{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T23:33:34Z","timestamp":1782344014829,"version":"3.54.5"},"reference-count":151,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2023NSFSC1752"],"award-info":[{"award-number":["2023NSFSC1752"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018525","name":"Key Research and Development Program of Sichuan Province","doi-asserted-by":"publisher","award":["2021YFS0166"],"award-info":[{"award-number":["2021YFS0166"]}],"id":[{"id":"10.13039\/501100018525","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.exer.2023.109716","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:39:24Z","timestamp":1699576764000},"page":"109716","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Advances in mesenchymal stem cell-derived extracellular vesicles therapy for Sjogren's syndrome-related dry eye disease"],"prefix":"10.1016","volume":"237","author":[{"given":"Su-Jia","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Juan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Xiong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Jing","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Yu","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"19","key":"10.1016\/j.exer.2023.109716_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20194750","article-title":"Mesenchymal stem cells extract (MSCsE)-Based therapy alleviates xerostomia and keratoconjunctivitis sicca in sjogren's syndrome-like disease","volume":"20","author":"Abughanam","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.exer.2023.109716_bib2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/cei.13077","article-title":"Activation of plasmacytoid dendritic cells by apoptotic particles - mechanism for the loss of immunological tolerance in Sjogren's syndrome","volume":"191","author":"Ainola","year":"2018","journal-title":"Clin. Exp. Immunol."},{"issue":"1","key":"10.1016\/j.exer.2023.109716_bib3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13075-017-1228-x","article-title":"Identification of potential saliva and tear biomarkers in primary Sjogren's syndrome, utilising the extraction of extracellular vesicles and proteomics analysis","volume":"19","author":"Aqrawi","year":"2017","journal-title":"Arthritis Res. Ther."},{"issue":"8","key":"10.1016\/j.exer.2023.109716_bib4","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1093\/rheumatology\/kez050","article-title":"The role of stroma and epithelial cells in primary Sjogren\u2019s syndrome","volume":"60","author":"Asam","year":"2019","journal-title":"Rheumatology."},{"issue":"5","key":"10.1016\/j.exer.2023.109716_bib5","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.exphem.2009.01.005","article-title":"Mesenchymal stem cells suppress B-cell terminal differentiation","volume":"37","author":"Asari","year":"2009","journal-title":"Exp. Hematol."},{"issue":"2","key":"10.1016\/j.exer.2023.109716_bib6","first-page":"389","article-title":"Immunomodulatory potential of human mesenchymal stem cells and their exosomes on multiple sclerosis","volume":"12","author":"Baharlooi","year":"2022","journal-title":"Adv. Pharmaceut. Bull."},{"issue":"5","key":"10.1016\/j.exer.2023.109716_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18050978","article-title":"Goblet cells contribute to ocular surface immune tolerance-implications for dry eye disease","volume":"18","author":"Barbosa","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2023.109716_bib8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jaut.2013.02.001","article-title":"Sjogren's syndrome and the epithelial target: a comprehensive review","volume":"42","author":"Barrera","year":"2013","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.exer.2023.109716_bib9","article-title":"Isolation and characterization of mesenchymal stromal cells from human umbilical cord and fetal placenta","volume":"122","author":"Beeravolu","year":"2017","journal-title":"J. Vis. Exp."},{"issue":"2","key":"10.1016\/j.exer.2023.109716_bib10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.survophthal.2019.10.004","article-title":"Primary Sjogren's syndrome and the eye","volume":"65","author":"Bjordal","year":"2020","journal-title":"Surv. Ophthalmol."},{"issue":"10","key":"10.1016\/j.exer.2023.109716_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/cells12101359","article-title":"The role of regulatory T cells in the onset and progression of primary sjogren's syndrome","volume":"12","author":"Blinova","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.exer.2023.109716_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2022.108937","article-title":"Long non-coding RNA Xist contribution in systemic lupus erythematosus and rheumatoid arthritis","volume":"236","author":"Bost","year":"2022","journal-title":"Clin. Immunol."},{"issue":"7","key":"10.1016\/j.exer.2023.109716_bib13","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1002\/art.40093","article-title":"Randomized controlled trial of rituximab and cost-effectiveness analysis in treating fatigue and oral dryness in primary sjogren's syndrome","volume":"69","author":"Bowman","year":"2017","journal-title":"Arthritis Rheumatol."},{"issue":"6","key":"10.1016\/j.exer.2023.109716_bib14","first-page":"1356","article-title":"Flow cytometric analysis of inflammatory markers in conjunctival epithelial cells of patients with dry eyes","volume":"41","author":"Brignole","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109716_bib15","article-title":"Sjogren syndrome","volume":"2","author":"Brito-Zeron","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.exer.2023.109716_bib16","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/978-1-0716-2839-3_7","article-title":"Adipose-derived stromal cells: isolation, expansion, and differentiation","volume":"2598","author":"Buchert","year":"2023","journal-title":"Methods Mol. Biol."