{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:04:56Z","timestamp":1780405496633,"version":"3.54.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.exer.2024.109906","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T15:45:43Z","timestamp":1713800743000},"page":"109906","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Metabolomic profiling of the aqueous humor in patients with pediatric cataract"],"prefix":"10.1016","volume":"243","author":[{"given":"Hui","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinglin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4853-2474","authenticated-orcid":false,"given":"Zhenzhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2024.109906_bib1","first-page":"706","article-title":"Generation of oxidants in the near-UV photooxidation of human lens alpha-crystallin","volume":"30","author":"Andley","year":"1989","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.109906_bib2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/978-3-319-98758-3_4","article-title":"Metabolomics in systems biology","volume":"1102","author":"Baharum","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2024.109906_bib3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF02761774","article-title":"Function of the N-acetyl-L-histidine system in the vertebrate eye. Evidence in support of a role as a molecular water pump","volume":"10","author":"Baslow","year":"1998","journal-title":"J. Mol. Neurosci. : MN"},{"key":"10.1016\/j.exer.2024.109906_bib4","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3390\/biom5020635","article-title":"N-acetyl-L-histidine, a prominent biomolecule in brain and eye of poikilothermic vertebrates","volume":"5","author":"Baslow","year":"2015","journal-title":"Biomolecules"},{"key":"10.1016\/j.exer.2024.109906_bib5","article-title":"Congenital cataract: a guide to genetic and clinical management","volume":"1","author":"Bell","year":"2020","journal-title":"Ther. Adv. Respir. Dis."},{"key":"10.1016\/j.exer.2024.109906_bib6","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s11010-012-1225-y","article-title":"Tyrosine impairs enzymes of energy metabolism in cerebral cortex of rats","volume":"364","author":"de Andrade","year":"2012","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.exer.2024.109906_bib7","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1111\/j.1751-1097.2011.00979.x","article-title":"Immunological detection of N-formylkynurenine in porphyrin-mediated photooxided lens \u03b1-crystallin","volume":"87","author":"Ehrenshaft","year":"2011","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.exer.2024.109906_bib8","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1002\/pro.5560071116","article-title":"Identification of tryptophan oxidation products in bovine alpha-crystallin","volume":"7","author":"Finley","year":"1998","journal-title":"Protein Sci. : Publ. Prot. Soc."},{"key":"10.1016\/j.exer.2024.109906_bib9","first-page":"564","article-title":"Elevated histamine levels in aqueous humor of patients with glaucoma","volume":"27","author":"Gowtham","year":"2021","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2024.109906_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2023.109592","article-title":"Untargeted metabolomics in the aqueous humor reveals the involvement of TAAR pathway in glaucoma","volume":"234","author":"Gowtham","year":"2023","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.109906_bib11","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1021\/acs.jproteome.8b00169","article-title":"Metabolomics analysis of human vitreous in diabetic retinopathy and rhegmatogenous retinal detachment","volume":"17","author":"Haines","year":"2018","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.exer.2024.109906_bib12","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1021\/acs.jproteome.0c00036","article-title":"Metabolomic profiling of the aqueous humor in patients with wet age-related macular degeneration using UHPLC-MS\/MS","volume":"19","author":"Han","year":"2020","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.exer.2024.109906_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/srep31424","article-title":"Exploratory metabolomics profiling in the kainic acid rat model reveals depletion of 25-hydroxyvitamin D3 during epileptogenesis","volume":"6","author":"Heischmann","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2024.109906_bib14","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1167\/iovs.10-6422","article-title":"Cellular localization of glutamate and glutamine metabolism and transport pathways in the rat ciliary epithelium","volume":"52","author":"Hu","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.109906_bib15","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.exer.2017.03.004","article-title":"Metabolic characterization of human aqueous humor in relation to high myopia","volume":"159","author":"Ji","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.109906_bib16","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000267181","article-title":"Morphological studies on cataract and small lens formation in neonatal rats treated with monosodium-L-glutamate","volume":"24","author":"Kawamura","year":"1992","journal-title":"Ophthalmic Res."