{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T09:00:28Z","timestamp":1781254828093,"version":"3.54.1"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010270","name":"Capital Health Research and Development of Special Fund","doi-asserted-by":"publisher","award":["2020-1-2052"],"award-info":[{"award-number":["2020-1-2052"]}],"id":[{"id":"10.13039\/501100010270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","award":["SZSM202311018"],"award-info":[{"award-number":["SZSM202311018"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82141128"],"award-info":[{"award-number":["82141128"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82220108017"],"award-info":[{"award-number":["82220108017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","award":["Z201100005520045"],"award-info":[{"award-number":["Z201100005520045"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.exer.2025.110701","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T06:55:31Z","timestamp":1761116131000},"page":"110701","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Multiomics data reveal microglia's promotion for choroidal neovascularization in endothelial cells"],"prefix":"10.1016","volume":"262","author":[{"given":"He-Yan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2386-0989","authenticated-orcid":false,"given":"Wen-Bin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2025.110701_bib1","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1056\/NEJM199412013312203","article-title":"Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders","volume":"331","author":"Aiello","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.exer.2025.110701_bib2","article-title":"Dimensionality reduction for visualizing single-cell data using UMAP","author":"Becht","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.exer.2025.110701_bib3","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.exer.2006.12.016","article-title":"Regulation of VEGF mRNA expression and protein secretion by TGF-beta2 in human retinal pigment epithelial cells","volume":"84","author":"Bian","year":"2007","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110701_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0102013","article-title":"Systemic treatment with erythropoietin protects the neurovascular unit in a rat model of retinal neurodegeneration","volume":"9","author":"Busch","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2025.110701_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2022.116319","article-title":"Cysteine and glycine rich protein 2 exacerbates vascular fibrosis in pulmonary hypertension through the nuclear translocation of yes-associated protein and transcriptional coactivator with PDZ-binding motif","volume":"457","author":"Chen","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.exer.2025.110701_bib6","article-title":"EFEMP1 overexpression contributes to neovascularization in age-related macular degeneration","volume":"11","author":"Cheng","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.exer.2025.110701_bib7","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1126\/science.1112304","article-title":"Achieving stability of lipopolysaccharide-induced NF-kappaB activation","volume":"309","author":"Covert","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.exer.2025.110701_bib8","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.ophtha.2013.10.019","article-title":"Risk of scar in the comparison of age-related macular degeneration treatments trials","volume":"121","author":"Daniel","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2025.110701_bib9","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00401-015-1524-y","article-title":"Microglia-blood vessel interactions: a double-edged sword in brain pathologies","volume":"131","author":"Dudvarski Stankovic","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.exer.2025.110701_bib10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41572-021-00265-2","article-title":"Age-related macular degeneration","volume":"7","author":"Fleckenstein","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.exer.2025.110701_bib11","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ophtha.2013.08.015","article-title":"Risk of geographic atrophy in the comparison of age-related macular degeneration treatments trials","volume":"121","author":"Grunwald","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2025.110701_bib12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ophtha.2016.09.012","article-title":"Incidence and growth of geographic atrophy during 5 years of comparison of age-related macular degeneration treatments trials","volume":"124","author":"Grunwald","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2025.110701_bib13","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/labinvest.2016.30","article-title":"Inhibition of development of laser-induced choroidal neovascularization with suppression of infiltration of macrophages in Smad3-null mice","volume":"96","author":"Iwanishi","year":"2016","journal-title":"Lab. Invest."},{"key":"10.1016\/j.exer.2025.110701_bib14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1136\/bjophthalmol-2016-308828","article-title":"The association between systemic vascular endothelial growth factor and retinopathy of prematurity in premature infants: a systematic review","volume":"101","author":"Kandasamy","year":"2017","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110701_bib15","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1177\/11206721211018348","article-title":"The role of future treatments in the management of neovascular age-related macular degeneration in Europe","volume":"31","author":"Kodjikian","year":"2021","journal-title":"Eur. J. