{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:55:48Z","timestamp":1781326548751,"version":"3.54.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2022J05302"],"award-info":[{"award-number":["2022J05302"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20240813145510014"],"award-info":[{"award-number":["JCYJ20240813145510014"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471048"],"award-info":[{"award-number":["82471048"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271045"],"award-info":[{"award-number":["82271045"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0908100"],"award-info":[{"award-number":["2020YFA0908100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.exer.2025.110769","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T15:59:19Z","timestamp":1763827159000},"page":"110769","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Reveal a risk and potential mechanism for keratoconus progression with isotretinoin: Toxicogenomic, transcriptomics and real-world evidence insights"],"prefix":"10.1016","volume":"263","author":[{"given":"Tao","family":"Tao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yabin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0449-3709","authenticated-orcid":false,"given":"Cheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.exer.2025.110769_bib1","doi-asserted-by":"crossref","DOI":"10.1111\/dth.15311","article-title":"Low-dose oral isotretinoin for the treatment of adult patients with mild-to-moderate acne vulgaris: systematic review and meta-analysis","volume":"35","author":"Al Muqarrab","year":"2022","journal-title":"Dermatol. Ther."},{"issue":"1","key":"10.1016\/j.exer.2025.110769_bib2","article-title":"Potential of machine learning for predicting sleep disorders: a comprehensive analysis of regression and classification models","volume":"14","author":"Alazaidah","year":"2023","journal-title":"Diagnostics (Basel)"},{"issue":"1","key":"10.1016\/j.exer.2025.110769_bib3","doi-asserted-by":"crossref","first-page":"2 1","DOI":"10.1002\/cpbi.27","article-title":"Searching online Mendelian inheritance in man (OMIM): a knowledgebase of human genes and genetic phenotypes","volume":"58","author":"Amberger","year":"2017","journal-title":"Curr. Protoc. Bioinform."},{"key":"10.1016\/j.exer.2025.110769_bib4","article-title":"Integrative epidemiology and immunotranscriptomics uncover a risk and potential mechanism for cutaneous lymphoma unmasking or progression with dupilumab therapy","author":"Cabrera-Perez","year":"2024","journal-title":"J. Allergy Clin. Immunol."},{"issue":"3","key":"10.1016\/j.exer.2025.110769_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2021.102763","article-title":"Interleukin 1alpha: a comprehensive review on the role of IL-1alpha in the pathogenesis and treatment of autoimmune and inflammatory diseases","volume":"20","author":"Cavalli","year":"2021","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.exer.2025.110769_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105314","article-title":"A comprehensive assessment of the association between common drugs and psychiatric disorders using Mendelian randomization and real-world pharmacovigilance database","volume":"107","author":"Chen","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.exer.2025.110769_bib7","article-title":"Non-genetic risk factors for keratoconus and its progression","volume":"1\u20139","author":"Cheung","year":"2025","journal-title":"Clin. Exp. Optom."},{"issue":"1","key":"10.1016\/j.exer.2025.110769_bib8","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s00239-019-09914-3","article-title":"Antimicrobial resistance in bacteria: mechanisms, evolution, and persistence","volume":"88","author":"Christaki","year":"2020","journal-title":"J. Mol. Evol."},{"issue":"1","key":"10.1016\/j.exer.2025.110769_bib9","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.bja.2024.07.042","article-title":"Sugammadex hypersensitivity: a multicentre retrospective analysis of a large Australian cohort","volume":"134","author":"Crimmins","year":"2025","journal-title":"Br. J. Anaesth."},{"issue":"5","key":"10.1016\/j.exer.2025.110769_bib10","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3109\/02713683.2011.635399","article-title":"Changes in anterior chamber parameters with the Pentacam rotating Scheimpflug and axial length measurements by ultrasound in patients who use isotretinoin","volume":"37","author":"Cumurcu","year":"2012","journal-title":"Curr. Eye Res."