{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:31:56Z","timestamp":1792495916516,"version":"4.5.0"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.exer.2024.110008","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T09:30:54Z","timestamp":1721122254000},"page":"110008","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Long-term high fructose intake reprograms the circadian transcriptome and disrupts homeostasis in mouse extra-orbital lacrimal glands"],"prefix":"10.1016","volume":"246","author":[{"given":"Di","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duliurui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengru","family":"Ba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingli","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenzhen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3186-144X","authenticated-orcid":false,"given":"Zhijie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2024.110008_bib1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.cmet.2020.05.012","article-title":"Deletion of fructokinase in the liver or in the intestine reveals differential effects on sugar-induced metabolic dysfunction","volume":"32","author":"Andres-Hernando","year":"2020","journal-title":"Cell Metabol."},{"key":"10.1016\/j.exer.2024.110008_bib2","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.stem.2021.02.024","article-title":"Exploring the human lacrimal gland using organoids and single-cell sequencing","volume":"28","author":"Bannier-H\u00e9laou\u00ebt","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.exer.2024.110008_bib3","article-title":"Dapagliflozin prevents NOX- and SGLT2-dependent oxidative stress in lens cells exposed to fructose-induced diabetes mellitus","volume":"20","author":"Chen","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2024.110008_bib4","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.humimm.2022.03.007","article-title":"High fructose diet: a risk factor for immune system dysregulation","volume":"83","author":"Cheng","year":"2022","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.exer.2024.110008_bib5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neulet.2008.06.008","article-title":"Alterations of nerve-growth factor and p75(NTR) expressions in urinary bladder of fructose-fed obese rats","volume":"441","author":"Cheng","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.exer.2024.110008_bib6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nature11048","article-title":"Regulation of circadian behaviour and metabolism by REV-ERB-\u03b1 and REV-ERB-\u03b2","volume":"485","author":"Cho","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.exer.2024.110008_bib7","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41575-021-00452-2","article-title":"Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism","volume":"18","author":"Choi","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.exer.2024.110008_bib8","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1096\/fj.13-247148","article-title":"Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis","volume":"28","author":"Choi","year":"2014","journal-title":"Faseb. J."},{"key":"10.1016\/j.exer.2024.110008_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/nu12040909","article-title":"Dietary fructose intake and hippocampal structure and connectivity during childhood","volume":"12","author":"Clark","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.exer.2024.110008_bib10","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.3389\/fphys.2019.01341","article-title":"Advances in nutrition science and integrative physiology: insights from controlled feeding studies","volume":"10","author":"Davy","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.exer.2024.110008_bib11","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.4110\/in.2019.19.e3","article-title":"Age-related autoimmune changes in lacrimal glands","volume":"19","author":"de Souza","year":"2019","journal-title":"Immune Netw"},{"key":"10.1016\/j.exer.2024.110008_bib12","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.cmet.2022.12.006","article-title":"Diurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals","volume":"35","author":"Deota","year":"2023","journal-title":"Cell Metabol."},{"key":"10.1016\/j.exer.2024.110008_bib13","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.2353\/ajpath.2007.070388","article-title":"Autoimmune dacryoadenitis of NOD\/LtJ mice and its subsequent effects on tear protein composition","volume":"171","author":"Doyle","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2024.110008_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/nu14010103","article-title":"Metabolic-associated fatty liver disease (MAFLD), diabetes, and cardiovascular disease: associations with fructose metabolism and gut microbiota","volume":"14","author":"Dro\u017cd\u017c","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.exer.2024.110008_bib15","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.cell.2013.11.034","article-title":"Reprogramming of the circadian clock by nutritional challenge","volume":"155","author":"Eckel-Mahan","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.exer.2024.110008_bib16","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijdevneu.2018.07.001","article-title":"Neurobehavioral effects of long-term maternal fructose intake in rat offspring","volume":"69","author":"Erbas","year":"2018","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.exer.2024.110008_bib17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41392-022-00899-y","article-title":"Molecular regulations of circadian rhythm and implications for physiology and diseases","volume":"7","author":"Fagiani","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.exer.2024.110008_bib18","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1016\/j.cmet.2021.09.004","article-title":"\"Sweet death\": fructose as a metabolic toxin that targets the gut-liver axis","volume":"33","author":"Febbraio","year":"2021","journal-title":"Cell Metabol."