{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:11:42Z","timestamp":1780391502996,"version":"3.54.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.exer.2024.110067","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T06:28:09Z","timestamp":1725344889000},"page":"110067","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Study on the relationship between adolescent myopia and gut microbiota via 16S rRNA sequencing"],"prefix":"10.1016","volume":"247","author":[{"given":"Yun","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Sha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuchang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2024.110067_bib1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41572-020-00231-4","article-title":"Myopia","volume":"6","author":"Baird","year":"2020","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.exer.2024.110067_bib2","first-page":"763","volume":"vol. 36","author":"Bremond-Gignac","year":"2020"},{"key":"10.1016\/j.exer.2024.110067_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.663131","article-title":"Alterations of gut microbiota in patients with graves' disease","volume":"11","author":"Chang","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.exer.2024.110067_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2023.106371","article-title":"Ocular microbial dysbiosis and its linkage with infectious keratitis patients in Northwest China: a cross-sectional study","volume":"184","author":"Cheng","year":"2023","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.exer.2024.110067_bib5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","article-title":"Gut microbiota in human metabolic health and disease","volume":"19","author":"Fan","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.exer.2024.110067_bib6","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s40123-020-00278-2","article-title":"The gut-eye Axis: lessons learned from murine models","volume":"9","author":"Floyd","year":"2020","journal-title":"Ophthalmol Ther"},{"key":"10.1016\/j.exer.2024.110067_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.107921","article-title":"Gut microbiota compositional profile and serum metabolic phenotype in patients with primary open-angle glaucoma","volume":"191","author":"Gong","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.110067_bib8","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40659-022-00390-6","article-title":"Intravitreal injection of mitochondrial DNA induces cell damage and retinal dysfunction in rats","volume":"55","author":"Guo","year":"2022","journal-title":"Biol. Res."},{"key":"10.1016\/j.exer.2024.110067_bib9","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12964-020-00637-3","article-title":"Mitochondrial DNA drives noncanonical inflammation activation via cGAS-STING signaling pathway in retinal microvascular endothelial cells","volume":"18","author":"Guo","year":"2020","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.exer.2024.110067_bib10","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/s41433-021-01805-6","article-title":"Myopia prediction: a systematic review","volume":"36","author":"Han","year":"2022","journal-title":"Eye"},{"key":"10.1016\/j.exer.2024.110067_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2023.109538","article-title":"Comprehensive metabolic profiling of diabetic retinopathy","volume":"233","author":"Han","year":"2023","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.110067_bib12","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.7150\/ijbs.24151","article-title":"Molecular alteration analysis of human gut microbial composition in graves' disease patients","volume":"14","author":"Ishaq","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.exer.2024.110067_bib13","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1167\/iovs.62.5.6","article-title":"IMI prevention of myopia and its progression","volume":"62","author":"Jonas","year":"2021","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.110067_bib14","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41433-020-0968-z","article-title":"Serum metabolic signatures of high myopia among older Chinese adults","volume":"35","author":"Ke","year":"2021","journal-title":"Eye"},{"key":"10.1016\/j.exer.2024.110067_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1251243","article-title":"Gut microbiome and plasma metabolome alterations in myopic mice","volume":"14","author":"Li","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.exer.2024.110067_bib16","article-title":"Characteristics of gut microbiota in patients with primary Sj\u00f6gren's syndrome in Northern China","volume":"17","author":"Li","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2024.110067_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2022.109184","article-title":"Metabolic characterization of human intraocular fluid in patients with pathological myopia","volume":"222","author":"Lian","year":"2022","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.110067_bib18","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1167\/iovs.63.11.5","article-title":"Enhanced apoptosis in choroidal tissues in lens-induced myopia Guinea pigs by activating the RASA1 signaling pathway","volume":"63","author":"Liu","year":"2022","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.110067_bib19","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12964-022-00970-9","article-title":"Lrpap1 deficiency leads to myopia through TGF-\u03b2-induced apoptosis in zebrafish","volume":"20","author":"Liu","year":"2022","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.exer.2024.110067_bib20","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.survophthal.2021.06.005","article-title":"The cause of myopia development and progression: theory, evidence, and treatment","volume":"67","author":"Medina","year":"2022","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2024.110067_bib21","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.preteyeres.2017.09.004","article-title":"The epidemics of myopia: aetiology and prevention","volume":"62","author":"Morgan","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2024.110067_bib22","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/S0140-6736(12)60272-4","article-title":"Myopia","volume":"379","author":"Morgan","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.exer.2024.110067_bib23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1167\/iovs.62.5.5","article-title":"IMI pathologic myopia","volume":"62","author":"Ohno-Matsui","year":"2021","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.110067_bib24","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1167\/iovs.65.5.2","article-title":"Gut microbiota profiles in myopes and nonmyopes","volume":"65","author":"Omar","year":"2024","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.110067_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/genes12030365","article-title":"Ophthalmologic manifestations of primary sj\u00f6gren's syndrome","volume":"12","author":"Roszkowska","year":"2021","journal-title":"Genes"},{"key":"10.1016\/j.exer.2024.110067_bib26","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.preteyeres.2018.10.005","article-title":"Myopic maculopathy: current status and proposal for a new classification and grading system (ATN)","volume":"69","author":"Ruiz-Medrano","year":"2019","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2024.110067_bib27","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1007\/s10067-020-05429-1","article-title":"Biologic therapy in Sj\u00f6gren's syndrome","volume":"40","author":"Shao","year":"2021","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.exer.2024.110067_bib28","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1007\/s10067-018-04419-8","article-title":"Relative abundance of Megamonas hypermegale and Butyrivibrio species decreased in the intestine and its possible association with the T cell aberration by metabolite alteration in patients with Behcet's disease (210 characters)","volume":"38","author":"Shimizu","year":"2019","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.exer.2024.110067_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153746","article-title":"Bifidobacteria abundance-featured gut microbiota compositional change in patients with Behcet's disease","volume":"11","author":"Shimizu","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2024.110067_bib30","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.4103\/ijo.IJO_2415_21","article-title":"Myopia, its prevalence, current therapeutic strategy and recent developments: a Review","volume":"70","author":"Singh","year":"2022","journal-title":"Indian J. Ophthalmol."},{"key":"10.1016\/j.exer.2024.110067_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2023.1226438","article-title":"Advances in myopia prevention strategies for school-aged children: a comprehensive review","volume":"11","author":"Tariq","year":"2023","journal-title":"Front. Public Health"},{"key":"10.1016\/j.exer.2024.110067_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.1033933","article-title":"Gut microbiota and calcium balance","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.exer.2024.110067_bib33","article-title":"Exploring the relationship between intestinal flora and the pathological mechanism of myopia in adolescents from the perspective of Chinese and Western medicine: a review","volume":"102","author":"Xi","year":"2023","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.exer.2024.110067_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1042849","article-title":"A novel uveitis model induced by lipopolysaccharide in zebrafish","volume":"13","author":"Xiao","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exer.2024.110067_bib35","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20191242","article-title":"Intestinal microbiota changes in Graves' disease: a prospective clinical study","volume":"40","author":"Yan","year":"2020","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.exer.2024.110067_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2022.101117","article-title":"The role of the gut microbiome in eye diseases","volume":"92","author":"Zysset-Burri","year":"2023","journal-title":"Prog. Retin. Eye Res."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483524002884?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483524002884?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T18:59:10Z","timestamp":1727549950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483524002884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":36,"alternative-id":["S0014483524002884"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2024.110067","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Study on the relationship between adolescent myopia and gut microbiota via 16S rRNA sequencing","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2024.110067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110067"}}