{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T06:00:17Z","timestamp":1780725617234,"version":"3.54.1"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY035771"],"award-info":[{"award-number":["EY035771"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY035462"],"award-info":[{"award-number":["EY035462"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.exer.2025.110628","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T09:15:41Z","timestamp":1757754941000},"page":"110628","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Distinct transcriptional regulation of the Wnt and TGF\u03b2 signaling families associated with wound healing and fibrotic outcomes to lens injury"],"prefix":"10.1016","volume":"261","author":[{"given":"Catherine","family":"Lalman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie R.","family":"Stabler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Disatham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Kantorow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8374-0551","authenticated-orcid":false,"given":"Janice L.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2025.110628_bib1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s004170050083","article-title":"The lens influences aqueous humor levels of transforming growth factor-beta 2","volume":"236","author":"Allen","year":"1998","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110628_bib2","series-title":"A Simultaneous Inhibition of ID1 and ID3 Protects Against Pulmonary Fibrosis","author":"Antar","year":"2025"},{"key":"10.1016\/j.exer.2025.110628_bib3","doi-asserted-by":"crossref","first-page":"36803","DOI":"10.1074\/jbc.M005912200","article-title":"Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration","volume":"275","author":"Bakin","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2025.110628_bib4","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1167\/iovs.05-1208","article-title":"Lens-specific expression of TGF-\u03b2 induces anterior subcapsular cataract formation in the absence of Smad3","volume":"47","author":"Banh","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110628_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108829","article-title":"The local wound environment is a key determinant of the outcome of TGFbeta signaling on the fibrotic response of CD44(+) leader cells in an ex vivo post-cataract-surgery model","volume":"213","author":"Basta","year":"2021","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110628_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106570","article-title":"Changes in nascent chromatin structure regulate activation of the pro-fibrotic transcriptome and myofibroblast emergence in organ fibrosis","volume":"26","author":"Basta","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.exer.2025.110628_bib7","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1242\/dev.129.16.3795","article-title":"Bone morphogenetic protein signaling and the initiation of lens fiber cell differentiation","volume":"129","author":"Belecky-Adams","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.exer.2025.110628_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046567","article-title":"Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase \u03b2-TrCP1","volume":"7","author":"Blees","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2025.110628_bib9","doi-asserted-by":"crossref","first-page":"4645","DOI":"10.3390\/ijms22094645","article-title":"Myocardial hypertrophy and fibrosis are associated with cardiomyocyte beta-catenin and TRPC6\/Calcineurin\/NFAT signaling in spontaneously hypertensive rats with 5\/6 nephrectomy","volume":"22","author":"Bogdanova","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2025.110628_bib10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.matbio.2018.03.017","article-title":"The WNT signaling pathways in wound healing and fibrosis","volume":"68\u201369","author":"Burgy","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.exer.2025.110628_bib11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3389\/fphar.2017.00111","article-title":"Dickkopf-3 upregulates VEGF in cultured human endothelial cells by activating activin receptor-like kinase 1 (ALK1) pathway","volume":"8","author":"Busceti","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.exer.2025.110628_bib12","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.3390\/ijms19051294","article-title":"TGF-\u03b2 and the tissue microenvironment: relevance in fibrosis and cancer","volume":"19","author":"Caja","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2025.110628_bib13","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.7150\/ijbs.57247","article-title":"NEDD4L-induced \u03b2-catenin ubiquitination suppresses the formation and progression of interstitial pulmonary fibrosis via inhibiting the CTHRC1\/HIF-1\u03b1 axis","volume":"17","author":"Chen","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.exer.2025.110628_bib14","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.162547","article-title":"alpha7nAChR activation in AT2 cells promotes alveolar regeneration through WNT7B signaling in acute lung