{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:00:14Z","timestamp":1790136014208,"version":"4.0.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016200","name":"Augusta University Medical College of Georgia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012127","name":"Augusta University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012127","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EY11766"],"award-info":[{"award-number":["R01 EY11766"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 EY031631"],"award-info":[{"award-number":["P30 EY031631"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001209","name":"Knights Templar Eye Foundation","doi-asserted-by":"publisher","award":["IGPP00069"],"award-info":[{"award-number":["IGPP00069"]}],"id":[{"id":"10.13039\/100001209","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001209","name":"Knights Templar Eye Foundation","doi-asserted-by":"publisher","award":["KTEYE00003"],"award-info":[{"award-number":["KTEYE00003"]}],"id":[{"id":"10.13039\/100001209","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.exer.2025.110742","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T03:52:17Z","timestamp":1762833137000},"page":"110742","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Inhibition of pathological angiogenesis in oxygen-induced retinopathy by arginine depletion with ADI-PEG20"],"prefix":"10.1016","volume":"262","author":[{"given":"Porsche V.","family":"Sandow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9177-0881","authenticated-orcid":false,"given":"Syed A.H.","family":"Zaidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth B.","family":"Caldwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. William","family":"Caldwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"18","key":"10.1016\/j.exer.2025.110742_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/cells11182890","article-title":"Systemic administration of pegylated Arginase-1 attenuates the progression of diabetic retinopathy","volume":"11","author":"Abdelrahman","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.exer.2025.110742_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2024.102020","article-title":"Arginine deprivation\/citrulline augmentation with ADI-PEG20 as novel therapy for complications in type 2 diabetes","volume":"89","author":"Abdelrahman","year":"2024","journal-title":"Mol. Metabol."},{"issue":"2","key":"10.1016\/j.exer.2025.110742_bib3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3390\/jcm9020317","article-title":"Role of arginase 2 in Murine retinopathy associated with Western diet-induced obesity","volume":"9","author":"Atawia","year":"2020","journal-title":"J. Clin. Med."},{"issue":"11","key":"10.1016\/j.exer.2025.110742_bib4","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1001\/archopht.124.11.1669-c","article-title":"Standard image of plus disease in retinopathy of prematurity","volume":"124","author":"Capone","year":"2006","journal-title":"Arch. Ophthalmol."},{"issue":"2","key":"10.1016\/j.exer.2025.110742_bib5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10456-007-9066-0","article-title":"Retinopathy of prematurity","volume":"10","author":"Chen","year":"2007","journal-title":"Angiogenesis"},{"issue":"12","key":"10.1016\/j.exer.2025.110742_bib6","doi-asserted-by":"crossref","first-page":"4291","DOI":"10.1128\/IAI.00880-12","article-title":"Expression of STM4467-encoded arginine deiminase controlled by the STM4463 regulator contributes to Salmonella enterica serovar Typhimurium virulence","volume":"80","author":"Choi","year":"2012","journal-title":"Infect. Immun."},{"issue":"11","key":"10.1016\/j.exer.2025.110742_bib7","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1038\/nprot.2009.187","article-title":"Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis","volume":"4","author":"Connor","year":"2009","journal-title":"Nat. Protoc."},{"issue":"6","key":"10.1016\/j.exer.2025.110742_bib8","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1136\/bjo.2007.135640","article-title":"VEGF-induced effects on proliferation, migration and tight junctions are restored by ranibizumab (Lucentis) in microvascular retinal endothelial cells","volume":"92","author":"Deissler","year":"2008","journal-title":"Br. J. Ophthalmol."},{"issue":"12","key":"10.1016\/j.exer.2025.110742_bib9","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1007\/s12098-017-2404-3","article-title":"An update on Retinopathy of Prematurity (ROP)","volume":"84","author":"Dogra","year":"2017","journal-title":"Indian J. Pediatr."},{"issue":"6","key":"10.1016\/j.exer.2025.110742_bib10","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nm0603-669","article-title":"The biology of VEGF and its receptors","volume":"9","author":"Ferrara","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.exer.2025.110742_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113923","article-title":"Preclinical investigation of pegylated arginase 1 as a treatment for retina and brain injury","volume":"348","author":"Fouda","year":"2022","journal-title":"Exp. Neurol."},{"issue":"8","key":"10.1016\/j.exer.2025.110742_bib12","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41419-022-05196-8","article-title":"Targeting proliferative retinopathy: arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair","volume":"13","author":"Fouda","year":"2022","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.exer.2025.110742_bib13","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.preteyeres.2009.06.003","article-title":"The neurovascular retina in retinopathy of prematurity","volume":"28","author":"Fulton","year":"2009","journal-title":"Prog. Retin. Eye Res."