{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T09:00:25Z","timestamp":1781254825523,"version":"3.54.1"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.exer.2025.110735","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T16:52:08Z","timestamp":1762534328000},"page":"110735","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Inhibition of chemokine MCP-1 with mNOX-E36 reduces scarring in a mouse model of glaucoma filtration surgery"],"prefix":"10.1016","volume":"262","author":[{"given":"Seok Ting","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sieh Yean","family":"Kiew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li Zhen","family":"Toh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moreno","family":"Zanardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyun","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina T.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.exer.2025.110735_bib1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1136\/bjo.2005.077800","article-title":"Mitomycin C augmented glaucoma surgery: evolution of filtering bleb avascularity, transconjunctival oozing, and leaks","volume":"90","author":"Anand","year":"2006","journal-title":"Br. J. Ophthalmol."},{"issue":"21","key":"10.1016\/j.exer.2025.110735_bib2","doi-asserted-by":"crossref","first-page":"8057","DOI":"10.3390\/ijms21218057","article-title":"The dual role of myeloperoxidase in immune response","volume":"21","author":"Arnhold","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.exer.2025.110735_bib3","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1136\/gutjnl-2011-300304","article-title":"Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury","volume":"61","author":"Baeck","year":"2012","journal-title":"Gut"},{"issue":"12","key":"10.1016\/j.exer.2025.110735_bib4","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1001\/archopht.1991.01080120109038","article-title":"The effects of subconjunctival mitomycin-C on glaucoma filtration surgery in rabbits","volume":"109","author":"Bergstrom","year":"1991","journal-title":"Arch. Ophthalmol."},{"issue":"3","key":"10.1016\/j.exer.2025.110735_bib5","doi-asserted-by":"crossref","first-page":"150","DOI":"10.4103\/ojo.OJO_61_2016","article-title":"The role of trabeculectomy in enhancing glaucoma patient's quality of life","volume":"10","author":"Binibrahim","year":"2017","journal-title":"Oman J. Ophthalmol."},{"issue":"3","key":"10.1016\/j.exer.2025.110735_bib6","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nri3156","article-title":"The role of interleukin-2 during homeostasis and activation of the immune system","volume":"12","author":"Boyman","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.exer.2025.110735_bib7","doi-asserted-by":"crossref","first-page":"602","DOI":"10.3389\/fimmu.2015.00602","article-title":"Macrophages during the fibrotic process: M2 as friend and foe","volume":"6","author":"Braga","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exer.2025.110735_bib8","author":"Buchner"},{"issue":"5","key":"10.1016\/j.exer.2025.110735_bib9","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.immuni.2021.04.021","article-title":"Fibroblast-macrophage reciprocal interactions in health, fibrosis, and cancer","volume":"54","author":"Buechler","year":"2021","journal-title":"Immunity"},{"issue":"9","key":"10.1016\/j.exer.2025.110735_bib10","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.1073\/pnas.91.9.3652","article-title":"Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant","volume":"91","author":"Carr","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.exer.2025.110735_bib11","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1038\/eye.2008.330","article-title":"Increased mast cell numbers in the conjunctiva of glaucoma patients: a possible indicator of preoperative glaucoma surgery inflammation","volume":"23","author":"Chang","year":"2009","journal-title":"Eye (Lond)"},{"issue":"3\u20134","key":"10.1016\/j.exer.2025.110735_bib12","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00424-017-1947-5","article-title":"Macrophage physiology in the eye","volume":"469","author":"Chinnery","year":"2017","journal-title":"Pfl\u00fcgers Archiv"},{"issue":"1","key":"10.1016\/j.exer.2025.110735_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-47438-4","article-title":"Increased antiangiogenic effect by blocking CCL2-dependent macrophages in a rodent glioblastoma model: correlation study with dynamic susceptibility contrast perfusion MRI","volume":"9","author":"Cho","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.exer.2025.110735_bib14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/aos.14485","article-title":"Experimental models of glaucoma filtration surgery","volume":"99","author":"Chong","year":"2021","journal-title":"Acta Ophthalmol."