},{"key":"10.1016\/j.exer.2024.110008_bib19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1146\/annurev-nutr-082117-051707","article-title":"Intestinal absorption of fructose","volume":"38","author":"Ferraris","year":"2018","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.exer.2024.110008_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.166036","article-title":"Dietary fructose as a model to explore the influence of peripheral metabolism on brain function and plasticity","volume":"1867","author":"Gomez-Pinilla","year":"2021","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.exer.2024.110008_bib21","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1126\/science.aba8984","article-title":"The hepatocyte clock and feeding control chronophysiology of multiple liver cell types","volume":"369","author":"Guan","year":"2020","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.exer.2024.110008_bib22","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cmet.2021.03.015","article-title":"Circadian rhythms and the gut microbiome synchronize the host's metabolic response to diet","volume":"33","author":"Gutierrez Lopez","year":"2021","journal-title":"Cell Metabol."},{"key":"10.1016\/j.exer.2024.110008_bib23","first-page":"57","article-title":"Tear volume in relation to contact lens wear and age","volume":"16","author":"Hamano","year":"1990","journal-title":"CLAO J."},{"key":"10.1016\/j.exer.2024.110008_bib24","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1093\/cercor\/bhab274","article-title":"Prolonged consumption of sweetened beverages lastingly deteriorates cognitive functions and reward processing in mice","volume":"32","author":"Hamelin","year":"2022","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.exer.2024.110008_bib25","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1172\/JCI96702","article-title":"Fructose metabolism and metabolic disease","volume":"128","author":"Hannou","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exer.2024.110008_bib26","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0031-9384(02)00810-7","article-title":"A study of VitalView for behavioural and physiological monitoring in laboratory rats","volume":"77","author":"Harkin","year":"2002","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.exer.2024.110008_bib27","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/s41583-018-0026-z","article-title":"Generation of circadian rhythms in the suprachiasmatic nucleus","volume":"19","author":"Hastings","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.exer.2024.110008_bib28","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41586-022-04613-4","article-title":"Generation of 3D lacrimal gland organoids from human pluripotent stem cells","volume":"605","author":"Hayashi","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.exer.2024.110008_bib29","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1167\/iovs.62.10.22","article-title":"Short-term high fructose intake impairs diurnal oscillations in the murine cornea","volume":"62","author":"He","year":"2021","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.110008_bib30","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/j.cmet.2021.09.010","article-title":"Molecular aspects of fructose metabolism and metabolic disease","volume":"33","author":"Herman","year":"2021","journal-title":"Cell Metabol."},{"key":"10.1016\/j.exer.2024.110008_bib31","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/hipo.22368","article-title":"Effects of sucrose and high fructose corn syrup consumption on spatial memory function and hippocampal neuroinflammation in adolescent rats","volume":"25","author":"Hsu","year":"2015","journal-title":"Hippocampus"},{"key":"10.1016\/j.exer.2024.110008_bib32","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jtos.2021.02.001","article-title":"Light cycle phase advance as a model for jet lag reprograms the circadian rhythms of murine extraorbital lacrimal glands","volume":"20","author":"Huang","year":"2021","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2024.110008_bib33","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1167\/iovs.63.6.19","article-title":"Sleep loss causes dysfunction in murine extraorbital lacrimal glands","volume":"63","author":"Huang","year":"2022","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.110008_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000442","article-title":"Harmonics of circadian gene transcription in