{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T05:13:59Z","timestamp":1781673239153,"version":"3.54.5"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015401","name":"Shaanxi Province Key Research and Development Projects","doi-asserted-by":"publisher","award":["2022 KW-43"],"award-info":[{"award-number":["2022 KW-43"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018611","name":"International Science and Technology Cooperation Program of Shanxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018611","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873674"],"award-info":[{"award-number":["81873674"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070947"],"award-info":[{"award-number":["82070947"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301189"],"award-info":[{"award-number":["82301189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.exer.2025.110421","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T10:55:57Z","timestamp":1747047357000},"page":"110421","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Grx2 maintains GSH\/GSSG homeostasis to enhance GPX4-mediated ferroptosis defense in UVB irradiation induced cataract"],"prefix":"10.1016","volume":"257","author":[{"given":"Chenjun","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaona","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.exer.2025.110421_bib1","first-page":"367","article-title":"Action spectrum for cytotoxicity in the UVA- and UVB-Wavelength region in cultured lens epithelial cells","volume":"35","author":"Andley","year":"1994","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.exer.2025.110421_bib2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0925-4439(95)00091-7","article-title":"Failure to withstand oxidative stress induced by phospholipid hydroperoxides as a possible cause of the lens opacities in systemic diseases and ageing","volume":"1315","author":"Babizhayev","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"issue":"16","key":"10.1016\/j.exer.2025.110421_bib3","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/0024-3205(86)90559-X","article-title":"Lipid peroxidation in cataract of the human","volume":"38","author":"Bhuyan","year":"1986","journal-title":"Life Sci."},{"key":"10.1016\/j.exer.2025.110421_bib4","doi-asserted-by":"crossref","DOI":"10.1194\/jlr.TR120000874","article-title":"Lipid conformational order and the etiology of cataract and dry eye","volume":"62","author":"Borchman","year":"2021","journal-title":"J. Lipid Res."},{"issue":"9","key":"10.1016\/j.exer.2025.110421_bib5","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1194\/jlr.R004119","article-title":"Lipids and the ocular lens","volume":"51","author":"Borchman","year":"2010","journal-title":"J. Lipid Res."},{"issue":"1","key":"10.1016\/j.exer.2025.110421_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0162-0134(94)00048-F","article-title":"Antioxidant effect of inorganic ions on UVC and UVB induced lipid peroxidation","volume":"59","author":"Costanzo","year":"1995","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.exer.2025.110421_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2019.107806","article-title":"Epha2 genotype influences ultraviolet radiation induced cataract in mice","volume":"188","author":"Dave","year":"2019","journal-title":"Exp. Eye Res."},{"issue":"11","key":"10.1016\/j.exer.2025.110421_bib8","doi-asserted-by":"crossref","first-page":"7619","DOI":"10.1167\/iovs.14-14471","article-title":"Lifetime exposure to ambient ultraviolet radiation and the risk for cataract extraction and age-related macular degeneration: the Alienor Study","volume":"55","author":"Delcourt","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.exer.2025.110421_bib9","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.exer.2025.110421_bib10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"issue":"1","key":"10.1016\/j.exer.2025.110421_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2021.166287","article-title":"NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury","volume":"1868","author":"Feng","year":"2022","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"1","key":"10.1016\/j.exer.2025.110421_bib12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1089\/152308604771978354","article-title":"Glutaredoxins: glutathione-dependent redox enzymes with functions far beyond a simple thioredoxin backup system","volume":"6","author":"Fernandes","year":"2004","journal-title":"Antioxidants Redox Signal."},{"issue":"9","key":"10.1016\/j.exer.2025.110421_bib13","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/cr.2016.95","article-title":"Ferroptosis is an autophagic cell death process","volume":"26","author":"Gao","year":"2016","journal-title":"Cell Res."