},{"issue":"9","key":"10.1016\/j.exer.2023.109716_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22094930","article-title":"Mesenchymal stem cell-derived extracellular vesicles protect human corneal endothelial cells from endoplasmic reticulum stress-mediated apoptosis","volume":"22","author":"Buono","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.exer.2023.109716_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17128-0","article-title":"Elevation of autophagy markers in Sjogren syndrome dry eye","volume":"7","author":"Byun","year":"2017","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.exer.2023.109716_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12347","article-title":"The importance of controlled clinical trials with extracellular vesicles","volume":"12","author":"Camussi","year":"2023","journal-title":"J. Extracell. Vesicles"},{"issue":"1","key":"10.1016\/j.exer.2023.109716_bib20","doi-asserted-by":"crossref","first-page":"7319","DOI":"10.1038\/s41598-019-43714-5","article-title":"Elevated cytokine levels in tears and saliva of patients with primary Sjogren's syndrome correlate with clinical ocular and oral manifestations","volume":"9","author":"Chen","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.exer.2023.109716_bib21","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s12906-023-04017-5","article-title":"Gut microbiota combined with fecal metabolomics reveals the effects of FuFang Runzaoling on the microbial and metabolic profiles in NOD mouse model of Sjogren's syndrome","volume":"23","author":"Chen","year":"2023","journal-title":"BMC Complement Med Ther"},{"key":"10.1016\/j.exer.2023.109716_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.624614","article-title":"Predicted disease-specific immune infiltration patterns decode the potential mechanisms of long non-coding RNAs in primary sjogren's syndrome","volume":"12","author":"Cheng","year":"2021","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.exer.2023.109716_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22020658","article-title":"The involvement of innate and adaptive immunity in the initiation and perpetuation of sjogren's syndrome","volume":"22","author":"Chivasso","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2023.109716_bib24","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","article-title":"Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles","volume":"30","author":"Colombo","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"21","key":"10.1016\/j.exer.2023.109716_bib25","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1089\/scd.2014.0091","article-title":"Microvescicles derived from mesenchymal stromal cells are not as effective as their cellular counterpart in the ability to modulate immune responses in vitro","volume":"23","author":"Conforti","year":"2014","journal-title":"Stem Cell. Dev."},{"issue":"10","key":"10.1016\/j.exer.2023.109716_bib26","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202200488R","article-title":"Exosomes derived from mesenchymal stem cells attenuate diabetic kidney disease by inhibiting cell apoptosis and epithelial-to-mesenchymal transition via miR-424-5p","volume":"36","author":"Cui","year":"2022","journal-title":"Faseb. J."},{"issue":"4","key":"10.1016\/j.exer.2023.109716_bib27","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"10.1016\/j.exer.2023.109716_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.684999","article-title":"The multiple roles of B cells in the pathogenesis of sjogren's syndrome","volume":"12","author":"Du","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.exer.2023.109716_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-29411-9","article-title":"Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjogren's Syndrome patients","volume":"8","author":"Edman","year":"2018","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.exer.2023.109716_bib30","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1002\/art.27362","article-title":"Disruption of tight junction structure in salivary glands from Sjogren's syndrome patients is linked to proinflammatory cytokine exposure","volume":"62","author":"Ewert","year":"2010","journal-title":"Arthritis Rheum."},{"issue":"4","key":"10.1016\/j.exer.2023.109716_bib31","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s10067-013-2476-z","article-title":"Clinical parameter and Th17 related to lymphocytes infiltrating degree of labial salivary gland in primary Sjogren's syndrome","volume":"33","author":"Fei","year":"2014","journal-title":"Clin. Rheumatol."},{"issue":"2","key":"10.1016\/j.exer.2023.109716_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbspin.2022.105502","article-title":"Non-primary sjogren's syndrome: secondary or associated?","volume":"90","author":"Felten","year":"2023","journal-title":"Joint Bone Spine"},{"issue":"11","key":"10.1016\/j.exer.2023.109716_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/ph14111093","article-title":"Mesenchymal stem cell-derived exosomes and MicroRNAs in cartilage regeneration: biogenesis, efficacy, miRNA enrichment and delivery","volume":"14","author":"Foo","year":"2021","journal-title":"Pharmaceuticals"},{"issue":"8","key":"10.1016\/j.exer.2023.109716_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/cells8080784","article-title":"Mesenchymal stem cell migration and tissue repair","volume":"8","author":"Fu","year":"2019","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.exer.2023.109716_bib35","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jcyt.2021.01.001","article-title":"Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles","volume":"23","author":"Gimona","year":"2021","journal-title":"Cytotherapy"},{"key":"10.1016\/j.exer.2023.109716_bib36","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jaut.2012.09.003","article-title":"A link between interferon and augmented plasmin generation in exocrine gland damage in Sjogren's syndrome","volume":"40","author":"Gliozzi","year":"2013","journal-title":"J. Autoimmun."},{"issue":"7","key":"10.1016\/j.exer.2023.109716_bib37","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.autrev.2016.03.004","article-title":"Primary Sjgren's syndrome: clinical phenotypes, outcome and the development of biomarkers","volume":"15","author":"Goules","year":"2016","journal-title":"Autoimmun. Rev."