{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:02:32Z","timestamp":1792252952239,"version":"4.4.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.exer.2024.110021","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T17:04:43Z","timestamp":1722963883000},"page":"110021","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Astragaloside IV attenuates ferroptosis and protects against iron overload-induced retinal injury"],"prefix":"10.1016","volume":"246","author":[{"given":"Qiang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongtao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2024.110021_bib1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s11064-021-03442-7","article-title":"Liraglutide alleviates cognitive deficit in db\/db mice: involvement in oxidative stress, iron overload, and ferroptosis","volume":"47","author":"An","year":"2022","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.exer.2024.110021_bib2","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.3390\/jcm3041542","article-title":"Inflammation and cell death in age-related macular degeneration: an immunopathological and ultrastructural model","volume":"3","author":"Ardeljan","year":"2014","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.exer.2024.110021_bib3","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.tibs.2015.11.012","article-title":"Regulators of iron homeostasis: new players in metabolism, cell death, and disease","volume":"41","author":"Bogdan","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.exer.2024.110021_bib4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.taap.2007.03.004","article-title":"Transport of thiol-conjugates of inorganic mercury in human retinal pigment epithelial cells","volume":"221","author":"Bridges","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.exer.2024.110021_bib5","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/MAJ.0b013e318271c031","article-title":"Induction of autophagic cell death in the rat brain caused by iron","volume":"345","author":"Chen","year":"2013","journal-title":"Am. J. Med. Sci."},{"key":"10.1016\/j.exer.2024.110021_bib6","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/jcb.27599","article-title":"Astragaloside suppresses tumor necrosis factor receptor-associated factor 5 signaling pathway and alleviates neurodegenerative changes in retinal pigment epithelial cells induced by isoflurane","volume":"120","author":"Chen","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.exer.2024.110021_bib7","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.exer.2024.110021_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.590226","article-title":"Iron metabolism in ferroptosis","volume":"8","author":"Chen","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.exer.2024.110021_bib9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.imlet.2020.06.005","article-title":"Ferroptosis mediated DSS-induced ulcerative colitis associated with Nrf2\/HO-1 signaling pathway","volume":"225","author":"Chen","year":"2020","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.exer.2024.110021_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115572","article-title":"A systematic review of the cell death mechanisms in retinal pigment epithelium cells and photoreceptors after subretinal hemorrhage-Implications for treatment options","volume":"167","author":"Chhatwal","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.exer.2024.110021_bib11","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1056\/NEJMra062326","article-title":"Age-related macular degeneration","volume":"355","author":"de Jong","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.exer.2024.110021_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112207","article-title":"Protective effects of astragaloside IV on db\/db mice with diabetic retinopathy","volume":"9","author":"Ding","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2024.110021_bib13","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.exer.2024.110021_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101107","article-title":"NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis","volume":"23","author":"Dodson","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.exer.2024.110021_bib15","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1167\/iovs.06-0568","article-title":"Iron induced oxidative damage as a potential factor in age-related macular degeneration: the cogan lecture","volume":"47","author":"Dunaief","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.110021_bib16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/exer.1996.0020","article-title":"ARPE-19, a human retinal pigment epithelial cell line with differentiated properties","volume":"62","author":"Dunn","year":"1996","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.110021_bib17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.bbrc.2018.06.019","article-title":"Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors","volume":"503","author":"Fang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2024.110021_bib18","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.exer.2024.110021_bib19","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1152\/physrev.00008.2013","article-title":"Systemic iron homeostasis","volume":"93","author":"Ganz","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.exer.2024.110021_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101537","article-title":"MITF protects against oxidative damage-induced retinal degeneration by regulating the NRF2 pathway in the retinal pigment epithelium","volume":"34","author":"Han","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.exer.2024.110021_bib21","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.preteyeres.2007.07.004","article-title":"Iron homeostasis and toxicity in retinal degeneration","volume":"26","author":"He","year":"2007","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2024.110021_bib22","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.freeradbiomed.2015.03.034","article-title":"Retinal damage induced by commercial light emitting diodes (LEDs)","volume":"84","author":"Jaadane","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exer.2024.110021_bib23","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.exer.2024.110021_bib24","doi-asserted-by":"crossref","first-page":"20826","DOI":"10.1074\/jbc.274.30.20826","article-title":"Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family","volume":"274","author":"Kawabata","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2024.110021_bib25","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1089\/ars.2017.7176","article-title":"The