{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:04:34Z","timestamp":1789430674527,"version":"build-2803163510"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"am","delay-in-days":294,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01 EY026155"],"award-info":[{"award-number":["R01 EY026155"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01 EY033346"],"award-info":[{"award-number":["R01 EY033346"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.exer.2025.110434","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T10:52:46Z","timestamp":1747651966000},"page":"110434","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Functional characterization of CatTohm, a mouse AQP0 mutation that causes oxidative stress, cytotoxicity, dominant congenital lens cataract and microphthalmia"],"prefix":"10.1016","volume":"257","author":[{"given":"Sindhu","family":"Kumari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Okamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2453-2741","authenticated-orcid":false,"given":"Kulandaiappan","family":"Varadaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2025.110434_bib1","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/ar.a.10080","article-title":"Lens structure in MIP-deficient mice","volume":"273","author":"Al-Ghoul","year":"2003","journal-title":"Anat. Rec. A Discov. Mol. Cell Evol. Biol."},{"key":"10.1016\/j.exer.2025.110434_bib2","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20231725","article-title":"Protective roles of peroxiporins AQP0 and AQP11 in human astrocyte and neuronal cell lines in response to oxidative and inflammatory stressors","volume":"44","author":"Amro","year":"2024","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.exer.2025.110434_bib3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/00004397-199203210-00011","article-title":"Infantile cataracts","volume":"32","author":"Arkin","year":"1992","journal-title":"Int. Ophthalmol. Clin."},{"key":"10.1016\/j.exer.2025.110434_bib4","first-page":"2448","article-title":"The membrane proteome of the mouse lens fiber cell","volume":"15","author":"Bassnett","year":"2009","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2025.110434_bib6","doi-asserted-by":"crossref","first-page":"7162","DOI":"10.1073\/pnas.92.16.7162","article-title":"Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide\/superoxide in cortical cell cultures","volume":"92","author":"Bonfoco","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.exer.2025.110434_bib7","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nsmb1275","article-title":"A novel tripartite motif involved in aquaporin topogenesis, monomer folding and tetramerization","volume":"14","author":"Buck","year":"2007","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.exer.2025.110434_bib8","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.tcb.2005.09.005","article-title":"Cell toxicity and conformational disease","volume":"15","author":"Carrell","year":"2005","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.exer.2025.110434_bib9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1056\/NEJMra010772","article-title":"Alpha1-antitrypsin deficiency: a model for conformational diseases","volume":"346","author":"Carrell","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.exer.2025.110434_bib10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1006\/exer.1993.1111","article-title":"The effect and recovery of long-term H2O2 exposure on lens morphology and biochemistry","volume":"57","author":"Cui","year":"1993","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110434_bib11","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/cbin.11137","article-title":"Cell death: a review of the major forms of apoptosis, necrosis and autophagy","volume":"43","author":"D'Arcy","year":"2019","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.exer.2025.110434_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2022.101152","article-title":"Regulation of lens water content: effects on the physiological optics of the lens","volume":"95","author":"Donaldson","year":"2023","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2025.110434_bib14","first-page":"5","article-title":"Blindness and partial sight in England and Wales: april 1990\u2013March 1991","volume":"28","author":"Evans","year":"1996","journal-title":"Health Trends"},{"key":"10.1016\/j.exer.2025.110434_bib15","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/eye.1999.118","article-title":"Mouse models of congenital cataract","volume":"13","author":"Graw","year":"1999","journal-title":"Eye"},{"key":"10.1016\/j.exer.2025.110434_bib16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1350-9462(98)00018-4","article-title":"Cataract mutations and lens development","volume":"18","author":"Graw","year":"1999","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2025.110434_bib17","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.exer.2012.12.004","article-title":"Verification and spatial localization of aquaporin-5 in the ocular lens","volume":"108","author":"Grey","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110434_bib66","doi-asserted-by":"crossref","first-page":"C1332","DOI":"10.1152\/ajpcell.1998.274.5.C1332","article-title":"Aquaporins in complex tissues: distribution of aquaporins 1-5 in human and rat eye","volume":"274","author":"Hamann","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.exer.2025.110434_bib18","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1146\/annurev.cellbio.18.011402.160624","article-title":"Transcriptional