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110701_bib16","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.exer.2025.110701_bib17","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12974-021-02088-0","article-title":"Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration","volume":"18","author":"Lee","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.exer.2025.110701_bib18","article-title":"Single-cell sequencing reveals an important role of SPP1 and microglial activation in age-related macular degeneration","volume":"17","author":"Lei","year":"2023","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.exer.2025.110701_bib19","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.exer.2015.04.020","article-title":"The microglia in healthy and diseased retina","volume":"136","author":"Li","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110701_bib20","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/jnr.20315","article-title":"(-)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammation-mediated dopaminergic neuronal injury","volume":"78","author":"Li","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.exer.2025.110701_bib21","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/cas.16037","article-title":"TGF-\u03b2 signaling promotes desmoid tumor formation via CSRP2 upregulation","volume":"115","author":"Li","year":"2024","journal-title":"Cancer Sci."},{"key":"10.1016\/j.exer.2025.110701_bib22","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/02713683.2024.2407361","article-title":"Dysfunction of endothelial cell-mediated intercellular communication and metabolic pathways in age-related macular degeneration","volume":"50","author":"Li","year":"2025","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.exer.2025.110701_bib23","article-title":"M-CSF, IL-6, and TGF-\u03b2 promote generation of a new subset of tissue repair macrophage for traumatic brain injury recovery","volume":"7","author":"Li","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.exer.2025.110701_bib24","doi-asserted-by":"crossref","first-page":"15003","DOI":"10.1074\/jbc.M801621200","article-title":"Transforming growth factor beta up-regulates cysteine-rich protein 2 in vascular smooth muscle cells via activating transcription factor 2","volume":"283","author":"Lin","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exer.2025.110701_bib25","article-title":"Identification of the CDH18 gene associated with age-related macular degeneration using weighted gene co-expression network analysis","volume":"15","author":"Liu","year":"2024","journal-title":"Front. Genet."},{"key":"10.1016\/j.exer.2025.110701_bib26","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay1371","article-title":"Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche","volume":"12","author":"Liu","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.exer.2025.110701_bib27","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1167\/iovs.65.13.30","article-title":"Oxidative stress and inflammation-related mRNAs are elevated in serum of a Finnish wet AMD cohort","volume":"65","author":"Liukkonen","year":"2024","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110701_bib28","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2118510119","article-title":"Mast cell infiltration of the choroid and protease release are early events in age-related macular degeneration associated with genetic risk at both chromosomes 1q32 and 10q26","volume":"119","author":"Mcharg","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2025.110701_bib29","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/j.1395-3907.2003.00170.x","article-title":"Regulation mechanisms of retinal pigment epithelial cell migration by the TGF-beta superfamily","volume":"81","author":"Mitsuhiro","year":"2003","journal-title":"Acta Ophthalmol. Scand."},{"key":"10.1016\/j.exer.2025.110701_bib30","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/jcp.10378","article-title":"Transforming growth factor-beta induces expression of vascular endothelial growth factor in human retinal pigment epithelial cells: involvement of mitogen-activated protein kinases","volume":"197","author":"Nagineni","year":"2003","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.exer.2025.110701_bib31","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/gm315","article-title":"Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks","volume":"4","author":"Newman","year":"2012","journal-title":"Genome Med."},{"key":"10.1016\/j.exer.2025.110701_bib32","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.celrep.2019.12.082","article-title":"Integration of eQTL and a single-cell Atlas in the human eye identifies causal genes for age-related macular degeneration","volume":"30","author":"Orozco","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.exer.2025.110701_bib33","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.preteyeres.2008.05.001","article-title":"Vascular endothelial growth factor in eye disease","volume":"27","author":"Penn","year":"2008","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2025.110701_bib34","doi-asserted-by":"crossref","first-page":"10714","DOI":"10.1523\/JNEUROSCI.1922-07.2007","article-title":"CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells","volume":"27","author":"Ponomarev","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2025.110701_bib35","doi-asserted-by":"crossref","first-page":"5347","DOI":"10.1167\/iovs.10-7119","article-title":"Analysis of complement expression in light-induced retinal degeneration: synthesis and deposition of C3 by microglia\/macrophages is associated with focal photoreceptor degeneration","volume":"52","author":"Rutar","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110701_bib36","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev-vision-091517-034425","article-title":"Microglia in the retina: roles in development, maturity, and disease","volume":"4","author":"Silverman","year":"2018","journal-title":"Annu Rev Vis Sci"},{"key":"10.1016\/j.exer.2025.110701_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108427","article-title":"circRNA-miRNA-mRNA network in age-related macular degeneration: from construction to identification","volume":"203","author":"Su","year":"2021","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110701_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2021.100954","article-title":"VEGFR1 signaling in retinal angiogenesis and microinflammation","volume":"84","author":"Uemura","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2025.110701_bib39","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tice.2018.03.010","article-title":"Spatial and temporal recruitment of the neurovascular unit during development of the mouse blood-retinal barrier","volume":"52","author":"van der Wijk","year":"2018","journal-title":"Tissue Cell"},{"key":"10.1016\/j.exer.2025.110701_bib40","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1167\/iovs.65.1.21","article-title":"Exploring corneal neovascularization: an integrated approach using transcriptomics and proteomics in an Alkali Burn Mouse model","volume":"65","author":"Wang","year":"2024","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110701_bib41","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nature12345","article-title":"LRG1 promotes angiogenesis by modulating endothelial TGF-\u03b2 signalling","volume":"499","author":"Wang","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.exer.2025.110701_bib42","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13059-023-02931-y","article-title":"YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2","volume":"24","author":"Wang","year":"2023","journal-title":"Genome Biol."