{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:40:24Z","timestamp":1790102424981,"version":"4.0.1"},"reference-count":108,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.exer.2024.110179","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T15:15:38Z","timestamp":1732288538000},"page":"110179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Role of vitamin A on the ocular surface"],"prefix":"10.1016","volume":"250","author":[{"given":"Huanhuan","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohu","family":"Di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peirong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenshuo","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7522-3813","authenticated-orcid":false,"given":"Peng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2024.110179_bib1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s40662-019-0150-5","article-title":"Update on pharmacotherapy for ocular surface squamous neoplasia","volume":"6","author":"Al Bayyat","year":"2019","journal-title":"Eye Vis. (Lond)"},{"key":"10.1016\/j.exer.2024.110179_bib2","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jtos.2019.12.006","article-title":"Immune - goblet cell interaction in the conjunctiva","volume":"18","author":"Alam","year":"2020","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2024.110179_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22031092","article-title":"Retinoid regulation of ocular surface innate inflammation","volume":"22","author":"Alam","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2024.110179_bib4","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.stem.2021.02.024","article-title":"Exploring the human lacrimal gland using organoids and single-cell sequencing","volume":"28","author":"Bannier-H\u00e9laou\u00ebt","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.exer.2024.110179_bib5","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1002\/mnfr.200800563","article-title":"Individual and combined action of pancreatic lipase and pancreatic lipase-related proteins 1 and 2 on native versus homogenized milk fat globules","volume":"53","author":"Berton","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.exer.2024.110179_bib6","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s10238-022-00860-x","article-title":"The immunomodulatory role of all-trans retinoic acid in tumor microenvironment","volume":"23","author":"Bi","year":"2023","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.exer.2024.110179_bib7","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/ajcn\/69.5.931","article-title":"Biochemical but not clinical vitamin A deficiency results from mutations in the gene for retinol binding protein","volume":"69","author":"Biesalski","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.exer.2024.110179_bib8","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1753-4887.2000.tb01848.x","article-title":"Hypervitaminosis A and bone","volume":"58","author":"Binkley","year":"2000","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.exer.2024.110179_bib9","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1017\/S0029665118002641","article-title":"\u03b2-Carotene in the human body: metabolic bioactivation pathways - from digestion to tissue distribution and excretion","volume":"78","author":"Bohn","year":"2019","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.exer.2024.110179_bib10","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF00254733","article-title":"Retinoids and cancer","volume":"3","author":"Bollag","year":"1979","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.exer.2024.110179_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/nu9030246","article-title":"Genetic variations associated with vitamin A status and vitamin A bioavailability","volume":"9","author":"Borel","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.exer.2024.110179_bib12","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","article-title":"TFOS DEWS II pathophysiology report","volume":"15","author":"Bron","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2024.110179_bib13","doi-asserted-by":"crossref","first-page":"R121","DOI":"10.1530\/EC-17-0101","article-title":"Vitamin A, endocrine tissues and hormones: interplay and interactions","volume":"6","author":"Brossaud","year":"2017","journal-title":"Endocr. Conn."},{"key":"10.1016\/j.exer.2024.110179_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/nu13051703","article-title":"Vitamin A update: forms, sources, kinetics, detection, function, deficiency, therapeutic use and toxicity","volume":"13","author":"Carazo","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.exer.2024.110179_bib15","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/ceo.12663","article-title":"Use of topical retinoic acid for limbal stem cell failure: a retrospective clinical case series","volume":"44","author":"Chew","year":"2016","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2024.110179_bib16","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.pharmtox.39.1.399","article-title":"Teratology of retinoids","volume":"39","author":"Collins","year":"1999","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.exer.2024.110179_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/srep32688","article-title":"Lysyl oxidase-like 