and translational control in the mammalian unfolded protein response","volume":"18","author":"Harding","year":"2002","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.exer.2025.110434_bib19","doi-asserted-by":"crossref","first-page":"14045","DOI":"10.1073\/pnas.0405274101","article-title":"The channel architecture of aquaporin 0 at a 2.2-A resolution","volume":"101","author":"Harries","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.exer.2025.110434_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108395","article-title":"H2O2-induced cataract as a model of age-related cataract: lessons learned from overexpressing the proteasome activator PA28\u03b1\u03b2 in mouse eye lens","volume":"203","author":"Hernebring","year":"2021","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110434_bib21","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1755-3768.1971.tb02963.x","article-title":"Genetic counseling in sporadic cases of congenital cataracts","volume":"49","author":"Jensen","year":"1971","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.exer.2025.110434_bib22","doi-asserted-by":"crossref","first-page":"6121","DOI":"10.1021\/bi00186a011","article-title":"Structure and function in rhodopsin. 7. Point mutations associated with autosomal dominant retinitis pigmentosa","volume":"33","author":"Kaushal","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.exer.2025.110434_bib23","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1110\/ps.0225503","article-title":"In vitro unfolding, refolding, and polymerization of human \u03b3-crystallin, a protein involved in cataract formation","volume":"12","author":"Kosinski-Collins","year":"2003","journal-title":"Protein Sci."},{"issue":"390","key":"10.1016\/j.exer.2025.110434_bib24","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.bbrc.2009.10.103","article-title":"Intact AQP0 performs cell-to-cell adhesion","volume":"18","author":"Kumari","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2025.110434_bib25","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.bbadis.2011.04.001","article-title":"Unique and analogous functions of aquaporin 0 for fiber cell architecture and ocular lens transparency","volume":"1812","author":"Kumari","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exer.2025.110434_bib78","first-page":"957","article-title":"Spatial expression of aquaporin 5 in mammalian cornea and lens, and regulation of its localization by phosphokinase A","volume":"18","author":"Kumari","year":"2012","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2025.110434_bib26","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.exer.2013.09.019","article-title":"Functional characterization of an AQP0 missense mutation, R33C, that causes dominant congenital lens cataract, reveals impaired cell-to-cell adhesion","volume":"116","author":"Kumari","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110434_bib67","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.bbrc.2014.09.032","article-title":"Aquaporin 0 plays a pivotal role in refractive index gradient development in mammalian eye lens to prevent spherical aberration","volume":"452","author":"Kumari","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2025.110434_bib68","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0014-4835(05)80129-0","article-title":"Ion,water and neutral solute transport in Xenopus oocytes expressing frog lens MIP","volume":"61","author":"Kushmerick","year":"1995","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110434_bib27","series-title":"Principles and Practice of Ophthalmology","first-page":"461","article-title":"Lens","author":"Lambert","year":"1994"},{"key":"10.1016\/j.exer.2025.110434_bib28","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/s42003-021-01849-0","article-title":"Development of a potent embryonic chick lens model for studying congenital cataracts in vivo","volume":"4","author":"Li","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.exer.2025.110434_bib29","article-title":"Beyond the channels: adhesion functions of Aquaporin 0 and Connexin 50 in lens development","volume":"10","author":"Li","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.exer.2025.110434_bib30","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1242\/jcs.00408","article-title":"The unfolded protein response","volume":"116","author":"Liu","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.exer.2025.110434_bib31","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1152\/physrev.1997.77.1.21","article-title":"Physiological properties of the normal lens","volume":"77","author":"Mathias","year":"1997","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.exer.2025.110434_bib32","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1017\/S0016672300027129","article-title":"A gene location for the inheritance of the Cataract Fraser (Catfr) mouse congenital cataract","volume":"49","author":"Muggleton-Harris","year":"1987","journal-title":"Genet. Res."