{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:46:05Z","timestamp":1792619165062,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["2509\/21 NGC"],"award-info":[{"award-number":["2509\/21 NGC"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.exer.2025.110589","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:32:51Z","timestamp":1755736371000},"page":"110589","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Teprotumumab reduces the proliferation and viability of pterygium fibroblasts"],"prefix":"10.1016","volume":"260","author":[{"given":"Stephen","family":"Richard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basel","family":"Obied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jawad","family":"Abu-dbai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jawad","family":"Massalha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yakov","family":"Rabinovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoav","family":"Vardizer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9451-5253","authenticated-orcid":false,"given":"Alon","family":"Zahavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5648-1873","authenticated-orcid":false,"given":"Nitza","family":"Goldenberg-Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2025.110589_bib1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10565-012-9212-3","article-title":"Cytoplasmic vacuolization during exposure to drugs and other substances","volume":"28","author":"Aki","year":"2012","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.exer.2025.110589_bib2","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1007\/s10792-021-01706-3","article-title":"Teprotumumab (tepezza): from the discovery and development of medicines to USFDA approval for active thyroid eye disease (TED) treatment","volume":"41","author":"Ali","year":"2021","journal-title":"Int. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110589_bib3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/02713680701799101","article-title":"Subconjunctival bevacizumab injection for corneal neovascularization in recurrent pterygium","volume":"33","author":"Bahar","year":"2008","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2025.110589_bib4","first-page":"527","article-title":"Proliferative and migratory aptitude in pterygium. Histochem","volume":"134","author":"Bai","year":"2010","journal-title":"Cell Biol."},{"key":"10.1016\/j.exer.2025.110589_bib5","first-page":"F105","article-title":"The IGF-I receptor in cell growth, transformation and apoptosis","volume":"1332","author":"Baserga","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exer.2025.110589_bib6","first-page":"26","article-title":"Biological roles of fibroblast growth factor-2","volume":"18","author":"Bikfalvi","year":"1997","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.exer.2025.110589_bib7","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1002\/ijc.24186","article-title":"Molecular mechanisms involved in activity of h7C10, a humanized monoclonal antibody, to IGF-1 receptor","volume":"124","author":"Broussas","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.exer.2025.110589_bib8","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1136\/bjo.67.9.604","article-title":"Histology of pterygium: an electron microscopic study","volume":"67","author":"Cameron","year":"1983","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110589_bib9","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1097\/ICO.0000000000001569","article-title":"Cellular proliferation and migration of human pterygium cells: mitomycin versus small-molecule inhibitors","volume":"37","author":"Cao","year":"2018","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2025.110589_bib10","doi-asserted-by":"crossref","first-page":"E1635","DOI":"10.1210\/jc.2014-1580","article-title":"Teprotumumab, an IGF-1R blocking monoclonal antibody inhibits TSH and IGF-1 action in fibrocytes","volume":"99","author":"Chen","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.exer.2025.110589_bib11","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1136\/bjo.77.11.734","article-title":"Pterygium as an early indicator of ultraviolet insolation: a hypothesis","volume":"77","author":"Coroneo","year":"1993","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110589_bib13","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/s41577-021-00540-z","article-title":"Fibroblasts as immune regulators in infection, inflammation and cancer","volume":"21","author":"Davidson","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.exer.2025.110589_bib14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.gendis.2014.10.004","article-title":"Insulin-like growth factor (IGF) signaling in tumorigenesis and the development of cancer drug resistance","volume":"2","author":"Denduluri","year":"2015","journal-title":"Genes Dis"},{"key":"10.1016\/j.exer.2025.110589_bib15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1210\/clinem\/dgad637","article-title":"Efficacy and safety of teprotumumab in patients with thyroid eye disease of long duration and low disease activity","volume":"109","author":"Douglas","year":"2023","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.exer.2025.110589_bib16","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2114244118","article-title":"Therapeutic IGF-I receptor inhibition alters fibrocyte immune phenotype in thyroid-associated ophthalmopathy","volume":"118","author":"Fernando","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2025.110589_bib17","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1039\/c8pp00023a","article-title":"The geospatial relationship of pterygium and senile cataract with ambient solar ultraviolet in tropical Ecuador","volume":"17","author":"Gar\u017aon-Chavez","year":"2018","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.exer.2025.110589_bib18","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s10792-013-9876-6","article-title":"The expression of vascular endothelial growth factor in pterygium tissue of atopic patients","volume":"34","author":"Gharaee","year":"2014","journal-title":"Int. