{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:02:17Z","timestamp":1772805737047,"version":"3.50.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970848"],"award-info":[{"award-number":["81970848"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.exer.2024.110011","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T16:01:44Z","timestamp":1721750504000},"page":"110011","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Targeted metabolomic analysis of serum free fatty acids: Lipidomics disturbance in patients with superior limbic keratoconjunctivitis"],"prefix":"10.1016","volume":"246","author":[{"given":"Yan","family":"Zong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yubin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sihao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3606-683X","authenticated-orcid":false,"given":"Kaili","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2024.110011_bib1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00417-002-0477-8","article-title":"Group IIA phospholipase A2 content of tears in patients with keratoconjunctivitis sicca","volume":"240","author":"Aho","year":"2002","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2024.110011_bib2","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1200\/JCO.2011.36.4109","article-title":"Fatigue, inflammation, and \u03c9-3 and \u03c9-6 fatty acid intake among breast cancer survivors","volume":"30","author":"Alfano","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.exer.2024.110011_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.prostaglandins.2020.106474","article-title":"Changes of tear lipid mediators after eyelid warming or thermopulsation treatment for meibomian gland dysfunction","volume":"151","author":"Ambaw","year":"2020","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.exer.2024.110011_bib4","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.exer.2016.02.005","article-title":"Linoleic acid content of human meibum is associated with telangiectasia and plugging of gland orifices in meibomian gland dysfunction","volume":"145","author":"Arita","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.110011_bib5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0181-5512(07)89584-2","article-title":"[A new approach for better comprehension of diseases of the ocular surface]","volume":"30","author":"Baudouin","year":"2007","journal-title":"J. Fr. Ophtalmol."},{"key":"10.1016\/j.exer.2024.110011_bib6","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.4049\/jimmunol.165.5.2790","article-title":"Type IIA secretory phospholipase A2 up-regulates cyclooxygenase-2 and amplifies cytokine-mediated prostaglandin production in human rheumatoid synoviocytes","volume":"165","author":"Bidgood","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.exer.2024.110011_bib7","first-page":"283","article-title":"Superficial punctate keratitis: the isolation of a virus","volume":"49","author":"Braley","year":"1951","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"10.1016\/j.exer.2024.110011_bib8","doi-asserted-by":"crossref","first-page":"18S","DOI":"10.1177\/0148607115595980","article-title":"Functional roles of fatty acids and their effects on human health","volume":"39","author":"Calder","year":"2015","journal-title":"J. Parenter. Enteral Nutr."},{"key":"10.1016\/j.exer.2024.110011_bib9","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/00055735-200212000-00002","article-title":"Thyroid and the eye","volume":"13","author":"Chavis","year":"2002","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.exer.2024.110011_bib10","first-page":"467","article-title":"Extensive superior limbic keratoconjunctivitis in Graves' disease: case report and mini-review of the literature","volume":"9","author":"Chelala","year":"2015","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.exer.2024.110011_bib11","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.exer.2008.11.035","article-title":"sPLA2-IIa is an inflammatory mediator when the ocular surface is compromised","volume":"88","author":"Chen","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.110011_bib12","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1007\/s00417-022-05575-z","article-title":"Recharacterization of superior limbic keratoconjunctivitis via a subdividing grading method in 236 Chinese patients","volume":"260","author":"Cheng","year":"2022","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2024.110011_bib13","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1001\/archopht.1969.00990020582002","article-title":"Clinical features of superior limbic keroconjunctivitis in Australia. A probable association withhyrotoxicosis","volume":"82","author":"Cher","year":"1969","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2024.110011_bib14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1046\/j.1442-9071.2000.00284.x","article-title":"Superior limbic keratoconjunctivitis: multifactorial mechanical pathogenesis","volume":"28","author":"Cher","year":"2000","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2024.110011_bib15","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1046\/j.1442-9071.2003.00633.x","article-title":"Blink-related microtrauma: when the ocular surface harms