{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T20:58:02Z","timestamp":1774558682449,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.exer.2024.109817","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:31:59Z","timestamp":1707438719000},"page":"109817","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["CircSTRBP contributes to H2O2-induced lens epithelium cell dysfunction through increasing NOX4 mRNA stability by recruiting IGF2BP1"],"prefix":"10.1016","volume":"241","author":[{"given":"Di","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanyi","family":"Che","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningning","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9459","key":"10.1016\/j.exer.2024.109817_bib1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0140-6736(05)70803-5","article-title":"Age-related cataract","volume":"365","author":"Asbell","year":"2005","journal-title":"Lancet (London, England)"},{"issue":"3","key":"10.1016\/j.exer.2024.109817_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15030775","article-title":"Genetics and RNA regulation of uveal melanoma","volume":"15","author":"Barbagallo","year":"2023","journal-title":"Cancers"},{"issue":"3","key":"10.1016\/j.exer.2024.109817_bib3","doi-asserted-by":"crossref","first-page":"C422","DOI":"10.1152\/ajpcell.00381.2008","article-title":"Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells","volume":"296","author":"Basuroy","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"1","key":"10.1016\/j.exer.2024.109817_bib4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol. Rev."},{"issue":"15","key":"10.1016\/j.exer.2024.109817_bib5","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1007\/s00018-012-1186-z","article-title":"Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?","volume":"70","author":"Bell","year":"2013","journal-title":"Cell. Mol. Life Sci. : CM"},{"issue":"1","key":"10.1016\/j.exer.2024.109817_bib6","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1186\/s12967-021-03182-w","article-title":"NOX4: a potential therapeutic target for pancreatic cancer and its mechanism","volume":"19","author":"Bi","year":"2021","journal-title":"J. Transl. Med."},{"issue":"12","key":"10.1016\/j.exer.2024.109817_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15123148","article-title":"METTL3-Modulated circUHRF2 promotes colorectal cancer stemness and metastasis through increasing DDX27 mRNA stability by recruiting IGF2BP1","volume":"15","author":"Chen","year":"2023","journal-title":"Cancers"},{"issue":"2","key":"10.1016\/j.exer.2024.109817_bib8","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s10528-022-10266-9","article-title":"Circ_HIPK3 inhibits H(2)O(2)-induced lens epithelial cell injury in age-related cataract depending on the regulation of miR-495-3p\/HDAC4 pathway","volume":"61","author":"Chen","year":"2023","journal-title":"Biochem. Genet."},{"issue":"8","key":"10.1016\/j.exer.2024.109817_bib9","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1167\/iovs.16-19114","article-title":"Nox4 plays a role in TGF-\u03b2-dependent lens epithelial to mesenchymal transition","volume":"57","author":"Das","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.exer.2024.109817_bib10","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1007\/s10637-021-01148-9","article-title":"The biological function of IGF2BPs and their role in tumorigenesis","volume":"39","author":"Du","year":"2021","journal-title":"Invest. N. Drugs"},{"issue":"21","key":"10.1016\/j.exer.2024.109817_bib11","doi-asserted-by":"crossref","first-page":"13386","DOI":"10.1074\/jbc.M115.655175","article-title":"Two isoforms of the RNA binding protein, coding region determinant-binding protein (CRD-BP\/IGF2BP1), are expressed in breast epithelium and support clonogenic growth of breast tumor cells","volume":"290","author":"Fakhraldeen","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.exer.2024.109817_bib12","doi-asserted-by":"crossref","first-page":"888","DOI":"10.3109\/1061186X.2015.1036276","article-title":"The human Nox4: gene, structure, physiological function and pathological significance","volume":"23","author":"Guo","year":"2015","journal-title":"J. Drug Target."},{"issue":"4","key":"10.1016\/j.exer.2024.109817_bib13","doi-asserted-by":"crossref","first-page":"513","DOI":"10.7150\/ijms.29750","article-title":"Circular RNAs: novel promising biomarkers in ocular diseases","volume":"16","author":"Guo","year":"2019","journal-title":"Int. J. Med. Sci."},{"issue":"7441","key":"10.1016\/j.exer.2024.109817_bib14","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA sponges","volume":"495","author":"Hansen","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.exer.2024.109817_bib15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-319-42059-2_1","article-title":"Non-coding RNAs: classification, biology and functioning","volume":"937","author":"Hombach","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"issue":"8","key":"10.1016\/j.exer.2024.109817_bib16","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.7150\/thno.42174","article-title":"Circular RNA-protein interactions: functions, mechanisms, and identification","volume":"10","author":"Huang","year":"2020","journal-title":"Theranostics"},{"issue":"5","key":"10.1016\/j.exer.2024.109817_bib17","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1006\/exer.1998.0551","article-title":"Human lens epithelial cell line","volume":"67","author":"Ibaraki","year":"1998","journal-title":"Exp. Eye Res."