mammals","volume":"5","author":"Hughes","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/j.exer.2024.110008_bib35","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/cei.13299","article-title":"High fructose-induced metabolic changes enhance inflammation in human dendritic cells","volume":"197","author":"Jaiswal","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.exer.2024.110008_bib36","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1249\/MSS.0000000000002011","article-title":"Endurance exercise prevents metabolic distress-induced senescence in the Hippocampus","volume":"51","author":"Jang","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.exer.2024.110008_bib37","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.jhep.2018.01.019","article-title":"Fructose and sugar: a major mediator of non-alcoholic fatty liver disease","volume":"68","author":"Jensen","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.exer.2024.110008_bib38","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jtos.2020.04.013","article-title":"Type 1 diabetes mellitus impairs diurnal oscillations in murine extraorbital lacrimal glands","volume":"18","author":"Jiao","year":"2020","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2024.110008_bib39","article-title":"Fructose induced endotoxemia in pediatric nonalcoholic Fatty liver disease","volume":"2014","author":"Jin","year":"2014","journal-title":"Bangladesh Liver J."},{"key":"10.1016\/j.exer.2024.110008_bib40","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/s41467-021-21461-4","article-title":"Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation","volume":"12","author":"Jones","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2024.110008_bib41","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev-nutr-062220-025831","article-title":"Dietary fructose and fructose-induced pathologies","volume":"42","author":"Jung","year":"2022","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.exer.2024.110008_bib42","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1016\/j.celrep.2018.11.077","article-title":"Fasting imparts a switch to alternative daily pathways in liver and muscle","volume":"25","author":"Kinouchi","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.exer.2024.110008_bib43","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cmet.2007.09.006","article-title":"High-fat diet disrupts behavioral and molecular circadian rhythms in mice","volume":"6","author":"Kohsaka","year":"2007","journal-title":"Cell Metabol."},{"key":"10.1016\/j.exer.2024.110008_bib44","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s40168-019-0713-7","article-title":"Dietary fructose-induced gut dysbiosis promotes mouse hippocampal neuroinflammation: a benefit of short-chain fatty acids","volume":"7","author":"Li","year":"2019","journal-title":"Microbiome"},{"key":"10.1016\/j.exer.2024.110008_bib45","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1167\/iovs.64.12.18","article-title":"Mechanisms of extraorbital lacrimal gland aging in mice: an integrative analysis of the temporal transcriptome","volume":"64","author":"Liu","year":"2023","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.110008_bib46","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.cmet.2016.06.001","article-title":"Fasting, circadian rhythms, and time-restricted feeding in healthy lifespan","volume":"23","author":"Longo","year":"2016","journal-title":"Cell Metabol."},{"key":"10.1016\/j.exer.2024.110008_bib47","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1167\/iovs.18-26030","article-title":"Short-term high fructose intake reprograms the transcriptional clock rhythm of the murine extraorbital lacrimal gland","volume":"60","author":"Lu","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.110008_bib48","doi-asserted-by":"crossref","first-page":"6509","DOI":"10.1073\/pnas.1503358112","article-title":"Differential effects of fructose versus glucose on brain and appetitive responses to food cues and decisions for food rewards","volume":"112","author":"Luo","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2024.110008_bib49","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1161\/CIRCULATIONAHA.115.018704","article-title":"Sugar-Sweetened beverage consumption is associated with change of visceral adipose tissue over 6 Years of follow-up","volume":"133","author":"Ma","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.exer.2024.110008_bib50","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3945\/ajcn.111.022533","article-title":"Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study","volume":"95","author":"Maersk","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.exer.2024.110008_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9113740","article-title":"Impact of air pollution and weather on dry eye","volume":"9","author":"Mandell","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.exer.2024.110008_bib52","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/ICU.0000000000000768","article-title":"Alternative therapies for dry eye disease","volume":"32","author":"Mittal","year":"2021","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.exer.2024.110008_bib53","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.cmet.2017.08.004","article-title":"Ketogenic diet reduces midlife mortality and improves memory in aging mice","volume":"26","author":"Newman","year":"2017","journal-title":"Cell Metabol."