},{"issue":"12","key":"10.1016\/j.exer.2025.110735_bib15","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1016\/j.ophtha.2010.03.064","article-title":"Tear cytokine profile in medicated glaucoma patients: effect of monocyte chemoattractant protein 1 on early posttrabeculectomy outcome","volume":"117","author":"Chong","year":"2010","journal-title":"Ophthalmology"},{"issue":"9","key":"10.1016\/j.exer.2025.110735_bib16","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1167\/iovs.17-21480","article-title":"Inhibition of monocyte chemoattractant protein 1 prevents conjunctival fibrosis in an experimental model of glaucoma filtration surgery","volume":"58","author":"Chong","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.exer.2025.110735_bib17","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1089\/jir.2008.0027","article-title":"Monocyte chemoattractant protein-1 (MCP-1): an overview","volume":"29","author":"Deshmane","year":"2009","journal-title":"J. Interferon Cytokine Res."},{"issue":"1","key":"10.1016\/j.exer.2025.110735_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1545","article-title":"Crosstalk between fibroblasts and immunocytes in fibrosis: from molecular mechanisms to clinical trials","volume":"14","author":"Di","year":"2024","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.exer.2025.110735_bib19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ajo.2020.07.002","article-title":"A randomized controlled trial comparing subconjunctival injection to direct scleral application of mitomycin C in trabeculectomy","volume":"220","author":"Do","year":"2020","journal-title":"Am. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.exer.2025.110735_bib20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.immuni.2014.06.013","article-title":"Origin and functions of tissue macrophages","volume":"41","author":"Epelman","year":"2014","journal-title":"Immunity"},{"issue":"10","key":"10.1016\/j.exer.2025.110735_bib21","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1002\/cbic.200300663","article-title":"Spiegelmers: biostable aptamers","volume":"4","author":"Eulberg","year":"2003","journal-title":"Chembiochem"},{"issue":"2","key":"10.1016\/j.exer.2025.110735_bib22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.5005\/jp-journals-10008-1159","article-title":"Wound healing modulation in glaucoma filtration surgery-conventional practices and new perspectives: the role of antifibrotic agents (part I)","volume":"8","author":"Fan Gaskin","year":"2014","journal-title":"J. Curr. Glaucoma Pract."},{"issue":"8","key":"10.1016\/j.exer.2025.110735_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0237932","article-title":"Disruption of fibronectin fibrillogenesis affects intraocular pressure (IOP) in BALB\/cJ mice","volume":"15","author":"Faralli","year":"2020","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.exer.2025.110735_bib24","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1038\/sj.jid.5700302","article-title":"Diminished induction of skin fibrosis in mice with MCP-1 deficiency","volume":"126","author":"Ferreira","year":"2006","journal-title":"J. Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.exer.2025.110735_bib25","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.pharmthera.2003.08.003","article-title":"Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex","volume":"100","author":"Fujihara","year":"2003","journal-title":"Pharmacol. Ther."},{"issue":"30","key":"10.1016\/j.exer.2025.110735_bib26","doi-asserted-by":"crossref","first-page":"17779","DOI":"10.1074\/jbc.271.30.17779","article-title":"Costimulation of fibroblast collagen and transforming growth factor beta1 gene expression by monocyte chemoattractant protein-1 via specific receptors","volume":"271","author":"Gharaee-Kermani","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.exer.2025.110735_bib27","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1001\/archopht.1996.01100140151007","article-title":"Endophthalmitis after filtering surgery with mitomycin","volume":"114","author":"Greenfield","year":"1996","journal-title":"Arch. Ophthalmol."},{"issue":"3","key":"10.1016\/j.exer.2025.110735_bib28","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/IJG.0000000000001438","article-title":"Historical considerations and innovations in the perioperative use of mitomycin C for glaucoma filtration surgery and bleb revisions","volume":"29","author":"Grover","year":"2020","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.exer.2025.110735_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.02759","article-title":"More than just attractive: how CCL2 influences myeloid cell behavior beyond chemotaxis","volume":"10","author":"Gschwandtner","year":"2019","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.exer.2025.110735_bib30","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/MNH.0000000000000186","article-title":"Monocyte chemoattractant protein-1 and the kidney","volume":"25","author":"Haller","year":"2016","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"9","key":"10.1016\/j.exer.2025.110735_bib31","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1001\/archopht.117.9.1211","article-title":"Probability of filtration surgery in patients with open-angle glaucoma","volume":"117","author":"Hattenhauer","year":"1999","journal-title":"Arch. Ophthalmol."