{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T08:58:54Z","timestamp":1781254734816,"version":"3.54.1"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009136","name":"Cognizant Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009136","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.exer.2025.110745","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T05:12:32Z","timestamp":1763183552000},"page":"110745","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Dysbiosis of bacterial and fungal microbiomes affects the disease process and treatment outcome in fungal keratitis"],"prefix":"10.1016","volume":"262","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2193-4609","authenticated-orcid":false,"given":"Bharanidharan","family":"Devarajan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sankalp","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalitha","family":"Prajna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prajna Namperumalsamy","family":"Venkatesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuppamuthu","family":"Dharmalingam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exer.2025.110745_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/froh.2024.1425937","article-title":"Investigating the role of a tannerella forsythia HtrA protease in host protein degradation and inflammatory response","volume":"5","author":"Bloch","year":"2024","journal-title":"Front. Oral Health"},{"key":"10.1016\/j.exer.2025.110745_bib2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejpb.2023.07.010","article-title":"Development of a time-dependent oral Colon delivery system of anaerobic Odoribacter splanchnicus for bacteriotherapy","volume":"190","author":"Bosch","year":"2023","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.exer.2025.110745_bib3","first-page":"1","article-title":"The altered gut microbiota in adults with cystic fibrosis","volume":"17","author":"Burke","year":"2017","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.exer.2025.110745_bib4","doi-asserted-by":"crossref","DOI":"10.1167\/tvst.10.2.19","article-title":"Ocular surface microbiome alterations are found in both eyes of individuals with unilateral infectious keratitis","volume":"10","author":"Cavuoto","year":"2021","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.exer.2025.110745_bib5","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/s41596-019-0264-1","article-title":"Using MicrobiomeAnalyst for comprehensive statistical, functional, and meta-analysis of microbiome data","volume":"15","author":"Chong","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.exer.2025.110745_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep23561","article-title":"Altered mucosal microbiome diversity and disease severity in sj\u00f6gren syndrome","volume":"6","author":"de Paiva","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exer.2025.110745_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2016.01706","article-title":"Mucosal prevalence and interactions with the epithelium indicate commensalism of sutterella spp","volume":"7","author":"Hiippala","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.exer.2025.110745_bib8","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02162-21","article-title":"Characterization of the ocular surface microbiome in keratitis patients after repeated ophthalmic antibiotic exposure","volume":"10","author":"Kang","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.exer.2025.110745_bib9","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.exer.2025.110745_bib10","doi-asserted-by":"crossref","first-page":"14547","DOI":"10.1073\/pnas.96.25.14547","article-title":"Bacterial diversity within the human subgingival crevice","volume":"96","author":"Kroes","year":"1999","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.exer.2025.110745_bib11","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jtos.2016.04.004","article-title":"Impact of microbiome on ocular health","volume":"14","author":"Kugadas","year":"2016","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exer.2025.110745_bib12","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.immuni.2017.06.014","article-title":"An ocular commensal protects against corneal infection by driving an interleukin-17 response from mucosal \u03b3\u03b4 T cells","volume":"47","author":"Leger","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.exer.2025.110745_bib13","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1007\/s11427-017-9303-9","article-title":"Characteristics of fecal microbiota in non-alcoholic fatty liver disease patients","volume":"61","author":"Li","year":"2018","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.exer.2025.110745_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2012-13-9-r79","article-title":"Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment","volume":"13","author":"Morgan","year":"2012","journal-title":"Genome Biol."},{"key":"10.1016\/j.exer.2025.110745_bib15","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3390\/microorganisms7090309","article-title":"Alterations in the ocular surface fungal microbiome in fungal keratitis patients","volume":"7","author":"Sai Prashanthi","year":"2019","journal-title":"Microorganisms"},{"key":"10.1016\/j.exer.2025.110745_bib16","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s40135-019-00217-w","article-title":"The microbiome and ocular surface disease","volume":"7","author":"Watane","year":"2019","journal-title":"Current Ophthalmology Reports"},{"key":"10.1016\/j.exer.2025.110745_bib17","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00261-11","article-title":"Application of novel PCR-based methods for detection, quantitation, and phylogenetic characterization of Sutterella species in intestinal biopsy samples from children with autism and gastrointestinal disturbances","volume":"3","author":"Williams","year":"2012","journal-title":"mBio"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525005184?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525005184?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T08:37:24Z","timestamp":1781253444000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483525005184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":17,"alternative-id":["S0014483525005184"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2025.110745","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysbiosis of bacterial and fungal microbiomes affects the disease process and treatment outcome in fungal keratitis","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2025.110745","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110745"}}