injury","volume":"8","author":"Chen","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.exer.2025.110628_bib15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ydbio.2008.09.002","article-title":"Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture","volume":"324","author":"Chen","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.exer.2025.110628_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027676","article-title":"A secreted BMP antagonist, Cer1, fine tunes the spatial organization of the ureteric bud tree during mouse kidney development","volume":"6","author":"Chi","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2025.110628_bib17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.bbrc.2006.12.035","article-title":"Snail is required for transforming growth factor-beta-induced epithelial-mesenchymal transition by activating PI3 Kinase\/akt signal pathway","volume":"353","author":"Cho","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exer.2025.110628_bib18","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.cellbi.2007.04.006","article-title":"Rho activation is required for transforming growth factor-beta-induced epithelial-mesenchymal transition in lens epithelial cells","volume":"31","author":"Cho","year":"2007","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.exer.2025.110628_bib19","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","article-title":"Wnt\/\u03b2-Catenin signaling and disease","volume":"149","author":"Clevers","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.exer.2025.110628_bib20","first-page":"2201","article-title":"Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor","volume":"32","author":"Cousins","year":"1991","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110628_bib21","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a015081","article-title":"Secreted and transmembrane wnt inhibitors and activators","volume":"5","author":"Cruciat","year":"2013","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.exer.2025.110628_bib22","doi-asserted-by":"crossref","first-page":"6789","DOI":"10.1074\/jbc.M114.612648","article-title":"Systematic mapping of WNT-FZD protein interactions reveals functional selectivity by distinct WNT-FZD pairs","volume":"290","author":"Dijksterhuis","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2025.110628_bib23","article-title":"A conditioned medium of umbilical cord mesenchymal stem cells overexpressing Wnt7a promotes wound repair and regeneration of hair follicles in mice","volume":"2017","author":"Dong","year":"2017","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.exer.2025.110628_bib24","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1098\/rstb.2010.0341","article-title":"The lens as a model for fibrotic disease","volume":"366","author":"Eldred","year":"2011","journal-title":"Phil. Trans. Biol. Sci."},{"key":"10.1016\/j.exer.2025.110628_bib25","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1101\/gad.12.23.3764","article-title":"BMP4 is essential for lens induction in the mouse embryo","volume":"12","author":"Furuta","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.exer.2025.110628_bib26","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.yexcr.2017.07.025","article-title":"Frizzled-7 mediates TGF-\u03b2-induced pulmonary fibrosis by transmitting non-canonical wnt signaling","volume":"359","author":"Guan","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.exer.2025.110628_bib27","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1016\/j.ymthe.2022.08.015","article-title":"Corneal fibrosis abrogation by a localized AAV-Mediated inhibitor of differentiation 3 (Id3) gene therapy in rabbit eyes in vivo","volume":"30","author":"Gupta","year":"2022","journal-title":"Mol. Ther."},{"key":"10.1016\/j.exer.2025.110628_bib28","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1080\/07853890.2023.2166981","article-title":"R-spondin family biology and emerging linkages to cancer","volume":"55","author":"He","year":"2023","journal-title":"Ann. Med."},{"key":"10.1016\/j.exer.2025.110628_bib29","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.2741\/1982","article-title":"WNT\/frizzled signaling in eye development and disease","volume":"11","author":"Iongh","year":"2006","journal-title":"Front. Biosci."},{"key":"10.1016\/j.exer.2025.110628_bib30","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1167\/iovs.65.2.18","article-title":"Smurf1 modulates smad signaling pathway in fibrotic cataract formation","volume":"65","author":"Jiang","year":"2024","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110628_bib31","article-title":"Dishevelled phase separation promotes wnt signalosome assembly and destruction complex disassembly","volume":"221","author":"Kang","year":"2022","journal-title":"JCB (J. Cell Biol.)"