{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T09:00:32Z","timestamp":1781254832479,"version":"3.54.1"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700808"],"award-info":[{"award-number":["81700808"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770962"],"award-info":[{"award-number":["81770962"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32100715"],"award-info":[{"award-number":["32100715"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171014"],"award-info":[{"award-number":["82171014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.exer.2025.110705","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T23:28:09Z","timestamp":1761089289000},"page":"110705","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Commentary: Toward a global atlas of ocular surface biology: Rationale, design, and clinical applications"],"prefix":"10.1016","volume":"262","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3186-144X","authenticated-orcid":false,"given":"Zhijie","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2025.110705_bib1","article-title":"Single cell analysis of short-term dry eye induced changes in cornea immune cell populations","volume":"11","author":"Alam","year":"2024","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.exer.2025.110705_bib2","article-title":"IL-17 producing lymphocytes cause dry eye and corneal disease with aging in RXRalpha mutant mouse","volume":"9","author":"Alam","year":"2022","journal-title":"Front Med (Lausanne)"},{"issue":"1","key":"10.1016\/j.exer.2025.110705_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-54306-x","article-title":"The commitment of the human cell atlas to humanity","volume":"15","author":"Amit","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2025.110705_bib4","article-title":"Mouse single-cell long-read splicing Atlas by Ouro-Seq","volume":"2025","author":"An","year":"2025","journal-title":"bioRxiv"},{"issue":"7","key":"10.1016\/j.exer.2025.110705_bib5","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1007\/s40123-025-01161-8","article-title":"Dry eye disease: from causes to patient care and clinical Collaboration-A narrative review","volume":"14","author":"Aragona","year":"2025","journal-title":"Ophthalmol .Ther."},{"issue":"6","key":"10.1016\/j.exer.2025.110705_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.clae.2022.101705","article-title":"Diurnal variation on tear stability and correlation with tear cytokine concentration","volume":"45","author":"Arroyo","year":"2022","journal-title":"Contact Lens Anterior Eye"},{"issue":"3","key":"10.1016\/j.exer.2025.110705_bib7","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41433-019-0517-9","article-title":"Literature review and suggested protocol for prevention and treatment of corneal graft rejection","volume":"34","author":"Azevedo Magalhaes","year":"2020","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.exer.2025.110705_bib8","article-title":"Integrating bulk and single cell RNA-seq refines transcriptomic profiles of individual <em>C. elegans<\/em> neurons","author":"Barrett","year":"2025","journal-title":"bioRxiv"},{"issue":"1","key":"10.1016\/j.exer.2025.110705_bib9","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/ICO.0b013e3181ac9fd0","article-title":"The diurnal secretory characteristics of individual meibomian glands","volume":"29","author":"Blackie","year":"2010","journal-title":"Cornea"},{"key":"10.1016\/j.exer.2025.110705_bib10","article-title":"Deconvolution and phylogeny inference of diverse variant types integrating bulk DNA-seq with single-cell RNA-seq","author":"Bristy","year":"2025","journal-title":"bioRxiv"},{"issue":"3","key":"10.1016\/j.exer.2025.110705_bib11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.exer.2003.09.019","article-title":"Functional aspects of the tear film lipid layer","volume":"78","author":"Bron","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110705_bib12","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jtos.2021.03.010","article-title":"A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells","volume":"21","author":"Collin","year":"2021","journal-title":"Ocul. Surf."