},{"issue":"6","key":"10.1016\/j.exer.2025.110421_bib14","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1006\/exer.2000.0912","article-title":"Distribution of ferritin and redox-active transition metals in normal and cataractous human lenses","volume":"71","author":"Garner","year":"2000","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110421_bib15","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.bbrc.2022.04.056","article-title":"The protective mechanism of Grx2 in ultraviolet-B (UVB)-induced cataract formation","volume":"613","author":"Guo","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.exer.2025.110421_bib16","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1751-1097.1993.tb02293.x","article-title":"Concentration dependence of transmission losses in UV-laser irradiated bovine alpha-, beta H-, beta L- and gamma-crystallin solutions","volume":"57","author":"Hott","year":"1993","journal-title":"Photochem. Photobiol."},{"issue":"5","key":"10.1016\/j.exer.2025.110421_bib17","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1167\/iovs.04-1155","article-title":"Human lens phospholipid changes with age and cataract","volume":"46","author":"Huang","year":"2005","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"7","key":"10.1016\/j.exer.2025.110421_bib18","article-title":"Ultraviolet radiation oxidative stress affects eye health","volume":"11","author":"Ivanov","year":"2018","journal-title":"J. Biophot."},{"issue":"1\u20132","key":"10.1016\/j.exer.2025.110421_bib19","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11010-014-2294-x","article-title":"The mechanism of UVB irradiation induced-apoptosis in cataract","volume":"401","author":"Ji","year":"2015","journal-title":"Mol. Cell. Biochem."},{"issue":"5","key":"10.1016\/j.exer.2025.110421_bib20","first-page":"3041","article-title":"UVB induces apoptosis via downregulation of CALML3-dependent JNK1\/2 and ERK1\/2 pathways in cataract","volume":"41","author":"Jia","year":"2018","journal-title":"Int. J. Mol. Med."},{"issue":"4","key":"10.1016\/j.exer.2025.110421_bib21","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.exer.2025.110421_bib22","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.exer.2025.110421_bib23","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.redox.2017.10.019","article-title":"Glutaredoxin-2 controls cardiac mitochondrial dynamics and energetics in mice, and protects against human cardiac pathologies","volume":"14","author":"Kanaan","year":"2018","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.exer.2025.110421_bib24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jdermsci.2021.06.005","article-title":"Intracellular oxidative stress induced by calcium influx initiates the activation of phagocytosis in keratinocytes accumulating at S-phase of the cell cycle after UVB irradiation","volume":"103","author":"Katsuyama","year":"2021","journal-title":"J. Dermatol. Sci."},{"issue":"11","key":"10.1016\/j.exer.2025.110421_bib25","doi-asserted-by":"crossref","first-page":"6762","DOI":"10.1167\/iovs.15-17201","article-title":"Number of people blind or visually impaired by cataract worldwide and in world regions, 1990 to 2010","volume":"56","author":"Khairallah","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"12","key":"10.1016\/j.exer.2025.110421_bib26","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.3109\/02713689009003475","article-title":"Ultraviolet light induced DNA damage and repair in Bovine lens epithelial cells","volume":"9","author":"Kleiman","year":"1990","journal-title":"Curr. Eye Res."},{"issue":"1","key":"10.1016\/j.exer.2025.110421_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-72413-9","article-title":"Synchrotron-based FTIR microspectroscopy of protein aggregation and lipids peroxidation changes in human cataractous lens epithelial cells","volume":"10","author":"Kreuzer","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.exer.2025.110421_bib28","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/ICU.0000000000000340","article-title":"The global state of cataract blindness","volume":"28","author":"Lee","year":"2017","journal-title":"Curr. Opin. Ophthalmol."},{"issue":"9","key":"10.1016\/j.exer.2025.110421_bib29","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1002\/glia.23178","article-title":"Iron-sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia","volume":"65","author":"Lepka","year":"2017","journal-title":"Glia"},{"issue":"2","key":"10.1016\/j.exer.2025.110421_bib30","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.exer.2025.110421_bib31","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0891-5849(96)02050-3","article-title":"Lens epithelial cell apoptosis is an early event in the development of UVB-induced cataract","volume":"20","author":"Li","year":"1996","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exer.2025.110421_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.604210","article-title":"Grx2 regulates skeletal muscle mitochondrial structure and autophagy","volume":"12","author":"Liaghati","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.exer.2025.110421_bib33","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.exer.2016.05.026","article-title":"Solar ultraviolet radiation cataract","volume":"156","author":"L\u00f6fgren","year":"2017","journal-title":"Exp. Eye Res."