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110589_bib19","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1369\/jhc.7A7287.2007","article-title":"An immunohistochemical method for identifying fibroblasts in formalin-fixed, paraffin-embedded tissue","volume":"56","author":"Goodpaster","year":"2008","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.exer.2025.110589_bib20","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1091\/mbc.11.1.255","article-title":"Biogenesis of multilamellar bodies via autophagy","volume":"11","author":"Hariri","year":"2000","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.exer.2025.110589_bib21","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0039-6257(02)00463-0","article-title":"The treatment of pterygium","volume":"48","author":"Hirst","year":"2003","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110589_bib22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.exer.2016.10.006","article-title":"In vitro secretomics study of pterygium-derived fibroblasts by iTRAQ-based quantitative proteomics strategy","volume":"153","author":"Hou","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110589_bib23","doi-asserted-by":"crossref","first-page":"283","DOI":"10.5301\/ejo.5000712","article-title":"Interleukin-17 and its correlation with vascular endothelial growth factor expression in ocular surface pathologies: a histologic study","volume":"26","author":"Jabarin","year":"2016","journal-title":"Eur. J. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110589_bib24","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.3390\/ijms24043665","article-title":"Autophagy and the insulin-like growth factor (IGF) system in colonic cells: implications for colorectal neoplasia","volume":"24","author":"Kasprzak","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2025.110589_bib25","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.exer.2015.01.010","article-title":"Fibroblast biology in pterygia","volume":"142","author":"Kim","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110589_bib26","doi-asserted-by":"crossref","first-page":"641","DOI":"10.3109\/00207454.2012.702821","article-title":"Insulin-like growth factor-1 inhibits 6-hydroxydopamine-mediated endoplasmic reticulum stress-induced apoptosis via regulation of heme oxygenase-1 and Nrf2 expression in PC12 cells","volume":"122","author":"Kim","year":"2012","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.exer.2025.110589_bib27","article-title":"Inhibition of pterygium fibroblast migration and outgrowth by bevacizumab and cyclosporine A involves down-regulation of matrix metalloproteinases-3 and -13","volume":"12","author":"Kim","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2025.110589_bib28","doi-asserted-by":"crossref","first-page":"680","DOI":"10.3109\/02713683.2013.867063","article-title":"Antifibrotic effect of pirfenidone on human pterygium fibroblasts","volume":"39","author":"Lee","year":"2014","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2025.110589_bib29","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.7150\/ijbs.64285","article-title":"The role of autophagy in lamellar body formation and surfactant production in type 2 alveolar epithelial cells","volume":"18","author":"Li","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.exer.2025.110589_bib30","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2013-003787","article-title":"Geographical prevalence and risk factors for pterygium: a systematic review and meta-analysis","volume":"3","author":"Liu","year":"2013","journal-title":"BMJ Open"},{"key":"10.1016\/j.exer.2025.110589_bib31","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.3109\/02713683.2013.823212","article-title":"Progress in the pathogenesis of pterygium","volume":"38","author":"Liu","year":"2013","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2025.110589_bib32","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1159\/000430347","article-title":"Insulin-like growth factor 1 activates PI3k\/Akt signaling to antagonize lumbar disc degeneration","volume":"37","author":"Liu","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.exer.2025.110589_bib33","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3892\/ijmm.2017.2944","article-title":"Efficacy of curcumin in inducing apoptosis and inhibiting the expression of VEGF in human pterygium fibroblasts","volume":"39","author":"Lu","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.exer.2025.110589_bib34","doi-asserted-by":"crossref","first-page":"847","DOI":"10.4103\/ijo.IJO_1034_20","article-title":"Expression of p53 and Ki-67 proteins in patients with increasing severity and duration of pterygium","volume":"69","author":"Mahesh","year":"2021","journal-title":"Indian J. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110589_bib35","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s40265-020-01287-y","article-title":"Teprotumumab: first approval","volume":"80","author":"Markham","year":"2020","journal-title":"Drugs"},{"key":"10.1016\/j.exer.2025.110589_bib36","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3390\/vision6040058","article-title":"Fibroblast growth factor-2 (FGF-2) expression in pterygia using cell spot arrays","volume":"6","author":"Mastronikolis","year":"2022","journal-title":"Vision (Basel)"},{"key":"10.1016\/j.exer.2025.110589_bib37","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.3390\/ijms24054329","article-title":"Synergic action of insulin-like growth factor-2 and miRNA-483 in pterygium pathogenesis","volume":"24","author":"Maxia","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2025.110589_bib38","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1089\/thy.2021.0176","article-title":"Mechanisms in graves eye disease: apoptosis as the end point of insulin-like growth factor 1 receptor inhibition","volume":"32","author":"Morshed","year":"2022","journal-title":"Thyroid"},{"key":"10.1016\/j.exer.2025.110589_bib39","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1097\/ICO.0b013e3182408bc7","article-title":"Treatment of pterygium by ligation and bevacizumab injection","volume":"31","author":"Nakasato","year":"2012","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2025.110589_bib40","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/cdd.2008.52","article-title":"Insulin-like growth factor-I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum","volume":"15","author":"Novosyadlyy","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.exer.2025.110589_bib41","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.2147\/OPTH.S186543","article-title":"How to minimize pterygium recurrence rates: clinical perspectives","volume":"12","author":"Nuzzi","year":"2018","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110589_bib42","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s13058-018-1063-2","article-title":"Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment","volume":"20","author":"Obr","year":"2018","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.exer.2025.110589_bib43","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1001\/jamaophthalmol.2022.3868","article-title":"Risk factors associated with pterygium reoperation in the IRIS registry","volume":"140","author":"Oke","year":"2022","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.exer.2025.110589_bib44","doi-asserted-by":"crossref","first-page":"357","DOI":"10.4196\/kjpp.2015.19.4.357","article-title":"Effect of bevacizumab on human Tenon's fibroblasts cultured from primary and recurrent pterygium","volume":"19","author":"Park","year":"2015","journal-title":"KOREAN J. PHYSIOL. PHARMACOL."