},{"issue":"2","key":"10.1016\/j.exer.2025.110705_bib13","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0092-8674(89)90958-6","article-title":"Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells","volume":"57","author":"Cotsarelis","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.exer.2025.110705_bib14","series-title":"Innovations in Optimization and Machine Learning","first-page":"181","article-title":"Strategies for spatial data management in cloud environments","author":"Das","year":"2025"},{"issue":"8","key":"10.1016\/j.exer.2025.110705_bib15","doi-asserted-by":"crossref","first-page":"R72","DOI":"10.1186\/gb-2006-7-8-r72","article-title":"Identification of 491 proteins in the tear fluid proteome reveals a large number of proteases and protease inhibitors","volume":"7","author":"de Souza","year":"2006","journal-title":"Genome Biol."},{"issue":"6","key":"10.1016\/j.exer.2025.110705_bib16","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.survophthal.2016.12.010","article-title":"Management of high-risk corneal transplantation","volume":"62","author":"Di Zazzo","year":"2017","journal-title":"Surv. Ophthalmol."},{"issue":"1","key":"10.1016\/j.exer.2025.110705_bib17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1167\/tvst.14.1.27","article-title":"Artificial intelligence for optical coherence tomography in glaucoma","volume":"14","author":"Djulbegovic","year":"2025","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.exer.2025.110705_bib18","article-title":"scGraphETM: Graph-based deep learning approach for unraveling cell type-specific gene regulatory networks from single-cell multi-omics data","author":"Dong","year":"2025","journal-title":"bioRxiv"},{"issue":"1","key":"10.1016\/j.exer.2025.110705_bib19","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41421-022-00397-z","article-title":"Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis","volume":"8","author":"Dou","year":"2022","journal-title":"Cell Discov."},{"issue":"S2","key":"10.1016\/j.exer.2025.110705_bib20","article-title":"Single\u2010cell transcriptomic landscapes of neurodegenerative diseases: towards mapping shared and distinct mechanisms","volume":"20","author":"Elliot Keats Shwab","year":"2025","journal-title":"Alzheimer's Dementia"},{"key":"10.1016\/j.exer.2025.110705_bib21","doi-asserted-by":"crossref","DOI":"10.2196\/67878","article-title":"Crisis text line and Loris.ai controversy highlights the complexity of informed consent on the internet and data-sharing ethics for machine learning and research","volume":"27","author":"Eysenbach","year":"2025","journal-title":"J. Med. Internet Res."},{"issue":"2","key":"10.1016\/j.exer.2025.110705_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25021208","article-title":"Exploring immune cell diversity in the lacrimal glands of healthy mice: a single-cell RNA-Sequencing Atlas","volume":"25","author":"Fan","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2025.110705_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.neucom.2024.128283","article-title":"A review of recent advances in spatially resolved transcriptomics data analysis","volume":"603","author":"Gao","year":"2024","journal-title":"Neurocomputing"},{"key":"10.1016\/j.exer.2025.110705_bib24","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.exer.2015.12.009","article-title":"Human conjunctival goblet cells express the membrane associated mucin MUC16: localization to mucin granules","volume":"145","author":"Gipson","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110705_bib25","article-title":"Integrated cancer cell-specific single-cell RNA-seq datasets of immune checkpoint blockade-treated patients","author":"Gondal","year":"2024","journal-title":"bioRxiv"},{"issue":"1","key":"10.1016\/j.exer.2025.110705_bib26","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/s41597-025-04381-6","article-title":"Integrated cancer cell-specific single-cell RNA-seq datasets of immune checkpoint blockade-treated patients","volume":"12","author":"Gondal","year":"2025","journal-title":"Sci. Data"},{"key":"10.1016\/j.exer.2025.110705_bib27","article-title":"Multi-species integration, alignment and annotation of single-cell RNA-seq data with CAMEX","author":"Guo","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.exer.2025.110705_bib28","series-title":"Paper Presented at the 2023 8th International Conference on Intelligent Informatics and Biomedical Sciences (ICIIBMS)","article-title":"EyeGen: a low-cost biomarker and machine learning-based risk assessment for the rapid, inexpensive detection of ophthalmological diseases","author":"Gurram","year":"2023"},{"issue":"10","key":"10.1016\/j.exer.2025.110705_bib29","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1167\/iovs.62.10.22","article-title":"Short-term high fructose intake impairs diurnal oscillations in the Murine Cornea","volume":"62","author":"He","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.exer.2025.110705_bib30","first-page":"83","article-title":"[Norwegian propositions for blood transfusion practices]","volume":"104","author":"Hogman","year":"1989","journal-title":"Nord. Med."