{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:14:56Z","timestamp":1791389696091,"version":"4.3.3"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T00:00:00Z","timestamp":1749254400000},"content-version":"am","delay-in-days":310,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.exer.2024.109951","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T15:38:08Z","timestamp":1717429088000},"page":"109951","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["The relationship between dry eye disease and human microbiota: A review of the science"],"prefix":"10.1016","volume":"245","author":[{"given":"Gal","family":"Antman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Ritzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Galor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Verticchio Vercellin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent A.","family":"Siesky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Alabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Vayner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fani","family":"Segev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8770-3726","authenticated-orcid":false,"given":"Alon","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.exer.2024.109951_bib1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1079-2104(98)90151-2","article-title":"Evaluation of the levels of oral Candida in patients with Sj\u00f6gren's syndrome","volume":"86","author":"Abraham","year":"1998","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"10.1016\/j.exer.2024.109951_bib2","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.2147\/OPTH.S415425","article-title":"The link between Gastrointestinal microbiome and ocular disorders","volume":"17","author":"Alfuzaie","year":"2023","journal-title":"Clin. Ophthalmol."},{"issue":"5","key":"10.1016\/j.exer.2024.109951_bib3","first-page":"1007","article-title":"Microflora in oral ecosystems in primary Sj\u00f6gren's syndrome","volume":"28","author":"Almst\u00e5hl","year":"2001","journal-title":"J. Rheumatol."},{"issue":"6","key":"10.1016\/j.exer.2024.109951_bib4","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.survophthal.2021.03.010","article-title":"The ocular microbiome and microbiota and their effects on ocular surface pathophysiology and disorders","volume":"66","author":"Aragona","year":"2021","journal-title":"Surv. Ophthalmol."},{"issue":"22","key":"10.1016\/j.exer.2024.109951_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21228733","article-title":"Connection between the gut microbiome, systemic inflammation, gut permeability and FOXP3 expression in patients with primary sj\u00f6gren's syndrome","volume":"21","author":"Cano-Ortiz","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2024.109951_bib6","article-title":"Gut microbiota and Sj\u00f6gren's syndrome: a two-sample Mendelian randomization study","volume":"14","author":"Cao","year":"2023","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.exer.2024.109951_bib7","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1167\/iovs.63.9.32","article-title":"Topical glaucoma therapy is associated with alterations of the ocular surface microbiome","volume":"63","author":"Chang","year":"2022","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.exer.2024.109951_bib8","doi-asserted-by":"crossref","first-page":"7319","DOI":"10.1038\/s41598-019-43714-5","article-title":"Elevated cytokine levels in tears and saliva of patients with primary Sj\u00f6gren's syndrome correlate with clinical ocular and oral manifestations","volume":"9","author":"Chen","year":"2019","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.exer.2024.109951_bib9","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1093\/rheumatology\/keaa835","article-title":"The oral and gut microbiome in rheumatoid arthritis patients: a systematic review","volume":"60","author":"Chu","year":"2021","journal-title":"Rheumatology"},{"issue":"3","key":"10.1016\/j.exer.2024.109951_bib10","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II definition and classification report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul. Surf."},{"issue":"1","key":"10.1016\/j.exer.2024.109951_bib11","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/cei.13158","article-title":"The microbiome in autoimmune diseases","volume":"195","author":"De Luca","year":"2019","journal-title":"Clin. Exp. Immunol."},{"issue":"19","key":"10.1016\/j.exer.2024.109951_bib12","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1128\/JB.00542-10","article-title":"The human oral microbiome","volume":"192","author":"Dewhirst","year":"2010","journal-title":"J. Bacteriol."