itself","volume":"31","author":"Cher","year":"2003","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2024.110011_bib16","doi-asserted-by":"crossref","first-page":"S488","DOI":"10.1097\/01.ccm.0000196028.19746.42","article-title":"Eicosanoids","volume":"33","author":"Cook","year":"2005","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.exer.2024.110011_bib17","doi-asserted-by":"crossref","first-page":"13968","DOI":"10.18632\/aging.203006","article-title":"Untargeted metabolomics for uncovering plasma biological markers of wet age-related macular degeneration","volume":"13","author":"Deng","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.exer.2024.110011_bib18","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1182\/blood-2007-11-122598","article-title":"Resolvin E1, an EPA-derived mediator in whole blood, selectively counterregulates leukocytes and platelets","volume":"112","author":"Dona","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.exer.2024.110011_bib19","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s11306-012-0434-4","article-title":"Mass appeal: metabolite identification in mass spectrometry-focused untargeted metabolomics","volume":"9","author":"Dunn","year":"2013","journal-title":"Metabolomics"},{"key":"10.1016\/j.exer.2024.110011_bib20","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ncb2818","article-title":"Tissue damage detection by osmotic surveillance","volume":"15","author":"Enyedi","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.exer.2024.110011_bib21","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1096\/fj.05-4724fje","article-title":"RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis","volume":"20","author":"Hasturk","year":"2006","journal-title":"Faseb j"},{"key":"10.1016\/j.exer.2024.110011_bib22","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1084\/jem.20051310","article-title":"Prostacyclin-IP signaling and prostaglandin E2-EP2\/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis","volume":"203","author":"Honda","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.exer.2024.110011_bib23","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/mas.21548","article-title":"Metabolomics toward personalized medicine","volume":"38","author":"Jacob","year":"2019","journal-title":"Mass Spectrom. Rev."},{"key":"10.1016\/j.exer.2024.110011_bib24","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1093\/ajcn\/31.6.990","article-title":"Lipids of human milk and infant formulas: a review","volume":"31","author":"Jensen","year":"1978","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.exer.2024.110011_bib25","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1097\/ICO.0b013e318295e6b9","article-title":"Treatment of superior limbic keratoconjunctivitis with topical tacrolimus 0.03% ointment","volume":"32","author":"Kymionis","year":"2013","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2024.110011_bib26","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.survophthal.2021.05.009","article-title":"Superior limbic keratoconjunctivitis: a comprehensive review","volume":"67","author":"Lahoti","year":"2022","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2024.110011_bib27","doi-asserted-by":"crossref","first-page":"16683","DOI":"10.1074\/jbc.M011695200","article-title":"Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4","volume":"276","author":"Lee","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2024.110011_bib28","first-page":"853","volume":"vol. 248","author":"Li","year":"2010"},{"key":"10.1016\/j.exer.2024.110011_bib30","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1089\/jop.2010.0019","article-title":"Resolvin E1 improves tear production and decreases inflammation in a dry eye mouse model","volume":"26","author":"Li","year":"2010","journal-title":"J Ocul Pharmacol Ther"},{"key":"10.1016\/j.exer.2024.110011_bib31","first-page":"336","article-title":"The role of omega-3 dietary supplementation in blepharitis and meibomian gland dysfunction (an AOS thesis)","volume":"106","author":"Macsai","year":"2008","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"10.1016\/j.exer.2024.110011_bib32","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1161\/ATVBAHA.109.188813","article-title":"Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activation","volume":"29","author":"Maloney","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.exer.2024.110011_bib33","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3390\/biom14030376","article-title":"Role of polyunsaturated fatty acids (PUFAs) and eicosanoids on dry eye symptoms and signs","volume":"14","author":"Mangwani-Mordani","year":"2024","journal-title":"Biomolecules"},{"issue":"Pt 2","key":"10.1016\/j.exer.2024.110011_bib34","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/eye.1989.26","article-title":"Superior limbic keratoconjunctivitis (SLK)","volume":"3","author":"Nelson","year":"1989","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.exer.2024.110011_bib35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40662-016-0051-9","article-title":"Tear biomarkers for keratoconus","volume":"3","author":"Nishtala","year":"2016","journal-title":"Eye Vis (Lond)"},{"key":"10.1016\/j.exer.2024.110011_bib36","doi-asserted-by":"crossref","first-page":"e204","DOI":"10.1111\/aos.14874","article-title":"Association between plasma free fatty acid levels and primary angle-closure glaucoma based on a mass spectrometry metabolomics analysis","volume":"100","author":"Qin","year":"2022","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.exer.2024.110011_bib37","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1053\/j.gastro.2022.01.004","article-title":"PUFA-induced