{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T13:30:46Z","timestamp":1793712646367,"version":"4.6.1"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T00:00:00Z","timestamp":1755302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008908","name":"University of Messina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008908","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.exer.2025.110584","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T05:22:17Z","timestamp":1755494537000},"page":"110584","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Effects of curcumin-liposome formulation on inflammatory cascade activated by oxidative stress in primary human corneal epithelial cells"],"prefix":"10.1016","volume":"260","author":[{"given":"Anna M.","family":"Roszkowska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Polito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Wierzbowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Licitri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Gasparo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Torre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Macaione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Aragona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M'Hammed","family":"Aguennouz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2025.110584_bib1","first-page":"1201","article-title":"Management of chronic anterior uveitis relapses: efficacy of oral phospholipidic curcumin treatment. Long-term follow-up","volume":"4","author":"Allegri","year":"2010","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110584_bib2","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.exer.2009.12.004","article-title":"Curcumin protects against hyperosmoticity-induced IL-1beta elevation in human corneal epithelial cell via MAPK pathways","volume":"90","author":"Chen","year":"2010","journal-title":"Exp. Eye Res."},{"issue":"1","key":"10.1016\/j.exer.2025.110584_bib3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1208\/s12248-012-9432-8","article-title":"Therapeutic roles of curcumin: lessons learned from clinical trials","volume":"15","author":"Gupta","year":"2013","journal-title":"AAPS J."},{"issue":"5","key":"10.1016\/j.exer.2025.110584_bib4","doi-asserted-by":"crossref","first-page":"9183","DOI":"10.3390\/molecules20059183","article-title":"Curcumin, inflammation, and chronic diseases: how are they linked?","volume":"20","author":"He","year":"2015","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.exer.2025.110584_bib5","doi-asserted-by":"crossref","first-page":"553","DOI":"10.2174\/1389201023666220609085614","article-title":"Therapeutic implications of curcumin in the treatment of inflammatory eye diseases: a review","volume":"24","author":"Heydari","year":"2023","journal-title":"Curr. Pharm. Biotechnol."},{"issue":"2","key":"10.1016\/j.exer.2025.110584_bib6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0301-4622(99)00070-8","article-title":"Free radical scavenging ability and antioxidant efficiency of curcumin and its substituted analogue","volume":"80","author":"Khopde","year":"1999","journal-title":"Biophys. Chem."},{"issue":"16","key":"10.1016\/j.exer.2025.110584_bib7","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.3390\/molecules24162930","article-title":"Curcumin: biological, pharmaceutical, nutraceutical, and analytical aspects","volume":"24","author":"Kotha","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.exer.2025.110584_bib8","first-page":"4","article-title":"Effects of curcumin on retinal oxidative stress and inflammation in diabetes","volume":"16","author":"Kowluru","year":"2007","journal-title":"Nutr Metab (Lond)"},{"key":"10.1016\/j.exer.2025.110584_bib9","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/(SICI)1099-1573(199906)13:4<318::AID-PTR445>3.0.CO;2-7","article-title":"Efficacy of curcumin in the management of chronic anterior uveitis","volume":"13","author":"Lal","year":"1999","journal-title":"Phytother Res."},{"key":"10.1016\/j.exer.2025.110584_bib10","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1002\/cncr.21300","article-title":"Liposome-encapsulated curcumin. in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis","volume":"104","author":"Li","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.exer.2025.110584_bib11","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"issue":"4","key":"10.1016\/j.exer.2025.110584_bib12","first-page":"249","article-title":"Curcumin: therapeutical potential in ophthalmology","volume":"80","author":"Pescosolido","year":"2014","journal-title":"Planta Med."},{"issue":"3","key":"10.1016\/j.exer.2025.110584_bib13","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s10787-023-01136-w","article-title":"Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases","volume":"31","author":"Sadeghi","year":"2023","journal-title":"Inflammopharmacology"},{"issue":"5","key":"10.1016\/j.exer.2025.110584_bib14","doi-asserted-by":"crossref","first-page":"725","DOI":"10.3390\/antiox10050725","article-title":"Systematic development and characterization of novel, high drug-loaded, photostable, curcumin solid lipid nanoparticle hydrogel for wound healing","volume":"10","author":"Sandhu","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.exer.2025.110584_bib15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/biof.1041","article-title":"Molecular mechanisms of curcumin action: gene expression","volume":"39","author":"Shishodia","year":"2013","journal-title":"Biofactors"},{"key":"10.1016\/j.exer.2025.110584_bib16","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.2147\/DDDT.S327378","article-title":"Anti-inflammatory effects of curcumin in the inflammatory diseases: status, limitations and countermeasures","volume":"15","author":"Ying","year":"2021","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.exer.2025.110584_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111119","article-title":"The role of curcumin in aging and senescence: molecular mechanisms","volume":"134","author":"Zia","year":"2021","journal-title":"Biomed. Pharmacother."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525003550?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525003550?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T20:07:22Z","timestamp":1759522042000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483525003550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":17,"alternative-id":["S0014483525003550"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2025.110584","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of curcumin-liposome formulation on inflammatory cascade activated by oxidative stress in primary human corneal epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2025.110584","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110584"}}