},{"issue":"5","key":"10.1016\/j.exer.2023.109716_bib38","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.3892\/ijmm.2014.1663","article-title":"Biodistribution of mesenchymal stem cell-derived extracellular vesicles in a model of acute kidney injury monitored by optical imaging","volume":"33","author":"Grange","year":"2014","journal-title":"Int. J. Mol. Med."},{"issue":"1","key":"10.1016\/j.exer.2023.109716_bib39","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s00395-021-00881-9","article-title":"Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice","volume":"116","author":"Gregorius","year":"2021","journal-title":"Basic Res. Cardiol."},{"issue":"25","key":"10.1016\/j.exer.2023.109716_bib40","doi-asserted-by":"crossref","first-page":"13625","DOI":"10.1073\/pnas.240309797","article-title":"Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo","volume":"97","author":"Gronthos","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"1","key":"10.1016\/j.exer.2023.109716_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/cells12010033","article-title":"Mesenchymal stromal cells-derived extracellular vesicles regulate dendritic cell functions in dry eye disease","volume":"12","author":"Guo","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.exer.2023.109716_bib42","article-title":"Inhibitory effects of iPSC-MSCs and their extracellular vesicles on the onset of sialadenitis in a mouse model of sjogren's syndrome","volume":"2018","author":"Hai","year":"2018","journal-title":"Stem Cell. Int."},{"issue":"7","key":"10.1016\/j.exer.2023.109716_bib43","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1002\/art.38633","article-title":"Tear cathepsin S as a candidate biomarker for Sjogren's syndrome","volume":"66","author":"Hamm-Alvarez","year":"2014","journal-title":"Arthritis Rheumatol."},{"issue":"5","key":"10.1016\/j.exer.2023.109716_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/cells8050467","article-title":"Molecular mechanisms responsible for therapeutic potential of mesenchymal stem cell-derived secretome","volume":"8","author":"Harrell","year":"2019","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.exer.2023.109716_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/cells8121605","article-title":"Mesenchymal stem cell-derived exosomes and other extracellular vesicles as new remedies in the therapy of inflammatory diseases","volume":"8","author":"Harrell","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.exer.2023.109716_bib46","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/5584_2018_306","article-title":"Molecular mechanisms responsible for anti-inflammatory and immunosuppressive effects of mesenchymal stem cell-derived factors","volume":"1084","author":"Harrell","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"issue":"8","key":"10.1016\/j.exer.2023.109716_bib47","doi-asserted-by":"crossref","first-page":"5906","DOI":"10.1002\/jcp.30275","article-title":"Adipose-derived mesenchymal stem cell-secreted exosome alleviates dextran sulfate sodium-induced acute colitis by Treg cell induction and inflammatory cytokine reduction","volume":"236","author":"Heidari","year":"2021","journal-title":"J. Cell. Physiol."},{"issue":"2","key":"10.1016\/j.exer.2023.109716_bib48","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.exer.2010.04.009","article-title":"Blockade of interleukin-6 signaling suppresses experimental autoimmune uveoretinitis by the inhibition of inflammatory Th17 responses","volume":"91","author":"Hohki","year":"2010","journal-title":"Exp. Eye Res."},{"issue":"8","key":"10.1016\/j.exer.2023.109716_bib49","first-page":"1603","article-title":"Primary Sjogren's syndrome in dizygotic adolescent twins: one case with lymphocytic interstitial pneumonia","volume":"32","author":"Houghton","year":"2005","journal-title":"J. Rheumatol."},{"issue":"7","key":"10.1016\/j.exer.2023.109716_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/nano11071858","article-title":"Periodontal and dental pulp cell-derived small extracellular vesicles: a review of the current status","volume":"11","author":"Hua","year":"2021","journal-title":"Nanomaterials"},{"issue":"11","key":"10.1016\/j.exer.2023.109716_bib51","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1136\/annrheumdis-2015-208659","article-title":"Genome-wide DNA methylation analysis in multiple tissues in primary Sjogren's syndrome reveals regulatory effects at interferon-induced genes","volume":"75","author":"Imgenberg-Kreuz","year":"2016","journal-title":"Ann. Rheum. Dis."},{"issue":"3","key":"10.1016\/j.exer.2023.109716_bib52","doi-asserted-by":"crossref","first-page":"86","DOI":"10.31083\/j.fbl2703086","article-title":"Mesenchymal stem cell derived exosomes-based immunological signature in a rat model of corneal allograft rejection therapy","volume":"27","author":"Jia","year":"2022","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"1","key":"10.1016\/j.exer.2023.109716_bib53","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12712","article-title":"Immune modulation by mesenchymal stem cells","volume":"53","author":"Jiang","year":"2020","journal-title":"Cell Prolif."},{"issue":"4","key":"10.1016\/j.exer.2023.109716_bib54","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/mr\/roab051","article-title":"Mast cells can produce transforming growth factor beta1 and promote tissue fibrosis during the development of Sjogren's syndrome-related sialadenitis","volume":"32","author":"Kaieda","year":"2022","journal-title":"Mod. Rheumatol."},{"key":"10.1016\/j.exer.2023.109716_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.833254","article-title":"Tear miRNAs identified in a murine model of sjogren's syndrome as potential diagnostic biomarkers and indicators of disease mechanism","volume":"13","author":"Kakan","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.exer.2023.109716_bib56","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13287-018-0791-7","article-title":"Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine","volume":"9","author":"Keshtkar","year":"2018","journal-title":"Stem Cell Res. Ther."