},{"issue":"W1","key":"10.1016\/j.exer.2025.110769_bib11","doi-asserted-by":"crossref","first-page":"W357","DOI":"10.1093\/nar\/gkz382","article-title":"SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules","volume":"47","author":"Daina","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.exer.2025.110769_bib12","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41421-022-00397-z","article-title":"Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis","volume":"8","author":"Dou","year":"2022","journal-title":"Cell Discov"},{"issue":"2","key":"10.1016\/j.exer.2025.110769_bib13","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1080\/09546634.2020.1774041","article-title":"The effect of oral isotretinoin therapy on meibomian gland morphology and dry eye tests","volume":"33","author":"Duzgun","year":"2022","journal-title":"J. Dermatol. Treat."},{"issue":"20","key":"10.1016\/j.exer.2025.110769_bib14","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1001\/jama.2021.17633","article-title":"Management of Acne Vulgaris: a review","volume":"326","author":"Eichenfield","year":"2021","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.exer.2025.110769_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v033.i01","article-title":"Regularization paths for generalized Linear models via coordinate descent","volume":"33","author":"Friedman","year":"2010","journal-title":"J. Stat. Software"},{"issue":"Suppl. 1","key":"10.1016\/j.exer.2025.110769_bib16","first-page":"S47","article-title":"Isotretinoin: state of the art treatment for acne vulgaris","volume":"8","author":"Ganceviciene","year":"2010","journal-title":"J. Dtsch. Dermatol. Ges."},{"issue":"Suppl. 2","key":"10.1016\/j.exer.2025.110769_bib17","doi-asserted-by":"crossref","first-page":"S225","DOI":"10.1542\/peds.2019-2056L","article-title":"Current issues in the treatment of Acne Vulgaris","volume":"145","author":"Habeshian","year":"2020","journal-title":"Pediatrics"},{"issue":"6","key":"10.1016\/j.exer.2025.110769_bib18","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1007\/s10528-023-10398-6","article-title":"Investigation of potential crucial genes and key pathways in Keratoconus: an analysis of gene expression omnibus data","volume":"61","author":"Hu","year":"2023","journal-title":"Biochem. Genet."},{"issue":"4","key":"10.1016\/j.exer.2025.110769_bib19","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1370\/afm.2995","article-title":"Comparative efficacy of pharmacological treatments for Acne Vulgaris: a network meta-analysis of 221 randomized controlled trials","volume":"21","author":"Huang","year":"2023","journal-title":"Ann. Fam. Med."},{"key":"10.1016\/j.exer.2025.110769_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaad.2025.04.046","article-title":"Post-Marketing safety analysis of upadacitinib in atopic dermatitis: an FDA adverse reporting System (FAERS) review of boxed warning related adverse events","author":"Joshi","year":"2025","journal-title":"J. Am. Acad. Dermatol."},{"issue":"5","key":"10.1016\/j.exer.2025.110769_bib21","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/ICO.0000000000002229","article-title":"Effects of different doses of systemic isotretinoin on eyes: a histopathological and immunohistochemical Study in rats","volume":"39","author":"Karadag","year":"2020","journal-title":"Cornea"},{"issue":"3","key":"10.1016\/j.exer.2025.110769_bib22","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s40257-020-00508-0","article-title":"Optimizing isotretinoin treatment of acne: update on Current recommendations for monitoring, dosing, safety, adverse effects, compliance, and outcomes","volume":"21","author":"Landis","year":"2020","journal-title":"Am. J. Clin. Dermatol."},{"issue":"2","key":"10.1016\/j.exer.2025.110769_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70094","article-title":"Once-weekly glucagon-like peptide receptor agonist polyethylene glycol loxenatide protects against major adverse cardiovascular events in patients with type 2 diabetes: a multicenter ambispective cohort study (FLYING trial)","volume":"6","author":"Li","year":"2025","journal-title":"MedComm"},{"issue":"12","key":"10.1016\/j.exer.2025.110769_bib24","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.exer.2025.110769_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2022.109062","article-title":"Pathogenesis of keratoconus: NRF2-antioxidant, extracellular matrix and cellular dysfunctions","volume":"219","author":"Monteiro de Barros","year":"2022","journal-title":"Exp. Eye Res."},{"issue":"6","key":"10.1016\/j.exer.2025.110769_bib26","doi-asserted-by":"crossref","first-page":"e777","DOI":"10.1111\/aos.14714","article-title":"Oxidative and antioxidative stress markers in keratoconus: a systematic review and meta-analysis","volume":"99","author":"Navel","year":"2021","journal-title":"Acta Ophthalmol."