},{"issue":"2","key":"10.1016\/j.exer.2025.110742_bib14","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0002-9440(10)62284-5","article-title":"Inhibition of tumor necrosis factor-alpha improves physiological angiogenesis and reduces pathological neovascularization in ischemic retinopathy","volume":"166","author":"Gardiner","year":"2005","journal-title":"Am. J. Pathol."},{"issue":"3","key":"10.1016\/j.exer.2025.110742_bib15","doi-asserted-by":"crossref","first-page":"C546","DOI":"10.1152\/ajpcell.00424.2002","article-title":"Hyperoxia induces retinal vascular endothelial cell apoptosis through formation of peroxynitrite","volume":"285","author":"Gu","year":"2003","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"1","key":"10.1016\/j.exer.2025.110742_bib16","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ophtha.2014.07.050","article-title":"Pathophysiology and mechanisms of severe retinopathy of prematurity","volume":"122","author":"Hartnett","year":"2015","journal-title":"Ophthalmology"},{"issue":"12","key":"10.1016\/j.exer.2025.110742_bib17","first-page":"1162","article-title":"Mechanisms and management of retinopathy of prematurity","volume":"368","author":"Hartnett","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.exer.2025.110742_bib18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2147\/EB.S94447","article-title":"Revisiting the mouse model of oxygen-induced retinopathy","volume":"8","author":"Kim","year":"2016","journal-title":"Eye Brain"},{"issue":"8","key":"10.1016\/j.exer.2025.110742_bib19","article-title":"Analysis of vessel tortuosity and its impact on hemodynamics in retinopathy of prematurity","volume":"64","author":"Koogler","year":"2023","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.exer.2025.110742_bib20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s13167-023-00314-8","article-title":"Diabetic retinopathy as the leading cause of blindness and early predictor of cascading complications-risks and mitigation","volume":"14","author":"Kropp","year":"2023","journal-title":"EPMA J."},{"issue":"8","key":"10.1016\/j.exer.2025.110742_bib21","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/eye.2011.92","article-title":"The burden of disease of retinal vein occlusion: review of the literature","volume":"25","author":"Laouri","year":"2011","journal-title":"Eye (Lond)"},{"issue":"2","key":"10.1016\/j.exer.2025.110742_bib22","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1084\/jem.20072041","article-title":"VEGF and TGF-beta are required for the maintenance of the choroid plexus and ependyma","volume":"205","author":"Maharaj","year":"2008","journal-title":"J. Exp. Med."},{"issue":"10","key":"10.1016\/j.exer.2025.110742_bib23","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1172\/JCI24612","article-title":"Rapid vascular regrowth in tumors after reversal of VEGF inhibition","volume":"116","author":"Mancuso","year":"2006","journal-title":"J. Clin. Investig."},{"issue":"3","key":"10.1016\/j.exer.2025.110742_bib24","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.molcel.2021.12.006","article-title":"Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses","volume":"82","author":"Mao","year":"2022","journal-title":"Mol. Cell"},{"issue":"10","key":"10.1016\/j.exer.2025.110742_bib25","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1097\/OPX.0000000000000941","article-title":"In vivo angiography quantifies oxygen-induced retinopathy vascular recovery","volume":"93","author":"Mezu-Ndubuisi","year":"2016","journal-title":"Optom. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110742_bib26","first-page":"257","article-title":"Long-term evaluation of retinal morphology and function in a mouse model of oxygen-induced retinopathy","volume":"26","author":"Mezu-Ndubuisi","year":"2020","journal-title":"Mol. Vis."},{"issue":"2","key":"10.1016\/j.exer.2025.110742_bib27","first-page":"228","article-title":"Treatment of retinopathy of prematurity: a review of conventional and promising new therapeutic options","volume":"6","author":"Mutlu","year":"2013","journal-title":"Int. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.exer.2025.110742_bib28","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2018.6801","article-title":"Prevalence of severe visual disability among preterm children with retinopathy of prematurity and Association with Adherence to best practice guidelines","volume":"2","author":"Norman","year":"2019","journal-title":"JAMA Netw. Open"},{"issue":"4","key":"10.1016\/j.exer.2025.110742_bib29","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.preteyeres.2008.05.001","article-title":"Vascular endothelial growth factor in eye disease","volume":"27","author":"Penn","year":"2008","journal-title":"Prog. Retin. Eye Res."