{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:55:48Z","timestamp":1781326548786,"version":"3.54.1"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32402067"],"award-info":[{"award-number":["32402067"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304954"],"award-info":[{"award-number":["82304954"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22304027"],"award-info":[{"award-number":["22304027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.exer.2025.110791","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T16:01:41Z","timestamp":1765036901000},"page":"110791","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Dual-target anti-vascular endothelial growth factor\/tumor necrosis factor-\u03b1 nanobody precisely intervenes in hypoxia-induced retinal neovascularization formation and inflammation activation"],"prefix":"10.1016","volume":"263","author":[{"given":"Qian","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yize","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfen","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaole","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6711-1560","authenticated-orcid":false,"given":"Nanwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.exer.2025.110791_bib1","first-page":"62","article-title":"Update of inflammatory proliferative retinopathy: ischemia, hypoxia and angiogenesis","volume":"67","author":"Aouiss","year":"2019","journal-title":"Curr. Res. Transl. Med."},{"issue":"10","key":"10.1016\/j.exer.2025.110791_bib2","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.7150\/ijms.35149","article-title":"Identifying circRNA-associated-ceRNA networks in retinal neovascularization in mice","volume":"16","author":"Cao","year":"2019","journal-title":"Int. J. Med. Sci."},{"issue":"1","key":"10.1016\/j.exer.2025.110791_bib3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s10456-020-09745-7","article-title":"A drug-tunable Flt23k gene therapy for controlled intervention in retinal neovascularization","volume":"24","author":"Chen","year":"2021","journal-title":"Angiogenesis"},{"issue":"2","key":"10.1016\/j.exer.2025.110791_bib4","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s10753-021-01595-9","article-title":"The therapeutic effect of an Anti-TNF-\u03b1\/HSA\/IL-6R triple-specific fusion protein under experimental septic conditions","volume":"45","author":"Chen","year":"2022","journal-title":"Inflammation"},{"issue":"2","key":"10.1016\/j.exer.2025.110791_bib5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/exer.1996.0020","article-title":"ARPE-19, a human retinal pigment epithelial cell line with differentiated properties","volume":"62","author":"Dunn","year":"1996","journal-title":"Exp. Eye Res."},{"issue":"1","key":"10.1016\/j.exer.2025.110791_bib6","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/s12886-021-01964-w","article-title":"Observation of retinal neovascularization using optical coherence tomography angiography after panretinal photocoagulation for proliferative diabetic retinopathy","volume":"21","author":"Feng","year":"2021","journal-title":"BMC Ophthalmol."},{"issue":"28","key":"10.1016\/j.exer.2025.110791_bib7","doi-asserted-by":"crossref","first-page":"9618","DOI":"10.1074\/jbc.RA120.012613","article-title":"Disruption of profilin1 function suppresses developmental and pathological retinal neovascularization","volume":"295","author":"Gau","year":"2020","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.exer.2025.110791_bib8","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1002\/fsn3.1590","article-title":"Aucuba japonica extract inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy, with its bioactive components preventing VEGF-induced retinal vascular hyperpermeability","volume":"8","author":"Jung","year":"2020","journal-title":"Food Sci. Nutr."},{"issue":"5","key":"10.1016\/j.exer.2025.110791_bib9","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1089\/jop.2018.0097","article-title":"A pilot clinical study of intravitreal injection of artesunate for ocular neovascularization","volume":"35","author":"Li","year":"2019","journal-title":"J. Ocul. Pharmacol. Therapeut."