},{"issue":"7","key":"10.1016\/j.exer.2023.109716_bib57","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.ymthe.2020.04.020","article-title":"Comprehensive molecular profiles of functionally effective MSC-derived extracellular vesicles in immunomodulation","volume":"28","author":"Kim","year":"2020","journal-title":"Mol. Ther."},{"issue":"6","key":"10.1016\/j.exer.2023.109716_bib58","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.14336\/AD.2021.0621","article-title":"Identification of molecules responsible for therapeutic effects of extracellular vesicles produced from iPSC-derived MSCs on sjo gren's syndrome","volume":"12","author":"Kim","year":"2021","journal-title":"Aging Dis"},{"issue":"4","key":"10.1016\/j.exer.2023.109716_bib59","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/leu.2014.41","article-title":"MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease","volume":"28","author":"Kordelas","year":"2014","journal-title":"Leukemia"},{"key":"10.1016\/j.exer.2023.109716_bib60","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/bs.ircmb.2019.08.005","article-title":"Dendritic cell extracellular vesicles","volume":"349","author":"Kowal","year":"2019","journal-title":"Int Rev Cell Mol Biol"},{"issue":"9","key":"10.1016\/j.exer.2023.109716_bib61","doi-asserted-by":"crossref","first-page":"5886","DOI":"10.4049\/jimmunol.179.9.5886","article-title":"Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration","volume":"179","author":"Kuchen","year":"2007","journal-title":"Journal of immunology (Baltimore, Md : 1950)"},{"issue":"4","key":"10.1016\/j.exer.2023.109716_bib62","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1365-3083.2011.02583.x","article-title":"Expression of interleukin-22 in Sj\u00f6gren's syndrome: significant correlation with disease parameters","volume":"74","author":"Lavoie","year":"2011","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.exer.2023.109716_bib63","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v4.30087","article-title":"Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper","volume":"4","author":"Lener","year":"2015","journal-title":"J. Extracell. Vesicles"},{"issue":"11","key":"10.1016\/j.exer.2023.109716_bib64","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/ng.2792","article-title":"Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren's syndrome","volume":"45","author":"Lessard","year":"2013","journal-title":"Nat. Genet."},{"issue":"11","key":"10.1016\/j.exer.2023.109716_bib65","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/ng.2779","article-title":"A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren's syndrome at 7q11.23","volume":"45","author":"Li","year":"2013","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.exer.2023.109716_bib66","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/nyas.13102","article-title":"Isolation and characterization of primary bone marrow mesenchymal stromal cells","volume":"1370","author":"Li","year":"2016","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"6","key":"10.1016\/j.exer.2023.109716_bib67","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006820","article-title":"Identification of a Sjogren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons","volume":"13","author":"Li","year":"2017","journal-title":"PLoS Genet."},{"issue":"1","key":"10.1016\/j.exer.2023.109716_bib68","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1186\/s13287-021-02541-0","article-title":"Labial gland-derived mesenchymal stem cells and their exosomes ameliorate murine Sjogren's syndrome by modulating the balance of Treg and Th17 cells","volume":"12","author":"Li","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.exer.2023.109716_bib69","article-title":"MSC-derived small extracellular vesicles attenuate autoimmune dacryoadenitis by promoting M2 macrophage polarization and inducing tregs via miR-100-5p","volume":"13","author":"Li","year":"2022","journal-title":"Front. Immunol."},{"issue":"22","key":"10.1016\/j.exer.2023.109716_bib70","first-page":"3252","article-title":"Clinical and prognostic characteristics of 573 cases of primary Sjogren's syndrome","volume":"123","author":"Lin","year":"2010","journal-title":"Chin Med J (Engl)"},{"issue":"21\u201322","key":"10.1016\/j.exer.2023.109716_bib71","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1080\/15384101.2018.1526603","article-title":"MSC-derived exosomes promote proliferation and inhibit apoptosis of chondrocytes via lncRNA-KLF3-AS1\/miR-206\/GIT1 axis in osteoarthritis","volume":"17","author":"Liu","year":"2018","journal-title":"Cell Cycle"},{"key":"10.1016\/j.exer.2023.109716_bib72","article-title":"Umbilical cord mesenchymal stem cell-derived small extracellular vesicles deliver miR-21 to promote corneal epithelial wound healing through PTEN\/PI3K\/akt pathway","volume":"2022","author":"Liu","year":"2022","journal-title":"Stem Cell. Int."},{"issue":"3","key":"10.1016\/j.exer.2023.109716_bib73","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/sctm.16-0363","article-title":"Mesenchymal stem cell-derived extracellular vesicles as mediators of anti-inflammatory effects: endorsement of macrophage polarization","volume":"6","author":"Lo Sicco","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.exer.2023.109716_bib74","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13020-020-00342-w","article-title":"The effect of total glucoside of paeony on gut microbiota in NOD mice with Sjogren's syndrome based on high-throughput sequencing of 16SrRNA gene","volume":"15","author":"Lu","year":"2020","journal-title":"Chin. Med."},{"issue":"4","key":"10.1016\/j.exer.2023.109716_bib75","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1007\/s10787-023-01189-x","article-title":"Immunomodulatory effects of umbilical mesenchymal stem cell-derived exosomes on CD4(+) T cells in patients with primary Sjogren's syndrome","volume":"31","author":"Ma","year":"2023","journal-title":"Inflammopharmacology"},{"issue":"2","key":"10.1016\/j.exer.2023.109716_bib76","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1365-2249.2012.04606.x","article-title":"Selective localization of T helper subsets in labial salivary glands from primary Sjogren's syndrome patients","volume":"169","author":"Maehara","year":"2012","journal-title":"Clin. Exp. Immunol."