{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:40:54Z","timestamp":1762148454802,"version":"build-2065373602"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.exer.2024.109835","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T11:06:27Z","timestamp":1708167987000},"page":"109835","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Influence of the calcium voltage-gated channel auxiliary subunit (CACNA2D1) absence on intraocular pressure in mice"],"prefix":"10.1016","volume":"241","author":[{"given":"Levi","family":"Lankford","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupalatha","family":"Maddala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica M.","family":"Jablonski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1553-1691","authenticated-orcid":false,"given":"P. Vasantha","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2024.109835_bib1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s00424-020-02420-2","article-title":"Neuronal alpha(2)delta proteins and brain disorders","volume":"472","author":"Ablinger","year":"2020","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.exer.2024.109835_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100897","article-title":"Normal and glaucomatous outflow regulation","volume":"82","author":"Acott","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2024.109835_bib3","doi-asserted-by":"crossref","first-page":"a003947","DOI":"10.1101\/cshperspect.a003947","article-title":"Voltage-gated calcium channels","volume":"3","author":"Catterall","year":"2011","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.exer.2024.109835_bib4","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1038\/s41467-017-00837-5","article-title":"Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility","volume":"8","author":"Chintalapudi","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2024.109835_bib5","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1111\/jcmm.17229","article-title":"Role of vasorin, an anti-apoptotic, anti-TGF-beta and hypoxia-induced glycoprotein in the trabecular meshwork cells and glaucoma","volume":"26","author":"Choi","year":"2022","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.exer.2024.109835_bib6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ejphar.2016.06.018","article-title":"Glucocorticoid therapy and ocular hypertension","volume":"787","author":"Dibas","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.exer.2024.109835_bib7","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.cell.2009.09.025","article-title":"Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis","volume":"139","author":"Eroglu","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.exer.2024.109835_bib8","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0028-3908(01)00172-1","article-title":"Inhibition of neuronal Ca(2+) influx by gabapentin and pregabalin in the human neocortex","volume":"42","author":"Fink","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.exer.2024.109835_bib9","doi-asserted-by":"crossref","DOI":"10.1172\/JCI156967","article-title":"Thrombospondin 1 missense alleles induce extracellular matrix protein aggregation and TM dysfunction in congenital glaucoma","volume":"132","author":"Fu","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exer.2024.109835_bib10","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1113\/jphysiol.2007.147959","article-title":"The calcium channel alpha2\/delta1 subunit is involved in extracellular signalling","volume":"586","author":"Garc\u00eda","year":"2008","journal-title":"J. Physiol."},{"key":"10.1016\/j.exer.2024.109835_bib11","doi-asserted-by":"crossref","first-page":"13728","DOI":"10.1021\/acsnano.9b07214","article-title":"Once daily pregabalin eye drops for management of glaucoma","volume":"13","author":"Ibrahim","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.exer.2024.109835_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2013.05.002","article-title":"Rho-associated kinase inhibitors: a novel glaucoma therapy","volume":"37","author":"Inoue","year":"2013","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2024.109835_bib13","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.exer.2018.03.001","article-title":"Consensus recommendations for trabecular meshwork cell isolation, characterization and culture","volume":"171","author":"Keller","year":"2018","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.109835_bib14","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1358\/dot.2018.54.8.2849627","article-title":"Netarsudil ophthalmic solution 0.02% for the treatment of patients with open-angle glaucoma or ocular hypertension","volume":"54","author":"Kopczynski","year":"2018","journal-title":"Drugs Today"},{"key":"10.1016\/j.exer.2024.109835_bib15","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/jcp.30953","article-title":"Glypican-4 regulated actin cytoskeletal reorganization in glucocorticoid treated trabecular meshwork cells and involvement of Wnt\/PCP signaling","volume":"238","author":"Maddala","year":"2023","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.exer.2024.109835_bib16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1042\/CBI20090018","article-title":"Proteomic analysis to identify early molecular targets of pregabalin in C6 glial cells","volume":"34","author":"Park","year":"2009","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.exer.2024.109835_bib17","first-page":"1029","article-title":"Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632","volume":"42","author":"Rao","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.109835_bib18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.exer.2016.08.023","article-title":"Role of the Rho GTPase\/Rho kinase signaling pathway in pathogenesis and treatment of glaucoma: bench to bedside research","volume":"158","author":"Rao","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.109835_bib19","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.3390\/biom12121857","article-title":"Gabapentin disrupts binding of perlecan to the \u03b12\u03b41 voltage sensitive calcium channel subunit and impairs skeletal mechanosensation","volume":"12","author":"Reyes Fernandez","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.exer.2024.109835_bib20","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.matbio.2012.01.004","article-title":"Thrombospondins as key regulators of synaptogenesis in the central nervous system","volume":"31","author":"Risher","year":"2012","journal-title":"Matrix Biol."},{"key":"10.1016\/j.exer.2024.109835_bib21","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1083\/jcb.201802057","article-title":"Thrombospondin receptor alpha2delta-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1","volume":"217","author":"Risher","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.exer.2024.109835_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019802","article-title":"Targeting of voltage-gated calcium channel \u03b12\u03b4-1 subunit to lipid rafts is independent from a GPI-anchoring motif","volume":"6","author":"Robinson","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2024.109835_bib23","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.coph.2005.11.003","article-title":"The mechanisms of action of gabapentin and pregabalin","volume":"6","author":"Sills","year":"2006","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.exer.2024.109835_bib24","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/40187","article-title":"Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension","volume":"389","author":"Uehata","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.exer.2024.109835_bib25","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The pathophysiology and treatment of glaucoma: a review","volume":"311","author":"Weinreb","year":"2014","journal-title":"JAMA"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483524000563?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483524000563?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:37:32Z","timestamp":1762148252000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483524000563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":25,"alternative-id":["S0014483524000563"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2024.109835","relation":{},"ISSN":["0014-4835"],"issn-type":[{"type":"print","value":"0014-4835"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of the calcium voltage-gated channel auxiliary subunit (CACNA2D1) absence on intraocular pressure in mice","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2024.109835","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109835"}}