{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:05:40Z","timestamp":1789128340166,"version":"build-2803163510"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100008752","name":"American Association of Neurological Surgeons","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008752","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["110-2314-B-320-003-MY3"],"award-info":[{"award-number":["110-2314-B-320-003-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["112-2811-B-320-004"],"award-info":[{"award-number":["112-2811-B-320-004"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["113-2811-B-415-001"],"award-info":[{"award-number":["113-2811-B-415-001"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.exer.2025.110489","type":"journal-article","created":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T02:23:33Z","timestamp":1749867813000},"page":"110489","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Tailoring UPS-to-autophagy transition to restore RGC prosperity and functionality in a rodent traumatic optic neuropathy model"],"prefix":"10.1016","volume":"258","author":[{"given":"Ching-Yun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Ying","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Yu","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Yi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6060-3095","authenticated-orcid":false,"given":"Shun-Ping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2025.110489_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.860070","article-title":"Neuroinflammation, microglia and implications for retinal ganglion cell survival and axon regeneration in traumatic optic neuropathy","volume":"13","author":"Au","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exer.2025.110489_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0235925","article-title":"An Angelman syndrome substitution in the HECT E3 ubiquitin ligase C-terminal Lobe of E6AP affects protein stability and activity","volume":"15","author":"Beasley","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2025.110489_bib3","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/s41590-023-01437-w","article-title":"Temporal single-cell atlas of non-neuronal retinal cells reveals dynamic, coordinated multicellular responses to central nervous system injury","volume":"24","author":"Benhar","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.exer.2025.110489_bib4","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nsmb.2780","article-title":"New insights into ubiquitin E3 ligase mechanism","volume":"21","author":"Berndsen","year":"2014","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.exer.2025.110489_bib5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/01.WCB.0000111614.19196.04","article-title":"Pathophysiology of cerebral ischemia and brain trauma: similarities and differences","volume":"24","author":"Bramlett","year":"2004","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.exer.2025.110489_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10091466","article-title":"The effects of two Nrf2 activators, bardoxolone methyl and Omaveloxolone, on retinal ganglion cell survival during ischemic optic neuropathy","volume":"10","author":"Chien","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.exer.2025.110489_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115861","article-title":"Protective effects of compound M01 on retinal ganglion cells in experimental anterior ischemic optic neuropathy by inhibiting TXNIP\/NLRP3 inflammasome pathway","volume":"169","author":"Chien","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.exer.2025.110489_bib8","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.abg8145","article-title":"NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome","volume":"17","author":"Coombs","year":"2024","journal-title":"Sci. Signal."},{"key":"10.1016\/j.exer.2025.110489_bib9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1479-7364-7-13","article-title":"Update on the Kelch-like (KLHL) gene family","volume":"7","author":"Dhanoa","year":"2013","journal-title":"Hum. Genom."},{"key":"10.1016\/j.exer.2025.110489_bib10","first-page":"153","article-title":"Autophagy as a universal intracellular process. A comment on the 2016 nobel prize in physiology or medicine","volume":"63","author":"Dlugonska","year":"2017","journal-title":"Ann Parasitol"},{"key":"10.1016\/j.exer.2025.110489_bib11","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1111\/ejn.12710","article-title":"Tumor necrosis factor-alpha mediates activation of NF-kappaB and JNK signaling cascades in retinal ganglion cells and astrocytes in opposite ways","volume":"40","author":"Dvoriantchikova","year":"2014","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.exer.2025.110489_bib12","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/hmg\/ddx394","article-title":"HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo","volume":"27","author":"Ehrnhoefer","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2025.110489_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.gim.2022.10.006","article-title":"Biallelic variants in HECT E3 paralogs, HECTD4 and UBE3C, encoding ubiquitin ligases cause neurodevelopmental disorders that overlap with Angelman syndrome","volume":"25","author":"Faqeih","year":"2023","journal-title":"Genet. Med."},{"key":"10.1016\/j.exer.2025.110489_bib14","doi-asserted-by":"crossref","first-page":"6301","DOI":"10.1172\/JCI138234","article-title":"HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection","volume":"130","author":"Guo","year":"2020","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.exer.2025.110489_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23073882","article-title":"The roles of NEDD4 subfamily of HECT E3 ubiquitin ligases in neurodevelopment and neurodegeneration","volume":"23","author":"Haouari","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2025.110489_bib16","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature04724","article-title":"Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice","volume":"441","author":"Hara","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.exer.2025.110489_bib17","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1159\/000357736","article-title":"Factors influencing the retrograde labeling of retinal ganglion cells with fluorogold in an animal optic nerve crush model","volume":"51","author":"Huang","year":"2014","journal-title":"Ophthalmic Res."