{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T06:00:20Z","timestamp":1780725620363,"version":"3.54.1"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371099"],"award-info":[{"award-number":["82371099"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["SL2023A03J00480"],"award-info":[{"award-number":["SL2023A03J00480"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.exer.2025.110683","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:28:41Z","timestamp":1759796921000},"page":"110683","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["circ-0007006 attenuates fibrosis in thyroid-associated ophthalmopathy by stabilizing HBEGF expression in vitro"],"prefix":"10.1016","volume":"261","author":[{"given":"Zhihui","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anqi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongru","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Te","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huasheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.exer.2025.110683_bib1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1056\/NEJMra0905750","article-title":"Graves' ophthalmopathy","volume":"362","author":"Bahn","year":"2010","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.exer.2025.110683_bib2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1159\/000356042","article-title":"Graves' orbitopathy: imperfect treatments for a rare disease","volume":"2","author":"Bartalena","year":"2013","journal-title":"Eur. Thyroid J."},{"issue":"10","key":"10.1016\/j.exer.2025.110683_bib3","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1056\/NEJMcp0806317","article-title":"Clinical practice. Graves' ophthalmopathy","volume":"360","author":"Bartalena","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.exer.2025.110683_bib4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrm.2015.32","article-title":"The biogenesis and emerging roles of circular RNAs","volume":"17","author":"Chen","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.exer.2025.110683_bib5","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1056\/NEJMoa1910434","article-title":"Teprotumumab for the treatment of active thyroid eye disease","volume":"382","author":"Douglas","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"7441","key":"10.1016\/j.exer.2025.110683_bib6","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA sponges","volume":"495","author":"Hansen","year":"2013","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.exer.2025.110683_bib7","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/1346-8138.14088","article-title":"Possible pro-inflammatory role of heparin-binding epidermal growth factor-like growth factor in the active phase of systemic sclerosis","volume":"45","author":"Hirabayashi","year":"2018","journal-title":"J. Dermatol."},{"issue":"5","key":"10.1016\/j.exer.2025.110683_bib8","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/labinvest.2012.3","article-title":"Heparin-binding epidermal growth factor-like growth factor suppresses experimental liver fibrosis in mice","volume":"92","author":"Huang","year":"2012","journal-title":"Lab. Invest."},{"issue":"11","key":"10.1016\/j.exer.2025.110683_bib9","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41576-019-0158-7","article-title":"The biogenesis, biology and characterization of circular RNAs","volume":"20","author":"Kristensen","year":"2019","journal-title":"Nat. Rev. Genet."},{"issue":"491","key":"10.1016\/j.exer.2025.110683_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aau8587","article-title":"HBEGF(+) macrophages in rheumatoid arthritis induce fibroblast invasiveness","volume":"11","author":"Kuo","year":"2019","journal-title":"Sci. Transl. Med."},{"issue":"8","key":"10.1016\/j.exer.2025.110683_bib11","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/cr.2015.82","article-title":"Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis","volume":"25","author":"Li","year":"2015","journal-title":"Cell Res."},{"issue":"1","key":"10.1016\/j.exer.2025.110683_bib12","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1186\/s12890-021-01726-w","article-title":"HB-EGF-induced IL-8 secretion from airway epithelium leads to lung fibroblast proliferation and migration","volume":"21","author":"Li","year":"2021","journal-title":"BMC Pulm. Med."},{"issue":"4","key":"10.1016\/j.exer.2025.110683_bib13","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.cell.2019.03.046","article-title":"Structure and degradation of circular RNAs regulate PKR activation in innate immunity","volume":"177","author":"Liu","year":"2019","journal-title":"Cell"},{"issue":"7441","key":"10.1016\/j.exer.2025.110683_bib14","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature11928","article-title":"Circular RNAs are a large class of animal RNAs with regulatory potency","volume":"495","author":"Memczak","year":"2013","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.exer.2025.110683_bib15","first-page":"61","article-title":"Analyzing the role of CircSnx5 in an animal model of multiple sclerosis","volume":"24","author":"Mohamed","year":"2025","journal-title":"Iran. J. Allergy Asthma Immunol."