},{"key":"10.1016\/j.exer.2024.109906_bib17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.exer.2007.04.004","article-title":"Protein-bound and free UV filters in cataract lenses. The concentration of UV filters is much lower than in normal lenses","volume":"85","author":"Korlimbinis","year":"2007","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.109906_bib18","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.21037\/atm-19-2377","article-title":"Developmental characteristics of the cytokine profile in aqueous humor and its relationship with the inflammatory response in children","volume":"8","author":"Lai","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.exer.2024.109906_bib19","article-title":"Association between serum lipids concentration and patients with age-related cataract in China: a cross-sectional, case-control study","volume":"8","author":"Li","year":"2018","journal-title":"BMJ Open"},{"key":"10.1016\/j.exer.2024.109906_bib20","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1080\/02713683.2022.2142943","article-title":"Metabolomic profile in the aqueous humor of congenital ectopia lentis","volume":"48","author":"Liu","year":"2023","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2024.109906_bib21","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.biocel.2010.04.014","article-title":"Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human lens epithelial cells: apoptosis through the formation of 3-hydroxykynurenine","volume":"42","author":"Mailankot","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.exer.2024.109906_bib22","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1080\/10715760500307107","article-title":"Accumulation of the hydroxyl free radical markers meta-, ortho-tyrosine and DOPA in cataractous lenses is accompanied by a lower protein and phenylalanine content of the water-soluble phase","volume":"39","author":"Moln\u00e1r","year":"2005","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.exer.2024.109906_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108024","article-title":"Differentiation of soluble aqueous humor metabolites in primary open angle glaucoma and controls","volume":"194","author":"Myer","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.109906_bib24","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.chroma.2006.01.058","article-title":"High-performance liquid-chromatographic determination of 5-aminosalicylic acid and its metabolites in blood plasma","volume":"1119","author":"Nobilis","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.exer.2024.109906_bib25","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00253-007-1029-2","article-title":"Metabolomics: current state and evolving methodologies and tools","volume":"76","author":"Oldiges","year":"2007","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.exer.2024.109906_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000442495","article-title":"Genetics of congenital cataract","volume":"57","author":"Pichi","year":"2016","journal-title":"Dev. Ophthalmol."},{"key":"10.1016\/j.exer.2024.109906_bib27","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.matbio.2017.07.004","article-title":"Marfan syndrome; A connective tissue disease at the crossroads of mechanotransduction, TGF\u03b2 signaling and cell stemness","volume":"71\u201372","author":"Ramirez","year":"2018","journal-title":"Matrix Biol. : J. Int. Soc. Matr. Biol."},{"key":"10.1016\/j.exer.2024.109906_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2019.108204","article-title":"Protective role of hesperetin against posttranslational oxidation of tryptophan residue of human \u03b3D-crystallin: a molecular level study","volume":"679","author":"Rana","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.exer.2024.109906_bib29","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1080\/07391102.2020.1738960","article-title":"Elucidation of molecular interactions between human \u03b3D-crystallin and quercetin, an inhibitor against tryptophan oxidation","volume":"39","author":"Rana","year":"2021","journal-title":"J. Biomol. Struct. Dynam."},{"key":"10.1016\/j.exer.2024.109906_bib30","doi-asserted-by":"crossref","first-page":"e450","DOI":"10.1111\/aos.12138","article-title":"Presence and distribution of L-kynurenine aminotransferases immunoreactivity in human cataractous lenses","volume":"91","author":"Rejdak","year":"2013","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.exer.2024.109906_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175491","article-title":"Lens metabolomic profiling as a tool to understand cataractogenesis in Atlantic salmon and rainbow trout reared at optimum and high temperature","volume":"12","author":"Rem\u00f8","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2024.109906_bib32","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1017\/S0007114513004418","article-title":"Dietary histidine requirement to reduce the risk and severity of cataracts is higher than the requirement for growth in Atlantic salmon smolts, independently of the dietary lipid source","volume":"111","author":"Rem\u00f8","year":"2014","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.exer.2024.109906_bib33","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.exer.2011.02.018","article-title":"Susceptibility