},{"issue":"42","key":"10.1016\/j.exer.2025.110735_bib32","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000035613","article-title":"Role of MCP-1\/CCR2 axis in renal fibrosis: mechanisms and therapeutic targeting","volume":"102","author":"He","year":"2023","journal-title":"Medicine"},{"issue":"36","key":"10.1016\/j.exer.2025.110735_bib33","doi-asserted-by":"crossref","first-page":"13174","DOI":"10.1073\/pnas.0404175101","article-title":"Inhibition of ghrelin action in vitro and in vivo by an RNA-spiegelmer","volume":"101","author":"Helmling","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.exer.2025.110735_bib34","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/S0161-6420(96)30639-8","article-title":"Bleb-related endophthalmitis after trabeculectomy with mitomycin C","volume":"103","author":"Higginbotham","year":"1996","journal-title":"Ophthalmology"},{"issue":"5","key":"10.1016\/j.exer.2025.110735_bib35","doi-asserted-by":"crossref","first-page":"L1038","DOI":"10.1152\/ajplung.00167.2003","article-title":"Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary fibrosis in mice","volume":"286","author":"Inoshima","year":"2004","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"2","key":"10.1016\/j.exer.2025.110735_bib36","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/sji.12310","article-title":"Spiegelmer inhibition of MCP-1\/CCR2 \u2013 Potential as an adjunct immunosuppressive therapy in transplantation","volume":"82","author":"Kalnins","year":"2015","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.exer.2025.110735_bib37","series-title":"Albert and Jakobiec's Principles and Practice of Ophthalmology","first-page":"1","article-title":"Glaucoma filtration surgery: indications, techniques, and complications","author":"Khaw","year":"2020"},{"issue":"2","key":"10.1016\/j.exer.2025.110735_bib38","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1124\/jpet.108.142711","article-title":"Anti-Ccl2 spiegelmer permits 75% dose reduction of cyclophosphamide to control diffuse proliferative lupus nephritis and pneumonitis in MRL-fas(lpr) mice","volume":"328","author":"Kulkarni","year":"2009","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"8","key":"10.1016\/j.exer.2025.110735_bib39","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1681\/ASN.2006121348","article-title":"Spiegelmer inhibition of CCL2\/MCP-1 ameliorates lupus nephritis in MRL-(fas)lpr mice","volume":"18","author":"Kulkarni","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"issue":"2","key":"10.1016\/j.exer.2025.110735_bib40","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3390\/biom13020333","article-title":"CC chemokines in idiopathic pulmonary fibrosis: pathogenic role and therapeutic potential","volume":"13","author":"Liu","year":"2023","journal-title":"Biomolecules"},{"issue":"5","key":"10.1016\/j.exer.2025.110735_bib41","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.bbamcr.2012.12.014","article-title":"CTGF induces monocyte chemoattractant protein-1 expression to enhance monocyte migration in human synovial fibroblasts","volume":"1833","author":"Liu","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.exer.2025.110735_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0122409","article-title":"Altered expression of fibrosis genes in capsules of failed ahmed glaucoma valve implants","volume":"10","author":"Mahale","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.exer.2025.110735_bib43","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/s41433-023-02816-1","article-title":"Long-term outcomes of Mitomycin-C augmented trabeculectomy using subconjunctival injections versus soaked sponges: a randomised controlled trial","volume":"38","author":"Maheshwari","year":"2024","journal-title":"Eye"},{"issue":"4","key":"10.1016\/j.exer.2025.110735_bib44","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1084\/jem.169.4.1485","article-title":"Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line","volume":"169","author":"Matsushima","year":"1989","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.exer.2025.110735_bib45","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/ndt\/gfv459","article-title":"C-C