},{"key":"10.1016\/j.exer.2025.110489_bib18","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1177\/1747493018778713","article-title":"Multisociety consensus quality improvement revised consensus statement for endovascular therapy of acute ischemic stroke","volume":"13","author":"World Stroke","year":"2018","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.exer.2025.110489_bib19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ymeth.2014.11.021","article-title":"LC3- and p62-based biochemical methods for the analysis of autophagy progression in Mammalian cells","volume":"75","author":"Jiang","year":"2015","journal-title":"Methods"},{"key":"10.1016\/j.exer.2025.110489_bib20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12929-018-0470-0","article-title":"Ubiquitination by HUWE1 in tumorigenesis and beyond","volume":"25","author":"Kao","year":"2018","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.exer.2025.110489_bib21","first-page":"166","article-title":"Traumatic optic neuropathy - case report with discussion on diagnostic procedures and therapy","volume":"57","author":"Kastelan","year":"2018","journal-title":"Acta Clin. Croat."},{"key":"10.1016\/j.exer.2025.110489_bib22","doi-asserted-by":"crossref","first-page":"6064","DOI":"10.1073\/pnas.0909794107","article-title":"Mechanisms of acute axonal degeneration in the optic nerve in vivo","volume":"107","author":"Knoferle","year":"2010","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.exer.2025.110489_bib23","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1038\/nprot.2011.403","article-title":"Imaging of rat optic nerve axons in vivo","volume":"6","author":"Koch","year":"2011","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.exer.2025.110489_bib24","doi-asserted-by":"crossref","first-page":"14489","DOI":"10.1073\/pnas.0701311104","article-title":"Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration","volume":"104","author":"Komatsu","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2025.110489_bib25","doi-asserted-by":"crossref","first-page":"710","DOI":"10.3389\/fneur.2017.00710","article-title":"Patterns of retinal ganglion cell damage in neurodegenerative disorders: parvocellular vs magnocellular degeneration in optical coherence tomography studies","volume":"8","author":"La Morgia","year":"2017","journal-title":"Front. Neurol."},{"key":"10.1016\/j.exer.2025.110489_bib26","doi-asserted-by":"crossref","first-page":"5767","DOI":"10.1038\/s41598-021-85181-x","article-title":"Characterization of the role of autophagy in retinal ganglion cell survival over time using a rat model of chronic ocular hypertension","volume":"11","author":"Lee","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2025.110489_bib27","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/S0161-6420(99)00707-1","article-title":"The treatment of traumatic optic neuropathy: the international optic nerve trauma study","volume":"106","author":"Levin","year":"1999","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2025.110489_bib28","article-title":"Oroxylin A promotes retinal ganglion cell survival in a rat optic nerve crush model","volume":"12","author":"Lin","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2025.110489_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-kappaB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.exer.2025.110489_bib30","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejmech.2017.09.011","article-title":"1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma","volume":"140","author":"Liu","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.exer.2025.110489_bib31","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1177\/0271678X18810617","article-title":"Molecular switching from ubiquitin-proteasome to autophagy pathways in mice stroke model","volume":"40","author":"Liu","year":"2020","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.exer.2025.110489_bib32","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.exer.2025.110489_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013984","article-title":"Enrichment map: a network-based method for gene-set enrichment visualization and interpretation","volume":"5","author":"Merico","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2025.110489_bib34","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.4161\/auto.29409","article-title":"BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta: implications for a proteasome-to-autophagy switch","volume":"10","author":"Minoia","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.exer.2025.110489_bib35","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1212\/01.WNL.0000072262.14931.80","article-title":"Rapsyn N88K is a frequent cause of congenital myasthenic syndromes in European patients","volume":"60","author":"Muller","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.exer.2025.110489_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.03.002","article-title":"Autophagy in axonal degeneration in glaucomatous optic neuropathy","volume":"47","author":"Munemasa","year":"2015","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2025.110489_bib37","doi-asserted-by":"crossref","first-page":"8195","DOI":"10.1074\/jbc.M808230200","article-title":"Control of rapsyn stability by the CUL-3-containing E3 ligase complex","volume":"284","author":"Nam","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2025.110489_bib38","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/nm.3232","article-title":"The role of autophagy in neurodegenerative disease","volume":"19","author":"Nixon","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.exer.2025.110489_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.905906","article-title":"The giant E3 ligase HUWE1 is linked to tumorigenesis, spermatogenesis, intellectual disability, and inflammatory diseases","volume":"12","author":"Qi","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.exer.2025.110489_bib40","doi-asserted-by":"crossref","first-page":"698","DOI":"10.2174\/1871527311312050015","article-title":"Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities","volume":"12","author":"Rodrigo","year":"2013","journal-title":"CNS