{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:14:04Z","timestamp":1783462444489,"version":"3.55.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.exer.2024.110169","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T07:53:53Z","timestamp":1732175633000},"page":"110169","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Electroacupuncture improves V1 cortex synaptic plasticity via the CREB\/BDNF\/TrkB pathway in juvenile rats with monocular deprivation"],"prefix":"10.1016","volume":"250","author":[{"given":"Lin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangbin","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huachun","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaiman","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4224-1545","authenticated-orcid":false,"given":"Jian","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2024.110169_bib1","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1523\/JNEUROSCI.2881-18.2019","article-title":"p75 neurotrophin receptor activation regulates the timing of the maturation of cortical parvalbumin interneuron connectivity and promotes juvenile-like plasticity in adult visual cortex","volume":"39","author":"Baho","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2024.110169_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2023.102413","article-title":"nNOS-induced tyrosine nitration of TRKB impairs BDNF signaling and restrains neuronal plasticity","volume":"222","author":"Biojone","year":"2023","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.exer.2024.110169_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2023.101168","article-title":"Amblyopia and the whole child","volume":"93","author":"Birch","year":"2023","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2024.110169_bib4","first-page":"747","article-title":"Observation of acupoint thread-embedding on refractive amblyopia in children","volume":"41","author":"Cai-Lian","year":"2021","journal-title":"Zhongguo Zhen Jiu"},{"key":"10.1016\/j.exer.2024.110169_bib5","first-page":"585","article-title":"Long-term monocular deprivation during juvenile critical period disrupts binocular integration in mouse visual thalamus","volume":"40","author":"Carey","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2024.110169_bib6","first-page":"153","article-title":"Effects of acupuncture on vision and visual function in children with anisometropic amblyopia","volume":"44","author":"Cui","year":"2024","journal-title":"Zhongguo Zhen Jiu"},{"key":"10.1016\/j.exer.2024.110169_bib7","first-page":"153","article-title":"Effects of acupuncture on vision and visual function in children with anisometropic amblyopia","volume":"44","author":"Cui","year":"2024","journal-title":"Zhongguo Zhen Jiu"},{"key":"10.1016\/j.exer.2024.110169_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154395","article-title":"Sinisan alleviates depression-like behaviors by regulating mitochondrial function and synaptic plasticity in maternal separation rats","volume":"106","author":"Deng","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.exer.2024.110169_bib9","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.cell.2022.12.035","article-title":"All-optical physiology resolves a synaptic basis for behavioral timescale plasticity","volume":"186","author":"Fan","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.exer.2024.110169_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2023.120141","article-title":"Crossmodal plasticity following short-term monocular deprivation","volume":"274","author":"Federici","year":"2023","journal-title":"Neuroimage"},{"key":"10.1016\/j.exer.2024.110169_bib11","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1167\/iovs.64.13.2","article-title":"The suppressive basis of ocular dominance changes induced by short-term monocular deprivation in normal and amblyopic adults","volume":"64","author":"Gong","year":"2023","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.110169_bib12","series-title":"Rehabilitation of Amblyopia Using a Digital Platform for Visual Training Combined with Patching in Children: a Prospective Study","author":"Hern\u00e1ndez-Rodr\u00edguez","year":"2024"},{"key":"10.1016\/j.exer.2024.110169_bib13","doi-asserted-by":"crossref","first-page":"9660","DOI":"10.1038\/s41598-022-13747-4","article-title":"Perceptual learning with dichoptic attention tasks improves attentional modulation in V1 and IPS and reduces interocular suppression in human amblyopia","volume":"12","author":"Hou","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2024.110169_bib14","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1002\/cne.25134","article-title":"Ocular dominance columns in V1 are more susceptible than associated callosal patches to imbalance of eye input during precritical and critical periods","volume":"529","author":"Jaime","year":"2021","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.exer.2024.110169_bib15","article-title":"Suppression of top-down influence decreases neuronal excitability and contrast sensitivity in the V1 cortex of cat","volume":"11","author":"Jian","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2024.110169_bib16","article-title":"Effects