roles of NRF2 in modulating cellular iron homeostasis","volume":"29","author":"Kerins","year":"2018","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.exer.2024.110021_bib26","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","article-title":"Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy","volume":"12","author":"Koppula","year":"2021","journal-title":"Protein Cell"},{"key":"10.1016\/j.exer.2024.110021_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.586578","article-title":"Oxidative damage and antioxidant defense in ferroptosis","volume":"8","author":"Kuang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.exer.2024.110021_bib28","article-title":"The cell biology of the retinal pigment epithelium","volume":"24","author":"Lakkaraju","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2024.110021_bib29","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/bph.15364","article-title":"Nuciferine protects against folic acid-induced acute kidney injury by inhibiting ferroptosis","volume":"178","author":"Li","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.exer.2024.110021_bib30","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.freeradbiomed.2020.10.323","article-title":"Inhibition of ferroptosis by up-regulating Nrf2 delayed the progression of diabetic nephropathy","volume":"162","author":"Li","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exer.2024.110021_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102142","article-title":"Ferroptosis in the ageing retina: a malevolent fire of diabetic retinopathy","volume":"93","author":"Li","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.exer.2024.110021_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2024.103920","article-title":"Ferroptosis as a potential therapeutic target for age-related macular degeneration","volume":"29","author":"Liu","year":"2024","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.exer.2024.110021_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114541","article-title":"Rhein attenuates cerebral ischemia-reperfusion injury via inhibition of ferroptosis through NRF2\/SLC7A11\/GPX4 pathway","volume":"369","author":"Liu","year":"2023","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.exer.2024.110021_bib34","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.chembiol.2020.02.005","article-title":"Autophagy-dependent ferroptosis: machinery and regulation","volume":"27","author":"Liu","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.exer.2024.110021_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101702","article-title":"NRF2 regulates the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via FOCAD-FAK signaling pathway","volume":"37","author":"Liu","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.exer.2024.110021_bib36","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.exer.2006.01.014","article-title":"Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell death","volume":"83","author":"Lohr","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.110021_bib37","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/eye.1998.149","article-title":"Photoreceptor rescue","volume":"12","author":"Luthert","year":"1998","journal-title":"Eye"},{"key":"10.1016\/j.exer.2024.110021_bib38","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2016.12.034","article-title":"A red carpet for iron metabolism","volume":"168","author":"Muckenthaler","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.exer.2024.110021_bib39","article-title":"Lycium barbarum polysaccharide-derived nanoparticles protect visual function by inhibiting RGC ferroptosis and microglial activation in retinal ischemia\u2012reperfusion mice","volume":"12","author":"Ni","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.exer.2024.110021_bib40","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.1167\/iovs.12-9517","article-title":"Neuroprotective effects of nonfeminizing estrogens in retinal photoreceptor neurons","volume":"53","author":"Nixon","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.110021_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0241054","article-title":"The distribution of toxic metals in the human retina and optic nerve head: implications for age-related macular degeneration","volume":"15","author":"Pamphlett","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2024.110021_bib42","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1007\/s11010-021-04347-3","article-title":"Effect of autophagy on ferroptosis in foam cells via Nrf2","volume":"477","author":"Peng","year":"2022","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.exer.2024.110021_bib43","article-title":"Effects of excess iron on the retina: insights from clinical cases and animal models of iron disorders","volume":"15","author":"Shahandeh","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.exer.2024.110021_bib44","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fnagi.2013.00024","article-title":"Retinal iron homeostasis in health and disease","volume":"5","author":"Song","year":"2013","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.exer.2024.110021_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202300123","article-title":"Puerarin attenuates iron overload-induced ferroptosis in retina through a Nrf2-mediated mechanism","volume":"68","author":"Song","year":"2024","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.exer.2024.110021_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109690","article-title":"Puerarin protects against iron overload-induced retinal injury through regulation of iron-handling proteins","volume":"122","author":"Song","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.exer.2024.110021_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115361","article-title":"Astragaloside IV protects against retinal iron overload toxicity through iron regulation and the inhibition of MAPKs and NF-\u03baB activation","volume":"410","author":"Song","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.exer.2024.110021_bib48","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1152\/physrev.00021.2004","article-title":"The