of Atlantic salmon lenses to hydrogen peroxide oxidation ex vivo after being fed diets with vegetable oil and methylmercury","volume":"92","author":"Rem\u00f8","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.109906_bib34","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/hmg\/ddy330","article-title":"GLS hyperactivity causes glutamate excess, infantile cataract and profound developmental delay","volume":"28","author":"Rumping","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2024.109906_bib35","first-page":"1013","article-title":"Intraocular cytokines imbalance in congenital cataract and its impact on posterior capsule opacification","volume":"vol. 254","author":"Sauer","year":"2016"},{"key":"10.1016\/j.exer.2024.109906_bib36","article-title":"Surgical interventions for bilateral congenital cataract in children aged two years and under","volume":"9","author":"Singh","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.exer.2024.109906_bib37","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jim.2007.05.002","article-title":"Detection of kynurenine modifications in proteins using a monoclonal antibody","volume":"324","author":"Staniszewska","year":"2007","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.exer.2024.109906_bib38","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1167\/iovs.04-0178","article-title":"Lenticular levels of amino acids and free UV filters differ significantly between normals and cataract patients","volume":"45","author":"Streete","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.109906_bib39","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/978-1-4615-0135-0_31","article-title":"Age-related nuclear cataract and indoleamine 2,3-dioxygenase-initiated tryptophan metabolism in the human lens","volume":"527","author":"Takikawa","year":"2003","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2024.109906_bib40","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1080\/10408347.2020.1848516","article-title":"Characteristics, properties and analytical\/bioanalytical methods of 5-aminosalicylic acid: a review","volume":"52","author":"Tavares Junior","year":"2022","journal-title":"Crit. Rev. Anal. Chem."},{"key":"10.1016\/j.exer.2024.109906_bib41","first-page":"107","article-title":"Congenital cataract and its genetics: the era of next-generation sequencing","volume":"51","author":"Taylan \u015eekero\u011flu","year":"2021","journal-title":"Turkish J. Orthod."},{"key":"10.1016\/j.exer.2024.109906_bib42","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/00006982-200604000-00009","article-title":"Glutamate levels in aqueous humor of patients with retinal artery occlusion","volume":"26","author":"Wakabayashi","year":"2006","journal-title":"Retina"},{"key":"10.1016\/j.exer.2024.109906_bib43","first-page":"414","article-title":"Preoperative profile of inflammatory factors in aqueous humor correlates with postoperative inflammatory response in patients with congenital cataract","volume":"24","author":"Wu","year":"2018","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2024.109906_bib44","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1021\/nn4054107","article-title":"Synthesis and evaluation of a nanoglobular dendrimer 5-aminosalicylic Acid conjugate with a hydrolyzable schiff base spacer for treating retinal degeneration","volume":"8","author":"Wu","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.exer.2024.109906_bib45","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.cmet.2023.06.004","article-title":"Tryptophan metabolism in health and disease","volume":"35","author":"Xue","year":"2023","journal-title":"Cell Metabol."},{"key":"10.1016\/j.exer.2024.109906_bib46","first-page":"29","article-title":"Quantitative metabolomic analysis of changes in the lens and aqueous humor under development of age-related nuclear cataract. Metabolomics","volume":"15","author":"Yanshole","year":"2019","journal-title":"Off. J. Metabol. Soc."},{"key":"10.1016\/j.exer.2024.109906_bib47","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3928\/01913913-20200224-01","article-title":"Proliferative status in the aqueous humor of eyes with congenital cataract","volume":"57","author":"Zhang","year":"2020","journal-title":"J. Pediatr. Ophthalmol. Strabismus"},{"key":"10.1016\/j.exer.2024.109906_bib48","doi-asserted-by":"crossref","first-page":"923","DOI":"10.18240\/ijo.2021.06.19","article-title":"Commentary review: challenges of intraocular lens implantation for congenital cataract infants","volume":"14","author":"Zhao","year":"2021","journal-title":"Int. J. Ophthalmol."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483524001271?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483524001271?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T13:08:39Z","timestamp":1715951319000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483524001271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":48,"alternative-id":["S0014483524001271"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2024.109906","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolomic profiling of the aqueous humor in patients with pediatric cataract","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2024.109906","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109906"}}