},{"key":"10.1016\/j.exer.2025.110628_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/cancers10060165","article-title":"CRISPR-mediated reactivation of DKK3 expression attenuates TGF-beta signaling in prostate cancer","volume":"10","author":"Kardooni","year":"2018","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.exer.2025.110628_bib33","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.mad.2017.11.004","article-title":"The role of TGFbeta in wound healing pathologies","volume":"172","author":"Kiritsi","year":"2018","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.exer.2025.110628_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-022-03370-4","article-title":"Functional role of the frizzled linker domain in the wnt signaling pathway","volume":"5","author":"Ko","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.exer.2025.110628_bib35","doi-asserted-by":"crossref","first-page":"713","DOI":"10.2119\/molmed.2016.00041","article-title":"RhoA\/ROCK signaling regulates TGF\u03b2-Induced epithelial-mesenchymal transition of lens epithelial cells through MRTF-A","volume":"22","author":"Korol","year":"2016","journal-title":"Mol. Med."},{"key":"10.1016\/j.exer.2025.110628_bib36","series-title":"Supervised Machine-based Learning and Computational Analysis to Reveal Unique Molecular Signatures Associated with Wound Healing and Fibrotic Outcomes to Lens Injury IJMS 26","author":"Lalman","year":"2025"},{"key":"10.1016\/j.exer.2025.110628_bib37","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1177\/154405910608500418","article-title":"Role of secreted frizzled-related protein 1 (SFRP1) in wound healing","volume":"85","author":"Li","year":"2006","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.exer.2025.110628_bib38","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.3390\/ijms24054421","article-title":"PPP3R1 promotes MSCs senescence by inducing plasma membrane depolarization and increasing Ca2+ influx","volume":"24","author":"Li","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2025.110628_bib39","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.biopha.2017.03.044","article-title":"DKK3 regulates cell proliferation, apoptosis and collagen synthesis in keloid fibroblasts via TGF-beta1\/Smad signaling pathway","volume":"91","author":"Li","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.exer.2025.110628_bib40","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/cr.2008.321","article-title":"Smad3 mediates immediate early induction of Id1 by TGF-beta","volume":"19","author":"Liang","year":"2009","journal-title":"Cell Res."},{"key":"10.1016\/j.exer.2025.110628_bib41","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/wrr.12398","article-title":"Transforming growth factor beta (TGF-beta) isoforms in wound healing and fibrosis","volume":"24","author":"Lichtman","year":"2016","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.exer.2025.110628_bib42","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1073\/pnas.0912228107","article-title":"Macrophage Wnt7b is critical for kidney repair and regeneration","volume":"107","author":"Lin","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2025.110628_bib43","article-title":"Wnt\/\u03b2-catenin signalling: function, biological mechanisms, and therapeutic opportunities","volume":"7","author":"Liu","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.exer.2025.110628_bib44","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.exer.2017.06.001","article-title":"Dickkopf-1 inhibits Wnt3a-induced migration and epithelial-mesenchymal transition of human lens epithelial cells","volume":"161","author":"Liu","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110628_bib45","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1136\/bjo.86.2.220","article-title":"TGFbeta induces morphological and molecular changes similar to human anterior subcapsular cataract","volume":"86","author":"Lovicu","year":"2002","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110628_bib46","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.exer.2015.02.004","article-title":"Fibrosis in the lens. Sprouty regulation of TGF\u03b2-signaling prevents lens EMT leading to cataract","volume":"142","author":"Lovicu","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110628_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.293","article-title":"Enhancer of zeste homolog 2 activates wnt signaling through downregulating CXXC finger protein 4","volume":"4","author":"Lu","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exer.2025.110628_bib48","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1681\/ASN.2017050574","article-title":"Wnt9a promotes renal fibrosis by accelerating cellular senescence in tubular epithelial cells","volume":"29","author":"Luo","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.exer.2025.110628_bib49","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s12032-014-0019-3","article-title":"TGF-beta1-induced expression of Id-1 is associated with tumor progression in gastric cancer","volume":"31","author":"Ma","year":"2014","journal-title":"Med. Oncol."