Neurol. Disord.: Drug Targets"},{"key":"10.1016\/j.exer.2025.110489_bib41","doi-asserted-by":"crossref","first-page":"286","DOI":"10.4161\/auto.8.2.18982","article-title":"Axonal damage, autophagy and neuronal survival","volume":"8","author":"Rodriguez-Muela","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.exer.2025.110489_bib42","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/cdd.2011.88","article-title":"Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice","volume":"19","author":"Rodriguez-Muela","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.exer.2025.110489_bib43","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1167\/iovs.15-17841","article-title":"Apoptotic retinal ganglion cell death after optic nerve transection or crush in mice: delayed RGC loss with BDNF or a caspase 3 inhibitor","volume":"57","author":"Sanchez-Migallon","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110489_bib44","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/sj.eye.6701571","article-title":"Traumatic optic neuropathy","volume":"18","author":"Sarkies","year":"2004","journal-title":"Eye (London, England)"},{"key":"10.1016\/j.exer.2025.110489_bib45","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1007\/s10792-023-02706-1","article-title":"Inhibition of p38 ameliorates axonal loss with modulation of autophagy in TNF-induced optic nerve damage","volume":"43","author":"Sase","year":"2023","journal-title":"Int. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110489_bib46","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/jnc.14225","article-title":"Activation of the NLRP3 inflammasome in microglia: the role of ceramide","volume":"143","author":"Scheiblich","year":"2017","journal-title":"J. Neurochem."},{"key":"10.1016\/j.exer.2025.110489_bib47","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12974-023-02754-5","article-title":"N,N-Dimethyl-3beta-hydroxycholenamide attenuates neuronal death and retinal inflammation in retinal ischemia\/reperfusion injury by inhibiting Ninjurin 1","volume":"20","author":"Shi","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.exer.2025.110489_bib48","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.cmet.2011.04.004","article-title":"Autophagy in the cellular energetic balance","volume":"13","author":"Singh","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.exer.2025.110489_bib49","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/01.wno.0000204646.94991.68","article-title":"Treatment of traumatic optic neuropathy with high-dose corticosteroid","volume":"26","author":"Steinsapir","year":"2006","journal-title":"J. Neuro Ophthalmol. : the official journal of the North American Neuro-Ophthalmology Society"},{"key":"10.1016\/j.exer.2025.110489_bib50","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2025.110489_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.916904","article-title":"Attenuation of HECT-E3 ligase expression rescued memory deficits in 3xTg-AD mice","volume":"14","author":"Suresh","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.exer.2025.110489_bib52","first-page":"1297","article-title":"Preconditioning with carbon monoxide inhalation promotes retinal ganglion cell survival against optic nerve crush via inhibition of the apoptotic pathway","volume":"17","author":"Wang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.exer.2025.110489_bib53","article-title":"HECT E3 ubiquitin ligases - emerging insights into their biological roles and disease relevance","volume":"133","author":"Wang","year":"2020","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.exer.2025.110489_bib54","first-page":"4946","article-title":"Melatonin regulates traumatic optic neuropathy via targeting autophagy","volume":"21","author":"Wei","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.exer.2025.110489_bib55","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The pathophysiology and treatment of glaucoma: a review","volume":"311","author":"Weinreb","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.exer.2025.110489_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0298-z","article-title":"mTORC2 activation protects retinal ganglion cells via Akt signaling after autophagy induction in traumatic optic nerve injury","volume":"51","author":"Wen","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.exer.2025.110489_bib57","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1177\/147323000803600503","article-title":"Traumatic optic neuropathy therapy: an update of clinical and experimental studies","volume":"36","author":"Wu","year":"2008","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.exer.2025.110489_bib58","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.tjo.2015.01.003","article-title":"Traumatic optic neuropathy-clinical features and management issues","volume":"5","author":"Yu-Wai-Man","year":"2015","journal-title":"Taiwan journal of ophthalmology"},{"key":"10.1016\/j.exer.2025.110489_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116204","article-title":"Emerging role and mechanism of HACE1 in the pathogenesis of neurodegenerative diseases: a promising target","volume":"172","author":"Zang","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.exer.2025.110489_bib60","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0896-6273(03)00429-X","article-title":"Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration","volume":"39","author":"Zhai","year":"2003","journal-title":"Neuron"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448352500260X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448352500260X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T02:25:29Z","timestamp":1778898329000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001448352500260X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":60,"alternative-id":["S001448352500260X"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2025.110489","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tailoring UPS-to-autophagy transition to restore RGC prosperity and functionality in a rodent traumatic optic neuropathy model","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2025.110489","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110489"}}