4 involvement in retinoic acid epithelial wound healing","volume":"6","author":"Comptour","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2024.110179_bib18","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.ajpath.2016.02.004","article-title":"Interferon-\u03b3-Induced unfolded protein response in conjunctival goblet cells as a cause of mucin deficiency in sj\u00f6gren syndrome","volume":"186","author":"Coursey","year":"2016","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2024.110179_bib19","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.exer.2009.04.012","article-title":"Retinoic acid signaling in mammalian eye development","volume":"89","author":"Cvekl","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.110179_bib20","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1006\/exer.2001.1076","article-title":"Regulation of lacrimal gland secretion by neurotransmitters and the EGF family of growth factors","volume":"73","author":"Dartt","year":"2001","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.110179_bib21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.preteyeres.2009.04.003","article-title":"Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases","volume":"28","author":"Dartt","year":"2009","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2024.110179_bib22","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1167\/iovs.07-0069","article-title":"Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma","volume":"48","author":"De Paiva","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.110179_bib23","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.exer.2012.09.005","article-title":"Changes in lysyl oxidase (LOX) distribution and its decreased activity in keratoconus corneas","volume":"104","author":"Dudakova","year":"2012","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.110179_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/cells11030322","article-title":"Towards a better vision of retinoic acid signaling during eye development","volume":"11","author":"Duester","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.exer.2024.110179_bib25","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1016\/S0190-9622(98)70450-5","article-title":"The role of retinoids in wound healing","volume":"39","author":"Elson","year":"1998","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.exer.2024.110179_bib26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.5935\/0004-2749.20160018","article-title":"Vitamin A and the eye: an old tale for modern times","volume":"79","author":"Faustino","year":"2016","journal-title":"Arq. Bras. Oftalmol."},{"key":"10.1016\/j.exer.2024.110179_bib27","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2021-242776","article-title":"Corneal perforation due to vitamin A deficiency in a patient with short bowel syndrome","volume":"14","author":"Fieldhouse","year":"2021","journal-title":"BMJ Case Rep."},{"key":"10.1016\/j.exer.2024.110179_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/nu13061998","article-title":"A review of topical and systemic vitamin supplementation in ocular surface diseases","volume":"13","author":"Fogagnolo","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.exer.2024.110179_bib29","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/mi.2015.53","article-title":"Interaction of IFN-\u03b3 with cholinergic agonists to modulate rat and human goblet cell function","volume":"9","author":"Garc\u00eda-Posadas","year":"2016","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.exer.2024.110179_bib30","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1124\/pr.58.4.2","article-title":"Overview of nomenclature of nuclear receptors","volume":"58","author":"Germain","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.exer.2024.110179_bib31","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1086\/518177","article-title":"Matthew-Wood syndrome is caused by truncating mutations in the retinol-binding protein receptor gene STRA6","volume":"80","author":"Golzio","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.exer.2024.110179_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/nu9010013","article-title":"Hepatic retinyl ester hydrolases and the mobilization of retinyl ester stores","volume":"9","author":"Grumet","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.exer.2024.110179_bib33","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev-pharmtox-052120-104428","article-title":"Synthetic retinoids beyond cancer therapy","volume":"62","author":"Gudas","year":"2022","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.exer.2024.110179_bib34","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1146\/annurev.nutr.25.050304.092614","article-title":"Mechanisms of digestion and absorption of dietary vitamin A","volume":"25","author":"Harrison","year":"2005","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.exer.2024.110179_bib35","first-page":"633","article-title":"Change of paracellular permeability of ocular surface epithelium by vitamin A deficiency","volume":"32","author":"Huang","year":"1991","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.110179_bib36","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jtos.2020.04.004","article-title":"The treatment of recurrent conjunctival and corneal intraepithelial neoplasia with interferon alfa-2b and retinoic acid: \u223c9 years' follow-up on tumor control","volume":"18","author":"Ip","year":"2020","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2024.110179_bib37","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.cmet.2008.01.009","article-title":"RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome","volume":"7","author":"Isken","year":"2008","journal-title":"Cell Metabol."