},{"key":"10.1016\/j.exer.2025.110628_bib50","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1165\/rcmb.2011-0237OC","article-title":"MEK-ERK pathway modulation ameliorates pulmonary fibrosis associated with epidermal growth factor receptor activation","volume":"46","author":"Madala","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.exer.2025.110628_bib51","doi-asserted-by":"crossref","first-page":"R524","DOI":"10.1016\/S0960-9822(01)00310-4","article-title":"Wnt signaling: the naked truth?","volume":"11","author":"McEwen","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.exer.2025.110628_bib52","first-page":"851","article-title":"Role of Smad3 signaling in the epithelial-mesenchymal transition of the lens epithelium following injury","volume":"42","author":"Meng","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.exer.2025.110628_bib53","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1091\/mbc.e12-12-0900","article-title":"A central role for vimentin in regulating repair function during healing of the lens epithelium","volume":"25","author":"Menko","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.exer.2025.110628_bib54","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2001-3-1-reviews3001","volume":"3","author":"Miller","year":"2001","journal-title":"Genome Biol."},{"key":"10.1016\/j.exer.2025.110628_bib55","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022095","article-title":"Regulation of TGF-\u03b2 family signaling by inhibitory smads","volume":"9","author":"Miyazawa","year":"2017","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.exer.2025.110628_bib56","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1016\/j.cell.2023.05.022","article-title":"Targeted alveolar regeneration with Frizzled-specific agonists","volume":"186","author":"Nabhan","year":"2023","journal-title":"Cell"},{"issue":"Pt 22","key":"10.1016\/j.exer.2025.110628_bib57","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1242\/jcs.113.22.3897","article-title":"ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis","volume":"113","author":"Norton","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.exer.2025.110628_bib58","doi-asserted-by":"crossref","DOI":"10.1186\/s12931-016-0357-0","article-title":"Profibrotic role of WNT10A via TGF-\u03b2 signaling in idiopathic pulmonary fibrosis","volume":"17","author":"Oda","year":"2016","journal-title":"Respir. Res."},{"key":"10.1016\/j.exer.2025.110628_bib59","doi-asserted-by":"crossref","first-page":"9759","DOI":"10.1074\/jbc.RA118.002743","article-title":"Differential activities and mechanisms of the four R-spondins in potentiating Wnt\/\u03b2-catenin signaling","volume":"293","author":"Park","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2025.110628_bib60","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1242\/jcs.018473","article-title":"Actin stress fibres","volume":"120","author":"Pellegrin","year":"2007","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.exer.2025.110628_bib61","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/s44161-024-00432-0","article-title":"Bone morphogenic protein-4 availability in the cardiac microenvironment controls inflammation and fibrosis in autoimmune myocarditis","volume":"3","author":"Perez-Shibayama","year":"2024","journal-title":"Nat.Cardiovasc. Research"},{"key":"10.1016\/j.exer.2025.110628_bib62","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1167\/iovs.63.2.3","article-title":"The c-Myc oncogene maintains corneal epithelial architecture at homeostasis, modulates p63 expression, and enhances proliferation during tissue repair","volume":"63","author":"Portal","year":"2022","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110628_bib63","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/carcin\/bgv153","article-title":"Dickkopf-3 regulates prostate epithelial cell acinar morphogenesis and prostate cancer cell invasion by limiting TGF-beta-dependent activation of matrix metalloproteases","volume":"37","author":"Romero","year":"2016","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.exer.2025.110628_bib64","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-016-0161-y","article-title":"The Id-protein family in developmental and cancer-associated pathways","volume":"15","author":"Roschger","year":"2017","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.exer.2025.110628_bib65","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/08977194.2018.1472089","article-title":"The biochemistry, signalling and disease relevance of RYK and other WNT-binding receptor tyrosine kinases","volume":"36","author":"Roy","year":"2018","journal-title":"Growth Factors"},{"key":"10.1016\/j.exer.2025.110628_bib66","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00446-18","article-title":"New player in endosomal trafficking: differential roles of smad anchor for receptor activation (SARA) protein","volume":"38","author":"Rozes-Salvador","year":"2018","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.exer.2025.110628_bib67","doi-asserted-by":"crossref","first-page":"25181","DOI":"10.1074\/jbc.M109.032847","article-title":"Role of SARA (SMAD anchor for receptor activation) in maintenance of epithelial cell phenotype","volume":"284","author":"Runyan","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2025.110628_bib68","doi-asserted-by":"crossref","first-page":"C282","DOI":"10.1152\/ajpcell.00306.2005","article-title":"Adenoviral gene transfer of BMP-7, Id2, or Id3 suppresses injury-induced epithelial-to-mesenchymal transition of lens epithelium in mice","volume":"290","author":"Saika","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.exer.2025.110628_bib69","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1038\/labinvest.3700151","article-title":"Transient adenoviral gene transfer of Smad7 prevents injury-induced epithelial-mesenchymal transition of lens epithelium in mice","volume":"84","author":"Saika","year":"2004","journal-title":"Lab. Invest."