},{"key":"10.1016\/j.exer.2024.110008_bib54","first-page":"E505","article-title":"Metabolic effects of oral fructose in the liver of fasted rats","volume":"247","author":"Niewoehner","year":"1984","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.exer.2024.110008_bib55","doi-asserted-by":"crossref","first-page":"F919","DOI":"10.1152\/ajprenal.00068.2011","article-title":"The Western-style diet: a major risk factor for impaired kidney function and chronic kidney disease","volume":"301","author":"Odermatt","year":"2011","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.exer.2024.110008_bib56","doi-asserted-by":"crossref","first-page":"17326","DOI":"10.1074\/jbc.RA119.010744","article-title":"Glucoselysine is derived from fructose and accumulates in the eye lens of diabetic rats","volume":"294","author":"Ohno","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2024.110008_bib57","doi-asserted-by":"crossref","first-page":"R337","DOI":"10.1152\/ajpregu.00322.2014","article-title":"Impact of nutrients on circadian rhythmicity","volume":"308","author":"Oosterman","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.exer.2024.110008_bib58","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/jama.2012.116975","article-title":"Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways","volume":"309","author":"Page","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.exer.2024.110008_bib59","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1126\/science.aah4967","article-title":"Circadian physiology of metabolism","volume":"354","author":"Panda","year":"2016","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.exer.2024.110008_bib60","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.amjmed.2006.06.004","article-title":"Increasing trends in incidence of overweight and obesity over 5 decades","volume":"120","author":"Parikh","year":"2007","journal-title":"Am. J. Med."},{"key":"10.1016\/j.exer.2024.110008_bib61","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.metabol.2017.11.017","article-title":"Circadian regulation of glucose, lipid, and energy metabolism in humans","volume":"84","author":"Poggiogalle","year":"2018","journal-title":"Metabolism"},{"key":"10.1016\/j.exer.2024.110008_bib62","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/MED.0b013e328357f0cb","article-title":"Fructose consumption and cancer: is there a connection?","volume":"19","author":"Port","year":"2012","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1016\/j.exer.2024.110008_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2023.109573","article-title":"Long-term high fructose intake promotes lacrimal gland dysfunction by inducing gut dysbiosis in mice","volume":"234","author":"Qi","year":"2023","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.110008_bib64","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41580-018-0096-9","article-title":"Crosstalk between metabolism and circadian clocks","volume":"20","author":"Reinke","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.exer.2024.110008_bib65","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/nature00965","article-title":"Coordination of circadian timing in mammals","volume":"418","author":"Reppert","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.exer.2024.110008_bib66","doi-asserted-by":"crossref","DOI":"10.1101\/pdb.prot5439","article-title":"Purification of RNA using TRIzol (TRI reagent)","volume":"2010","author":"Rio","year":"2010","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.exer.2024.110008_bib67","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1542-0124(12)70177-5","article-title":"The aging lacrimal gland: changes in structure and function","volume":"6","author":"Rocha","year":"2008","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2024.110008_bib68","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/nrc2747","article-title":"Metabolism and cancer: the circadian clock connection","volume":"9","author":"Sahar","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.exer.2024.110008_bib69","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202152412","article-title":"Nutrition, metabolism, and epigenetics: pathways of circadian reprogramming","volume":"23","author":"Sato","year":"2022","journal-title":"EMBO Rep."},{"key":"10.1016\/j.exer.2024.110008_bib70","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1159\/000500071","article-title":"Effect of circadian rhythm on metabolic processes and the regulation of energy balance","volume":"74","author":"Serin","year":"2019","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.exer.2024.110008_bib71","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.cub.2013.01.048","article-title":"Circadian disruption leads to insulin resistance and obesity","volume":"23","author":"Shi","year":"2013","journal-title":"Curr. Biol."