of top-down influence suppression on behavioral and V1 neuronal contrast sensitivity functions in cats","volume":"25","author":"Jian","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.exer.2024.110169_bib17","doi-asserted-by":"crossref","first-page":"339","DOI":"10.18240\/ijo.2024.02.17","article-title":"Brain mechanism of acupuncture for children with anisometropic amblyopia: a resting functional magnetic resonance imaging study based on voxel-mirrored homotopic connectivity","volume":"17","author":"Jue","year":"2024","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.exer.2024.110169_bib18","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1093\/emboj\/19.6.1290","article-title":"BDNF regulates eating behavior and locomotor activity in mice","volume":"19","author":"Kernie","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.exer.2024.110169_bib19","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s10571-017-0510-4","article-title":"BDNF: a key factor with multipotent impact on brain signaling and synaptic plasticity","volume":"38","author":"Kowia\u0144ski","year":"2018","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.exer.2024.110169_bib20","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41419-023-05839-4","article-title":"Electroacupuncture prevents astrocyte atrophy to alleviate depression","volume":"14","author":"Lin","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2024.110169_bib21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s10827-022-00823-x","article-title":"Deciphering functional roles of synaptic plasticity and intrinsic neural firing in developing mouse visual cortex layer IV microcircuit","volume":"51","author":"Liu","year":"2023","journal-title":"J. Comput. Neurosci."},{"key":"10.1016\/j.exer.2024.110169_bib22","first-page":"664","article-title":"Combined bazedoxifene and genistein ameliorate ovariectomy-induced hippocampal neuro-alterations via activating CREB\/BDNF\/TrkB signaling pathway","volume":"16","author":"Mai A","year":"2022","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.exer.2024.110169_bib23","doi-asserted-by":"crossref","first-page":"5636","DOI":"10.1093\/cercor\/bhac448","article-title":"Neuromodulation in the developing visual cortex after long-term monocular deprivation","volume":"33","author":"Malik","year":"2023","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.exer.2024.110169_bib24","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.2147\/JPR.S436258","article-title":"Electroacupuncture alleviates dry eye ocular pain through TNF-\u0251 mediated ERK1\/2\/P2X(3)R signaling pathway in SD rats","volume":"16","author":"Mi-Mi","year":"2023","journal-title":"J. Pain Res."},{"key":"10.1016\/j.exer.2024.110169_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2023.110724","article-title":"Electroacupuncture attenuates ketamine-induced neuronal injury in the locus coeruleus of rats through modulation of the CAMK II\/CREB pathway","volume":"202","author":"Miao","year":"2023","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.exer.2024.110169_bib26","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/s41593-023-01316-5","article-title":"Psychedelics promote plasticity by directly binding to BDNF receptor TrkB","volume":"26","author":"Moliner","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.exer.2024.110169_bib27","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.3390\/ijms23052438","article-title":"Chronic monocular deprivation reveals MMP9-dependent and -independent aspects of murine visual system plasticity","author":"Murase","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2024.110169_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaw9960","article-title":"Interfering MSN-NONO complex\u2013activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer","volume":"6","author":"Qin","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.exer.2024.110169_bib29","article-title":"Electroacupuncture at GB20 improves cognitive ability and synaptic plasticity via the CaM-CaMKII-CREB signaling pathway following cerebral ischemia-reperfusion injury in rats","volume":"42","author":"Qing","year":"2024","journal-title":"Acupunct. Med."},{"key":"10.1016\/j.exer.2024.110169_bib30","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/opo.12123","article-title":"Binocular vision in amblyopia: structure, suppression and plasticity","volume":"34","author":"Robert","year":"2014","journal-title":"Ophthalmic Physiol. Opt."