},{"key":"10.1016\/j.exer.2024.110179_bib38","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1186\/s13287-022-03053-1","article-title":"All-trans retinoic acid modulates pigmentation, neuroretinal maturation, and corneal transparency in human multiocular organoids","volume":"13","author":"Isla-Magran\u00e9","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.exer.2024.110179_bib39","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/jbiol29","article-title":"Compound developmental eye disorders following inactivation of TGFbeta signaling in neural-crest stem cells","volume":"4","author":"Ittner","year":"2005","journal-title":"J. Biol."},{"key":"10.1016\/j.exer.2024.110179_bib40","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.micinf.2018.04.007","article-title":"On the role of retinoic acid in virus induced inflammatory response in cornea","volume":"20","author":"Jaggi","year":"2018","journal-title":"Microb. Infect."},{"key":"10.1016\/j.exer.2024.110179_bib41","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1126\/science.1136244","article-title":"A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A","volume":"315","author":"Kawaguchi","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.exer.2024.110179_bib42","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1080\/13816810.2016.1227453","article-title":"Vitamin A deficiency due to bi-allelic mutation of RBP4: there's more to it than meets the eye","volume":"38","author":"Khan","year":"2017","journal-title":"Ophthalmic Genet."},{"key":"10.1016\/j.exer.2024.110179_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/nu13093162","article-title":"An updated comprehensive review on vitamin A and carotenoids in breast cancer: mechanisms, genetics, assessment, current evidence, and future clinical implications","volume":"13","author":"Kim","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.exer.2024.110179_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113856","article-title":"Retinol binding protein 4 antagonists and protein synthesis inhibitors: potential for therapeutic development","volume":"226","author":"Kim","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.exer.2024.110179_bib45","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.98222","article-title":"Goblet cell loss abrogates ocular surface immune tolerance","volume":"3","author":"Ko","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.exer.2024.110179_bib46","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1039\/C7FO00021A","article-title":"Are lutein, lycopene, and \u03b2-carotene lost through the digestive process?","volume":"8","author":"Kopec","year":"2017","journal-title":"Food Funct."},{"key":"10.1016\/j.exer.2024.110179_bib47","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1016\/j.ophtha.2012.03.045","article-title":"Treatment of conjunctival and corneal epithelial neoplasia with retinoic acid and topical interferon alfa-2b: long-term follow-up","volume":"119","author":"Krilis","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2024.110179_bib48","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.exer.2016.11.009","article-title":"Endogenous retinoic acid signaling is required for maintenance and regeneration of cornea","volume":"154","author":"Kumar","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.110179_bib49","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ydbio.2010.01.027","article-title":"Retinoic acid signaling in perioptic mesenchyme represses Wnt signaling via induction of Pitx2 and Dkk2","volume":"340","author":"Kumar","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.exer.2024.110179_bib50","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.cell.2011.11.034","article-title":"SnapShot: retinoic acid signaling","volume":"147","author":"Kumar","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.exer.2024.110179_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/cells8111392","article-title":"Regulation of RXR-RAR heterodimers by RXR- and RAR-specific ligands and their combinations","volume":"8","author":"le Maire","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.exer.2024.110179_bib52","doi-asserted-by":"crossref","first-page":"E671","DOI":"10.1503\/cmaj.191568","article-title":"Refractory hypercalcemia owing to vitamin A toxicity in a 4-year-old boy","volume":"192","author":"Lorenzo","year":"2020","journal-title":"CMAJ (Can. Med. Assoc. J.)"