},{"issue":"1","key":"10.1016\/j.exer.2024.109951_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000713","article-title":"Characterization of the oral fungal microbiome (mycobiome) in healthy individuals","volume":"6","author":"Ghannoum","year":"2010","journal-title":"PLoS Pathog."},{"issue":"11","key":"10.1016\/j.exer.2024.109951_bib14","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1097\/ICO.0000000000003195","article-title":"Case-control study examining the composition of the gut microbiome in individuals with and without immune-mediated dry eye","volume":"42","author":"Goodman","year":"2023","journal-title":"Cornea"},{"issue":"Si-2","key":"10.1016\/j.exer.2024.109951_bib15","first-page":"1611","article-title":"The negative effects of dry eye disease on quality of life and visual function","volume":"50","author":"Guo","year":"2020","journal-title":"Turk. J. Med. Sci."},{"issue":"1","key":"10.1016\/j.exer.2024.109951_bib16","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2022-002234","article-title":"Characteristics of Sj\u00f6gren's syndrome associated with rheumatoid arthritis","volume":"8","author":"Hassold","year":"2022","journal-title":"RMD Open"},{"issue":"3","key":"10.1016\/j.exer.2024.109951_bib17","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/ICL.0000000000000249","article-title":"Characteristics of ocular pain complaints in patients with idiopathic dry eye symptoms","volume":"43","author":"Kalangara","year":"2017","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.exer.2024.109951_bib18","article-title":"Correlation between salivary microbiome of parotid glands and clinical features in primary sj\u00f6gren's syndrome and non-sj\u00f6gren's sicca subjects","volume":"13","author":"Kim","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exer.2024.109951_bib19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-319-47656-8_1","article-title":"Metabolomics: definitions and significance in systems biology","volume":"965","author":"Klassen","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.exer.2024.109951_bib20","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.archoralbio.2016.06.016","article-title":"A preliminary study of the oral microbiota in Chinese patients with Sj\u00f6gren's syndrome","volume":"70","author":"Li","year":"2016","journal-title":"Arch. Oral Biol."},{"issue":"11","key":"10.1016\/j.exer.2024.109951_bib21","article-title":"Characteristics of gut microbiota in patients with primary Sj\u00f6gren's syndrome in Northern China","volume":"17","author":"Li","year":"2022","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.exer.2024.109951_bib22","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1136\/jcp.27.5.416","article-title":"Changes in the oral flora in Sj\u00f6gren's syndrome","volume":"27","author":"MacFarlane","year":"1974","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.exer.2024.109951_bib23","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jtos.2023.04.003","article-title":"TFOS Lifestyle: impact of nutrition on the ocular surface","volume":"29","author":"Markoulli","year":"2023","journal-title":"Ocul. Surf."},{"issue":"1","key":"10.1016\/j.exer.2024.109951_bib24","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12934-020-01348-7","article-title":"Gut microbial dysbiosis in individuals with Sj\u00f6gren's syndrome","volume":"19","author":"Mendez","year":"2020","journal-title":"Microb. Cell Factories"},{"issue":"2","key":"10.1016\/j.exer.2024.109951_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0229029","article-title":"Gut dysbiosis is prevailing in Sj\u00f6gren's syndrome and is related to dry eye severity","volume":"15","author":"Moon","year":"2020","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.exer.2024.109951_bib26","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00281-014-0457-1","article-title":"Microbiome and cancer","volume":"37","author":"Ohtani","year":"2015","journal-title":"Semin. Immunopathol."},{"issue":"1\u20132","key":"10.1016\/j.exer.2024.109951_bib27","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/pr.2014.170","article-title":"Understanding the role of gut microbiome in metabolic disease risk","volume":"77","author":"Sanz","year":"2015","journal-title":"Pediatr. Res."},{"issue":"2","key":"10.1016\/j.exer.2024.109951_bib28","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/odi.13191","article-title":"Saliva microbiome in primary Sj\u00f6gren's syndrome reveals distinct set of disease-associated microbes","volume":"26","author":"Sharma","year":"2020","journal-title":"Oral Dis."},{"issue":"3","key":"10.1016\/j.exer.2024.109951_bib29","doi-asserted-by":"crossref","first-page":"535","DOI":"10.4103\/ijo.IJO_1362_20","article-title":"A systematic review of gut microbiome and ocular inflammatory diseases: are they associated?","volume":"69","author":"Shivaji","year":"2021","journal-title":"Indian J. Ophthalmol."