},{"issue":"12","key":"10.1016\/j.exer.2023.109716_bib77","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1136\/annrheumdis-2012-201477","article-title":"Interleukin-21 contributes to germinal centre formation and immunoglobulin G4 production in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease","volume":"71","author":"Maehara","year":"2012","journal-title":"Ann. Rheum. Dis."},{"issue":"3","key":"10.1016\/j.exer.2023.109716_bib78","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/0002-9343(91)80007-9","article-title":"Detection of Epstein-Barr virus DNA by in situ hybridization and polymerase chain reaction in salivary gland biopsy specimens from patients with Sjogren's syndrome","volume":"90","author":"Mariette","year":"1991","journal-title":"Am. J. Med."},{"issue":"3","key":"10.1016\/j.exer.2023.109716_bib79","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1136\/annrheumdis-2013-203991","article-title":"Efficacy and safety of belimumab in primary Sjogren's syndrome: results of the BELISS open-label phase II study","volume":"74","author":"Mariette","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.exer.2023.109716_bib80","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.biomaterials.2019.01.016","article-title":"Mesenchymal stem cell-derived extracellular vesicles and retinal ischemia-reperfusion","volume":"197","author":"Mathew","year":"2019","journal-title":"Biomaterials"},{"issue":"7","key":"10.1016\/j.exer.2023.109716_bib81","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1136\/annrheumdis-2013-204653","article-title":"Abatacept treatment reduces disease activity in early primary Sjogren's syndrome (open-label proof of concept ASAP study)","volume":"73","author":"Meiners","year":"2014","journal-title":"Ann. Rheum. Dis."},{"issue":"8","key":"10.1016\/j.exer.2023.109716_bib82","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.99263","article-title":"Generation and testing of clinical-grade exosomes for pancreatic cancer","volume":"3","author":"Mendt","year":"2018","journal-title":"JCI Insight"},{"issue":"6","key":"10.1016\/j.exer.2023.109716_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2016.01.024","article-title":"Cytometry by time-of-flight immunophenotyping identifies a blood Sjogren's signature correlating with disease activity and glandular inflammation","volume":"137","author":"Mingueneau","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"issue":"2","key":"10.1016\/j.exer.2023.109716_bib84","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0229029","article-title":"Gut dysbiosis is prevailing in Sjogren's syndrome and is related to dry eye severity","volume":"15","author":"Moon","year":"2020","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.exer.2023.109716_bib85","doi-asserted-by":"crossref","DOI":"10.1093\/pnasnexus\/pgac156","article-title":"Extracellular vesicle fusion visualized by cryo-electron microscopy","volume":"1","author":"Morandi","year":"2022","journal-title":"PNAS Nexus"},{"issue":"8","key":"10.1016\/j.exer.2023.109716_bib86","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12080734","article-title":"In vitro study of extracellular vesicles migration in cartilage-derived osteoarthritis samples using real-time quantitative multimodal nonlinear optics imaging","volume":"12","author":"Mortati","year":"2020","journal-title":"Pharmaceutics"},{"issue":"2","key":"10.1016\/j.exer.2023.109716_bib87","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/odi.12825","article-title":"Sjogren's syndrome X-chromosome dose effect: an epigenetic perspective","volume":"25","author":"Mougeot","year":"2019","journal-title":"Oral Dis."},{"issue":"1","key":"10.1016\/j.exer.2023.109716_bib88","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/gene.2008.94","article-title":"Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjogren's syndrome","volume":"10","author":"Nordmark","year":"2009","journal-title":"Gene Immun."},{"issue":"2","key":"10.1016\/j.exer.2023.109716_bib89","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/gene.2010.44","article-title":"Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjogren's syndrome","volume":"12","author":"Nordmark","year":"2011","journal-title":"Gene Immun."},{"issue":"11","key":"10.1016\/j.exer.2023.109716_bib90","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19113548","article-title":"Interferons and dry eye in sjogren's syndrome","volume":"19","author":"Ogawa","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.exer.2023.109716_bib91","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24087456","article-title":"Mesenchymal stem cell exosomes as immunomodulatory therapy for corneal scarring","volume":"24","author":"Ong","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.exer.2023.109716_bib92","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1177\/0271678X17708917","article-title":"Exosomes promote restoration after an experimental animal model of intracerebral hemorrhage","volume":"38","author":"Otero-Ortega","year":"2018","journal-title":"J. Cerebr. Blood Flow Metabol."},{"issue":"1","key":"10.1016\/j.exer.2023.109716_bib93","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/s13287-019-1398-3","article-title":"Enhancement of therapeutic potential of mesenchymal stem cell-derived extracellular vesicles","volume":"10","author":"Park","year":"2019","journal-title":"Stem Cell Res. Ther."},{"issue":"12","key":"10.1016\/j.exer.2023.109716_bib94","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1002\/1529-0131(200012)43:12<2807::AID-ANR22>3.0.CO;2-M","article-title":"Differential expression of matrix metalloproteinases in labial salivary glands of patients with primary Sjogren's syndrome","volume":"43","author":"Perez","year":"2000","journal-title":"Arthritis Rheum."