},{"issue":"10","key":"10.1016\/j.exer.2025.110742_bib30","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1038\/eye.2008.88","article-title":"Anti-VEGF therapy: comparison of current and future agents","volume":"22","author":"Pieramici","year":"2008","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.exer.2025.110742_bib31","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/3940241","article-title":"Ischemic retinopathies: oxidative stress and inflammation","volume":"2017","author":"Rivera","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"3","key":"10.1016\/j.exer.2025.110742_bib32","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/eye.2009.306","article-title":"Oxygen-induced retinopathy: a model for vascular pathology in the retina","volume":"24","author":"Scott","year":"2010","journal-title":"Eye (Lond)"},{"issue":"2","key":"10.1016\/j.exer.2025.110742_bib33","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1369\/0022155412467635","article-title":"Endothelial tip cells in ocular angiogenesis: potential target for anti-angiogenesis therapy","volume":"61","author":"Siemerink","year":"2013","journal-title":"J. Histochem. Cytochem."},{"issue":"2","key":"10.1016\/j.exer.2025.110742_bib34","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/path.2858","article-title":"Retinal ganglion cell death is induced by microglia derived pro-inflammatory cytokines in the hypoxic neonatal retina","volume":"224","author":"Sivakumar","year":"2011","journal-title":"J. Pathol."},{"issue":"1","key":"10.1016\/j.exer.2025.110742_bib35","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00018-021-04042-y","article-title":"eNOS controls angiogenic sprouting and retinal neovascularization through the regulation of endothelial cell polarity","volume":"79","author":"Smith","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"issue":"6","key":"10.1016\/j.exer.2025.110742_bib36","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1167\/iovs.09-4344","article-title":"Reduced nitro-oxidative stress and neural cell death suggests a protective role for microglial cells in TNFalpha-\/- mice in ischemic retinopathy","volume":"51","author":"Stevenson","year":"2010","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.exer.2025.110742_bib37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.mayocp.2011.10.001","article-title":"The expanding role of vascular endothelial growth factor inhibitors in ophthalmology","volume":"87","author":"Stewart","year":"2012","journal-title":"Mayo Clin. Proc."},{"issue":"7 Pt 1","key":"10.1016\/j.exer.2025.110742_bib38","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1523\/JNEUROSCI.15-07-04738.1995","article-title":"Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia","volume":"15","author":"Stone","year":"1995","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.exer.2025.110742_bib39","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1001\/jamaoncol.2023.6789","article-title":"Pegargiminase plus first-line chemotherapy in patients with Nonepithelioid pleural Mesothelioma: the ATOMIC-Meso randomized clinical trial","volume":"10","author":"Szlosarek","year":"2024","journal-title":"JAMA Oncol."},{"issue":"17","key":"10.1016\/j.exer.2025.110742_bib40","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.2995","article-title":"Human endothelial cell spheroid-based sprouting angiogenesis assay in collagen","volume":"8","author":"Tetzlaff","year":"2018","journal-title":"Bio Protoc"},{"key":"10.1016\/j.exer.2025.110742_bib41","doi-asserted-by":"crossref","first-page":"873","DOI":"10.3389\/fphar.2020.00873","article-title":"Exploration of oxygen-induced retinopathy model to discover new therapeutic drug targets in retinopathies","volume":"11","author":"Vahatupa","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.exer.2025.110742_bib42","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nrc2152","article-title":"Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition","volume":"7","author":"Verheul","year":"2007","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.exer.2025.110742_bib43","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1001\/jamaophthalmol.2013.986","article-title":"Signaling pathways triggered by oxidative stress that mediate features of severe retinopathy of prematurity","volume":"131","author":"Wang","year":"2013","journal-title":"JAMA Ophthalmol"},{"issue":"5","key":"10.1016\/j.exer.2025.110742_bib44","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s11427-018-9337-0","article-title":"Long-lasting impairments in rodent oxygen-induced retinopathy measured by retinal vessel density and visual function","volume":"62","author":"Wang","year":"2019","journal-title":"Sci. China Life Sci."},{"issue":"2","key":"10.1016\/j.exer.2025.110742_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/jpm13020291","article-title":"Systemic cytokines in retinopathy of prematurity","volume":"13","author":"Wu","year":"2023","journal-title":"J. Personalized Med."},{"issue":"1","key":"10.1016\/j.exer.2025.110742_bib46","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12974-023-02700-5","article-title":"Role of acyl-coenzyme A: cholesterol transferase 1 (ACAT1) in retinal neovascularization","volume":"20","author":"Zaidi","year":"2023","journal-title":"J. Neuroinflammation"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525005159?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525005159?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T08:44:16Z","timestamp":1781253856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483525005159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":46,"alternative-id":["S0014483525005159"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2025.110742","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of pathological angiogenesis in oxygen-induced retinopathy by arginine depletion with ADI-PEG20","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2025.110742","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110742"}}