},{"key":"10.1016\/j.exer.2025.110434_bib69","doi-asserted-by":"crossref","first-page":"9010","DOI":"10.1074\/jbc.270.15.9010","article-title":"Water channel properties of major intrinsic protein of lens","volume":"270","author":"Mulders","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2025.110434_bib33","doi-asserted-by":"crossref","first-page":"454","DOI":"10.18240\/ijo.2024.03.06","article-title":"Novel MIP gene mutation causes autosomal-dominant congenital cataract","volume":"17","author":"Ni","year":"2024","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110434_bib34","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0888-7543(03)00029-6","article-title":"Bilateral congenital cataracts result from a gain-of-function mutation in the gene for aquaporin-0 in mice","volume":"81","author":"Okamura","year":"2003","journal-title":"Genomics"},{"key":"10.1016\/j.exer.2025.110434_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150320","article-title":"Aquaporin-0-protein interactions elucidated by crosslinking mass spectrometry","volume":"727","author":"O'Neale","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2025.110434_bib36","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1038\/s12276-023-01078-x","article-title":"Diversity and complexity of cell death: a historical review","volume":"55","author":"Park","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.exer.2025.110434_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2024.109828","article-title":"Verification of the gene and protein expression of the aquaglyceroporin AQP3 in the mammalian lens","volume":"240","author":"Petrova","year":"2024","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110434_bib38","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.bbamem.2006.04.021","article-title":"Molecular mechanisms of aquaporin biogenesis by the endoplasmic reticulum Sec61 translocon","volume":"1758","author":"Pitonzo","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exer.2025.110434_bib39","first-page":"3247","article-title":"Glutathione peroxidase-1 deficiency leads to increased nuclear light scattering, membrane damage, and cataract formation in gene-knockout mice","volume":"42","author":"Reddy","year":"2001","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110434_bib40","doi-asserted-by":"crossref","first-page":"6005","DOI":"10.1093\/emboj\/cdf609","article-title":"Altered aggregation properties of mutant \u03b3-crystallins cause inherited cataract","volume":"21","author":"Sandilands","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.exer.2025.110434_bib41","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.bbagen.2013.10.037","article-title":"Aquaporins in the eye: expression, function, and roles in ocular disease","volume":"1840","author":"Schey","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exer.2025.110434_bib42","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.3390\/ijms18122693","article-title":"The role of aquaporins in ocular lens homeostasis","volume":"18","author":"Schey","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2025.110434_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.882550","article-title":"Lens aquaporins in health and disease: location is everything","volume":"13","author":"Schey","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.exer.2025.110434_bib45","doi-asserted-by":"crossref","first-page":"913","DOI":"10.3109\/02713689309020398","article-title":"Aberrant expression of the gene for lens major intrinsic protein in the CAT mouse","volume":"12","author":"Shiels","year":"1993","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2025.110434_bib46","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/ng0296-212","article-title":"Mutations in the founder of the MIP gene family underlie cataract development in the mouse","volume":"12","author":"Shiels","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exer.2025.110434_bib47","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1096\/fj.99-1071com","article-title":"Disruption of lens fiber cell architecture in mice expressing a chimeric AQP0-LTR protein","volume":"14","author":"Shiels","year":"2000","journal-title":"FASEB J."},{"key":"10.1016\/j.exer.2025.110434_bib48","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1152\/physiolgenomics.00078.2001","article-title":"Optical dysfunction of the crystalline lens in aquaporin-0-deficient mice","volume":"7","author":"Shiels","year":"2001","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.exer.2025.110434_bib50","first-page":"617","article-title":"Oxidative stress: damage to intact cells and organs","volume":"311","author":"Sies","year":"1985","journal-title":"Philos. Trans. R. Soc. B"},{"key":"10.1016\/j.exer.2025.110434_bib51","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.bbrc.2015.04.138","article-title":"Role of aquaporin 0 in lens biomechanics","volume":"462","author":"Sindhu Kumari","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2025.110434_bib52","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1007\/s00109-003-0464-5","article-title":"Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution","volume":"81","author":"Stefani","year":"2003","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.exer.2025.110434_bib53","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0925-4439(01)00031-X","article-title":"Glycation decreases calmodulin binding to lens transmembrane protein","volume":"1536","author":"Swamy-Mruthinti","year":"2001","journal-title":"MIP. Biochim. Biophys. Acta."