{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:24:34Z","timestamp":1787631874764,"version":"build-2736575974"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"am","delay-in-days":324,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007284","name":"School of Medicine, Wayne State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007284","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01EY030129-04"],"award-info":[{"award-number":["R01EY030129-04"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.exer.2024.110123","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T06:41:35Z","timestamp":1728628895000},"page":"110123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Foxp3+ regulatory T cells reside within the corneal epithelium and co-localize with limbal stem cells"],"prefix":"10.1016","volume":"249","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1541-118X","authenticated-orcid":false,"given":"Maryam","family":"Tahvildari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rao","family":"Me","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizumi","family":"Setia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratima","family":"Suvas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon A.","family":"McClellan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susmit","family":"Suvas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2024.110123_bib1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/imm.12999","article-title":"Regulatory T-cells: receptors, repertoires and roles in disease","volume":"155","author":"Altmann","year":"2018","journal-title":"Immunology"},{"issue":"7","key":"10.1016\/j.exer.2024.110123_bib2","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.stem.2021.04.003","article-title":"Discrete limbal epithelial stem cell populations mediate corneal homeostasis and wound healing","volume":"28","author":"Altshuler","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.exer.2024.110123_bib3","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.cell.2015.08.021","article-title":"A distinct function of regulatory T cells in tissue protection","volume":"162","author":"Arpaia","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.exer.2024.110123_bib4","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.cell.2013.10.054","article-title":"A special population of regulatory T cells potentiates muscle repair","volume":"155","author":"Burzyn","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.exer.2024.110123_bib5","doi-asserted-by":"crossref","first-page":"148","DOI":"10.4049\/jimmunol.182.1.148","article-title":"Levels of Foxp3 in regulatory T cells reflect their functional status in transplantation","volume":"182","author":"Chauhan","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.exer.2024.110123_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2022.109007","article-title":"Immune regulation of the ocular surface","volume":"218","author":"Chen","year":"2022","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.110123_bib7","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1002\/jcp.24268","article-title":"New insights in wound response and repair of epithelium","volume":"228","author":"Chi","year":"2013","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.exer.2024.110123_bib8","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.130651","article-title":"Immune cell landscaping reveals a protective role for regulatory T cells during kidney injury and fibrosis","volume":"5","author":"do Valle Duraes","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.exer.2024.110123_bib9","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nature10160","article-title":"In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche","volume":"474","author":"Fujisaki","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.exer.2024.110123_bib10","doi-asserted-by":"crossref","first-page":"273","DOI":"10.4049\/jimmunol.1401285","article-title":"IL-2\/anti-IL-2 antibody complex treatment inhibits the development but not the progression of herpetic stromal keratitis","volume":"194","author":"Gaddipati","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.exer.2024.110123_bib11","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1167\/iovs.02-0838","article-title":"The corneal stroma is endowed with a significant number of resident dendritic cells","volume":"44","author":"Hamrah","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.110123_bib12","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/imcb.12481","article-title":"Tissue-resident regulatory T cells accumulate at human barrier lymphoid organs","volume":"99","author":"Hewavisenti","year":"2021","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.exer.2024.110123_bib13","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s41586-018-0824-5","article-title":"Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery","volume":"565","author":"Ito","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.exer.2024.110123_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2020.104173","article-title":"Tolerogenic vaccines: targeting the antigenic and cytokine niches of FOXP3(+) regulatory T cells","volume":"355","author":"Mannie","year":"2020","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.exer.2024.110123_bib15","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.2147\/OPTH.S299141","article-title":"Management of persistent corneal epithelial defects with human amniotic membrane-derived dry matrix","volume":"15","author":"Maqsood","year":"2021","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.exer.2024.110123_bib16","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1006\/exer.2000.0979","article-title":"The epidermal growth factor receptor (EGFR): role in corneal wound healing and homeostasis","volume":"72","author":"Nakamura","year":"2001","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.110123_bib17","doi-asserted-by":"crossref","first-page":"36166","DOI":"10.18632\/oncotarget.26322","article-title":"Differential gene expression in human tissue resident regulatory T cells from lung, colon, and blood","volume":"9","author":"Niedzielska","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.exer.2024.110123_bib18","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.4049\/jimmunol.1502139","article-title":"Cutting edge: regulatory T cells facilitate cutaneous wound healing","volume":"196","author":"Nosbaum","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.exer.2024.110123_bib19","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/978-1-0716-0845-6_15","article-title":"Corneal repair models in mice: epithelial\/mechanical versus stromal\/chemical injuries","volume":"2193","author":"Pan","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.exer.2024.110123_bib20","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.cell.2008.05.009","article-title":"Regulatory T cells and immune tolerance","volume":"133","author":"Sakaguchi","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.exer.2024.110123_bib21","article-title":"Flow cytometry protocol to quantify immune cells in the separated epithelium and stroma of herpes simplex virus-1-infected mouse cornea","volume":"4","author":"Setia","year":"2023","journal-title":"STAR Protoc"},{"key":"10.1016\/j.exer.2024.110123_bib22","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1097\/TP.0000000000002442","article-title":"Local delivery of regulatory T cells promotes corneal allograft survival","volume":"103","author":"Shao","year":"2019","journal-title":"Transplantation"},{"key":"10.1016\/j.exer.2024.110123_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082355","article-title":"Development, alteration and real time dynamics of conjunctiva-associated lymphoid tissue","volume":"8","author":"Siebelmann","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2024.110123_bib24","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4049\/jimmunol.1800917","article-title":"Cutting edge: dynamic expression of Id3 defines the stepwise differentiation of tissue-resident regulatory T cells","volume":"202","author":"Sullivan","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.exer.2024.110123_bib25","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.4049\/jimmunol.172.7.4123","article-title":"CD4+CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions","volume":"172","author":"Suvas","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.exer.2024.110123_bib26","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/TP.0000000000001044","article-title":"In vivo expansion of regulatory T cells by low-dose interleukin-2 treatment increases allograft survival in corneal transplantation","volume":"100","author":"Tahvildari","year":"2016","journal-title":"Transplantation"},{"key":"10.1016\/j.exer.2024.110123_bib27","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1167\/iovs.61.14.22","article-title":"Subconjunctival injection of regulatory T cells potentiates corneal healing via orchestrating inflammation and tissue repair after acute alkali burn","volume":"61","author":"Yan","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.110123_bib28","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/imm.13057","article-title":"Immune- and non-immune-mediated roles of regulatory T-cells during wound healing","volume":"157","author":"Zaiss","year":"2019","journal-title":"Immunology"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483524003452?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483524003452?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T22:23:16Z","timestamp":1732832596000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483524003452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":28,"alternative-id":["S0014483524003452"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2024.110123","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Foxp3+ regulatory T cells reside within the corneal epithelium and co-localize with limbal stem cells","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2024.110123","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110123"}}