{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:03:46Z","timestamp":1784156626998,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.exer.2023.109726","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T20:49:50Z","timestamp":1700254190000},"page":"109726","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Exploration of the pathophysiology of high myopia via proteomic profiling of human corneal stromal lenticules"],"prefix":"10.1016","volume":"238","author":[{"given":"Yanze","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengtao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3465-1579","authenticated-orcid":false,"given":"Xingtao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.exer.2023.109726_bib1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/s41433-020-1096-5","article-title":"Refractive surgery beyond 2020","volume":"35","author":"Ang","year":"2021","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.exer.2023.109726_bib2","article-title":"Novel corneal protein biomarker candidates reveal iron metabolic disturbance in high myopia eyes","volume":"9","author":"Chen","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.exer.2023.109726_bib3","first-page":"14","article-title":"Introduction to machine learning, neural networks, and deep learning","volume":"9","author":"Choi","year":"2020","journal-title":"Transl. Vis. Sci. Technol."},{"issue":"1\u20132","key":"10.1016\/j.exer.2023.109726_bib4","article-title":"Towards comprehensive and quantitative proteomics for diagnosis and therapy of human disease","volume":"17","author":"Cifani","year":"2017","journal-title":"Proteomics"},{"issue":"5","key":"10.1016\/j.exer.2023.109726_bib5","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.ophtha.2012.10.022","article-title":"Effect of day length on eye growth, myopia progression, and change of corneal power in myopic children","volume":"120","author":"Cui","year":"2013","journal-title":"Ophthalmology"},{"issue":"7543","key":"10.1016\/j.exer.2023.109726_bib6","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/519276a","article-title":"The myopia boom","volume":"519","author":"Dolgin","year":"2015","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.exer.2023.109726_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9113464","article-title":"Omics in myopia","volume":"9","author":"Grochowski","year":"2020","journal-title":"J. Clin. Med."},{"issue":"2","key":"10.1016\/j.exer.2023.109726_bib8","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/ajmg.a.38568","article-title":"Elsahy-Waters syndrome is caused by biallelic mutations in CDH11","volume":"176","author":"Harms","year":"2018","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.exer.2023.109726_bib9","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.exer.2014.07.015","article-title":"The dynamic sclera: extracellular matrix remodeling in normal ocular growth and myopia development","volume":"133","author":"Harper","year":"2015","journal-title":"Exp. Eye Res."},{"issue":"5","key":"10.1016\/j.exer.2023.109726_bib10","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.ophtha.2016.01.006","article-title":"Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050","volume":"123","author":"Holden","year":"2016","journal-title":"Ophthalmology"},{"issue":"2","key":"10.1016\/j.exer.2023.109726_bib11","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00439-007-0388-1","article-title":"The COL1A1 gene and high myopia susceptibility in Japanese","volume":"122","author":"Inamori","year":"2007","journal-title":"Hum. Genet."},{"issue":"2","key":"10.1016\/j.exer.2023.109726_bib12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1167\/iovs.64.2.2","article-title":"Calcipotriol attenuates form deprivation myopia through a signaling pathway parallel to TGF-beta2-induced increases in collagen expression","volume":"64","author":"Jiao","year":"2023","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.exer.2023.109726_bib13","first-page":"604","article-title":"Association of COL1A1 polymorphism with high myopia: a Meta-analysis","volume":"9","author":"Jin","year":"2016","journal-title":"Int. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.exer.2023.109726_bib14","doi-asserted-by":"crossref","first-page":"5495","DOI":"10.1038\/s41598-021-84904-4","article-title":"Corneal proteome and differentially expressed corneal proteins in highly myopic chicks using a label-free SWATH-MS quantification approach","volume":"11","author":"Kang","year":"2021","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.exer.2023.109726_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003299","article-title":"Genome-Wide analysis points to roles for extracellular matrix remodeling, the visual cycle, and neuronal development in myopia","volume":"9","author":"Kiefer","year":"2013","journal-title":"PLoS Genet."},{"issue":"12","key":"10.1016\/j.exer.2023.109726_bib16","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1038\/s41596-018-0074-x","article-title":"Efficient and robust proteome-wide approaches for cross-linking mass spectrometry","volume":"13","author":"Klykov","year":"2018","journal-title":"Nat. Protoc."},{"issue":"7","key":"10.1016\/j.exer.2023.109726_bib17","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s00439-021-02274-3","article-title":"Pathogenic variants in CDH11 impair cell adhesion and cause Teebi hypertelorism syndrome","volume":"140","author":"Li","year":"2021","journal-title":"Hum. Genet."},{"issue":"8","key":"10.1016\/j.exer.2023.109726_bib18","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1158\/0008-5472.CAN-21-1331","article-title":"Extracellular vesicle-packaged CDH11 and ITGA5 induce the premetastatic niche for bone colonization of breast cancer cells","volume":"82","author":"Li","year":"2022","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.exer.2023.109726_bib19","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.survophthal.2021.06.005","article-title":"The cause of myopia development and progression: theory, evidence, and treatment","volume":"67","author":"Medina","year":"2022","journal-title":"Surv. Ophthalmol."