{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:13:03Z","timestamp":1772896383904,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30EY014801"],"award-info":[{"award-number":["P30EY014801"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005800","name":"Eye Bank Association of America Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005800","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016850","name":"Beauty Of Sight Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.exer.2025.110614","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T06:23:32Z","timestamp":1756535012000},"page":"110614","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Safety of a novel dual-chamber vial for corneal preservation"],"prefix":"10.1016","volume":"260","author":[{"given":"Joana","family":"Karanxha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3924-5633","authenticated-orcid":false,"given":"Jack","family":"Cipolla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego A.","family":"Ojeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarp","family":"Orgul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrina N.","family":"Llanes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Buras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Fout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charissa H.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sander R.","family":"Dubovy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6383-2558","authenticated-orcid":false,"given":"Alfonso L.","family":"Sabater","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2025.110614_bib1","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1007\/s13346-015-0275-6","article-title":"In vitro and ex vivo corneal penetration and absorption models","volume":"6","author":"Agarwal","year":"2016","journal-title":"Drug. Deliv. Trans. Res."},{"key":"10.1016\/j.exer.2025.110614_bib2","series-title":"Eye Banking Statistical Report","author":"America","year":"2018"},{"key":"10.1016\/j.exer.2025.110614_bib26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000326632","article-title":"Preservation of Human Cornea","volume":"38","author":"Armitage","year":"2011","journal-title":"Transfus. Med. Hemotherapy"},{"key":"10.1016\/j.exer.2025.110614_bib3","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/ICU.0000000000000684","article-title":"Eye banking in the coronavirus disease 2019 era","volume":"31","author":"Ballouz","year":"2020","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110614_bib4","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4805986","article-title":"The role of E-Cadherin in maintaining the barrier function of corneal epithelium after treatment with cultured autologous oral mucosa epithelial cell sheet grafts for limbal stem deficiency","volume":"2016","author":"Bardag-Gorce","year":"2016","journal-title":"J. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110614_bib5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.exer.2011.06.004","article-title":"Molecular mechanisms underlying the corneal endothelial pump","volume":"95","author":"Bonanno","year":"2012","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110614_bib6","doi-asserted-by":"crossref","first-page":"517","DOI":"10.4103\/ijo.IJO_574_20","article-title":"Specular microscopy in clinical practice","volume":"69","author":"Chaurasia","year":"2021","journal-title":"Indian J. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110614_bib7","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/ICO.0000000000002242","article-title":"Cost-benefit and cost-utility analysis of amphotericin B supplementation of corneal storage media with endothelial keratoplasty-prepared tissue","volume":"39","author":"Chiang","year":"2020","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2025.110614_bib8","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1001\/jamaophthalmol.2016.0008","article-title":"The effect of light exposure on the efficacy and safety of amphotericin B in corneal storage media","volume":"134","author":"Duncan","year":"2016","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.exer.2025.110614_bib9","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1089\/hum.2010.079","article-title":"Corneal endothelial cells are protected from apoptosis by gene therapy","volume":"22","author":"Fuchsluger","year":"2011","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.exer.2025.110614_bib10","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1097\/ICO.0000000000002068","article-title":"Antimycotic efficacy and safety of a new cold corneal storage medium by time-kill and toxicity studies","volume":"38","author":"Giurgola","year":"2019","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2025.110614_bib11","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1001\/archopht.1991.01080060128040","article-title":"Optisol corneal storage medium","volume":"109","author":"Kaufman","year":"1991","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110614_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.xops.2022.100239","article-title":"The biologic character of donor corneal endothelial cells influences endothelial cell density post successful corneal transplantation","volume":"3","author":"Kitazawa","year":"2023","journal-title":"Ophthalmol. Sci."},{"key":"10.1016\/j.exer.2025.110614_bib13","first-page":"2827","article-title":"Cell death during corneal storage at 4 degrees C","volume":"40","author":"Komuro","year":"1999","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110614_bib14","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1097\/ICO.0000000000000417","article-title":"Cornea preservation time study: methods and potential impact on the cornea donor pool in the United States","volume":"34","author":"Lass","year":"2015","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2025.110614_bib15","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1001\/jamaophthalmol.2014.397","article-title":"Efficacy and safety of antifungal additives in Optisol-GS corneal storage medium","volume":"132","author":"Layer","year":"2014","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.exer.2025.110614_bib16","first-page":"3","article-title":"Apoptosis, oncosis, and necrosis. An overview of cell death","volume":"146","author":"Majno","year":"1995","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2025.110614_bib17","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2147\/OPTH.S181534","article-title":"A paradigm shift in eye banking: how new models are challenging the status quo","volume":"13","author":"Moshirfar","year":"2019","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110614_bib18","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1016\/S0161-6420(99)90409-8","article-title":"Initial endothelial cell density and chronic endothelial cell loss rate in corneal transplants with late endothelial failure","volume":"106","author":"Nishimura","year":"1999","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2025.110614_bib19","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1097\/ICO.0000000000002333","article-title":"Performance of new hypothermic corneal storage media with an antimycotic tablet in comparison to traditional hypothermic media during simulated eye bank processing","volume":"39","author":"Perry","year":"2020","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2025.110614_bib20","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4103\/ijo.IJO_646_17","article-title":"Anatomy of cornea and ocular surface","volume":"66","author":"Sridhar","year":"2018","journal-title":"Indian J. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110614_bib21","doi-asserted-by":"crossref","DOI":"10.1097\/ICO.0000000000001025","article-title":"Factors influencing the quality of the donor cornea","volume":"35","author":"Tripathy","year":"2016","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2025.110614_bib22","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.trsl.2022.05.003","article-title":"Corneal endothelial wound healing: understanding the regenerative capacity of the innermost layer of the cornea","volume":"248","author":"Vercammen","year":"2022","journal-title":"Transl. Res."},{"key":"10.1016\/j.exer.2025.110614_bib23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/cxo.12869","article-title":"Anterior segment optical coherence tomography and its clinical applications","volume":"102","author":"Wang","year":"2019","journal-title":"Clin. Exp. Optom."},{"key":"10.1016\/j.exer.2025.110614_bib24","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/j.transproceed.2014.02.029","article-title":"Functional tumor necrosis factor alpha polymorphisms and haplotype analysis in high-risk corneal transplantation","volume":"46","author":"Winton","year":"2014","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.exer.2025.110614_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/17469899.2021.1829476","article-title":"Corneal storage methods: considerations and impact on surgical outcomes","volume":"16","author":"Wojcik","year":"2021","journal-title":"Expet Rev. Ophthalmol."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525003859?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525003859?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T19:22:42Z","timestamp":1772824962000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483525003859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":26,"alternative-id":["S0014483525003859"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2025.110614","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety of a novel dual-chamber vial for corneal preservation","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2025.110614","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110614"}}