},{"issue":"14","key":"10.1016\/j.exer.2025.110705_bib31","doi-asserted-by":"crossref","first-page":"DES151","DOI":"10.1167\/iovs.17-23623","article-title":"Secreted mucins on the ocular surface","volume":"59","author":"Hori","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110705_bib32","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jtos.2024.06.005","article-title":"Analysis of the heterogeneity and complexity of murine extraorbital lacrimal gland via single-cell RNA sequencing","volume":"34","author":"Huang","year":"2024","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2025.110705_bib33","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jtos.2021.02.001","article-title":"Light cycle phase advance as a model for jet lag reprograms the circadian rhythms of murine extraorbital lacrimal glands","volume":"20","author":"Huang","year":"2021","journal-title":"Ocul. Surf."},{"issue":"1","key":"10.1016\/j.exer.2025.110705_bib34","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13073-025-01475-z","article-title":"Spatiotemporal single-cell analysis elucidates the cellular and molecular dynamics of human cornea aging","volume":"17","author":"Jiang","year":"2025","journal-title":"Genome Med."},{"issue":"3","key":"10.1016\/j.exer.2025.110705_bib35","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jtos.2020.04.013","article-title":"Type 1 diabetes mellitus impairs diurnal oscillations in murine extraorbital lacrimal glands","volume":"18","author":"Jiao","year":"2020","journal-title":"Ocul. Surf."},{"issue":"1","key":"10.1016\/j.exer.2025.110705_bib36","doi-asserted-by":"crossref","first-page":"7061","DOI":"10.1038\/s41598-024-57311-8","article-title":"Investigation of the rhythmic recruitment of tear neutrophils to the ocular surface and their phenotypes","volume":"14","author":"Jin","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.exer.2025.110705_bib37","first-page":"43","article-title":"MUC5AC mucin is a component of the human precorneal tear film","volume":"40","author":"Jumblatt","year":"1999","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110705_bib38","article-title":"A review of the diagnosis and treatment of limbal stem cell deficiency","volume":"9","author":"Kate","year":"2022","journal-title":"Front Med (Lausanne)"},{"issue":"23","key":"10.1016\/j.exer.2025.110705_bib39","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.1158\/0008-5472.CAN-24-0857","article-title":"Single-cell transcriptomic analysis identifies senescent osteocytes that trigger bone destruction in breast cancer metastasis","volume":"84","author":"Kaur","year":"2024","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.exer.2025.110705_bib40","doi-asserted-by":"crossref","first-page":"9901","DOI":"10.1038\/s41467-024-54300-3","article-title":"Data sharing ethics toolkit: the human cell Atlas","volume":"15","author":"Kirby","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2025.110705_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109911","article-title":"Single-cell RNA sequencing highlights the regulatory role of T cell marker genes Ctla4, Ccl5 and Tcf7 in corneal allograft rejection of mouse model","volume":"117","author":"Lai","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.exer.2025.110705_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109840","article-title":"Kynurenine pathway metabolites modulated the comorbidity of IBD and depressive symptoms through the immune response","volume":"117","author":"Lai","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.exer.2025.110705_bib43","article-title":"SpaIM: single-Cell spatial transcriptomics imputation via style transfer","author":"Li","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.exer.2025.110705_bib44","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jtos.2020.12.004","article-title":"Single-cell transcriptomics identifies limbal stem cell population and cell types mapping its differentiation trajectory in limbal basal epithelium of human cornea","volume":"20","author":"Li","year":"2021","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2025.110705_bib45","article-title":"A pan-cancer atlas of therapeutic T cell targets","author":"Li","year":"2025","journal-title":"bioRxiv"},{"issue":"9","key":"10.1016\/j.exer.2025.110705_bib46","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1167\/iovs.62.9.36","article-title":"Single-cell