},{"key":"10.1016\/j.exer.2024.110179_bib53","first-page":"33","article-title":"Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells","volume":"605","author":"Lotan","year":"1980","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exer.2024.110179_bib54","doi-asserted-by":"crossref","first-page":"E3432","DOI":"10.1073\/pnas.1408780111","article-title":"Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions","volume":"111","author":"Lu","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2024.110179_bib55","doi-asserted-by":"crossref","first-page":"8698","DOI":"10.1073\/pnas.1103802108","article-title":"Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme","volume":"108","author":"Lupo","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2024.110179_bib56","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.pharmtox.46.120604.141156","article-title":"Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis","volume":"46","author":"Mark","year":"2006","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.exer.2024.110179_bib57","doi-asserted-by":"crossref","first-page":"4789","DOI":"10.1242\/dev.02031","article-title":"Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells","volume":"132","author":"Matt","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.exer.2024.110179_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/cells12222600","article-title":"Acne transcriptomics: fundamentals of acne pathogenesis and isotretinoin treatment","volume":"12","author":"Melnik","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.exer.2024.110179_bib59","doi-asserted-by":"crossref","first-page":"5916","DOI":"10.1021\/jf501683s","article-title":"\u03b2-lactoglobulin as a vector for \u03b2-carotene food fortification","volume":"62","author":"Mensi","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.exer.2024.110179_bib60","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1242\/dev.02328","article-title":"Retinoic acid guides eye morphogenetic movements via paracrine signaling but is unnecessary for retinal dorsoventral patterning","volume":"133","author":"Molotkov","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.exer.2024.110179_bib61","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/ejhg.2013.157","article-title":"A missense mutation in ALDH1A3 causes isolated microphthalmia\/anophthalmia in nine individuals from an inbred Muslim kindred","volume":"22","author":"Mory","year":"2014","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.exer.2024.110179_bib62","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1101\/gad.1276605","article-title":"Vax genes ventralize the embryonic eye","volume":"19","author":"Mui","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.exer.2024.110179_bib63","first-page":"641","article-title":"Successful use of topical retinoic acid in severe dry eye due to chronic graft-versus-host disease","volume":"18","author":"Murphy","year":"1996","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.exer.2024.110179_bib64","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1080\/10408398.2018.1509201","article-title":"The success and the challenge of all-trans retinoic acid in the treatment of cancer","volume":"59","author":"Ni","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.exer.2024.110179_bib65","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1194\/jlr.R037648","article-title":"Retinol and retinyl esters: biochemistry and physiology","volume":"54","author":"O'Byrne","year":"2013","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.exer.2024.110179_bib66","doi-asserted-by":"crossref","first-page":"35647","DOI":"10.1074\/jbc.M507924200","article-title":"Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT)","volume":"280","author":"O'Byrne","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2024.110179_bib67","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1086\/512203","article-title":"Mutations in STRA6 cause a broad spectrum of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia, and mental retardation","volume":"80","author":"Pasutto","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.exer.2024.110179_bib68","doi-asserted-by":"crossref","DOI":"10.3390\/nu12040952","article-title":"The role of nutrition and nutritional supplements in ocular surface diseases","volume":"12","author":"Pellegrini","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.exer.2024.110179_bib69","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ejmg.2016.02.004","article-title":"Incomplete penetrance of biallelic ALDH1A3 mutations","volume":"59","author":"Plaisanci\u00e9","year":"2016","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.exer.2024.110179_bib70","doi-asserted-by":"crossref","first-page":"30191","DOI":"10.1074\/jbc.M205046200","article-title":"Muscle expression of human retinol-binding protein (RBP). Suppression of the visual defect of RBP knockout mice","volume":"277","author":"Quadro","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2024.110179_bib71","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1093\/emboj\/18.17.4633","article-title":"Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein","volume":"18","author":"Quadro","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.exer.2024.110179_bib72","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1167\/iovs.05-0820","article-title":"Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases","volume":"46","author":"Radu","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.110179_bib73","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1167\/iovs.07-1470","article-title":"Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following Vitamin A supplementation","volume":"49","author":"Radu","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2024.110179_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2021.100055","article-title":"LRAT