},{"key":"10.1016\/j.exer.2025.110589_bib45","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/S0161-6420(97)30197-3","article-title":"Comparison of conjunctival autografts, amniotic membrane grafts, and primary closure for pterygium excision","volume":"104","author":"Prabhasawat","year":"1997","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2025.110589_bib46","doi-asserted-by":"crossref","first-page":"4528","DOI":"10.1093\/hmg\/ddt300","article-title":"IGF-1 receptor antagonism inhibits autophagy","volume":"22","author":"Renna","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.exer.2025.110589_bib47","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.survophthal.2018.03.001","article-title":"Prevalence and risk factors of pterygium: a systematic review and meta-analysis","volume":"63","author":"Rezvan","year":"2018","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110589_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016482","article-title":"Comparative proteomic analysis of lung lamellar bodies and lysosome-related organelles","volume":"6","author":"Ridsdale","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2025.110589_bib49","doi-asserted-by":"crossref","first-page":"8348","DOI":"10.1038\/s41598-020-65320-6","article-title":"IRE1\u03b1 and IGF signaling predict resistance to an endoplasmic reticulum stress-inducing drug in glioblastoma cells","volume":"10","author":"Rodvold","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2025.110589_bib50","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/S0161-6420(92)31749-X","article-title":"Serious complications of topical mitomycin-C after pterygium surgery","volume":"99","author":"Rubinfeld","year":"1992","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2025.110589_bib51","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1056\/NEJMoa1614949","article-title":"Teprotumumab for thyroid-associated ophthalmopathy","volume":"376","author":"Smith","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.exer.2025.110589_bib52","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1089\/thy.2007.0404","article-title":"Unique attributes of orbital fibroblasts and global alterations in IGF-1 receptor signaling could explain thyroid-associated ophthalmopathy","volume":"18","author":"Smith","year":"2008","journal-title":"Thyroid"},{"key":"10.1016\/j.exer.2025.110589_bib53","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1167\/iovs.01-1185","article-title":"Overexpression of insulin-like growth factor-binding protein-2 in pterygium body fibroblasts","volume":"44","author":"Solomon","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110589_bib54","first-page":"2154","article-title":"Regulation of collagenase, stromelysin, and urokinase-type plasminogen activator in primary pterygium body fibroblasts by inflammatory cytokines","volume":"41","author":"Solomon","year":"2000","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110589_bib55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0185164","article-title":"Nuclear insulin-like growth factor-1 receptor (IGF1R) displays proliferative and regulatory activities in non-malignant cells","volume":"12","author":"Solomon-Zemler","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2025.110589_bib56","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1182\/blood-2005-01-0306","article-title":"IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2\/M-phase accumulation and apoptosis in multiple myeloma cells","volume":"107","author":"Str\u00f6mberg","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.exer.2025.110589_bib57","doi-asserted-by":"crossref","first-page":"734","DOI":"10.7150\/ijms.43238","article-title":"The in vitro anti-fibrotic effect of pirfenidone on human pterygium fibroblasts is associated with down-regulation of autocrine TGF-\u03b2 and MMP-1","volume":"17","author":"Tao","year":"2020","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.exer.2025.110589_bib58","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s13046-021-01944-4","article-title":"Deciphering the temporal heterogeneity of cancer-associated fibroblast subpopulations in breast cancer","volume":"40","author":"Venning","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.exer.2025.110589_bib59","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s10792-024-03358-5","article-title":"Advances of IGF-1R inhibitors in graves' ophthalmopathy","volume":"44","author":"Wang","year":"2024","journal-title":"Int. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110589_bib60","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S1084952102000551","article-title":"Biogenesis of lamellar bodies, lysosome-related organelles involved in storage and secretion of pulmonary surfactant","volume":"13","author":"Weaver","year":"2002","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.exer.2025.110589_bib61","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1002\/jcb.27707","article-title":"Continuous exposure of nicotine and cotinine retards human primary pterygium cell proliferation and migration","volume":"120","author":"Yang","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.exer.2025.110589_bib62","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1016\/j.ophtha.2013.05.033","article-title":"Ten-year results of a randomized controlled trial comparing 0.02% mitomycin C and limbal conjunctival autograft in pterygium surgery","volume":"120","author":"Young","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2025.110589_bib63","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1146\/annurev-bioeng-071910-124736","article-title":"Nuclear mechanics in disease","volume":"13","author":"Zwerger","year":"2011","journal-title":"Annu. Rev. Biomed. Eng."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525003604?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525003604?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:25:14Z","timestamp":1777382714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483525003604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":62,"alternative-id":["S0014483525003604"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2025.110589","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Teprotumumab reduces the proliferation and viability of pterygium fibroblasts","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2025.110589","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110589"}}