},{"issue":"11","key":"10.1016\/j.exer.2025.110769_bib27","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1167\/tvst.10.11.6","article-title":"Changes in nuclear gene expression related to mitochondrial function affect extracellular matrix, collagens, and focal adhesion in Keratoconus","volume":"10","author":"Nowak-Malczewska","year":"2021","journal-title":"Transl. Vis. Sci. Technol."},{"issue":"5","key":"10.1016\/j.exer.2025.110769_bib28","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/dth.12084","article-title":"Isotretinoin updates","volume":"26","author":"On","year":"2013","journal-title":"Dermatol. Ther."},{"issue":"2","key":"10.1016\/j.exer.2025.110769_bib29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.oftal.2022.07.001","article-title":"Update on contraindications in laser corneal refractive surgery","volume":"98","author":"Ortega-Usobiaga","year":"2023","journal-title":"Arch. Soc. Esp. Oftalmol."},{"issue":"6","key":"10.1016\/j.exer.2025.110769_bib30","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/ICL.0000000000000769","article-title":"Remodeling of cornea with isotretinoin treatment","volume":"47","author":"Ozyol","year":"2021","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.exer.2025.110769_bib31","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.2147\/DDDT.S427530","article-title":"Oral isotretinoin and its uses in dermatology: a review","volume":"17","author":"Paichitrojjana","year":"2023","journal-title":"Drug Des. Dev. Ther."},{"issue":"D1","key":"10.1016\/j.exer.2025.110769_bib32","first-page":"D845","article-title":"The DisGeNET knowledge platform for disease genomics: 2019 update","volume":"48","author":"Pinero","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.exer.2025.110769_bib33","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00403-025-04019-y","article-title":"Exploring the multifaceted side effects of isotretinoin: a deep dive into case reports and observational studies","volume":"317","author":"Ruchitha","year":"2025","journal-title":"Arch. Dermatol. Res."},{"issue":"1","key":"10.1016\/j.exer.2025.110769_bib34","doi-asserted-by":"crossref","DOI":"10.1111\/dth.14438","article-title":"Systematic review of low-dose isotretinoin for treatment of acne vulgaris: focus on indication, dosage, regimen, efficacy, safety, satisfaction, and follow up, based on clinical studies","volume":"34","author":"Sadeghzadeh-Bazargan","year":"2021","journal-title":"Dermatol. Ther."},{"key":"10.1016\/j.exer.2025.110769_bib35","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.artmed.2018.04.002","article-title":"Absolute cosine-based SVM-RFE feature selection method for prostate histopathological grading","volume":"87","author":"Sahran","year":"2018","journal-title":"Artif. Intell. Med."},{"issue":"5","key":"10.1016\/j.exer.2025.110769_bib36","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1475-1313.2008.00590.x","article-title":"Drug-induced ocular side-effects with isotretinoin","volume":"28","author":"Santodomingo-Rubido","year":"2008","journal-title":"Ophthalmic Physiol. Opt."},{"key":"10.1016\/j.exer.2025.110769_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2024.110122","article-title":"Experimental models for keratoconus: insights and challenges","volume":"248","author":"Shankar","year":"2024","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110769_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2024.102684","article-title":"Characterization of second primary malignancies post CAR T-cell therapy: real-world insights from the two global pharmacovigilance databases of FAERS and VigiBase","volume":"73","author":"Shen","year":"2024","journal-title":"eClinicalMedicine"},{"issue":"1","key":"10.1016\/j.exer.2025.110769_bib39","doi-asserted-by":"crossref","first-page":"30 31","DOI":"10.1002\/cpbi.5","article-title":"The GeneCards suite: from gene data mining to disease genome sequence analyses","volume":"54","author":"Stelzer","year":"2016","journal-title":"Curr. Protoc. Bioinform."},{"key":"10.1016\/j.exer.2025.110769_bib40","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fendo.2020.00024","article-title":"The IGF\/Insulin-IGFBP axis in corneal development, wound healing, and disease","volume":"11","author":"Stuard","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"D1","key":"10.1016\/j.exer.2025.110769_bib41","doi-asserted-by":"crossref","first-page":"D380","DOI":"10.1093\/nar\/gkv1277","article-title":"Stitch 5: augmenting protein-chemical interaction networks with tissue and affinity data","volume":"44","author":"Szklarczyk","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"21","key":"10.1016\/j.exer.2025.110769_bib42","doi-asserted-by":"crossref","first-page":"11717","DOI":"10.1080\/07391102.2023.2264394","article-title":"Structure-guided computational insecticide discovery targeting beta-N-acetyl-D-hexosaminidase of Ostrinia furnacalis","volume":"42","author":"Tahir","year":"2024","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.exer.2025.110769_bib43","first-page":"1","article-title":"Unveiling the hidden ocular risks of isotretinoin: a comprehensive FAERS-Based analysis","author":"Tao","year":"2025","journal-title":"Expet Opin. Drug Saf."