coordinates the negative-feedback regulation of intestinal retinoid biosynthesis from \u03b2-carotene","volume":"62","author":"Ramkumar","year":"2021","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.exer.2024.110179_bib75","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1152\/physrev.2000.80.3.1021","article-title":"Retinoids in embryonal development","volume":"80","author":"Ross","year":"2000","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.exer.2024.110179_bib76","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.survophthal.2014.10.001","article-title":"Retinoic acid and the ocular surface","volume":"60","author":"Samarawickrama","year":"2015","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2024.110179_bib77","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ydbio.2008.09.030","article-title":"The temporal requirement for vitamin A in the developing eye: mechanism of action in optic fissure closure and new roles for the vitamin in regulating cell proliferation and adhesion in the embryonic retina","volume":"325","author":"See","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.exer.2024.110179_bib78","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jpeds.2020.12.010","article-title":"Bitot's spots and a bilirubin ring","volume":"231","author":"Sen Sarma","year":"2021","journal-title":"J. Pediatr."},{"key":"10.1016\/j.exer.2024.110179_bib79","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s00439-018-1949-1","article-title":"Genetics of anophthalmia and microphthalmia. Part 2: syndromes associated with anophthalmia-microphthalmia","volume":"138","author":"Slavotinek","year":"2019","journal-title":"Hum. Genet."},{"key":"10.1016\/j.exer.2024.110179_bib80","doi-asserted-by":"crossref","DOI":"10.1242\/dev.167171","article-title":"Lens-regulated retinoic acid signalling controls expansion of the developing eye","volume":"145","author":"Smith","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.exer.2024.110179_bib81","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1350-9462(97)00001-3","article-title":"Xerophthalmia and vitamin A status","volume":"17","author":"Sommer","year":"1998","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2024.110179_bib82","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1093\/jn\/138.10.1835","article-title":"Vitamin a deficiency and clinical disease: an historical overview","volume":"138","author":"Sommer","year":"2008","journal-title":"J. Nutr."},{"key":"10.1016\/j.exer.2024.110179_bib83","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/0002-9394(79)90072-2","article-title":"Vitamin A-responsive punctate keratopathy in xerophthalmia","volume":"87","author":"Sommer","year":"1979","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.exer.2024.110179_bib84","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/S0140-6736(81)92581-2","article-title":"Incidence, prevalence, and scale of blinding malnutrition","volume":"1","author":"Sommer","year":"1981","journal-title":"Lancet"},{"key":"10.1016\/j.exer.2024.110179_bib85","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.ajhg.2013.08.014","article-title":"Recessive and dominant mutations in retinoic acid receptor beta in cases with microphthalmia and diaphragmatic hernia","volume":"93","author":"Srour","year":"2013","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.exer.2024.110179_bib86","doi-asserted-by":"crossref","DOI":"10.3390\/nu14061236","article-title":"Retinoid homeostasis and beyond: how retinol binding protein 4 contributes to health and disease","volume":"14","author":"Steinhoff","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.exer.2024.110179_bib87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2004.08.037","article-title":"Early development of the cranial sensory nervous system: from a common field to individual placodes","volume":"276","author":"Streit","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.exer.2024.110179_bib88","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1002\/mnfr.201200041","article-title":"Effects of physicochemical properties of carotenoids on their bioaccessibility, intestinal cell uptake, and blood and tissue concentrations","volume":"56","author":"Sy","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.exer.2024.110179_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107942","article-title":"Vitamin A in health care: suppression of growth and induction of differentiation in cancer cells by vitamin A and its derivatives and their mechanisms of action","volume":"230","author":"Takahashi","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.exer.2024.110179_bib90","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1136\/bjophthalmol-2015-307411","article-title":"Treatment of partial limbal stem cell deficiency with topical interferon \u03b1-2b and retinoic acid","volume":"100","author":"Tan","year":"2016","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2024.110179_bib91","doi-asserted-by":"crossref","first-page":"7799","DOI":"10.1039\/D3FO02330C","article-title":"Revisiting carotenoids as dietary antioxidants for human health and disease prevention","volume":"14","author":"Terao","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.exer.2024.110179_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104331","article-title":"The