},{"key":"10.1016\/j.exer.2024.110008_bib72","doi-asserted-by":"crossref","first-page":"C847","DOI":"10.1152\/ajpcell.00439.2021","article-title":"Dietary fructose as a metabolic risk factor","volume":"323","author":"Sindhunata","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.exer.2024.110008_bib73","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nature11030","article-title":"Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists","volume":"485","author":"Solt","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.exer.2024.110008_bib74","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","article-title":"TFOS DEWS II epidemiology report","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2024.110008_bib75","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1097\/ICO.0000000000000264","article-title":"Extraorbital lacrimal gland excision: a reproducible model of severe aqueous tear-deficient dry eye disease","volume":"33","author":"Stevenson","year":"2014","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2024.110008_bib76","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2024.110008_bib77","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.654074","article-title":"Intestinal microbiota mediates high-fructose and high-fat diets to induce chronic intestinal inflammation","volume":"11","author":"Tan","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.exer.2024.110008_bib78","doi-asserted-by":"crossref","DOI":"10.3390\/nu14091882","article-title":"Short-Chain fatty acids ameliorate depressive-like behaviors of high fructose-fed mice by rescuing hippocampal neurogenesis decline and blood-brain barrier damage","volume":"14","author":"Tang","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.exer.2024.110008_bib79","doi-asserted-by":"crossref","DOI":"10.1242\/jeb.164202","article-title":"Fructose-containing caloric sweeteners as a cause of obesity and metabolic disorders","volume":"221","author":"Tappy","year":"2018","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.exer.2024.110008_bib80","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41586-021-03827-2","article-title":"Dietary fructose improves intestinal cell survival and nutrient absorption","volume":"597","author":"Taylor","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.exer.2024.110008_bib81","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.cmet.2017.08.015","article-title":"Distinct circadian Signatures in liver and gut clocks revealed by ketogenic diet","volume":"26","author":"Tognini","year":"2017","journal-title":"Cell Metabol."},{"key":"10.1016\/j.exer.2024.110008_bib82","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.1108750","article-title":"Obesity and metabolic syndrome in circadian Clock mutant mice","volume":"308","author":"Turek","year":"2005","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.exer.2024.110008_bib83","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3390\/metabo5020364","article-title":"Fructose alters intermediary metabolism of glucose in human adipocytes and diverts glucose to serine oxidation in the one-carbon cycle energy producing pathway","volume":"5","author":"Varma","year":"2015","journal-title":"Metabolites"},{"key":"10.1016\/j.exer.2024.110008_bib84","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jtos.2022.06.005","article-title":"Lacrimal gland regeneration: the unmet challenges and promise for dry eye therapy","volume":"25","author":"Veernala","year":"2022","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2024.110008_bib85","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/s41593-020-0586-x","article-title":"Spatiotemporal single-cell analysis of gene expression in the mouse suprachiasmatic nucleus","volume":"23","author":"Wen","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.exer.2024.110008_bib86","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.nlm.2016.02.004","article-title":"Environmental stimulation rescues maternal high fructose intake-impaired learning and memory in female offspring: its correlation with redistribution of histone deacetylase 4","volume":"130","author":"Wu","year":"2016","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.exer.2024.110008_bib87","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1126\/science.1238599","article-title":"Mice genetically deficient in vasopressin V1a and V1b receptors are resistant to jet lag","volume":"342","author":"Yamaguchi","year":"2013","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.exer.2024.110008_bib88","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1167\/iovs.63.5.23","article-title":"High-fat nutritional challenge reshapes circadian Signatures in murine extraorbital lacrimal glands","volume":"63","author":"Zou","year":"2022","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448352400229X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448352400229X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T04:05:16Z","timestamp":1723867516000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001448352400229X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":88,"alternative-id":["S001448352400229X"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2024.110008","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term high fructose intake reprograms the circadian transcriptome and disrupts homeostasis in mouse extra-orbital lacrimal glands","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2024.110008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110008"}}