{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:58:18Z","timestamp":1780340298120,"version":"3.54.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100014717","name":"National Natural Science Foundation of China National Outstanding Youth Science Fund Project","doi-asserted-by":"publisher","award":["82104714"],"award-info":[{"award-number":["82104714"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010031","name":"Postdoctoral Research Foundation of China","doi-asserted-by":"publisher","award":["2023MD734185"],"award-info":[{"award-number":["2023MD734185"]}],"id":[{"id":"10.13039\/501100010031","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.exer.2023.109744","type":"journal-article","created":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T17:48:14Z","timestamp":1702144094000},"page":"109744","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["An enhanced model for environmental dry eye: Exploring pathological features and underlying factors"],"prefix":"10.1016","volume":"239","author":[{"given":"Lei","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JJ Jiajia","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyue","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9848-9800","authenticated-orcid":false,"given":"Baoqiang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.exer.2023.109744_bib1","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.4049\/jimmunol.180.5.3543","article-title":"Mast cell-fibroblast interactions induce matrix metalloproteinase-9 release from fibroblasts: role for IgE-mediated mast cell activation","volume":"180","author":"Abel","year":"2008","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.exer.2023.109744_bib2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1006\/jaut.2001.0524","article-title":"Induction of salivary gland epithelial cell injury in Sjogren's syndrome: in vitro assessment of T cell-derived cytokines and Fas protein expression","volume":"17","author":"Abu-Helu","year":"2001","journal-title":"J. Autoimmun."},{"issue":"6","key":"10.1016\/j.exer.2023.109744_bib3","article-title":"Diurnal variation on tear stability and correlation with tear cytokine concentration","volume":"45","author":"Arroyo-del Arroyo","year":"2022","journal-title":"Contact Lens Anterior Eye"},{"issue":"1\u20132","key":"10.1016\/j.exer.2023.109744_bib4","article-title":"Transcriptional control of matrix metalloproteinases and the tissue inhibitors of matrix metalloproteinases","volume":"7","author":"Borden","year":"1997","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"issue":"1","key":"10.1016\/j.exer.2023.109744_bib5","first-page":"90","article-title":"Flow cytometric analysis of inflammatory markers in KCS: 6-month treatment with topical cyclosporin A","volume":"42","author":"Brignole","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.exer.2023.109744_bib6","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","article-title":"Tfos dews ii pathophysiology report","volume":"15","author":"Bron","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2023.109744_bib7","series-title":"Master's Thesis, Nanjing University of Traditional Chinese Medicine","article-title":"Effects of acupuncture on ocular surface damage and apoptosis of lacrimal gland cells in rabbit dry eye model","author":"Chen","year":"2017"},{"issue":"5","key":"10.1016\/j.exer.2023.109744_bib8","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.3892\/mmr.2014.2041","article-title":"Decreased PPAR-\u03b3 expression in the conjunctiva and increased expression of TNF-\u03b1 and IL-1\u03b2 in the conjunctiva and tear fluid of dry eye mice","volume":"9","author":"Chen","year":"2014","journal-title":"Mol. Med. Rep."},{"issue":"6","key":"10.1016\/j.exer.2023.109744_bib9","article-title":"The consensus of Chinese dry eye Experts: definition and classification (2020)","volume":"56","year":"2020","journal-title":"Chin. J. Ophthalmol."},{"key":"10.1016\/j.exer.2023.109744_bib10","series-title":"The 51st Statistical Report on the Development of China's","year":"2023"},{"issue":"4","key":"10.1016\/j.exer.2023.109744_bib11","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.jtos.2017.08.003","article-title":"TFOS DEWS II report executive summary","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul. Surf."},{"issue":"3","key":"10.1016\/j.exer.2023.109744_bib12","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/1097-0029(20000801)50:3<184::AID-JEMT2>3.0.CO;2-H","article-title":"TNF\u03b1 and the TNF receptor superfamily: structure-function relationship (s)","volume":"50","author":"Idriss","year":"2000","journal-title":"Microsc. Res. Tech."},{"issue":"1","key":"10.1016\/j.exer.2023.109744_bib13","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1515\/bmc-2018-0007","article-title":"Interferon-gamma (IFN-\u03b3): exploring its implications in infectious diseases","volume":"9","author":"Kak","year":"2018","journal-title":"Biomol. Concepts"},{"issue":"1","key":"10.1016\/j.exer.2023.109744_bib14","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2332\/allergolint.55.67","article-title":"Production of matrix Metalloproteinases in human cultured mast cells: involvement of protein kinase C\u2014mitogen activated protein kinase kinase\u2014extracellular signal-regulated kinase pathway","volume":"55","author":"Kimata","year":"2006","journal-title":"Allergol. Int."},{"issue":"2","key":"10.1016\/j.exer.2023.109744_bib15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1542-0124(12)70081-2","article-title":"The definition and classification of dry eye disease: report of the definition and classification subcommittee of the international dry eye WorkShop (2007)","volume":"5","author":"Lemp","year":"2007","journal-title":"Ocul. Surf."