},{"issue":"8","key":"10.1016\/j.exer.2023.109716_bib95","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/S0161-6420(90)32476-4","article-title":"Amplification of Epstein-Barr virus genomic sequences in blood cells, lacrimal glands, and tears from primary Sjogren's syndrome patients","volume":"97","author":"Pflugfelder","year":"1990","journal-title":"Ophthalmology"},{"issue":"11","key":"10.1016\/j.exer.2023.109716_bib96","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1136\/annrheumdis-2014-205375","article-title":"Epidemiology of primary Sjogren's syndrome: a systematic review and meta-analysis","volume":"74","author":"Qin","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.exer.2023.109716_bib97","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.3389\/fimmu.2018.02538","article-title":"Mesenchymal stromal cell-derived extracellular vesicles attenuate dendritic cell maturation and function","volume":"9","author":"Reis","year":"2018","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.exer.2023.109716_bib98","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.1021\/acsnano.9b01004","article-title":"Stem cell-derived exosomes as nanotherapeutics for autoimmune and neurodegenerative disorders","volume":"13","author":"Riazifar","year":"2019","journal-title":"ACS Nano"},{"issue":"4","key":"10.1016\/j.exer.2023.109716_bib99","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/art.41558","article-title":"Interleukin-7\/Interferon Axis drives T cell and salivary gland epithelial cell interactions in sjogren's syndrome","volume":"73","author":"Riviere","year":"2021","journal-title":"Arthritis Rheumatol."},{"issue":"2","key":"10.1016\/j.exer.2023.109716_bib100","article-title":"Primary sjogren syndrome: focus on innate immune cells and inflammation","volume":"8","author":"Rizzo","year":"2020","journal-title":"Vaccines (Basel)"},{"issue":"3","key":"10.1016\/j.exer.2023.109716_bib101","doi-asserted-by":"crossref","DOI":"10.3390\/genes12030365","article-title":"Ophthalmologic manifestations of primary sjogren's syndrome","volume":"12","author":"Roszkowska","year":"2021","journal-title":"Genes"},{"key":"10.1016\/j.exer.2023.109716_bib102","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2021.102660","article-title":"Mesenchymal stromal cells-derived extracellular vesicles alleviate systemic sclerosis via miR-29a-3p","volume":"121","author":"Rozier","year":"2021","journal-title":"J. Autoimmun."},{"issue":"2","key":"10.1016\/j.exer.2023.109716_bib103","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/s41423-020-00587-3","article-title":"Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjogren's syndrome by modulating the function of myeloid-derived suppressor cells","volume":"18","author":"Rui","year":"2021","journal-title":"Cell. Mol. Immunol."},{"issue":"4","key":"10.1016\/j.exer.2023.109716_bib104","doi-asserted-by":"crossref","first-page":"198","DOI":"10.2478\/rir-2022-0035","article-title":"Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine sjogren's syndrome via suppressing Tfh cell response","volume":"3","author":"Rui","year":"2022","journal-title":"Rheumatol Immunol Res"},{"issue":"195","key":"10.1016\/j.exer.2023.109716_bib105","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3005727","article-title":"NCR3\/NKp30 contributes to pathogenesis in primary Sjogren's syndrome","volume":"5","author":"Rusakiewicz","year":"2013","journal-title":"Sci. Transl. Med."},{"issue":"23","key":"10.1016\/j.exer.2023.109716_bib106","doi-asserted-by":"crossref","DOI":"10.3390\/cells11233892","article-title":"Bone marrow mesenchymal stromal\/stem cell-derived extracellular vesicles promote corneal wound repair by regulating inflammation and angiogenesis","volume":"11","author":"Saccu","year":"2022","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.exer.2023.109716_bib107","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12346","article-title":"Single extracellular VEsicle nanoscopy","volume":"12","author":"Saftics","year":"2023","journal-title":"J. Extracell. Vesicles"},{"issue":"12","key":"10.1016\/j.exer.2023.109716_bib108","doi-asserted-by":"crossref","first-page":"5194","DOI":"10.1167\/iovs.18-24803","article-title":"Effect of human corneal mesenchymal stromal cell-derived exosomes on corneal epithelial wound healing","volume":"59","author":"Samaeekia","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.exer.2023.109716_bib109","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s40744-017-0074-2","article-title":"Chronic autoimmune epithelitis in sjogren's syndrome and primary biliary cholangitis: a comprehensive review","volume":"4","author":"Selmi","year":"2017","journal-title":"Rheumatol Ther"},{"issue":"14","key":"10.1016\/j.exer.2023.109716_bib110","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1089\/scd.2014.0316","article-title":"Mesenchymal stem cell exosomes induce proliferation and migration of normal and chronic wound fibroblasts, and enhance angiogenesis in vitro","volume":"24","author":"Shabbir","year":"2015","journal-title":"Stem Cell. Dev."},{"issue":"9","key":"10.1016\/j.exer.2023.109716_bib111","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1007\/s00109-022-02205-3","article-title":"X-linked genes exhibit miR6891-5p-regulated skewing in Sjogren's syndrome","volume":"100","author":"Shaw","year":"2022","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.exer.2023.109716_bib112","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.749192","article-title":"Effects of mesenchymal stem cell-derived exosomes on autoimmune diseases","volume":"12","author":"Shen","year":"2021","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.exer.2023.109716_bib113","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/sctm.18-0297","article-title":"Mesenchymal stem cells reduce corneal fibrosis and inflammation via extracellular vesicle-mediated delivery of miRNA","volume":"8","author":"Shojaati","year":"2019","journal-title":"Stem Cells Transl. Med."},{"issue":"3","key":"10.1016\/j.exer.2023.109716_bib114","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jaut.2012.05.019","article-title":"The T cell in Sjogren's syndrome: force majeure, not spectateur","volume":"39","author":"Singh","year":"2012","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.exer.2023.109716_bib115","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jtos.2022.07.013","article-title":"Salivary gland transplantation for dry eye disease: indications, techniques, and outcomes","volume":"26","author":"Singh","year":"2022","journal-title":"Ocul. Surf."