metabolic Enteritis as a fuel for crohn's disease","volume":"162","author":"Schw\u00e4rzler","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.exer.2024.110011_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/life12071093","article-title":"Fatty acid composition of milk from mothers with normal weight, obesity, or gestational diabetes","volume":"12","author":"Simon Sarkadi","year":"2022","journal-title":"Life"},{"key":"10.1016\/j.exer.2024.110011_bib39","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0753-3322(02)00253-6","article-title":"The importance of the ratio of omega-6\/omega-3 essential fatty acids","volume":"56","author":"Simopoulos","year":"2002","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.exer.2024.110011_bib40","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cca.2013.11.008","article-title":"Standardization of collection requirements for fasting samples: for the working group on preanalytical phase (WG-PA) of the European federation of clinical chemistry and laboratory medicine (EFLM)","volume":"432","author":"Simundic","year":"2014","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.exer.2024.110011_bib41","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.plipres.2010.07.005","article-title":"Old and new generation lipid mediators in acute inflammation and resolution","volume":"50","author":"Stables","year":"2011","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.exer.2024.110011_bib42","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/ni970","article-title":"Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment","volume":"4","author":"Tager","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.exer.2024.110011_bib43","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.1038\/s41598-021-84661-4","article-title":"Tear film break-up patterns in thyroid eye disease","volume":"11","author":"Takahashi","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2024.110011_bib44","first-page":"25","article-title":"Superior limbic keratoconjunctivitis","volume":"42","author":"Theodore","year":"1963","journal-title":"Eye Ear Nose Throat Mon."},{"key":"10.1016\/j.exer.2024.110011_bib45","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1167\/iovs.06-0998","article-title":"Comparative analysis of human conjunctival and corneal epithelial gene expression with oligonucleotide microarrays","volume":"48","author":"Turner","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.110011_bib46","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ophtha.2016.12.011","article-title":"A metabolome-wide study of dry eye disease reveals serum androgens as biomarkers","volume":"124","author":"Vehof","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2024.110011_bib47","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.ophtha.2018.01.025","article-title":"Influence of meibomian gland dysfunction and friction-related disease on the severity of dry eye","volume":"125","author":"Vu","year":"2018","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2024.110011_bib48","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.biochi.2010.04.007","article-title":"Phospholipases A2 in ocular homeostasis and diseases","volume":"92","author":"Wang","year":"2010","journal-title":"Biochimie"},{"key":"10.1016\/j.exer.2024.110011_bib49","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1161\/01.CIR.89.4.1786","article-title":"Liposome-bound prostaglandin E1 often prevents cyclic flow variations in stenosed and endothelium-injured canine coronary arteries","volume":"89","author":"Willerson","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.exer.2024.110011_bib50","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1159\/000057318","article-title":"Prostanoid signal integration and cross talk","volume":"11","author":"Wise","year":"2002","journal-title":"Neurosignals"},{"key":"10.1016\/j.exer.2024.110011_bib51","doi-asserted-by":"crossref","first-page":"27384","DOI":"10.1074\/jbc.M109.044065","article-title":"Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner","volume":"284","author":"Wong","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2024.110011_bib52","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.psychres.2019.01.095","article-title":"An investigation of calcium-independent phospholipase A2 (iPLA2) and cytosolic phospholipase A2 (cPLA2) in schizophrenia","volume":"273","author":"Xu","year":"2019","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.exer.2024.110011_bib53","article-title":"Metabolomic alterations in the tear fluids of patients with superior limbic keratoconjunctivitis","volume":"8","author":"Zong","year":"2021","journal-title":"Front. Med."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448352400232X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448352400232X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T04:05:14Z","timestamp":1723867514000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001448352400232X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":52,"alternative-id":["S001448352400232X"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2024.110011","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted metabolomic analysis of serum free fatty acids: Lipidomics disturbance in patients with superior limbic keratoconjunctivitis","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2024.110011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110011"}}