},{"issue":"11","key":"10.1016\/j.exer.2023.109744_bib16","first-page":"1183","article-title":"Mouse dry eye model and evaluation made with hypertonic saline","volume":"32","author":"Li","year":"2010","journal-title":"Academiae Medicinae Militaris Tertiae"},{"issue":"3","key":"10.1016\/j.exer.2023.109744_bib17","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/jcp.20992","article-title":"Interleukin-1\u03b2 induces MMP-9 expression via p42\/p44 MAPK, p38 MAPK, JNK, and nuclear factor-\u03baB signaling pathways in human tracheal smooth muscle cells","volume":"211","author":"Liang","year":"2007","journal-title":"J. Cell. Physiol."},{"issue":"8","key":"10.1016\/j.exer.2023.109744_bib19","first-page":"4664","article-title":"Exploration of the protective mechanism of fructus corni on corneal anti-inflammatory effect in a dry eye model mice based on the theory of \u2019acid entering the liver","volume":"36","author":"Liu","year":"2021","journal-title":"Chinese J. Tradition. Med."},{"issue":"4","key":"10.1016\/j.exer.2023.109744_bib20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cytogfr.2011.10.001","article-title":"Understanding the mechanism of IL-1\u03b2 secretion","volume":"22","author":"Lopez-Castejon","year":"2011","journal-title":"Cytokine Growth Factor Rev."},{"issue":"5","key":"10.1016\/j.exer.2023.109744_bib21","first-page":"71","article-title":"The pathophysiology, diagnosis, and treatment of dry eye disease","volume":"112","author":"Messmer","year":"2015","journal-title":"Deutsches \u00c4rzteblatt International"},{"issue":"7","key":"10.1016\/j.exer.2023.109744_bib22","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1167\/iovs.04-1344","article-title":"D-\u03b2-hydroxybutyrate protects against corneal epithelial disorders in a rat dry eye model with jogging board","volume":"46","author":"Nakamura","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.exer.2023.109744_bib23","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.3390\/ijms19041221","article-title":"Proinflammatory markers, chemokines, and enkephalin in patients suffering from dry eye disease","volume":"19","author":"Nicolle","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.exer.2023.109744_bib24","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0002-9440(10)62232-8","article-title":"Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye","volume":"166","author":"Pflugfelder","year":"2005","journal-title":"Am. J. Pathol."},{"issue":"3","key":"10.1016\/j.exer.2023.109744_bib25","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jtos.2018.05.001","article-title":"Severity, therapeutic, and activity tear biomarkers in dry eye disease: an analysis from a phase III clinical trial","volume":"16","author":"Pinto-Fraga","year":"2018","journal-title":"Ocul. Surf."},{"issue":"5","key":"10.1016\/j.exer.2023.109744_bib26","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1167\/iovs.17-23743","article-title":"Alterations of murine subbasal corneal nerves after environmental dry eye stress","volume":"59","author":"Simsek","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2023.109744_bib27","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1167\/iovs.02-1319","article-title":"Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca","volume":"44","author":"Song","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"19","key":"10.1016\/j.exer.2023.109744_bib28","first-page":"6","article-title":"Specifications for preparation of dry eye animal models (draft)","volume":"24","year":"2018","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"issue":"2","key":"10.1016\/j.exer.2023.109744_bib29","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1159\/000088436","article-title":"Apoptosis and loss of adhesion of bronchial epithelial cells in asthma","volume":"138","author":"Trautmann","year":"2005","journal-title":"Int. Arch. Allergy Immunol."},{"issue":"1","key":"10.1016\/j.exer.2023.109744_bib30","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1097\/ICL.0000000000000643","article-title":"A new perspective on dry eye classification: proposal by the asia dry eye society","volume":"46","author":"Tsubota","year":"2020","journal-title":"Eye Contact Lens"},{"issue":"5","key":"10.1016\/j.exer.2023.109744_bib31","doi-asserted-by":"crossref","first-page":"L921","DOI":"10.1152\/ajplung.1997.273.5.L921","article-title":"Dexamethasone inhibits lung epithelial cell apoptosis induced by IFN-\u03b3 and Fas","volume":"273","author":"Wen","year":"1997","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.exer.2023.109744_bib32","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1007\/s10792-014-9969-x","article-title":"The role and treatment of inflammation in dry eye disease","volume":"34","author":"Yagci","year":"2014","journal-title":"Int. Ophthalmol."},{"issue":"1","key":"10.1016\/j.exer.2023.109744_bib33","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1167\/iovs.02-0581","article-title":"Apoptosis of ocular surface cells in experimentally induced dry eye","volume":"44","author":"Yeh","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483523003652?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483523003652?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:35:40Z","timestamp":1762148140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483523003652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":32,"alternative-id":["S0014483523003652"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2023.109744","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An enhanced model for environmental dry eye: Exploring pathological features and underlying factors","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2023.109744","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109744"}}