{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T06:00:59Z","timestamp":1780725659608,"version":"3.54.1"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006364","name":"James A. Haley Veterans' Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","award":["W81XWH2010694"],"award-info":[{"award-number":["W81XWH2010694"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.exer.2025.110690","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:24:58Z","timestamp":1760145898000},"page":"110690","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Prophylactic treatment with amnion progenitor cell secretome mitigates traumatic optic neuropathy"],"prefix":"10.1016","volume":"261","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1125-8356","authenticated-orcid":false,"given":"Mackenzie","family":"Browning","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"McCartan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arissa","family":"Gratkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Paris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Morin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Wessel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radouil","family":"Tzekov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mullan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Mouzon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2025.110690_bib1","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.bbi.2020.01.020","article-title":"In-vivo imaging of neuroinflammation in veterans with gulf war illness","volume":"87","author":"Alshelh","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.exer.2025.110690_bib2","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.neuropharm.2015.04.029","article-title":"Myelin and oligodendrocyte lineage cells in white matter pathology and plasticity after traumatic brain injury","volume":"110","author":"Armstrong","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.exer.2025.110690_bib3","article-title":"Neuroinflammation, microglia and implications for retinal ganglion cell survival and axon regeneration in traumatic optic neuropathy","volume":"vol. 13","author":"Au","year":"2022"},{"key":"10.1016\/j.exer.2025.110690_bib4","article-title":"Neuroinflammation, microglia and implications for retinal ganglion cell survival and axon regeneration in traumatic optic neuropathy","volume":"vol. 13","author":"Au","year":"2022"},{"issue":"Issues 1\u20132","key":"10.1016\/j.exer.2025.110690_bib5","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/milmed\/usac060","article-title":"Traumatic optic neuropathy: the forgotten concussion","volume":"188","author":"Chalela","year":"2023","journal-title":"Mil. Med."},{"issue":"1","key":"10.1016\/j.exer.2025.110690_bib6","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-019-1499-z","article-title":"CCL20-CCR6 axis modulated traumatic brain injury-induced visual pathologies","volume":"16","author":"Das","year":"2019","journal-title":"J. Neuroinflammation"},{"issue":"2","key":"10.1016\/j.exer.2025.110690_bib7","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1089\/neu.2019.6602","article-title":"Multiple mild traumatic brain injuries lead to visual dysfunction in a mouse model","volume":"37","author":"Desai","year":"2020","journal-title":"J. Neurotrauma"},{"issue":"11","key":"10.1016\/j.exer.2025.110690_bib8","doi-asserted-by":"crossref","first-page":"7852","DOI":"10.1167\/iovs.11-7604","article-title":"Light-induced trigeminal sensitization without central visual pathways: another mechanism for photophobia","volume":"52","author":"Dolgonos","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110690_bib9","author":"Dratviman-Storobinsky"},{"issue":"18","key":"10.1016\/j.exer.2025.110690_bib10","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1212\/WNL.0000000000010830","article-title":"Connections between intrinsically photosensitive retinal ganglion cells and TBI symptoms","volume":"95","author":"Elenberger","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.exer.2025.110690_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2025.111483","article-title":"Neural network classification of Barnes maze search strategy utilization","volume":"230","author":"Ferguson","year":"2025","journal-title":"Brain Res. Bull."},{"issue":"Issue PB","key":"10.1016\/j.exer.2025.110690_bib12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mcn.2015.03.001","article-title":"Epidemiology of mild traumatic brain injury and neurodegenerative disease","volume":"66","author":"Gardner","year":"2015","journal-title":"Mol. Cell. Neurosci."},{"issue":"2","key":"10.1016\/j.exer.2025.110690_bib13","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3171\/jns.1989.71.2.0244","article-title":"Axonal injury in the optic nerve: a model simulating diffuse axonal injury in the brain","volume":"71","author":"Gennarelli","year":"1989","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.exer.2025.110690_bib14","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.90.11.5066","article-title":"The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development (fetal tau\/adult tau\/paired helical fIlament\/neuropathology)","volume":"90","author":"Goedert","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.exer.2025.110690_bib15","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s12017-019-08532-y","article-title":"Pre-treatment with microRNA-181a antagomir prevents loss of parvalbumin expression and preserves novel object recognition following mild traumatic brain injury","volume":"21","author":"Griffiths","year":"2019","journal-title":"NeuroMolecular Med."