},{"issue":"11","key":"10.1016\/j.exer.2024.109817_bib18","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41576-019-0158-7","article-title":"The biogenesis, biology and characterization of circular RNAs","volume":"20","author":"Kristensen","year":"2019","journal-title":"Nat. Rev. Genet."},{"issue":"12","key":"10.1016\/j.exer.2024.109817_bib19","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20191773","article-title":"MicroRNA-15a modulates lens epithelial cells apoptosis and proliferation through targeting B-cell lymphoma-2 and E2F transcription factor 3 in age-related cataracts","volume":"39","author":"Li","year":"2019","journal-title":"Biosci. Rep."},{"issue":"10","key":"10.1016\/j.exer.2024.109817_bib20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1167\/iovs.61.10.13","article-title":"Identification and characterization of N6-methyladenosine CircRNAs and methyltransferases in the lens epithelium cells from age-related cataract","volume":"61","author":"Li","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.exer.2024.109817_bib21","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/s12886-020-01489-8","article-title":"MicroRNA-182-5p protects human lens epithelial cells against oxidative stress-induced apoptosis by inhibiting NOX4 and p38 MAPK signalling","volume":"20","author":"Li","year":"2020","journal-title":"BMC Ophthalmol."},{"issue":"17","key":"10.1016\/j.exer.2024.109817_bib22","doi-asserted-by":"crossref","first-page":"17271","DOI":"10.18632\/aging.103683","article-title":"Profiling of circular RNAs in age-related cataract reveals circZNF292 as an antioxidant by sponging miR-23b-3p","volume":"12","author":"Liang","year":"2020","journal-title":"Aging"},{"issue":"8","key":"10.1016\/j.exer.2024.109817_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11081516","article-title":"Redox homeostasis in ocular tissues: circadian regulation of Glutathione in the lens?","volume":"11","author":"Lim","year":"2022","journal-title":"Antioxidants"},{"issue":"10094","key":"10.1016\/j.exer.2024.109817_bib24","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/S0140-6736(17)30544-5","article-title":"Cataracts","volume":"390","author":"Liu","year":"2017","journal-title":"Lancet (London, England)"},{"issue":"4","key":"10.1016\/j.exer.2024.109817_bib25","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1016\/j.bbrc.2018.06.149","article-title":"Circular RNA HIPK3 regulates human lens epithelial cells proliferation and apoptosis by targeting the miR-193a\/CRYAA axis","volume":"503","author":"Liu","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.exer.2024.109817_bib26","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1097\/j.jcrs.0000000000000319","article-title":"Fluid-jet technique to polish the posterior capsule for phacoemulsification surgeries: efficacy and safety evaluation","volume":"46","author":"Liu","year":"2020","journal-title":"J. Cataract Refract. Surg."},{"issue":"1","key":"10.1016\/j.exer.2024.109817_bib27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13046-023-02614-3","article-title":"HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1\/PKM2 pathway","volume":"42","author":"Lv","year":"2023","journal-title":"J. Exp. Clin. Cancer Res. : CRN"},{"issue":"3","key":"10.1016\/j.exer.2024.109817_bib28","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1080\/15384101.2022.2114587","article-title":"CircMAP3K4 protects human lens epithelial cells from H(2)O(2)-induced dysfunction by targeting miR-193a-3p\/PLCD3 axis in age-related cataract","volume":"22","author":"Ma","year":"2023","journal-title":"Cell Cycle"},{"issue":"4","key":"10.1016\/j.exer.2024.109817_bib29","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/jcmm.12213","article-title":"The roles of \u03b1V integrins in lens EMT and posterior capsular opacification","volume":"18","author":"Mamuya","year":"2014","journal-title":"J. Cell Mol. Med."},{"issue":"3","key":"10.1016\/j.exer.2024.109817_bib30","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1002\/ajmg.c.31833","article-title":"Insights into the regulatory molecules involved in glaucoma pathogenesis","volume":"184","author":"Moazzeni","year":"2020","journal-title":"Am. J. Med. Genet. Part C, Seminars in medical genetics"},{"key":"10.1016\/j.exer.2024.109817_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102492","article-title":"RNA binding protein IGF2BP1 meditates oxidative stress-induced granulosa cell dysfunction by regulating MDM2 mRNA stability in an m(6)A-dependent manner","volume":"57","author":"Mu","year":"2022","journal-title":"Redox Biol."