},{"issue":"9","key":"10.1016\/j.exer.2023.109726_bib20","doi-asserted-by":"crossref","first-page":"4080","DOI":"10.1167\/iovs.08-3346","article-title":"COL1A1 and COL2A1 genes and myopia susceptibility: evidence of association and suggestive linkage to the COL2A1 locus","volume":"50","author":"Metlapally","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"9827","key":"10.1016\/j.exer.2023.109726_bib21","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/S0140-6736(12)60272-4","article-title":"Myopia","volume":"379","author":"Morgan","year":"2012","journal-title":"Lancet"},{"issue":"16","key":"10.1016\/j.exer.2023.109726_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/polym13162642","article-title":"Current insights into collagen type I","volume":"13","author":"Naomi","year":"2021","journal-title":"Polymers"},{"issue":"6","key":"10.1016\/j.exer.2023.109726_bib23","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/s41433-022-02013-6","article-title":"Gene expression profile analyses to identify potential biomarkers for myopia","volume":"37","author":"Ni","year":"2023","journal-title":"Eye (Lond)"},{"issue":"4","key":"10.1016\/j.exer.2023.109726_bib24","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1053\/j.gastro.2020.11.044","article-title":"Cadherin 11 promotes immunosuppression and extracellular matrix deposition to support growth of pancreatic tumors and resistance to gemcitabine in mice","volume":"160","author":"Peran","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.exer.2023.109726_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2021.107739","article-title":"Using machine learning approaches for multi-omics data analysis: a review","volume":"49","author":"Reel","year":"2021","journal-title":"Biotechnol. Adv."},{"issue":"2","key":"10.1016\/j.exer.2023.109726_bib26","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41596-018-0103-9","article-title":"Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, Cytoscape and EnrichmentMap","volume":"14","author":"Reimand","year":"2019","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.exer.2023.109726_bib27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.eswa.2019.05.028","article-title":"A comparison of random forest variable selection methods for classification prediction modeling","volume":"134","author":"Speiser","year":"2019","journal-title":"Expert Syst. Appl."},{"key":"10.1016\/j.exer.2023.109726_bib28","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.trsl.2021.05.005","article-title":"Immune responses to injury and their links to eye disease","volume":"236","author":"Stepp","year":"2021","journal-title":"Transl. Res."},{"key":"10.1016\/j.exer.2023.109726_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2022.109275","article-title":"MicroRNA-29a inhibits collagen expression and induces apoptosis in human fetal scleral fibroblasts by targeting the Hsp47\/Smad3 signaling pathway","volume":"225","author":"Tang","year":"2022","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2023.109726_bib30","first-page":"55","article-title":"Cadherin expression in the eye","volume":"278","author":"Van Aken","year":"2000","journal-title":"Bull. Soc. Belge Ophtalmol."},{"issue":"5","key":"10.1016\/j.exer.2023.109726_bib31","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s00417-020-04634-7","article-title":"Genipin inhibits the scleral expression of miR-29 and MMP2 and promotes COL1A1 expression in myopic eyes of Guinea pigs","volume":"258","author":"Wang","year":"2020","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"issue":"6","key":"10.1016\/j.exer.2023.109726_bib32","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1093\/bioinformatics\/btp041","article-title":"Genome-wide association analysis by lasso penalized logistic regression","volume":"25","author":"Wu","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.exer.2023.109726_bib33","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.ajo.2019.07.007","article-title":"Comparison of corneal biomechanics between low and high myopic eyes-A meta-analysis","volume":"207","author":"Wu","year":"2019","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2023.109726_bib34","doi-asserted-by":"crossref","DOI":"10.1007\/s00417-023-06158-2","article-title":"Comparisons of the protein expressions between high myopia and moderate myopia on the anterior corneal stroma in human","author":"Wu","year":"2023","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"issue":"5","key":"10.1016\/j.exer.2023.109726_bib35","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1159\/000525189","article-title":"A potential research target for scleral remodeling: effect of MiR-29a on scleral fibroblasts","volume":"65","author":"Yang","year":"2022","journal-title":"Ophthalmic Res."},{"issue":"137\u201341","key":"10.1016\/j.exer.2023.109726_bib36","first-page":"1312","article-title":"Experimental murine myopia induces collagen type I alpha 1 (COL1A1) DNA methylation and altered COL1A1 messenger RNA expression in sclera","volume":"18","author":"Zhou","year":"2012","journal-title":"Mol. Vis."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483523003470?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483523003470?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T18:51:33Z","timestamp":1719687093000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483523003470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":36,"alternative-id":["S0014483523003470"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2023.109726","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploration of the pathophysiology of high myopia via proteomic profiling of human corneal stromal lenticules","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2023.109726","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109726"}}