},{"issue":"6","key":"10.1016\/j.exer.2025.110690_bib16","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1167\/iovs.18-24096","article-title":"RGC neuroprotection following optic nerve trauma mediated by intranasal delivery of amnion cell secretome","volume":"59","author":"Grinblat","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110690_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114613","article-title":"Model matters: differential outcomes in traumatic optic neuropathy pathophysiology between blunt and blast-wave mediated head injuries","volume":"372","author":"Hetzer","year":"2024","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.exer.2025.110690_bib18","first-page":"1","article-title":"Microglia: a potential drug target for traumatic axonal injury","author":"Huang","year":"2021","journal-title":"Neural Plast."},{"key":"10.1016\/j.exer.2025.110690_bib19","first-page":"1","article-title":"Microglia: a potential drug target for traumatic axonal injury","author":"Huang","year":"2021","journal-title":"Neural Plast."},{"issue":"17","key":"10.1016\/j.exer.2025.110690_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21176204","article-title":"The role of NLRP3 inflammasome in the pathogenesis of traumatic brain injury","volume":"21","author":"Irrera","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"17","key":"10.1016\/j.exer.2025.110690_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21176204","article-title":"The role of NLRP3 inflammasome in the pathogenesis of traumatic brain injury","volume":"21","author":"Irrera","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2025.110690_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5553885","article-title":"A systematic literature review on traumatic optic neuropathy","volume":"2021","author":"Karimi","year":"2021","journal-title":"Journal of Ophthalmology"},{"issue":"7","key":"10.1016\/j.exer.2025.110690_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e18033","article-title":"Pretreatment with troxerutin protects\/improves neurological deficits in a mouse model of traumatic brain injury","volume":"9","author":"Khan Malik","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.exer.2025.110690_bib24","article-title":"Intranasal delivery of a novel amnion cell secretome prevents neuronal damage and preserves function in a mouse multiple sclerosis model","volume":"7","author":"Khan","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.exer.2025.110690_bib25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/WNO.0000000000000760","article-title":"Effects of varying intranasal treatment regimens in ST266-Mediated retinal ganglion cell neuroprotection","volume":"39","author":"Khan","year":"2019","journal-title":"J. Neuro Ophthalmol. : The Official Journal of the North American Neuro-Ophthalmology Society"},{"issue":"7","key":"10.1016\/j.exer.2025.110690_bib26","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/S0161-6420(99)00707-1","article-title":"The treatment of traumatic optic neuropathy: the international optic nerve trauma study","volume":"106","author":"Levin","year":"1999","journal-title":"Ophthalmology"},{"issue":"6","key":"10.1016\/j.exer.2025.110690_bib27","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1111\/jnc.13169","article-title":"Liraglutide is neurotrophic and neuroprotective in neuronal cultures and mitigates mild traumatic brain injury in mice","volume":"135","author":"Li","year":"2015","journal-title":"J. Neurochem."},{"issue":"7","key":"10.1016\/j.exer.2025.110690_bib28","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/s41593-019-0418-z","article-title":"Central nervous system regeneration is driven by microglia necroptosis and repopulation","volume":"22","author":"Lloyd","year":"2019","journal-title":"Nat. Neurosci."},{"issue":"4","key":"10.1016\/j.exer.2025.110690_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci10040229","article-title":"Diffuse axonal injury in the rat brain: axonal injury and oligodendrocyte activity following rotational injury","volume":"10","author":"Losurdo","year":"2020","journal-title":"Brain Sci."},{"issue":"13","key":"10.1016\/j.exer.2025.110690_bib30","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1089\/neu.2013.3303","article-title":"Linking traumatic brain injury to chronic traumatic encephalopathy: identification of potential mechanisms leading to neurofibrillary tangle development","volume":"31","author":"Lucke-Wold","year":"2014","journal-title":"J. Neurotrauma"},{"issue":"MAY","key":"10.1016\/j.exer.2025.110690_bib31","article-title":"Implication of melanopsin and trigeminal neural pathways in blue light photosensitivity in vivo","volume":"13","author":"Marek","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.exer.2025.110690_bib32","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.exer.2012.09.012","article-title":"Intrinsically photosensitive retinal ganglion cells are the primary but not exclusive circuit for light aversion","volume":"105","author":"Matynia","year":"2012","journal-title":"Exp. Eye Res."},{"issue":"3","key":"10.1016\/j.exer.2025.110690_bib33","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.3390\/brainsci3031374","article-title":"Damage to myelin and oligodendrocytes: a role in chronic outcomes following traumatic brain injury?","volume":"3","author":"Maxwell","year":"2013","journal-title":"Brain Sci."