motif-ligand 2 inhibition with emapticap pegol (NOX-E36) in type 2 diabetic patients with albuminuria","volume":"32","author":"Menne","year":"2017","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.exer.2025.110735_bib46","article-title":"A ticking time bomb: how to fix a leaking bleb","author":"Mott","year":"2018","journal-title":"EyeNet Magazine"},{"issue":"1","key":"10.1016\/j.exer.2025.110735_bib47","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/SHK.0000000000001601","article-title":"Tissue-resident macrophages in the control of infection and resolution of inflammation","volume":"55","author":"Mu","year":"2021","journal-title":"Shock"},{"key":"10.1016\/j.exer.2025.110735_bib48","series-title":"Ophthalmic Product Development: from Bench to Bedside","first-page":"3","article-title":"Introduction and history of ophthalmic product development","author":"Neervannan","year":"2021"},{"issue":"3","key":"10.1016\/j.exer.2025.110735_bib49","doi-asserted-by":"crossref","first-page":"628","DOI":"10.2353\/ajpath.2008.070601","article-title":"Late onset of Ccl2 blockade with the spiegelmer mNOX-E36-3'PEG prevents glomerulosclerosis and improves glomerular filtration rate in db\/db mice","volume":"172","author":"Ninichuk","year":"2008","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.exer.2025.110735_bib50","doi-asserted-by":"crossref","first-page":"6923","DOI":"10.1038\/ncomms7923","article-title":"Crystal structure of a mirror-image L-RNA aptamer (spiegelmer) in complex with the natural L-protein target CCL2","volume":"6","author":"Oberth\u00fcr","year":"2015","journal-title":"Nat. Commun."},{"issue":"9774","key":"10.1016\/j.exer.2025.110735_bib51","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/S0140-6736(10)61423-7","article-title":"Glaucoma","volume":"377","author":"Quigley","year":"2011","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.exer.2025.110735_bib52","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.0603252","article-title":"Interferon-\u03b3: an overview of signals, mechanisms and functions","volume":"75","author":"Schroder","year":"2004","journal-title":"J. Leukoc. Biol."},{"issue":"6","key":"10.1016\/j.exer.2025.110735_bib53","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s00109-021-02171-2","article-title":"Valproic acid modulates collagen architecture in the postoperative conjunctival scar","volume":"100","author":"Seet","year":"2022","journal-title":"J. Mol. Med."},{"issue":"2","key":"10.1016\/j.exer.2025.110735_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009415","article-title":"SPARC deficiency results in improved surgical survival in a novel mouse model of glaucoma filtration surgery","volume":"5","author":"Seet","year":"2010","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.exer.2025.110735_bib55","doi-asserted-by":"crossref","first-page":"6495","DOI":"10.1364\/BOE.403555","article-title":"Assessment of progressive alterations in collagen organization in the postoperative conjunctiva by multiphoton microscopy","volume":"11","author":"Seet","year":"2020","journal-title":"Biomed. Opt. Express"},{"issue":"6","key":"10.1016\/j.exer.2025.110735_bib56","doi-asserted-by":"crossref","first-page":"911","DOI":"10.2174\/15665240113139990021","article-title":"Novel insight into the inflammatory and cellular responses following experimental glaucoma surgery: a roadmap for inhibiting fibrosis","volume":"13","author":"Seet","year":"2013","journal-title":"Curr. Mol. Med."},{"issue":"5\u20136","key":"10.1016\/j.exer.2025.110735_bib57","doi-asserted-by":"crossref","first-page":"557","DOI":"10.2119\/molmed.2010.00188","article-title":"Validation of the glaucoma filtration surgical mouse model for antifibrotic drug evaluation","volume":"17","author":"Seet","year":"2011","journal-title":"Mol Med."},{"issue":"3","key":"10.1016\/j.exer.2025.110735_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11030657","article-title":"Novel therapies for the prevention of fibrosis in glaucoma filtration surgery","volume":"11","author":"Shao","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.exer.2025.110735_bib59","article-title":"The pros and cons of using Mitomycin-C","author":"Sherwood","year":"2016","journal-title":"Rev. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110735_bib60","series-title":"Bleb Associated Infections","author":"Slabaugh","year":"2024"},{"key":"10.1016\/j.exer.2025.110735_bib61","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.2147\/OPTH.S370082","article-title":"Proportion of glaucoma types and surgeries among young, pre-old, old, and oldest-old age groups or different sex groups","volume":"16","author":"Tanito","year":"2022","journal-title":"Clin. Ophthalmol."