},{"key":"10.1016\/j.exer.2024.110169_bib31","article-title":"Electroacupuncture ameliorates inflammatory response induced by retinal ischemia-reperfusion injury and protects the retina through the DOR-BDNF\/Trkb pathway","volume":"16","author":"Runjie","year":"2023","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.exer.2024.110169_bib32","article-title":"Rapidly repeated visual stimulation induces long-term potentiation of VEPs and increased content of membrane AMPA and NMDA receptors in the V1 cortex of cats","volume":"18","author":"Shunshun","year":"2024","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.exer.2024.110169_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.108990","article-title":"Hippocampal NR6A1 impairs CREB-BDNF signaling and leads to the development of depression-like behaviors in mice","volume":"209","author":"Tan","year":"2022","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.exer.2024.110169_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-14918-z","article-title":"Study on the mechanism of visual aging in cats' primary visual cortex based on BDNF-TrkB signal pathway","volume":"12","author":"Tong","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2024.110169_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2023.109651","article-title":"Activation of p38 MAPK hinders the reactivation of visual cortical plasticity in adult amblyopic mice","volume":"236","author":"Wang","year":"2023","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.110169_bib36","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1152\/jn.1963.26.6.1003","article-title":"SINGLE-CELL responses in striate cortex of kittens deprived OF VISION IN one eye","volume":"26","author":"Wiesel","year":"1963","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.exer.2024.110169_bib37","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1113\/JP279340","article-title":"Anodal and cathodal tDCS modulate neural activity and selectively affect GABA and glutamate syntheses in the visual cortex of cats","volume":"598","author":"Xiaojing","year":"2020","journal-title":"J. Physiol."},{"key":"10.1016\/j.exer.2024.110169_bib38","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1161\/STROKEAHA.120.033285","article-title":"CCR5 activation promotes NLRP1-dependent neuronal pyroptosis via CCR5\/PKA\/CREB pathway after intracerebral hemorrhage","volume":"52","author":"Yan","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.exer.2024.110169_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.3310","article-title":"Electroacupuncture promotes synaptic plasticity in rats with chronic inflammatory pain\u2013related depression by upregulating BDNF\/TrkB\/CREB signaling pathway","volume":"13","author":"Yang","year":"2023","journal-title":"Brain Behav."},{"key":"10.1016\/j.exer.2024.110169_bib40","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40659-022-00396-0","article-title":"Acupuncture attenuates comorbid anxiety- and depressive-like behaviors of atopic dermatitis through modulating neuroadaptation in the brain reward circuit in mice","volume":"55","author":"Yeom","year":"2022","journal-title":"Biol. Res."},{"key":"10.1016\/j.exer.2024.110169_bib41","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jtcme.2023.03.006","article-title":"Comparison and effect of moxibustion and acupuncture on Nogo\/NgR signaling pathway in rats with cerebral ischemia\/reperfusion injury","volume":"13","author":"You-Jiang","year":"2023","journal-title":"J Tradit Complement Med"},{"key":"10.1016\/j.exer.2024.110169_bib42","article-title":"Structural and functional alterations in the brains of patients with anisometropic and strabismic amblyopia: a systematic review of magnetic resonance imaging studies","volume":"18","author":"Yuxia","year":"2023","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.exer.2024.110169_bib43","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1167\/iovs.61.4.44","article-title":"Monocular deprivation affects visual cortex plasticity through cPKC\u03b3-modulated GluR1 phosphorylation in mice","volume":"61","author":"Zhang","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.110169_bib44","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s12264-019-00445-x","article-title":"NLRP3 deficiency attenuates secondary degeneration of visual cortical neurons following optic nerve injury","volume":"36","author":"Zhang","year":"2020","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.exer.2024.110169_bib45","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1097\/WNR.0000000000001814","article-title":"The effect of electroacupuncture on the expression of Sirt1 and STAT3 in hippocampus and amygdala of vascular dementia rats","volume":"33","author":"Zhao","year":"2022","journal-title":"Neuroreport"},{"key":"10.1016\/j.exer.2024.110169_bib46","first-page":"61","article-title":"Intervention of acupuncture on abnormal spatiotemporal pattern of visual cortex area 17 neuron in monocular deprivation amblyopia rats","volume":"37","author":"Zhu","year":"2017","journal-title":"Zhongguo Zhen Jiu"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483524003919?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483524003919?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T18:21:32Z","timestamp":1738088492000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483524003919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":46,"alternative-id":["S0014483524003919"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2024.110169","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Electroacupuncture improves V1 cortex synaptic plasticity via the CREB\/BDNF\/TrkB pathway in juvenile rats with monocular deprivation","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2024.110169","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110169"}}