},{"key":"10.1016\/j.exer.2025.110690_bib34","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.omtm.2023.04.002","article-title":"Human amnionic progenitor cell secretome mitigates the consequence of traumatic optic neuropathy in a mouse model","volume":"29","author":"McCartan","year":"2023","journal-title":"Molecular Therapy Methods and Clinical Development"},{"key":"10.1016\/j.exer.2025.110690_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2022.147945","article-title":"Comparing imaging biomarkers of cerebral edema after TBI in young adult male and female rats","volume":"1789","author":"Minchew","year":"2022","journal-title":"Brain Res."},{"issue":"9","key":"10.1016\/j.exer.2025.110690_bib36","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/nn.3469","article-title":"M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination","volume":"16","author":"Miron","year":"2013","journal-title":"Nat. Neurosci."},{"issue":"9","key":"10.1016\/j.exer.2025.110690_bib37","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/nn.3469","article-title":"M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination","volume":"16","author":"Miron","year":"2013","journal-title":"Nat. Neurosci."},{"issue":"2","key":"10.1016\/j.exer.2025.110690_bib38","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/ana.24064","article-title":"Chronic neuropathological and neurobehavioral changes in a repetitive mild traumatic brain injury model","volume":"75","author":"Mouzon","year":"2014","journal-title":"Ann. Neurol."},{"issue":"18","key":"10.1016\/j.exer.2025.110690_bib39","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1089\/neu.2012.2498","article-title":"Repetitive mild traumatic brain injury in a mouse model produces learning and memory deficits accompanied by histological changes","volume":"29","author":"Mouzon","year":"2012","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.exer.2025.110690_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2021.647054","article-title":"Tau: a signaling hub protein","volume":"14","author":"Mueller","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.exer.2025.110690_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2022.113918","article-title":"Prophylactic zinc supplementation modulates hippocampal ionic zinc and partially remediates neurological recovery following repetitive mild head injury in mice","volume":"430","author":"Neely","year":"2022","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.exer.2025.110690_bib42","article-title":"The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target","volume":"17","author":"O'Brien","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.exer.2025.110690_bib43","article-title":"The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target","volume":"17","author":"O'Brien","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"10","key":"10.1016\/j.exer.2025.110690_bib44","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1089\/neu.2020.7479","article-title":"Elevated serum Interleukin-1\u03b2 levels in Male, but not female, collision sport athletes with a concussion history","volume":"38","author":"O'Brien","year":"2021","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.exer.2025.110690_bib45","first-page":"59","article-title":"Intrinsically photosensitive retinal ganglion cells","volume":"162","author":"Pickard","year":"2012","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"issue":"5","key":"10.1016\/j.exer.2025.110690_bib46","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1093\/jnen\/nlac018","article-title":"Traumatic brain injury-related optic nerve damage","volume":"81","author":"Qiu","year":"2022","journal-title":"JNEN (J. Neuropathol. Exp. Neurol.)"},{"key":"10.1016\/j.exer.2025.110690_bib47","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.cyto.2018.01.012","article-title":"Pro- and anti-inflammatory biomarkers and traumatic brain injury outcomes: a review","volume":"110","author":"Rodney","year":"2018","journal-title":"Cytokine"},{"issue":"11","key":"10.1016\/j.exer.2025.110690_bib48","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/sj.eye.6701571","article-title":"Traumatic optic neuropathy","volume":"18","author":"Sarkies","year":"2004","journal-title":"Eye"},{"issue":"1","key":"10.1016\/j.exer.2025.110690_bib49","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-018-1227-0","article-title":"Inflammation and blood-brain barrier breach remote from the primary injury following neurotrauma","volume":"15","author":"Smith","year":"2018","journal-title":"J. Neuroinflammation"},{"issue":"3","key":"10.1016\/j.exer.2025.110690_bib50","doi-asserted-by":"crossref","first-page":"G265","DOI":"10.1152\/ajpgi.00364.2021","article-title":"The administration of amnion-derived multipotent cell secretome ST266 protects against necrotizing enterocolitis in mice and piglets","volume":"323","author":"Sodhi","year":"2022","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.exer.2025.110690_bib51","article-title":"Amnion-derived cellular cytokine solution: a physiological combination of cytokines for wound healing","volume":"8","author":"Steed","year":"2008","journal-title":"Eplasty"},{"key":"10.1016\/j.exer.2025.110690_bib52","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0079-6123(06)61024-8","article-title":"Sex differences in brain damage and recovery of function: experimental and clinical findings","volume":"161","author":"Stein","year":"2007","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.exer.2025.110690_bib53","doi-asserted-by":"crossref","unstructured":"Steinsapir, K. D., & Goldberg, R. A. (n.d.). MAJOR REVIEW traumatic optic neuropathy. In Surv. Ophthalmol. (Vol. 38).","DOI":"10.1016\/0039-6257(94)90145-7"},{"issue":"4","key":"10.1016\/j.exer.2025.110690_bib54","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1002\/glia.24322","article-title":"Identification