{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:14:16Z","timestamp":1791386056797,"version":"4.3.3"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000851"],"award-info":[{"award-number":["82000851"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070927"],"award-info":[{"award-number":["82070927"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["tstp20221163"],"award-info":[{"award-number":["tstp20221163"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020QH144"],"award-info":[{"award-number":["ZR2020QH144"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015507","name":"Shandong First Medical University","doi-asserted-by":"publisher","award":["2019RC008"],"award-info":[{"award-number":["2019RC008"]}],"id":[{"id":"10.13039\/501100015507","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.exer.2024.109814","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T02:39:53Z","timestamp":1706841593000},"page":"109814","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Establishment of mouse model of neurotrophic keratopathy through TRPV1 neuronal ablation"],"prefix":"10.1016","volume":"240","author":[{"given":"Leilei","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3103-0328","authenticated-orcid":false,"given":"Xiaolei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7770-9275","authenticated-orcid":false,"given":"Qingjun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2024.109814_bib1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nm.4501","article-title":"Nociceptor sensory neurons suppress neutrophil and \u03b3\u03b4 T cell responses in bacterial lung infections and lethal pneumonia","volume":"24","author":"Baral","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.exer.2024.109814_bib2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/0014-4886(80)90154-5","article-title":"Sensory denervation of the rabbit cornea affects epithelial properties","volume":"69","author":"Beuerman","year":"1980","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.exer.2024.109814_bib3","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1167\/iovs.18-24843","article-title":"Corneal neurotization improves ocular surface health in a novel rat model of neurotrophic keratopathy and corneal neurotization","volume":"59","author":"Catapano","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.109814_bib4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jtos.2023.09.001","article-title":"Neurotrophic keratopathy: an updated understanding","volume":"30","author":"Cheung","year":"2023","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2024.109814_bib5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/s12886-021-02092-1","article-title":"Expert consensus on the identification, diagnosis, and treatment of neurotrophic keratopathy","volume":"21","author":"Dana","year":"2021","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.exer.2024.109814_bib6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.preteyeres.2009.04.003","article-title":"Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases","volume":"28","author":"Dartt","year":"2009","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2024.109814_bib7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.preteyeres.2018.04.003","article-title":"Neurotrophic keratopathy","volume":"66","author":"Dua","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2024.109814_bib8","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41582-018-0003-1","article-title":"CGRP as the target of new migraine therapies - successful translation from bench to clinic","volume":"14","author":"Edvinsson","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.exer.2024.109814_bib9","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1167\/iovs.10-5688","article-title":"A novel mouse model for neurotrophic keratopathy: trigeminal nerve stereotactic electrolysis through the brain","volume":"52","author":"Ferrari","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.109814_bib10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0014-4835(84)90100-3","article-title":"Capsaicin-induced neuroparalytic keratitis-like corneal changes in the mouse","volume":"38","author":"Fujita","year":"1984","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.109814_bib11","doi-asserted-by":"crossref","first-page":"C1151","DOI":"10.1152\/ajpcell.1998.275.4.C1151","article-title":"Localization and expression of AQP5 in cornea, serous salivary glands, and pulmonary epithelial cells","volume":"275","author":"Funaki","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.exer.2024.109814_bib12","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0161-6420(90)32587-3","article-title":"Tear film and ocular surface changes in a rabbit model of neurotrophic keratitis","volume":"97","author":"Gilbard","year":"1990","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2024.109814_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2020.610342","article-title":"Morphological and functional changes of corneal nerves and their contribution to peripheral and central sensory abnormalities","volume":"14","author":"Guerrero-Moreno","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.exer.2024.109814_bib14","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.exer.2015.03.005","article-title":"Morphology and neurochemistry of rabbit iris innervation","volume":"135","author":"He","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.109814_bib15","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1167\/iovs.62.9.6","article-title":"Distribution of corneal TRPV1 and its association with immune cells during homeostasis and injury","volume":"62","author":"Jiao","year":"2021","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.109814_bib16","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.ajpath.2019.05.015","article-title":"Corneal sensory experience via transient receptor potential vanilloid 1 accelerates the maturation of neonatal tearing","volume":"189","author":"Jin","year":"2019","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2024.109814_bib17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3390\/jcto1020006","article-title":"The activity of substance P (SP) on the corneal epithelium","volume":"1","author":"Kopel","year":"2023","journal-title":"J. Clin. Translation.Ophthalmol."},{"key":"10.1016\/j.exer.2024.109814_bib18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cell.2019.11.014","article-title":"Gut-Innervating nociceptor neurons regulate peyer's patch microfold cells and SFB levels to mediate Salmonella host defense","volume":"180","author":"Lai","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.exer.2024.109814_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2021.100974","article-title":"The two-faced effects of nerves and neuropeptides in corneal diseases","volume":"86","author":"Lasagni Vitar","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2024.109814_bib20","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1038\/s41467-019-13536-0","article-title":"TRPV1 activity and substance P release are required for corneal cold nociception","volume":"10","author":"Li","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2024.109814_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009557","article-title":"Pseudomonas aeruginosa-induced nociceptor activation increases susceptibility to infection","volume":"17","author":"Lin","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.exer.2024.109814_bib22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1167\/tvst.12.10.21","article-title":"Establishing a mouse model of chlorpromazine-induced corneal trigeminal denervation","volume":"12","author":"Lin","year":"2023","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.exer.2024.109814_bib23","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.ymthe.2020.12.007","article-title":"Current clinical applications of in vivo gene therapy with AAVs","volume":"29","author":"Mendell","year":"2021","journal-title":"Mol. Ther."