},{"issue":"2","key":"10.1016\/j.exer.2025.110683_bib16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s40618-021-01663-9","article-title":"2021 update on thyroid-associated ophthalmopathy","volume":"45","author":"Neag","year":"2022","journal-title":"J. Endocrinol. Investig."},{"key":"10.1016\/j.exer.2025.110683_bib17","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ijcard.2019.04.006","article-title":"Inhibition of circHIPK3 prevents angiotensin II-induced cardiac fibrosis by sponging miR-29b-3p","volume":"292","author":"Ni","year":"2019","journal-title":"Int. J. Cardiol."},{"issue":"2","key":"10.1016\/j.exer.2025.110683_bib18","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/00002341-199306000-00001","article-title":"The association of cigarette smoking with clinical subtypes of ophthalmic graves' disease","volume":"9","author":"Nunery","year":"1993","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"issue":"3","key":"10.1016\/j.exer.2025.110683_bib19","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1365-2249.2005.02824.x","article-title":"Insights into the role of fibroblasts in human autoimmune diseases","volume":"141","author":"Smith","year":"2005","journal-title":"Clin. Exp. Immunol."},{"issue":"5","key":"10.1016\/j.exer.2025.110683_bib20","doi-asserted-by":"crossref","first-page":"F957","DOI":"10.1152\/ajprenal.90490.2008","article-title":"Soluble HB-EGF induces epithelial-to-mesenchymal transition in inner medullary collecting duct cells by upregulating Snail-2","volume":"296","author":"Smith","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"16","key":"10.1016\/j.exer.2025.110683_bib21","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1056\/NEJMra1510030","article-title":"Graves' disease","volume":"375","author":"Smith","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"18","key":"10.1016\/j.exer.2025.110683_bib22","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1056\/NEJMoa1614949","article-title":"Teprotumumab for thyroid-associated ophthalmopathy","volume":"376","author":"Smith","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.exer.2025.110683_bib23","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.bbrc.2013.05.097","article-title":"Conditional loss of heparin-binding EGF-like growth factor results in enhanced liver fibrosis after bile duct ligation in mice","volume":"437","author":"Takemura","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.exer.2025.110683_bib24","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12943-017-0598-7","article-title":"Circular RNAs in human cancer","volume":"16","author":"Wang","year":"2017","journal-title":"Mol. Cancer"},{"issue":"17","key":"10.1016\/j.exer.2025.110683_bib25","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.1158\/0008-5472.CAN-18-0532","article-title":"CircNT5E acts as a sponge of miR-422a to promote glioblastoma tumorigenesis","volume":"78","author":"Wang","year":"2018","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.exer.2025.110683_bib26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1167\/iovs.63.12.27","article-title":"Differential circular RNA expression profiling of orbital connective tissue from patients with type I and type II thyroid-associated ophthalmopathy","volume":"63","author":"Ye","year":"2022","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.exer.2025.110683_bib27","doi-asserted-by":"crossref","first-page":"F695","DOI":"10.1152\/ajprenal.00377.2015","article-title":"Specific endothelial heparin-binding EGF-like growth factor deletion ameliorates renal injury induced by chronic angiotensin II infusion","volume":"311","author":"Zeng","year":"2016","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"7","key":"10.1016\/j.exer.2025.110683_bib28","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s41419-019-1744-5","article-title":"Roles of circular RNAs in immune regulation and autoimmune diseases","volume":"10","author":"Zhou","year":"2019","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.exer.2025.110683_bib29","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/kisup.2014.13","article-title":"EGFR signaling in renal fibrosis","volume":"4","author":"Zhuang","year":"2014","journal-title":"Kidney Int. Suppl."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525004555?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525004555?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T05:04:14Z","timestamp":1780722254000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483525004555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":29,"alternative-id":["S0014483525004555"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2025.110683","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"circ-0007006 attenuates fibrosis in thyroid-associated ophthalmopathy by stabilizing HBEGF expression in vitro","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2025.110683","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110683"}}