},{"key":"10.1016\/j.exer.2025.110628_bib70","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0002-9440(10)63153-7","article-title":"Smad3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury","volume":"164","author":"Saika","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2025.110628_bib71","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1046\/j.1523-1747.2002.01719.x","article-title":"Role of p38 MAPK in transforming growth factor \u03b2 stimulation of collagen production by scleroderma and healthy dermal fibroblasts","volume":"118","author":"Sato","year":"2002","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.exer.2025.110628_bib72","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1091\/mbc.E19-11-0647","article-title":"Wnt regulation: exploring axin-disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex","volume":"31","author":"Schaefer","year":"2020","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.exer.2025.110628_bib73","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.preteyeres.2017.08.001","article-title":"Myofibroblast transdifferentiation: the dark force in ocular wound healing and fibrosis","volume":"60","author":"Shu","year":"2017","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2025.110628_bib74","first-page":"10","article-title":"Insights into bone morphogenetic Protein-(BMP-) signaling in ocular lens biology and pathology","author":"Shu","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.exer.2025.110628_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108546","article-title":"Contrasting roles for BMP-4 and ventromorphins (BMP agonists) in TGFbeta-induced lens EMT","volume":"206","author":"Shu","year":"2021","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110628_bib76","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1167\/iovs.16-20611","article-title":"Bone morphogenetic Protein-7 suppresses TGFbeta2-Induced epithelial-mesenchymal transition in the lens: implications for cataract prevention","volume":"58","author":"Shu","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110628_bib77","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ydbio.2009.11.033","article-title":"Secreted frizzled-related protein disrupts PCP in eye lens fiber cells that have polarised primary cilia","volume":"338","author":"Sugiyama","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.exer.2025.110628_bib78","doi-asserted-by":"crossref","DOI":"10.1186\/s12915-022-01252-z","article-title":"Competition between type I activin and BMP receptors for binding to ACVR2A regulates signaling to distinct smad pathways","volume":"20","author":"Szil\u00e1gyi","year":"2022","journal-title":"BMC Biol."},{"key":"10.1016\/j.exer.2025.110628_bib79","doi-asserted-by":"crossref","first-page":"5736","DOI":"10.1167\/iovs.16-20162","article-title":"beta-Catenin\/CBP-Dependent signaling regulates TGF-beta-Induced epithelial to mesenchymal transition of lens epithelial cells","volume":"57","author":"Taiyab","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110628_bib80","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0294236","article-title":"SRplot: a free online platform for data visualization and graphing","volume":"18","author":"Tang","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2025.110628_bib81","first-page":"857","article-title":"Smad anchor for receptor activation (SARA) in TGF-beta signaling","volume":"2","author":"Tang","year":"2010","journal-title":"Front Biosci (Elite Ed)"},{"key":"10.1016\/j.exer.2025.110628_bib82","doi-asserted-by":"crossref","DOI":"10.1186\/s13569-018-0096-8","article-title":"Non-canonical WNT6\/WNT10A signal factor expression in EBV+ post-transplant smooth muscle tumors","volume":"8","author":"Teiken","year":"2018","journal-title":"Clin. Sarcoma Res."},{"key":"10.1016\/j.exer.2025.110628_bib83","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/00061198-199400330-00011","article-title":"Growth factors in the aqueous humor and their clinical significance","volume":"3","author":"Tripathi","year":"1994","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.exer.2025.110628_bib84","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0092-8674(00)81701-8","article-title":"SARA, a FYVE domain protein that recruits Smad2 to the TGF\u03b2 receptor","volume":"95","author":"Tsukazaki","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.exer.2025.110628_bib85","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/s41433-019-0630-9","article-title":"5 year incidence of YAG capsulotomy and PCO after cataract surgery with single-piece monofocal intraocular lenses: a real-world evidence study of 20,763 eyes","volume":"34","author":"Ursell","year":"2020","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.exer.2025.110628_bib86","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1091\/mbc.e04-08-0658","article-title":"TGF-\u03b2 and the smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition","volume":"16","author":"Valcourt","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.exer.2025.110628_bib87","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13058-023-01651-2","article-title":"Vangl-dependent