},{"issue":"7","key":"10.1016\/j.exer.2025.110421_bib34","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.bbagen.2008.11.001","article-title":"Iron homeostasis and eye disease","volume":"1790","author":"Loh","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"issue":"10","key":"10.1016\/j.exer.2025.110421_bib35","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1177\/153537020422901012","article-title":"Apoptotic and necrotic mechanisms of stress-induced human lens epithelial cell death","volume":"229","author":"Long","year":"2004","journal-title":"Exp Biol Med (Maywood)"},{"issue":"7860","key":"10.1016\/j.exer.2025.110421_bib36","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41586-021-03539-7","article-title":"DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer","volume":"593","author":"Mao","year":"2021","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.exer.2025.110421_bib37","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1128\/aem.49.5.1348-1349.1985","article-title":"Application of a simplified method for recovery of Yersinia enterocolitica from surface waters","volume":"49","author":"Marinelli","year":"1985","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.exer.2025.110421_bib38","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.redox.2015.08.006","article-title":"The role of lipoxygenases in pathophysiology; new insights and future perspectives","volume":"6","author":"Mashima","year":"2015","journal-title":"Redox Biol."},{"issue":"10","key":"10.1016\/j.exer.2025.110421_bib39","doi-asserted-by":"crossref","first-page":"6789","DOI":"10.1167\/iovs.13-12644","article-title":"UV-B-induced DNA damage and repair in the mouse lens","volume":"54","author":"Mesa","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110421_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.114048","article-title":"Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6\/p-Nrf2\/GPX4 and SIRT6\/NCOA4\/FTH1 pathways","volume":"157","author":"Mi","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.exer.2025.110421_bib41","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1667\/0033-7587(2002)157[0402:TAVCAE]2.0.CO;2","article-title":"Topical antioxidant vitamins C and E prevent UVB-radiation-induced peroxidation of eicosapentaenoic acid in pig skin","volume":"157","author":"Moison","year":"2002","journal-title":"Radiat. Res."},{"key":"10.1016\/j.exer.2025.110421_bib42","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4162465","article-title":"Neuronal damage induced by Perinatal Asphyxia is attenuated by postinjury Glutaredoxin-2 administration","author":"Romero","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.exer.2025.110421_bib43","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.freeradbiomed.2018.09.014","article-title":"Role of GPX4 in ferroptosis and its pharmacological implication","volume":"133","author":"Seibt","year":"2019","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.exer.2025.110421_bib44","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1021\/acscentsci.7b00589","article-title":"Resolving the role of lipoxygenases in the initiation and execution of ferroptosis","volume":"4","author":"Shah","year":"2018","journal-title":"ACS Cent. Sci."},{"issue":"11","key":"10.1016\/j.exer.2025.110421_bib45","doi-asserted-by":"crossref","first-page":"11355","DOI":"10.1021\/acsnano.8b06201","article-title":"Fenton-reaction-acceleratable magnetic nanoparticles for ferroptosis therapy of orthotopic brain tumors","volume":"12","author":"Shen","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.exer.2025.110421_bib46","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.freeradbiomed.2020.04.024","article-title":"UVA irradiation increases ferrous iron release from human skin fibroblast and endothelial cell ferritin: consequences for cell senescence and aging","volume":"155","author":"Smith","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"14","key":"10.1016\/j.exer.2025.110421_bib47","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.exer.2025.110421_bib48","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.tcb.2020.02.009","article-title":"Emerging mechanisms and disease relevance of ferroptosis","volume":"30","author":"Stockwell","year":"2020","journal-title":"Trends Cell Biol."},{"issue":"1","key":"10.1016\/j.exer.2025.110421_bib49","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bbrc.2020.07.028","article-title":"Down-regulation of CRTAC1 attenuates UVB-induced pyroptosis in HLECs through inhibiting ROS production","volume":"532","author":"Sun","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.exer.2025.110421_bib50","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41422-019-0164-5","article-title":"The molecular machinery of regulated cell death","volume":"29","author":"Tang","year":"2019","journal-title":"Cell Res."