},{"issue":"10","key":"10.1016\/j.exer.2025.110735_bib62","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1038\/eye.2008.382","article-title":"Ocular immune privilege","volume":"23","author":"Taylor","year":"2009","journal-title":"Eye"},{"issue":"11","key":"10.1016\/j.exer.2025.110735_bib63","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2025.110735_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2022.108972","article-title":"Animal models and drug candidates for use in glaucoma filtration surgery: a systematic review","volume":"217","author":"van Mechelen","year":"2022","journal-title":"Exp. Eye Res."},{"issue":"1","key":"10.1016\/j.exer.2025.110735_bib65","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.drudis.2014.09.004","article-title":"Turning mirror-image oligonucleotides into drugs: the evolution of spiegelmer\u00ae therapeutics","volume":"20","author":"Vater","year":"2015","journal-title":"Drug Discov. Today"},{"issue":"4","key":"10.1016\/j.exer.2025.110735_bib66","article-title":"Intra-operative mitomycin C for glaucoma surgery","volume":"2005","author":"Wilkins","year":"2005","journal-title":"Cochrane Database Syst. Rev."},{"issue":"13","key":"10.1016\/j.exer.2025.110735_bib67","doi-asserted-by":"crossref","first-page":"8898","DOI":"10.1073\/pnas.132067399","article-title":"In vivo properties of an anti-GnRH spiegelmer: an example of an oligonucleotide-based therapeutic substance class","volume":"99","author":"Wlotzka","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.exer.2025.110735_bib68","doi-asserted-by":"crossref","DOI":"10.1097\/ICU.0000000000000729","article-title":"History, presence, and future of mitomycin C in glaucoma filtration surgery","volume":"32","author":"Wolters","year":"2021","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110735_bib69","first-page":"1705","article-title":"Mechanism of mitomycin-induced apoptosis in cultured corneal endothelial cells","volume":"14","author":"Wu","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.exer.2025.110735_bib70","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.2741\/2875","article-title":"Pathogenic role of CCL2\/MCP-1 in scleroderma","volume":"13","author":"Yamamoto","year":"2008","journal-title":"Front. Biosci."},{"issue":"12","key":"10.1016\/j.exer.2025.110735_bib71","doi-asserted-by":"crossref","first-page":"6174","DOI":"10.4049\/jimmunol.164.12.6174","article-title":"Monocyte chemoattractant Protein-1 enhances gene expression and synthesis of matrix Metalloproteinase-1 in human fibroblasts by an autocrine IL-1\u03b1 Loop1","volume":"164","author":"Yamamoto","year":"2000","journal-title":"J. Immunol."},{"issue":"Suppl. 1","key":"10.1016\/j.exer.2025.110735_bib72","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12886-015-0134-8","article-title":"Pathobiology of wound healing after glaucoma filtration surgery","volume":"15","author":"Yamanaka","year":"2015","journal-title":"BMC Ophthalmol."},{"issue":"12","key":"10.1016\/j.exer.2025.110735_bib73","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00011-006-5144-9","article-title":"Transforming growth factor-beta stimulates IL-1beta-induced monocyte chemoattractant protein-1 expression in human synovial cells via the ERK\/AP-1 pathway","volume":"55","author":"Yoshimura","year":"2006","journal-title":"Inflamm. Res."},{"issue":"34","key":"10.1016\/j.exer.2025.110735_bib74","doi-asserted-by":"crossref","first-page":"7981","DOI":"10.1002\/chem.201900149","article-title":"Mirror-image oligonucleotides: history and emerging applications","volume":"25","author":"Young","year":"2019","journal-title":"Chemistry"},{"issue":"9","key":"10.1016\/j.exer.2025.110735_bib75","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1089\/wound.2015.0677","article-title":"Personalized medicine in ocular fibrosis: myth or future biomarkers","volume":"5","author":"Yu-Wai-Man","year":"2016","journal-title":"Adv. Wound Care"},{"key":"10.1016\/j.exer.2025.110735_bib76","doi-asserted-by":"crossref","DOI":"10.3410\/B2-3","article-title":"Ocular immune privilege","volume":"2","author":"Zhou","year":"2010","journal-title":"F1000 Biol Rep"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525005081?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525005081?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T08:42:09Z","timestamp":1781253729000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483525005081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":76,"alternative-id":["S0014483525005081"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2025.110735","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of chemokine MCP-1 with mNOX-E36 reduces scarring in a mouse model of glaucoma filtration surgery","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2025.110735","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110735"}}