potential of retinoids for combination therapy of lung cancer: updates and future directions","volume":"147","author":"Tripathi","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.exer.2024.110179_bib93","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1074\/jbc.R111.303990","article-title":"Metabolism of carotenoids and retinoids related to vision","volume":"287","author":"von Lintig","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2024.110179_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100864","article-title":"Molecular components affecting ocular carotenoid and retinoid homeostasis","volume":"80","author":"von Lintig","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2024.110179_bib95","article-title":"Carotenoid metabolism at the intestinal barrier","volume":"1865","author":"von Lintig","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.exer.2024.110179_bib96","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/nature05479","article-title":"Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression","volume":"445","author":"Wan","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.exer.2024.110179_bib97","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s10875-006-9068-5","article-title":"Retinoic acid enhances the production of IL-10 while reducing the synthesis of IL-12 and TNF-alpha from LPS-stimulated monocytes\/macrophages","volume":"27","author":"Wang","year":"2007","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.exer.2024.110179_bib98","article-title":"The molecular aspects of absorption and metabolism of carotenoids and retinoids in vertebrates","volume":"1865","author":"Widjaja-Adhi","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.exer.2024.110179_bib99","doi-asserted-by":"crossref","first-page":"11530","DOI":"10.1073\/pnas.1714963114","article-title":"Transcription factor ISX mediates the cross talk between diet and immunity","volume":"114","author":"Widjaja-Adhi","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2024.110179_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108850","article-title":"Topical retinoic acid induces corneal strengthening by upregulating transglutaminase 2 in murine cornea","volume":"214","author":"Wu","year":"2022","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2024.110179_bib101","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/intimm\/dxy045","article-title":"Goblet cell-produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow-derived cells","volume":"30","author":"Xiao","year":"2018","journal-title":"Int. Immunol."},{"key":"10.1016\/j.exer.2024.110179_bib102","doi-asserted-by":"crossref","first-page":"6725","DOI":"10.4049\/jimmunol.178.11.6725","article-title":"Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta","volume":"178","author":"Xu","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.exer.2024.110179_bib103","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.67315","article-title":"Canonical NF-\u03baB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid","volume":"10","author":"Yu","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.exer.2024.110179_bib104","first-page":"4583","article-title":"Effects of vitamin A on expressions of apoptosis genes bax and bcl-2 in epithelial cells of corneal tissues induced by benzalkonium chloride in mice with dry eye","volume":"25","author":"Zhang","year":"2019","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res."},{"key":"10.1016\/j.exer.2024.110179_bib105","doi-asserted-by":"crossref","DOI":"10.3390\/nu13124251","article-title":"Excessive vitamin A supplementation increased the incidence of acute respiratory tract infections: a systematic review and meta-analysis","volume":"13","author":"Zhang","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.exer.2024.110179_bib106","doi-asserted-by":"crossref","first-page":"9857","DOI":"10.1073\/pnas.1918540117","article-title":"Regulatory mechanism for the transmembrane receptor that mediates bidirectional vitamin A transport","volume":"117","author":"Zhong","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exer.2024.110179_bib107","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/ni.1774","article-title":"Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo","volume":"10","author":"Zhou","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.exer.2024.110179_bib108","doi-asserted-by":"crossref","first-page":"5155","DOI":"10.1242\/dev.00723","article-title":"Specification of the vertebrate eye by a network of eye field transcription factors","volume":"130","author":"Zuber","year":"2003","journal-title":"Development"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483524004019?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483524004019?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T18:21:54Z","timestamp":1738088514000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483524004019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":108,"alternative-id":["S0014483524004019"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2024.110179","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of vitamin A on the ocular surface","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2024.110179","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110179"}}