wnt\/planar cell polarity signaling mediates collective breast carcinoma motility and distant metastasis","volume":"25","author":"VanderVorst","year":"2023","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.exer.2025.110628_bib88","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1158\/0008-5472.CAN-18-2757","article-title":"Wnt\/PCP signaling contribution to carcinoma collective cell migration and metastasis","volume":"79","author":"VanderVorst","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.exer.2025.110628_bib89","doi-asserted-by":"crossref","first-page":"4832","DOI":"10.1096\/fj.201700144R","article-title":"Mapping of wnt-frizzled interactions by multiplex CRISPR targeting of receptor gene families","volume":"31","author":"Voloshanenko","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.exer.2025.110628_bib90","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1091\/mbc.E17-06-0364","article-title":"In wound repair vimentin mediates the transition of mesenchymal leader cells to a myofibroblast phenotype","volume":"29","author":"Walker","year":"2018","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.exer.2025.110628_bib91","doi-asserted-by":"crossref","DOI":"10.3791\/52886","article-title":"Establishment of a clinically relevant Ex vivo mock cataract surgery model for investigating epithelial wound repair in a native microenvironment","author":"Walker","year":"2015","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.exer.2025.110628_bib92","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1167\/iovs.06-1059","article-title":"Activation of SRC kinases signals induction of posterior capsule opacification","volume":"48","author":"Walker","year":"2007","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110628_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdermsci.2018.02.007","article-title":"Wnt7a promotes wound healing by regulation of angiogenesis and inflammation: issues on diabetes and obesity","author":"Wang","year":"2018","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.exer.2025.110628_bib94","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.exer.2018.06.020","article-title":"Spatiotemporal dynamics of canonical wnt signaling during embryonic eye development and posterior capsular opacification (PCO)","volume":"175","author":"Wang","year":"2018","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110628_bib95","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41523-021-00266-0","article-title":"Anti-tumor effects of an ID antagonist with no observed acquired resistance","volume":"7","author":"Wojnarowicz","year":"2021","journal-title":"NPJ Breast Cancer"},{"key":"10.1016\/j.exer.2025.110628_bib96","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.exer.2008.10.016","article-title":"Posterior capsule opacification","volume":"88","author":"Wormstone","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110628_bib97","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s10792-025-03506-5","article-title":"Wnt7a can upregulate cell adhesion and migration related genes expression and facilitate the repair of corneal epithelial cells after injury","volume":"45","author":"Wu","year":"2025","journal-title":"Int. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110628_bib98","doi-asserted-by":"crossref","DOI":"10.1186\/s12872-023-03492-5","article-title":"Calcineurin\/NFATc3 pathway mediates myocardial fibrosis in diabetes by impairing enhancer of zeste homolog 2 of cardiac fibroblasts","volume":"23","author":"Zhang","year":"2023","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.exer.2025.110628_bib99","article-title":"Activin A plays an essential role in migration and proliferation of hepatic stellate cells via Smad3 and calcium signaling","volume":"14","author":"Zhang","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2025.110628_bib100","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/cr.2008.328","article-title":"Non-smad pathways in TGF-\u03b2 signaling","volume":"19","author":"Zhang","year":"2009","journal-title":"Cell Res."},{"key":"10.1016\/j.exer.2025.110628_bib101","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.ajpath.2011.04.008","article-title":"Follistatin improves skeletal muscle healing after injury and disease through an interaction with muscle regeneration, angiogenesis, and fibrosis","volume":"179","author":"Zhu","year":"2011","journal-title":"Am. J. Pathol."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525003999?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525003999?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T05:02:38Z","timestamp":1780722158000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483525003999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":101,"alternative-id":["S0014483525003999"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2025.110628","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distinct transcriptional regulation of the Wnt and TGF\u03b2 signaling families associated with wound healing and fibrotic outcomes to lens injury","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2025.110628","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110628"}}