},{"issue":"6","key":"10.1016\/j.exer.2024.109817_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagrm.2019.194417","article-title":"Non-coding RNA regulatory networks","volume":"1863","author":"Panni","year":"2020","journal-title":"Biochimica et biophysica acta Gene regulatory mechanisms"},{"issue":"16","key":"10.1016\/j.exer.2024.109817_bib33","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2018100836","article-title":"Past, present, and future of circRNAs","volume":"38","author":"Patop","year":"2019","journal-title":"EMBO J."},{"issue":"2","key":"10.1016\/j.exer.2024.109817_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/cells12020273","article-title":"Silencing of circCRIM1 drives IGF2BP1-mediated NSCLC immune evasion","volume":"12","author":"Peng","year":"2023","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.exer.2024.109817_bib35","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1517\/13543784.13.6.691","article-title":"Cataract formation and prevention","volume":"13","author":"Shichi","year":"2004","journal-title":"Expet Opin. Invest. Drugs"},{"issue":"1","key":"10.1016\/j.exer.2024.109817_bib36","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ejphar.2010.09.076","article-title":"Honokiol inhibits H(2)O(2)-induced apoptosis in human lens epithelial cells via inhibition of the mitogen-activated protein kinase and Akt pathways","volume":"650","author":"Tang","year":"2011","journal-title":"Eur. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.exer.2024.109817_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10060890","article-title":"NADPH oxidases (NOX): an overview from discovery, molecular mechanisms to physiology and pathology","volume":"10","author":"Vermot","year":"2021","journal-title":"Antioxidants"},{"issue":"8","key":"10.1016\/j.exer.2024.109817_bib38","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1515\/hsz-2013-0111","article-title":"Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains","volume":"394","author":"W\u00e4chter","year":"2013","journal-title":"Biol. Chem."},{"issue":"1","key":"10.1016\/j.exer.2024.109817_bib39","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12886-018-0766-6","article-title":"Identification of H2O2 induced oxidative stress associated microRNAs in HLE-B3 cells and their clinical relevance to the progression of age-related nuclear cataract","volume":"18","author":"Wang","year":"2018","journal-title":"BMC Ophthalmol."},{"issue":"4","key":"10.1016\/j.exer.2024.109817_bib40","first-page":"497","article-title":"Circular and long non-coding RNAs and their role in ophthalmologic diseases","volume":"65","author":"Wawrzyniak","year":"2018","journal-title":"Acta Biochim. Pol."},{"issue":"2","key":"10.1016\/j.exer.2024.109817_bib41","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.preteyeres.2009.12.001","article-title":"Development and use of the lens epithelial explant system to study lens differentiation and cataractogenesis","volume":"29","author":"West-Mays","year":"2010","journal-title":"Prog. Retin. Eye Res."},{"issue":"1","key":"10.1016\/j.exer.2024.109817_bib42","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12943-021-01359-x","article-title":"CircPTPRA blocks the recognition of RNA N(6)-methyladenosine through interacting with IGF2BP1 to suppress bladder cancer progression","volume":"20","author":"Xie","year":"2021","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.exer.2024.109817_bib43","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/jnr.24356","article-title":"The interaction of circRNAs and RNA binding proteins: an important part of circRNA maintenance and function","volume":"98","author":"Zang","year":"2020","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.exer.2024.109817_bib44","doi-asserted-by":"crossref","first-page":"850","DOI":"10.3389\/fcell.2020.00850","article-title":"CircRNA is a rising star in researches of ocular diseases","volume":"8","author":"Zhang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"24","key":"10.1016\/j.exer.2024.109817_bib45","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.21037\/atm-20-7365","article-title":"Long non-coding RNA nuclear paraspeckle assembly transcript 1 protects human lens epithelial cells against H2O2 stimuli through the nuclear factor kappa b\/p65 and p38\/mitogen-activated protein kinase axis","volume":"8","author":"Zhou","year":"2020","journal-title":"Ann. Transl. Med."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483524000381?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483524000381?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:25:38Z","timestamp":1758000338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483524000381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":45,"alternative-id":["S0014483524000381"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2024.109817","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CircSTRBP contributes to H2O2-induced lens epithelium cell dysfunction through increasing NOX4 mRNA stability by recruiting IGF2BP1","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2024.109817","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109817"}}