transcriptomics identifies a unique entity and signature markers of transit-amplifying cells in human corneal limbus","volume":"62","author":"Li","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.exer.2025.110705_bib47","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/ICL.0b013e31825fed57","article-title":"Daytime variations of tear osmolarity and tear meniscus volume","volume":"38","author":"Li","year":"2012","journal-title":"Eye Contact Lens"},{"issue":"3","key":"10.1016\/j.exer.2025.110705_bib48","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s11306-025-02273-9","article-title":"Metabolomics of ocular immune diseases","volume":"21","author":"Li","year":"2025","journal-title":"Metabolomics"},{"issue":"2","key":"10.1016\/j.exer.2025.110705_bib49","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2204134120","article-title":"Dry eye disease in mice activates adaptive corneal epithelial regeneration distinct from constitutive renewal in homeostasis","volume":"120","author":"Lin","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exer.2025.110705_bib50","article-title":"Resident innate immune cells in the cornea","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exer.2025.110705_bib51","article-title":"Tacrolimus prolongs corneal allograft survival and prevents dendritic cell infiltration in a myeloid-derived suppressor cell-dependent manner","author":"Liu","year":"2025","journal-title":"Am. J. Transplant."},{"issue":"3","key":"10.1016\/j.exer.2025.110705_bib52","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.mucimm.2023.11.008","article-title":"Single-cell landscape reveals the epithelial cell-centric pro-inflammatory immune microenvironment in dry eye development","volume":"17","author":"Liu","year":"2024","journal-title":"Mucosal Immunol."},{"issue":"4","key":"10.1016\/j.exer.2025.110705_bib53","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1158\/1078-0432.CCR-24-2183","article-title":"Human pancreatic cancer single-cell Atlas reveals association of CXCL10+ fibroblasts and basal subtype tumor cells","volume":"31","author":"Loveless","year":"2025","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.exer.2025.110705_bib54","article-title":"A cross-species Atlas of the dorsal vagal complex reveals neural mediators of cagrilintide's effects on energy balance","author":"Ludwig","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.exer.2025.110705_bib55","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jtos.2025.01.008","article-title":"Spatial transcriptomics and single-cell RNA-sequencing revealed dendritic cell-mediated inflammation in keratoconus","volume":"36","author":"Luo","year":"2025","journal-title":"Ocul. Surf."},{"issue":"1","key":"10.1016\/j.exer.2025.110705_bib56","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41525-025-00507-2","article-title":"Integrating explainable machine learning and transcriptomics data reveals cell-type specific immune signatures underlying macular degeneration","volume":"10","author":"Ma","year":"2025","journal-title":"NPJ .Genom. Med."},{"issue":"5","key":"10.1016\/j.exer.2025.110705_bib57","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1109\/TCBB.2023.3284795","article-title":"Artificial intelligence models for cell type and subtype identification based on single-cell RNA sequencing data in vision science","volume":"20","author":"Madadi","year":"2023","journal-title":"IEEE ACM Trans. Comput. Biol. Bioinf"},{"issue":"4","key":"10.1016\/j.exer.2025.110705_bib58","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.exer.2009.12.010","article-title":"Anatomy of the human corneal innervation","volume":"90","author":"Marfurt","year":"2010","journal-title":"Exp. Eye Res."},{"issue":"34","key":"10.1016\/j.exer.2025.110705_bib59","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2306153120","article-title":"Transcriptomic analysis of the ocular posterior segment completes a cell atlas of the human eye","volume":"120","author":"Monavarfeshani","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.exer.2025.110705_bib60","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0014-4835(03)00050-2","article-title":"Corneal nerves: structure, contents and function","volume":"76","author":"Muller","year":"2003","journal-title":"Exp. Eye Res."},{"issue":"6","key":"10.1016\/j.exer.2025.110705_bib61","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1111\/opo.12888","article-title":"The global prevalence of dry eye disease: a Bayesian view","volume":"41","author":"Papas","year":"2021","journal-title":"Ophthalmic Physiol. Opt."