","article-title":"Three-dimensional distribution of transverse collagen fibers in the anterior human corneal stroma","volume":"54","author":"Winkler","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109701_bib60","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1167\/iovs.09-4651","article-title":"Microstructural differences in the human posterior sclera as a function of age and race","volume":"52","author":"Yan","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109701_bib61","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.23.10.106001","article-title":"Structured polarized light microscopy for collagen fiber structure and orientation quantification in thick ocular tissues","volume":"23","author":"Yang","year":"2018","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.exer.2023.109701_bib62","doi-asserted-by":"crossref","DOI":"10.1002\/jbio.201700356","article-title":"Polarized light microscopy for 3\u2010dimensional mapping of collagen fiber architecture in ocular tissues","volume":"11","author":"Yang","year":"2018","journal-title":"J. Biophot."},{"key":"10.1016\/j.exer.2023.109701_bib63","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1167\/iovs.14-15734","article-title":"Collagen microstructural factors influencing optic nerve head biomechanics","volume":"56","author":"Zhang","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483523003226?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483523003226?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:25:20Z","timestamp":1758000320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483523003226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":63,"alternative-id":["S0014483523003226"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2023.109701","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"2D or not 2D? Mapping the in-depth inclination of the collagen fibers of the corneoscleral shell","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2023.109701","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109701"}}