},{"issue":"4","key":"10.1016\/j.exer.2023.109716_bib116","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1167\/iovs.64.4.1","article-title":"The miRNA landscape of lacrimal glands in a murine model of autoimmune dacryoadenitis","volume":"64","author":"Singh Kakan","year":"2023","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.exer.2023.109716_bib117","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s10565-020-09530-8","article-title":"Human umbilical cord blood-derived MSCs exosome attenuate myocardial injury by inhibiting ferroptosis in acute myocardial infarction mice","volume":"37","author":"Song","year":"2021","journal-title":"Cell Biol. Toxicol."},{"issue":"8","key":"10.1016\/j.exer.2023.109716_bib118","doi-asserted-by":"crossref","first-page":"7613","DOI":"10.1021\/acsnano.7b07643","article-title":"Human mesenchymal stem cell derived exosomes alleviate type 2 diabetes mellitus by reversing peripheral insulin resistance and relieving beta-cell destruction","volume":"12","author":"Sun","year":"2018","journal-title":"ACS Nano"},{"issue":"6","key":"10.1016\/j.exer.2023.109716_bib119","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1080\/08820139.2022.2055478","article-title":"Mesenchymal stem cells-derived exosomes ameliorate lupus by inducing M2 macrophage polarization and regulatory T cell expansion in MRL\/lpr mice","volume":"51","author":"Sun","year":"2022","journal-title":"Immunol. Invest."},{"issue":"8","key":"10.1016\/j.exer.2023.109716_bib120","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nri3865","article-title":"The multifaceted biology of plasmacytoid dendritic cells","volume":"15","author":"Swiecki","year":"2015","journal-title":"Nat. Rev. Immunol."},{"issue":"7","key":"10.1016\/j.exer.2023.109716_bib121","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.126751","article-title":"Altered X-chromosome inactivation in T cells may promote sex-biased autoimmune diseases","volume":"4","author":"Syrett","year":"2019","journal-title":"JCI Insight"},{"issue":"9","key":"10.1016\/j.exer.2023.109716_bib122","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12353","article-title":"Critical considerations in determining the surface charge of small extracellular vesicles","volume":"12","author":"Tamrin","year":"2023","journal-title":"J. Extracell. Vesicles"},{"issue":"4","key":"10.1016\/j.exer.2023.109716_bib123","doi-asserted-by":"crossref","DOI":"10.3390\/ph14040345","article-title":"Assessment of tumorigenic potential in mesenchymal-stem\/stromal-cell-derived small extracellular vesicles (MSC-sEV)","volume":"14","author":"Tan","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.exer.2023.109716_bib124","article-title":"Mesenchymal stem cell-derived extracellular vesicles for corneal wound repair","volume":"2019","author":"Tao","year":"2019","journal-title":"Stem Cell. Int."},{"issue":"3","key":"10.1016\/j.exer.2023.109716_bib125","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/bmt.2011.89","article-title":"Mucosal microvilli in dry eye patients with chronic GVHD","volume":"47","author":"Tatematsu","year":"2012","journal-title":"Bone Marrow Transplant."},{"issue":"8930","key":"10.1016\/j.exer.2023.109716_bib126","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/S0140-6736(94)90630-0","article-title":"Prevalence of serum and salivary antibodies to HTLV-1 in Sjogren's syndrome","volume":"344","author":"Terada","year":"1994","journal-title":"Lancet (London, England)"},{"issue":"1","key":"10.1016\/j.exer.2023.109716_bib127","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Thery","year":"2018","journal-title":"J. Extracell. Vesicles"},{"issue":"5","key":"10.1016\/j.exer.2023.109716_bib128","doi-asserted-by":"crossref","first-page":"F1626","DOI":"10.1152\/ajprenal.00339.2006","article-title":"Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury","volume":"292","author":"Togel","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"9","key":"10.1016\/j.exer.2023.109716_bib129","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1002\/art.20463","article-title":"Evidence for coxsackievirus infection in primary Sjogren's syndrome","volume":"50","author":"Triantafyllopoulou","year":"2004","journal-title":"Arthritis Rheum."},{"issue":"12","key":"10.1016\/j.exer.2023.109716_bib130","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1093\/rheumatology\/key215","article-title":"Dysbiosis of the buccal mucosa microbiome in primary Sjogren's syndrome patients","volume":"57","author":"van der Meulen","year":"2018","journal-title":"Rheumatology"},{"issue":"5","key":"10.1016\/j.exer.2023.109716_bib131","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1136\/annrheumdis-2018-214404","article-title":"Normal vaginal microbiome in women with primary Sjogren's syndrome-associated vaginal dryness","volume":"78","author":"van der Meulen","year":"2019","journal-title":"Ann. Rheum. Dis."},{"issue":"4","key":"10.1016\/j.exer.2023.109716_bib132","first-page":"301","article-title":"Advances, limitations and future perspectives in the diagnosis and management of dry eye in Sjogren's syndrome","volume":"38","author":"Vehof","year":"2020","journal-title":"Clin. Exp. Rheumatol."},{"issue":"6","key":"10.1016\/j.exer.2023.109716_bib133","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41584-021-00605-2","article-title":"Epithelial-immune cell interplay in primary Sjogren syndrome salivary gland pathogenesis","volume":"17","author":"Verstappen","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"issue":"1","key":"10.1016\/j.exer.2023.109716_bib134","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/bcpt.13478","article-title":"Mesenchymal stem cell-derived small extracellular vesicles and bone regeneration","volume":"128","author":"Wang","year":"2021","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"12","key":"10.1016\/j.exer.2023.109716_bib135","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/1348-0421.12202","article-title":"Hepatitis C virus infection and the risk of Sjogren or sicca syndrome: a meta-analysis","volume":"58","author":"Wang","year":"2014","journal-title":"Microbiol. Immunol."