},{"key":"10.1016\/j.exer.2025.110705_bib62","article-title":"Deciphering the role of metal ion transport-related genes in T2D pathogenesis and immune cell infiltration via scRNA-seq and machine learning","volume":"15","author":"Pu","year":"2024","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.exer.2025.110705_bib63","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1177\/17557380241312583","article-title":"Dry eyes","volume":"18","author":"Raja","year":"2025","journal-title":"InnovAIT"},{"key":"10.1016\/j.exer.2025.110705_bib64","series-title":"Single-Cell RNA Sequencing of Murine Limbal Epithelia Reveals Gas1 as a Novel stem\/progenitor Cell Marker for the Corneal Epithelium","author":"Richardson","year":"2024"},{"issue":"12","key":"10.1016\/j.exer.2025.110705_bib65","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1038\/s41591-022-02104-7","article-title":"Impact of the human cell Atlas on medicine","volume":"28","author":"Rood","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.exer.2025.110705_bib66","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1016\/j.csbj.2025.06.043","article-title":"Leveraging multiple labeled datasets for the automated annotation of single-cell RNA and ATAC data","volume":"27","author":"Sancho-Zamora","year":"2025","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"6","key":"10.1016\/j.exer.2025.110705_bib67","doi-asserted-by":"crossref","first-page":"344","DOI":"10.4274\/tjo.galenos.2024.49769","article-title":"The role of in vivo confocal microscopy in ocular allergies","volume":"54","author":"Simsek","year":"2024","journal-title":"Turk J.Ophthalmol."},{"issue":"6294","key":"10.1016\/j.exer.2025.110705_bib68","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1126\/science.aaf2403","article-title":"Visualization and analysis of gene expression in tissue sections by spatial transcriptomics","volume":"353","author":"Stahl","year":"2016","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.exer.2025.110705_bib69","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/nri1224","article-title":"Ocular immune privilege: therapeutic opportunities from an experiment of nature","volume":"3","author":"Streilein","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.exer.2025.110705_bib70","article-title":"Single-cell RNA sequencing and AlphaFold 3 insights into cytokine signaling and its role in uveal melanoma","volume":"15","author":"Sun","year":"2024","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.exer.2025.110705_bib71","first-page":"1442","article-title":"The X, Y, Z hypothesis of corneal epithelial maintenance","volume":"24","author":"Thoft","year":"1983","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110705_bib72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-024922-0.50005-9","article-title":"The lipid secretion of the meibomian glands","volume":"22","author":"Tiffany","year":"1987","journal-title":"Adv. Lipid Res."},{"key":"10.1016\/j.exer.2025.110705_bib73","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2025.1614288","article-title":"An integrated approach for analyzing spatially resolved multi-omics datasets from the same tissue section","volume":"12","author":"Tran","year":"2025","journal-title":"Front. Mol. Biosci."},{"issue":"5","key":"10.1016\/j.exer.2025.110705_bib74","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1097\/TP.0000000000005280","article-title":"Corneal graft rejection: is it reflected in peripheral immune cells? Results of a prospective multicenter study (VISICORT)","volume":"109","author":"Vabres","year":"2025","journal-title":"Transplantation"},{"issue":"29","key":"10.1016\/j.exer.2025.110705_bib75","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2200914119","article-title":"Cell atlas of the human ocular anterior segment: tissue-specific and shared cell types","volume":"119","author":"van Zyl","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"10.1016\/j.exer.2025.110705_bib76","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/s41592-019-0548-y","article-title":"High-definition spatial transcriptomics for in situ tissue profiling","volume":"16","author":"Vickovic","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.exer.2025.110705_bib77","doi-asserted-by":"crossref","first-page":"652","DOI":"10.34133\/research.0652","article-title":"A noninvasive menstrual blood-based diagnostic platform for endometriosis using digital droplet enzyme-linked immunosorbent assay and single-cell RNA sequencing","volume":"8","author":"Wang","year":"2025","journal-title":"Research"},{"key":"10.1016\/j.exer.2025.110705_bib78","doi-asserted-by":"crossref","DOI":"10.1093\/gpbjnl\/qzaf002","article-title":"HemaScope: a tool for analyzing single-cell and spatial transcriptomics data of hematopoietic cells","author":"Wang","year":"2025","journal-title":"Genom. Proteom. Bioinform."