},{"issue":"2","key":"10.1016\/j.exer.2025.110769_bib44","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1002\/jcp.26948","article-title":"Mutual regulation between IGF-1R and IGFBP-3 in human corneal epithelial cells","volume":"234","author":"Titone","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.exer.2025.110769_bib45","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/15569527.2022.2152042","article-title":"Analysis of corneal topographic and densitometric properties in patients receiving systemic isotretinoin therapy","volume":"42","author":"Tosun","year":"2023","journal-title":"Cutan. Ocul. Toxicol."},{"key":"10.1016\/j.exer.2025.110769_bib46","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baaf013","article-title":"Integrating AI-powered text mining from PubTator into the manual curation workflow at the Comparative Toxicogenomics Database","volume":"2025","author":"Wiegers","year":"2025","journal-title":"Database"},{"issue":"5","key":"10.1016\/j.exer.2025.110769_bib47","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1167\/iovs.65.5.29","article-title":"Association of novel loci with keratoconus susceptibility in a Chinese genome-wide Association Study","volume":"65","author":"Xu","year":"2024","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"9","key":"10.1016\/j.exer.2025.110769_bib48","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1161\/STROKEAHA.124.046544","article-title":"Genome-Wide mendelian randomization Study reveals druggable genes for cerebral small vessel disease","volume":"55","author":"Yang","year":"2024","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.exer.2025.110769_bib49","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jtcm.2018.04.004","article-title":"Efficacy of herb-partitioned moxibustion at Qihai (CV 6) and bilateral Tianshu (ST 25) on colonic damage and the TLR4\/NF-I masculineB signaling pathway in rats with Crohn's disease","volume":"38","author":"Zhang","year":"2018","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.exer.2025.110769_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.117820","article-title":"Elucidating the mechanism of phthalates induced osteoporosis through network toxicology and molecular docking","volume":"291","author":"Zhang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.exer.2025.110769_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106830","article-title":"Machine learning model for anti-cancer drug combinations: analysis, prediction, and validation","volume":"194","author":"Zhou","year":"2023","journal-title":"Pharmacol. Res."},{"issue":"11","key":"10.1016\/j.exer.2025.110769_bib52","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1167\/iovs.65.11.43","article-title":"Single-Cell transcriptomic analysis reveals dynamic cellular processes in corneal epithelium during wound healing in cynomolgus monkeys","volume":"65","author":"Zhou","year":"2024","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110769_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2025.103160","article-title":"Disproportionality analysis of interstitial lung disease associated with novel antineoplastic agents during breast cancer treatment: a pharmacovigilance study","volume":"82","author":"Zhu","year":"2025","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.exer.2025.110769_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2025.110330","article-title":"Advances in keratoconus animal models: from genetics to biomechanics","volume":"254","author":"Zou","year":"2025","journal-title":"Exp. Eye Res."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525005421?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525005421?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:04:34Z","timestamp":1781323474000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483525005421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":54,"alternative-id":["S0014483525005421"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2025.110769","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reveal a risk and potential mechanism for keratoconus progression with isotretinoin: Toxicogenomic, transcriptomics and real-world evidence insights","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2025.110769","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110769"}}