retinal pigment epithelium in visual function","volume":"85","author":"Strauss","year":"2005","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.exer.2024.110021_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101971","article-title":"HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration","volume":"43","author":"Tang","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.exer.2024.110021_bib50","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.exer.2018.08.019","article-title":"Oxidative stress induces ferroptotic cell death in retinal pigment epithelial cells","volume":"181","author":"Totsuka","year":"2019","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.110021_bib51","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: the role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exer.2024.110021_bib52","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1042\/BJ20101825","article-title":"Regulation of cellular iron metabolism","volume":"434","author":"Wang","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.exer.2024.110021_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109186","article-title":"Astragaloside IV regulates the ferroptosis signaling pathway via the Nrf2\/SLC7A11\/GPX4 axis to inhibit PM2.5-mediated lung injury in mice","volume":"112","author":"Wang","year":"2022","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.exer.2024.110021_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102131","article-title":"Fibroblast growth factor 21 attenuates iron overload-induced liver injury and fibrosis by inhibiting ferroptosis","volume":"46","author":"Wu","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.exer.2024.110021_bib55","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.7150\/thno.54113","article-title":"Ferroptosis as a novel therapeutic target for cardiovascular disease","volume":"11","author":"Wu","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.exer.2024.110021_bib56","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.exer.2024.110021_bib57","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1007\/s12011-020-02508-x","article-title":"Iron overload induces apoptosis and cytoprotective autophagy regulated by ROS generation in Mc3t3-E1 cells","volume":"199","author":"Xu","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.exer.2024.110021_bib58","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.3390\/antiox12091739","article-title":"NRF2, a superstar of ferroptosis","volume":"12","author":"Yan","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.exer.2024.110021_bib59","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.chembiol.2008.02.010","article-title":"Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells","volume":"15","author":"Yang","year":"2008","journal-title":"Chem. Biol."},{"key":"10.1016\/j.exer.2024.110021_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115547","article-title":"Fructus Lycii and Salvia miltiorrhiza Bunge extract attenuate oxidative stress-induced photoreceptor ferroptosis in retinitis pigmentosa","volume":"167","author":"Yang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.exer.2024.110021_bib61","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41418-022-01046-4","article-title":"Pathologically high intraocular pressure disturbs normal iron homeostasis and leads to retinal ganglion cell ferroptosis in glaucoma","volume":"30","author":"Yao","year":"2023","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.exer.2024.110021_bib62","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s00417-002-0427-5","article-title":"Caspase-3 inhibitor transiently delays inherited retinal degeneration in C3H mice carrying the rd gene","volume":"240","author":"Yoshizawa","year":"2002","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2024.110021_bib63","doi-asserted-by":"crossref","first-page":"923","DOI":"10.3390\/biom11070923","article-title":"Kaempferol ameliorates oxygen-glucose deprivation\/reoxygenation-induced neuronal ferroptosis by activating Nrf2\/SLC7A11\/GPX4 axis","volume":"11","author":"Yuan","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.exer.2024.110021_bib64","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/bs.apha.2019.08.002","article-title":"Astragaloside IV derived from Astragalus membranaceus: a research review on the pharmacological effects","volume":"87","author":"Zhang","year":"2020","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.exer.2024.110021_bib65","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.freeradbiomed.2020.03.015","article-title":"Ferroptosis was more initial in cell death caused by iron overload and its underlying mechanism in Parkinson's disease","volume":"152","author":"Zhang","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exer.2024.110021_bib66","doi-asserted-by":"crossref","first-page":"529","DOI":"10.14336\/AD.2020.0912","article-title":"Iron accumulation and lipid peroxidation in the aging retina: implication of ferroptosis in age-related macular degeneration","volume":"12","author":"Zhao","year":"2021","journal-title":"Aging Dis"},{"key":"10.1016\/j.exer.2024.110021_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115140","article-title":"Protective benefits of salvianic acid A against retinal iron overload by inhibition of ferroptosis","volume":"165","author":"Zhao","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.exer.2024.110021_bib68","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s12975-015-0388-8","article-title":"Iron-induced necrotic brain cell death in rats with different aerobic capacity","volume":"6","author":"Zheng","year":"2015","journal-title":"Transl. Stroke Res"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483524002422?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483524002422?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T15:09:27Z","timestamp":1725030567000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483524002422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":68,"alternative-id":["S0014483524002422"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2024.110021","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Astragaloside IV attenuates ferroptosis and protects against iron overload-induced retinal injury","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2024.110021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110021"}}