},{"issue":"3","key":"10.1016\/j.exer.2024.109951_bib30","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","article-title":"TFOS DEWS II epidemiology report","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul. Surf."},{"issue":"3","key":"10.1016\/j.exer.2024.109951_bib31","article-title":"The case for a more holistic approach to dry eye disease: is it time to move beyond antibiotics?","volume":"8","author":"Tavakoli","year":"2019","journal-title":"Antibiotics (Basel)"},{"issue":"1","key":"10.1016\/j.exer.2024.109951_bib32","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1111\/j.1753-4887.2012.00493.x","article-title":"Defining the human microbiome","volume":"70","author":"Ursell","year":"2012","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.exer.2024.109951_bib33","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jaut.2018.10.009","article-title":"Shared gut, but distinct oral microbiota composition in primary Sj\u00f6gren's syndrome and systemic lupus erythematosus","volume":"97","author":"van der Meulen","year":"2019","journal-title":"J. Autoimmun."},{"issue":"9","key":"10.1016\/j.exer.2024.109951_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0233872","article-title":"Alpha-, beta-, and gamma-diversity of bacteria varies across habitats","volume":"15","author":"Walters","year":"2020","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.exer.2024.109951_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111352","article-title":"Microbiota dysbiosis in primary Sj\u00f6gren's syndrome and the ameliorative effect of hydroxychloroquine","volume":"40","author":"Wang","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.exer.2024.109951_bib36","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ajo.2021.06.022","article-title":"Fecal microbial transplant in individuals with immune-mediated dry eye","volume":"233","author":"Watane","year":"2022","journal-title":"Am. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.exer.2024.109951_bib37","doi-asserted-by":"crossref","DOI":"10.1136\/bmjophth-2021-000956","article-title":"Microbiome and immune-mediated dry eye: a review","volume":"7","author":"Watane","year":"2022","journal-title":"BMJ Open Ophthalmol"},{"issue":"5","key":"10.1016\/j.exer.2024.109951_bib38","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1365-2672.1992.tb04993.x","article-title":"A comparison of the sensitivity of wound-infecting species of bacteria to the antibacterial activity of manuka honey and other honey","volume":"73","author":"Willix","year":"1992","journal-title":"J. Appl. Bacteriol."},{"key":"10.1016\/j.exer.2024.109951_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.974648","article-title":"Th17 cells in primary Sj\u00f6gren's syndrome negatively correlate with increased Roseburia and Coprococcus","volume":"13","author":"Xin","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exer.2024.109951_bib40","article-title":"Comprehensive analysis of the relationships between the gut microbiota and fecal metabolome in individuals with primary sjogren's syndrome by 16S rRNA sequencing and LC-MS-based metabolomics","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.exer.2024.109951_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/metabo11120812","article-title":"Metabolomics in autoimmune diseases: focus on rheumatoid arthritis, systemic lupus erythematous, and multiple sclerosis","volume":"11","author":"Yoon","year":"2021","journal-title":"Metabolites"},{"issue":"5","key":"10.1016\/j.exer.2024.109951_bib42","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1097\/ACI.0b013e328364ebeb","article-title":"Microbiome and skin diseases","volume":"13","author":"Zeeuwen","year":"2013","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"issue":"6","key":"10.1016\/j.exer.2024.109951_bib43","first-page":"4895","article-title":"Oral microbial flora of patients with Sicca syndrome","volume":"18","author":"Zhou","year":"2018","journal-title":"Mol. Med. Rep."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483524001726?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483524001726?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:52:26Z","timestamp":1724374346000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483524001726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":43,"alternative-id":["S0014483524001726"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2024.109951","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The relationship between dry eye disease and human microbiota: A review of the science","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2024.109951","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109951"}}