},{"issue":"12","key":"10.1016\/j.exer.2025.110421_bib51","doi-asserted-by":"crossref","first-page":"9179","DOI":"10.1002\/jcp.26954","article-title":"Ferritinophagy\/ferroptosis: Iron-Related newcomers in human diseases","volume":"233","author":"Tang","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.exer.2025.110421_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2024.1449216","article-title":"Ferroptosis: a new perspective on the pathogenesis of radiation-induced cataracts","volume":"12","author":"Tang","year":"2024","journal-title":"Front. Public Health"},{"key":"10.1016\/j.exer.2025.110421_bib53","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: the role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.exer.2025.110421_bib54","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0005-2760(82)90150-3","article-title":"Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides","volume":"710","author":"Ursini","year":"1982","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exer.2025.110421_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102143","article-title":"Keratinocyte death by ferroptosis initiates skin inflammation after UVB exposure","volume":"47","author":"Vats","year":"2021","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.exer.2025.110421_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejcb.2019.151058","article-title":"Mitochondria regulation in ferroptosis","volume":"99","author":"Wang","year":"2020","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.exer.2025.110421_bib57","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.freeradbiomed.2023.11.020","article-title":"Glycine recalibrates iron homeostasis of lens epithelial cells by blocking lysosome-dependent ferritin degradation","volume":"210","author":"Wang","year":"2024","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.exer.2025.110421_bib58","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1186\/s12886-023-03205-8","article-title":"Lens epithelium cell ferroptosis mediated by m(6)A-lncRNA and GPX4 expression in lens tissue of age-related cataract","volume":"23","author":"Wang","year":"2023","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.exer.2025.110421_bib59","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.freeradbiomed.2021.02.010","article-title":"Aging lens epithelium is susceptible to ferroptosis","volume":"167","author":"Wei","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"48","key":"10.1016\/j.exer.2025.110421_bib60","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2407842121","article-title":"Deficiency in glutathione peroxidase 4 (GPX4) results in abnormal lens development and newborn cataract","volume":"121","author":"Wei","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"11","key":"10.1016\/j.exer.2025.110421_bib61","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1016\/j.freeradbiomed.2011.09.011","article-title":"Glutaredoxin 2 knockout increases sensitivity to oxidative stress in mouse lens epithelial cells","volume":"51","author":"Wu","year":"2011","journal-title":"Free Radic. Biol. Med."},{"issue":"52","key":"10.1016\/j.exer.2025.110421_bib62","doi-asserted-by":"crossref","first-page":"36125","DOI":"10.1074\/jbc.M114.620047","article-title":"Glutaredoxin 2 (Grx2) gene deletion induces early onset of age-dependent cataracts in mice","volume":"289","author":"Wu","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.exer.2025.110421_bib63","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1562\/2005-08-17-RA-652","article-title":"Inhibitory effects of mizolastine on ultraviolet B-induced leukotriene B4 production and 5-lipoxygenase expression in normal human dermal fibroblasts in vitro","volume":"82","author":"Yan","year":"2006","journal-title":"Photochem. Photobiol."},{"issue":"11","key":"10.1016\/j.exer.2025.110421_bib64","doi-asserted-by":"crossref","first-page":"7276","DOI":"10.1167\/iovs.12-10482","article-title":"Ultraviolet radiation-induced cataract in mice: the effect of age and the potential biochemical mechanism","volume":"53","author":"Zhang","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"11","key":"10.1016\/j.exer.2025.110421_bib65","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.31330","article-title":"LncRNA MEG3 regulates ferroptosis of lens epithelial cells via PTBP1\/GPX4 axis to participate in age-related cataract","volume":"239","author":"Zhang","year":"2024","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.exer.2025.110421_bib66","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cca.2017.07.010","article-title":"New cataract markers: mechanisms of disease","volume":"472","author":"Zhu","year":"2017","journal-title":"Clin. Chim. Acta Int. J. Clin. Chem."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525001927?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525001927?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T04:22:27Z","timestamp":1778473347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483525001927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":66,"alternative-id":["S0014483525001927"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2025.110421","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Grx2 maintains GSH\/GSSG homeostasis to enhance GPX4-mediated ferroptosis defense in UVB irradiation induced cataract","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2025.110421","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110421"}}