},{"key":"10.1016\/j.exer.2024.109814_bib24","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1006\/exer.1999.0814","article-title":"Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5","volume":"70","author":"Moore","year":"2000","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.109814_bib25","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1167\/iovs.03-0189","article-title":"Effects of substance P and IGF-1 in corneal epithelial barrier function and wound healing in a rat model of neurotrophic keratopathy","volume":"44","author":"Nagano","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.109814_bib26","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1167\/iovs.02-0868","article-title":"Restoration of corneal epithelial barrier function and wound healing by substance P and IGF-1 in rats with capsaicin-induced neurotrophic keratopathy","volume":"44","author":"Nakamura","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.109814_bib27","first-page":"112","article-title":"Sprouting of corneal sensory fibers in rats treated at birth with capsaicin","volume":"32","author":"Ogilvy","year":"1991","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.109814_bib28","doi-asserted-by":"crossref","first-page":"5533","DOI":"10.1523\/JNEUROSCI.5788-12.2013","article-title":"The cellular code for mammalian thermosensation","volume":"33","author":"Pogorzala","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2024.109814_bib29","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.1167\/iovs.19-26928","article-title":"Therapeutic effects of STAT3 inhibition on experimental murine dry eye","volume":"60","author":"Qu","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.109814_bib30","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.freeradbiomed.2021.02.036","article-title":"Hyperglycemia-induced severe mitochondrial bioenergetic deficit of lacrimal gland contributes to the early onset of dry eye in diabetic mice","volume":"166","author":"Qu","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exer.2024.109814_bib31","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/nn.4350","article-title":"The coding of cutaneous temperature in the spinal cord","volume":"19","author":"Ran","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.exer.2024.109814_bib32","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.jtos.2020.09.007","article-title":"The molecular basis of neurotrophic keratopathy: diagnostic and therapeutic implications. A review","volume":"19","author":"Ruiz-Lozano","year":"2021","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2024.109814_bib33","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1152\/physrev.00034.2013","article-title":"Calcitonin gene-related peptide: physiology and pathophysiology","volume":"94","author":"Russell","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.exer.2024.109814_bib34","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jtos.2022.06.007","article-title":"Modulating the tachykinin: role of substance P and neurokinin receptor expression in ocular surface disorders","volume":"25","author":"Singh","year":"2022","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2024.109814_bib35","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","article-title":"TFOS DEWS II epidemiology report","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2024.109814_bib36","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1167\/iovs.13-13077","article-title":"Impairment of corneal epithelial wound healing in a TRPV1-deficient mouse","volume":"55","author":"Sumioka","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.109814_bib37","first-page":"1372","article-title":"Suppression of nitric oxide generated by inflammatory macrophages by calcitonin gene-related peptide in aqueous humor","volume":"39","author":"Taylor","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.109814_bib38","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1136\/bjo.2005.079533","article-title":"Risk factors for perforation in microbial corneal ulcers in north India","volume":"90","author":"Titiyal","year":"2006","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2024.109814_bib39","doi-asserted-by":"crossref","first-page":"11515","DOI":"10.1073\/pnas.1411032111","article-title":"Population of sensory neurons essential for asthmatic hyperreactivity of inflamed airways","volume":"111","author":"Tr\u00e4nkner","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2024.109814_bib40","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1167\/iovs.19-26983","article-title":"Induction of fibroblast senescence during mouse corneal wound healing","volume":"60","author":"Wang","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.109814_bib41","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1111\/ajt.16071","article-title":"The NLRP3 inflammasome regulates corneal allograft rejection through enhanced phosphorylation of STAT3","volume":"20","author":"Wei","year":"2020","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.exer.2024.109814_bib42","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.exer.2004.05.010","article-title":"A rat model of radiofrequency ablation of trigeminal innervation via a ventral approach with stereotaxic surgery","volume":"79","author":"Wong","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.109814_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.731234","article-title":"Revealing the angiopathy of lacrimal gland lesion in type 2 diabetes","volume":"12","author":"Xue","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.exer.2024.109814_bib44","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1016\/j.cell.2022.09.024","article-title":"Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection","volume":"185","author":"Yang","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.exer.2024.109814_bib45","doi-asserted-by":"crossref","first-page":"4170","DOI":"10.1016\/j.cell.2022.09.008","article-title":"Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection","volume":"185","author":"Zhang","year":"2022","journal-title":"Cell"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483524000356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483524000356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T19:20:33Z","timestamp":1719688833000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483524000356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":45,"alternative-id":["S0014483524000356"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2024.109814","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Establishment of mouse model of neurotrophic keratopathy through TRPV1 neuronal ablation","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2024.109814","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109814"}}