},{"key":"10.1016\/j.exer.2025.110705_bib79","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jtos.2024.08.005","article-title":"The effects of age and dysfunction on meibomian gland population dynamics","volume":"34","author":"Wiedemann","year":"2024","journal-title":"Ocul. Surf."},{"issue":"3","key":"10.1016\/j.exer.2025.110705_bib80","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1167\/iovs.16-21154","article-title":"Modulation of circadian rhythms affects corneal epithelium renewal and repair in mice","volume":"58","author":"Xue","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110705_bib81","doi-asserted-by":"crossref","first-page":"108","DOI":"10.12688\/f1000research.153698.1","article-title":"scRICA: an R package for multiple-sample single-cell RNA-seq data integrative comparative analysis","volume":"14","author":"Li","year":"2025","journal-title":"F1000Research"},{"issue":"8039","key":"10.1016\/j.exer.2025.110705_bib82","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/d41586-024-03552-6","article-title":"Cellular atlases are unlocking the mysteries of the human body","volume":"635","author":"Yanai","year":"2024","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.exer.2025.110705_bib83","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12967-024-06066-x","article-title":"Single-cell sequencing in diabetic retinopathy: progress and prospects","volume":"23","author":"Yang","year":"2025","journal-title":"J. Transl. Med."},{"issue":"15","key":"10.1016\/j.exer.2025.110705_bib84","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20153755","article-title":"Tear metabolomics in dry eye disease: a review","volume":"20","author":"Yazdani","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2025.110705_bib85","article-title":"CellPhenoX: an eXplainable cell-specific machine learning method to predict clinical phenotypes using single-cell multi-omics","author":"Young","year":"2025","journal-title":"bioRxiv"},{"issue":"5","key":"10.1016\/j.exer.2025.110705_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115612","article-title":"Single-cell and spatial transcriptomics reveal the pathogenesis of chronic granulomatous disease in a natural model","volume":"44","author":"Yu","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.exer.2025.110705_bib87","article-title":"Single-cell analysis of the epigenome and 3D chromatin architecture in the human retina","author":"Yuan","year":"2025","journal-title":"bioRxiv"},{"issue":"13","key":"10.1016\/j.exer.2025.110705_bib88","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1016\/j.jprot.2012.04.053","article-title":"In-depth analysis of the human tear proteome","volume":"75","author":"Zhou","year":"2012","journal-title":"J. Proteonomics"},{"issue":"1","key":"10.1016\/j.exer.2025.110705_bib89","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1038\/s41467-025-56907-6","article-title":"Identification of meibomian gland stem cell populations and mechanisms of aging","volume":"16","author":"Zhu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exer.2025.110705_bib90","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1146916","article-title":"High-fat intake reshapes the circadian transcriptome profile and metabolism in murine meibomian glands","volume":"10","author":"Zou","year":"2023","journal-title":"Front. Nutr."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525004786?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525004786?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T08:43:14Z","timestamp":1781253794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483525004786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":90,"alternative-id":["S0014483525004786"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2025.110705","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Commentary: Toward a global atlas of ocular surface biology: Rationale, design, and clinical applications","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2025.110705","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110705"}}