of Tau protein as a novel marker for maturation and pathological changes of oligodendrocytes","volume":"71","author":"Torii","year":"2023","journal-title":"Glia"},{"issue":"9","key":"10.1016\/j.exer.2025.110690_bib55","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1089\/neu.2015.3977","article-title":"Performance of Male and female C57BL\/6J mice on motor and cognitive tasks commonly used in pre-clinical traumatic brain injury research","volume":"33","author":"Tucker","year":"2016","journal-title":"J. Neurotrauma"},{"issue":"4","key":"10.1016\/j.exer.2025.110690_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153608","article-title":"Sub-chronic neuropathological and biochemical changes in mouse visual system after repetitive mild traumatic brain injury","volume":"11","author":"Tzekov","year":"2016","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.exer.2025.110690_bib57","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1080\/02699052.2016.1219062","article-title":"Inflammatory changes in optic nerve after closed-head repeated traumatic brain injury: preliminary study","volume":"30","author":"Tzekov","year":"2016","journal-title":"Brain Inj."},{"issue":"12","key":"10.1016\/j.exer.2025.110690_bib58","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1080\/02699052.2016.1219062","article-title":"Inflammatory changes in optic nerve after closed-head repeated traumatic brain injury: preliminary study","volume":"30","author":"Tzekov","year":"2016","journal-title":"Brain Inj."},{"issue":"4","key":"10.1016\/j.exer.2025.110690_bib59","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/NEN.0000000000000059","article-title":"Repetitive mild traumatic brain injury causes optic nerve and retinal damage in a mouse model","volume":"73","author":"Tzekov","year":"2014","journal-title":"JNEN (J. Neuropathol. Exp. Neurol.)"},{"key":"10.1016\/j.exer.2025.110690_bib60","author":"Tzekov"},{"issue":"9","key":"10.1016\/j.exer.2025.110690_bib61","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1007\/s00221-022-06417-4","article-title":"Prophylactic treatment with CN-105 improves functional outcomes in a murine model of closed head injury","volume":"240","author":"Van Wyck","year":"2022","journal-title":"Exp. Brain Res."},{"issue":"1","key":"10.1016\/j.exer.2025.110690_bib62","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1089\/neu.2019.6979","article-title":"Early versus late profiles of inflammatory cytokines after mild traumatic brain injury and their association with neuropsychological outcomes","volume":"38","author":"Vedantam","year":"2021","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.exer.2025.110690_bib63","series-title":"Short-Term Acute Bright Light Exposure Induces a Prolonged Anxiogenic Effect in Mice via a Retinal ipRGC-CeA Circuit","author":"Wang","year":"2023"},{"issue":"12","key":"10.1016\/j.exer.2025.110690_bib64","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1038\/jcbfm.2013.146","article-title":"Microglia\/macrophage polarization dynamics in white matter after traumatic brain injury","volume":"33","author":"Wang","year":"2013","journal-title":"J. Cerebr. Blood Flow Metabol."},{"issue":"12","key":"10.1016\/j.exer.2025.110690_bib65","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1038\/jcbfm.2013.146","article-title":"Microglia\/macrophage polarization dynamics in white matter after traumatic brain injury","volume":"33","author":"Wang","year":"2013","journal-title":"J. Cerebr. Blood Flow Metabol."},{"issue":"2","key":"10.1016\/j.exer.2025.110690_bib66","article-title":"Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors. In cell death and disease","volume":"10","author":"Yang","year":"2019","journal-title":"Nature Publishing Group"},{"issue":"2","key":"10.1016\/j.exer.2025.110690_bib67","article-title":"Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors. In cell death and disease","volume":"10","author":"Yang","year":"2019","journal-title":"Nature Publishing Group"},{"key":"10.1016\/j.exer.2025.110690_bib68","series-title":"Neuroanatomy, pupillary light reflexes and pathway [Internet]","author":"Yoo","year":"2023"},{"key":"10.1016\/j.exer.2025.110690_bib69","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1109938","article-title":"The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors","volume":"13","author":"Zhan","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exer.2025.110690_bib70","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1109938","article-title":"The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors","volume":"13","author":"Zhan","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exer.2025.110690_bib71","article-title":"Pyroptosis: a new insight into eye disease therapy","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Pharmacol."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525004622?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525004622?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T05:05:43Z","timestamp":1780722343000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483525004622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":71,"alternative-id":["S0014483525004622"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2025.110690","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prophylactic treatment with amnion progenitor cell secretome mitigates traumatic optic neuropathy","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2025.110690","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110690"}}