},{"key":"10.1016\/j.exer.2025.110434_bib54","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1172\/JCI2303","article-title":"Defective aquaporin-2 trafficking in nephrogenic diabetes insipidus and correction by chemical chaperones","volume":"101","author":"Tamarappoo","year":"1998","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.exer.2025.110434_bib55","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.exer.2004.12.007","article-title":"Age-related nuclear cataract-oxidation is the key","volume":"80","author":"Truscott","year":"2005","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110434_bib71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-1119(94)90723-4","article-title":"Denaturants or cosolvents improve the specificityof PCR amplification of a G \u00fe C-rich DNA using genetically-engineered DNA polymerases","volume":"140","author":"Varadaraj","year":"1994","journal-title":"Gene"},{"key":"10.1016\/j.exer.2025.110434_bib72","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0378-1119(96)00018-2","article-title":"Actin-encoding cDNAs and geneexpression during the intermolt cycle of the Bermuda land crab Gecarcinus lateralis","volume":"171","author":"Varadaraj","year":"1996","journal-title":"Gene"},{"key":"10.1016\/j.exer.2025.110434_bib56","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s002329900549","article-title":"The role of MIP in lens fiber cell membrane transport","volume":"170","author":"Varadaraj","year":"1999","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.exer.2025.110434_bib73","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1167\/iovs.04-1217","article-title":"Regulation of aquaporin water permeability in the lens","volume":"46","author":"Varadaraj","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110434_bib76","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1002\/dvdy.21125","article-title":"Functional expression of aquaporins in embryonic, postnatal, and adult mouse lenses","volume":"236","author":"Varadaraj","year":"2007","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.exer.2025.110434_bib57","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.exer.2008.04.001","article-title":"Functional characterization of a human aquaporin 0 mutation that leads to a congenital dominant lens cataract","volume":"87","author":"Varadaraj","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110434_bib58","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.exer.2010.06.013","article-title":"Transgenic expression of AQP1 in the fiber cells of AQP0 knockout mouse: effects on lens transparency","volume":"91","author":"Varadaraj","year":"2010","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110434_bib79","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1167\/iovs.19-26787","article-title":"C-Terminal end of Aquaporin 0 regulates lens gap junction channel function","volume":"60","author":"Varadaraj","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110434_bib59","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.bbrc.2020.02.031","article-title":"Lens aquaporins function as peroxiporins to facilitate membrane transport of hydrogen peroxide","volume":"524","author":"Varadaraj","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2025.110434_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108645","article-title":"Deletion of beaded filament proteins or the C-terminal end of Aquaporin 0 causes analogous abnormal distortion aberrations in mouse lens","volume":"209","author":"Varadaraj","year":"2021","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110434_bib61","first-page":"11","article-title":"GPX1 knockout, not catalase knockout, causes accelerated abnormal optical aberrations and cataract in the aging lens","volume":"28","author":"Varadaraj","year":"2022","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2025.110434_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2024.109957","article-title":"Effect of hydrogen peroxide on lens transparency, intracellular pH, gap junction coupling, hydrostatic pressure and membrane water permeability","volume":"245","author":"Varadaraj","year":"2024","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110434_bib63","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00232-008-9141-5","article-title":"The effects of GPX-1 knockout on membrane transport and intracellular homeostasis in the lens","volume":"227","author":"Wang","year":"2009","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.exer.2025.110434_bib64","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050737","article-title":"A 5-bp insertion in Mip causes recessive congenital cataract in KFRS4\/Kyo rats","volume":"7","author":"Watanabe","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2025.110434_bib65","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/j.bbadis.2016.05.003","article-title":"Lens ER-stress response during cataract development in Mip-mutant mice","volume":"1862","author":"Zhou","year":"2016","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525002052?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525002052?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T04:23:48Z","timestamp":1778473428000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483525002052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":71,"alternative-id":["S0014483525002052"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2025.110434","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional characterization of CatTohm, a mouse AQP0 mutation that causes oxidative stress, cytotoxicity, dominant congenital lens cataract and microphthalmia","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2025.110434","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110434"}}