},{"key":"10.1016\/j.exer.2025.110701_bib43","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neuroscience.2017.08.010","article-title":"Blocking the CD38\/cADPR pathway plays a double-edged role in LPS stimulated microglia","volume":"361","author":"Wang","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.exer.2025.110701_bib44","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1161\/01.RES.0000194331.76925.5c","article-title":"Increased neointima formation in cysteine-rich protein 2-deficient mice in response to vascular injury","volume":"97","author":"Wei","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.exer.2025.110701_bib45","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.preteyeres.2016.04.002","article-title":"Age-related macular degeneration and polypoidal choroidal vasculopathy in Asians","volume":"53","author":"Wong","year":"2016","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2025.110701_bib46","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1478-811X-12-22","article-title":"Divergent signaling pathways cooperatively regulate TGF\u03b2 induction of cysteine-rich protein 2 in vascular smooth muscle cells","volume":"12","author":"Wu","year":"2014","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.exer.2025.110701_bib47","article-title":"Microglia enhanced the angiogenesis, migration and proliferation of co-cultured RMECs","volume":"18","author":"X","year":"2018","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.exer.2025.110701_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156817","article-title":"Comprehensive multi-omics and pharmacokinetics reveal sclareol's role in inhibiting ocular neovascularization","volume":"143","author":"Yang","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.exer.2025.110701_bib49","first-page":"1857","article-title":"Resistance to anti-VEGF therapy in neovascular age-related macular degeneration: a comprehensive review","volume":"10","author":"Yang","year":"2016","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.exer.2025.110701_bib50","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/glia.23276","article-title":"Activation of EP2 receptor suppresses poly(I: C) and LPS-mediated inflammation in primary microglia and organotypic hippocampal slice cultures: contributing role for MAPKs","volume":"66","author":"Yousif","year":"2018","journal-title":"Glia"},{"key":"10.1016\/j.exer.2025.110701_bib51","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/s41568-023-00591-5","article-title":"Understanding tumour endothelial cell heterogeneity and function from single-cell omics","volume":"23","author":"Zeng","year":"2023","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.exer.2025.110701_bib52","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1186\/s12885-024-12703-x","article-title":"Comprehensive pan-cancer analysis of ZNF337 as a potential diagnostic, immunological, and prognostic biomarker","volume":"24","author":"Zhang","year":"2024","journal-title":"BMC Cancer"},{"key":"10.1016\/j.exer.2025.110701_bib53","first-page":"307","article-title":"Transforming growth factor-\u03b2 neutralizing antibodies inhibit subretinal fibrosis in a mouse model","volume":"5","author":"Zhang","year":"2012","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110701_bib54","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.1186\/s12889-024-21047-x","article-title":"Global burden of low vision and blindness due to age-related macular degeneration from 1990 to 2021 and projections for 2050","volume":"24","author":"Zhang","year":"2024","journal-title":"BMC Public Health"},{"key":"10.1016\/j.exer.2025.110701_bib55","first-page":"1132","article-title":"Crosstalk between microglia and m\u00fcller glia in the age-related macular degeneration: role and therapeutic value of neuroinflammation","volume":"15","author":"Zhao","year":"2024","journal-title":"Aging Dis"},{"key":"10.1016\/j.exer.2025.110701_bib56","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10753-017-0658-6","article-title":"Propofol attenuates inflammatory response in LPS-activated microglia by regulating the miR-155\/SOCS1 pathway","volume":"41","author":"Zheng","year":"2018","journal-title":"Inflammation"},{"key":"10.1016\/j.exer.2025.110701_bib57","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1007\/s10753-017-0571-z","article-title":"Paeoniflorin suppressed high glucose-induced retinal microglia MMP-9 expression and inflammatory response via inhibition of TLR4\/NF-\u03baB pathway through upregulation of SOCS3 in diabetic retinopathy","volume":"40","author":"Zhu","year":"2017","journal-title":"Inflammation"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525004749?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525004749?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T08:42:35Z","timestamp":1781253755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483525004749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":57,"alternative-id":["S0014483525004749"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2025.110701","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiomics data reveal microglia's promotion for choroidal neovascularization in endothelial cells","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2025.110701","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110701"}}