},{"issue":"1","key":"10.1016\/j.exer.2023.109716_bib136","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000519458","article-title":"Exosomes derived from mouse adipose-derived mesenchymal stem cells alleviate benzalkonium chloride-induced mouse dry eye model via inhibiting NLRP3 inflammasome","volume":"65","author":"Wang","year":"2022","journal-title":"Ophthalmic Res."},{"issue":"5","key":"10.1016\/j.exer.2023.109716_bib137","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1007\/s10067-022-06451-1","article-title":"The composition and function profile of the gut microbiota of patients with primary Sjogren's syndrome","volume":"42","author":"Wang","year":"2023","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.exer.2023.109716_bib138","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jtos.2023.03.002","article-title":"MicroRNAs of extracellular vesicles derived from mesenchymal stromal cells alleviate inflammation in dry eye disease by targeting the IRAK1\/TAB2\/NF-kappaB pathway","volume":"28","author":"Wang","year":"2023","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2023.109716_bib139","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.0105-2896.2004.00211.x","article-title":"Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4","volume":"202","author":"Watford","year":"2004","journal-title":"Immunol. Rev."},{"issue":"4","key":"10.1016\/j.exer.2023.109716_bib140","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1111\/jcmm.15857","article-title":"miR-34a in extracellular vesicles from bone marrow mesenchymal stem cells reduces rheumatoid arthritis inflammation via the cyclin I\/ATM\/ATR\/p53 axis","volume":"25","author":"Wu","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.exer.2023.109716_bib141","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.974648","article-title":"Th17 cells in primary Sjogren's syndrome negatively correlate with increased Roseburia and Coprococcus","volume":"13","author":"Xin","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exer.2023.109716_bib142","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.871096","article-title":"Labial gland mesenchymal stem cell derived exosomes-mediated miRNA-125b attenuates experimental sjogren's syndrome by targeting PRDM1 and suppressing plasma cells","volume":"13","author":"Xing","year":"2022","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.exer.2023.109716_bib143","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/s41419-022-05305-7","article-title":"Bone marrow mesenchymal stem cell-derived exosomal miR-21a-5p alleviates renal fibrosis by attenuating glycolysis by targeting PFKM","volume":"13","author":"Xu","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2023.109716_bib144","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116733","article-title":"Human umbilical cord mesenchymal stem cells derived-exosomes in diseases treatment","volume":"233","author":"Yaghoubi","year":"2019","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.exer.2023.109716_bib145","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/JLB.6MA0921-752RR","article-title":"Stem cells from exfoliated deciduous teeth transplantation ameliorates Sjogren's syndrome by secreting soluble PD-L1","volume":"111","author":"Yang","year":"2022","journal-title":"J. Leukoc. Biol."},{"issue":"13\u201314","key":"10.1016\/j.exer.2023.109716_bib146","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1089\/ten.tea.2021.0190","article-title":"Mesenchymal stem cell-derived exosomes attenuate epithelial-mesenchymal transition of HK-2 cells","volume":"28","author":"Yin","year":"2022","journal-title":"Tissue Eng."},{"issue":"13","key":"10.1016\/j.exer.2023.109716_bib147","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241311179","article-title":"Outline of salivary gland pathogenesis of sjogren's syndrome and current therapeutic approaches","volume":"24","author":"Yura","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2023.109716_bib148","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12967-015-0417-0","article-title":"Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis","volume":"13","author":"Zhang","year":"2015","journal-title":"J. Transl. Med."},{"issue":"15","key":"10.1016\/j.exer.2023.109716_bib149","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1093\/hmg\/ddaa131","article-title":"Skewed allelic expression on X chromosome associated with aberrant expression of XIST on systemic lupus erythematosus lymphocytes","volume":"29","author":"Zhang","year":"2020","journal-title":"Hum. Mol. Genet."},{"issue":"2","key":"10.1016\/j.exer.2023.109716_bib150","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2021.166302","article-title":"Plasmacytoid dendritic cells promote the pathogenesis of Sjogren's syndrome","volume":"1868","author":"Zhou","year":"2022","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"issue":"2","key":"10.1016\/j.exer.2023.109716_bib151","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj9617","article-title":"miR-204-containing exosomes ameliorate GVHD-associated dry eye disease","volume":"8","author":"Zhou","year":"2022","journal-title":"Sci. Adv."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483523003378?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483523003378?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:35:33Z","timestamp":1762148133000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483523003378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":151,"alternative-id":["S0014483523003378"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2023.109716","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advances in mesenchymal stem cell-derived extracellular vesicles therapy for Sjogren's syndrome-related dry eye disease","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2023.109716","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109716"}}