},{"issue":"2","key":"10.1016\/j.exer.2025.110791_bib10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10456-019-09689-7","article-title":"Role of melatonin in controlling angiogenesis under physiological and pathological conditions","volume":"23","author":"Ma","year":"2020","journal-title":"Angiogenesis"},{"issue":"5","key":"10.1016\/j.exer.2025.110791_bib11","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/ceo.14245","article-title":"Let's NOT sleep on it: we epidemiologists can do better about recommendations based on our study findings","volume":"51","author":"McCarty","year":"2023","journal-title":"Clin. Exp. Ophthalmol."},{"issue":"2","key":"10.1016\/j.exer.2025.110791_bib12","first-page":"455","article-title":"Vascular endothelial growth factor (VEGF) - key factor in normal and pathological angiogenesis","volume":"59","author":"Melincovici","year":"2018","journal-title":"Rom. J. Morphol. Embryol."},{"key":"10.1016\/j.exer.2025.110791_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100906","article-title":"Incomplete response to Anti-VEGF therapy in neovascular AMD: exploring disease mechanisms and therapeutic opportunities","volume":"82","author":"Mettu","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"issue":"10153","key":"10.1016\/j.exer.2025.110791_bib14","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0140-6736(18)31550-2","article-title":"Age-related macular degeneration","volume":"392","author":"Mitchell","year":"2018","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.exer.2025.110791_bib15","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s12094-019-02217-5","article-title":"MiR-130b\/TNF-\u03b1\/NF-\u03baB\/VEGFA loop inhibits prostate cancer angiogenesis","volume":"22","author":"Mu","year":"2020","journal-title":"Clin. Transl. Oncol."},{"issue":"9","key":"10.1016\/j.exer.2025.110791_bib16","doi-asserted-by":"crossref","first-page":"12419","DOI":"10.1096\/fj.202000964R","article-title":"Ferrochelatase regulates retinal neovascularization","volume":"34","author":"Pran Babu","year":"2020","journal-title":"FASEB J."},{"issue":"9","key":"10.1016\/j.exer.2025.110791_bib17","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1172\/JCI126655","article-title":"Roles of HIFs and VEGF in angiogenesis in the retina and brain","volume":"129","author":"Rattner","year":"2019","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.exer.2025.110791_bib18","article-title":"Prevalence, risk factors and burden of diabetic retinopathy in China: a systematic review and meta-analysis","volume":"8","author":"Song","year":"2018","journal-title":"J. Glob. Health"},{"issue":"5","key":"10.1016\/j.exer.2025.110791_bib19","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s00417-018-3940-x","article-title":"Inhibition of integrin \u03b15\u03b21 ameliorates VEGF-induced retinal neovascularization and leakage by suppressing NLRP3 inflammasome signaling in a mouse model","volume":"256","author":"Sui","year":"2018","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"issue":"3","key":"10.1016\/j.exer.2025.110791_bib20","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s10456-018-9614-9","article-title":"SNAI1, an endothelial-mesenchymal transition transcription factor, promotes the early phase of ocular neovascularization","volume":"21","author":"Sun","year":"2018","journal-title":"Angiogenesis"},{"issue":"4","key":"10.1016\/j.exer.2025.110791_bib21","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S2213-8587(19)30411-5","article-title":"Screening for diabetic retinopathy: new perspectives and challenges","volume":"8","author":"Vujosevic","year":"2020","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"1","key":"10.1016\/j.exer.2025.110791_bib22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1167\/iovs.63.1.37","article-title":"The long-noncoding RNA TUG1 regulates oxygen-induced retinal neovascularization in mice via MiR-299","volume":"63","author":"Wang","year":"2022","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"19","key":"10.1016\/j.exer.2025.110791_bib23","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.3390\/ijms20194755","article-title":"Proteomic biomarkers of retinal inflammation in diabetic retinopathy","volume":"20","author":"Youngblood","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"14","key":"10.1016\/j.exer.2025.110791_bib24","doi-asserted-by":"crossref","first-page":"8236","DOI":"10.1111\/jcmm.15499","article-title":"lncRNA NR2F1-AS1 promotes breast cancer angiogenesis through activating IGF-1\/IGF-1R\/ERK pathway","volume":"24","author":"Zhang","year":"2020","journal-title":"J. Cell Mol. Med."},{"issue":"1","key":"10.1016\/j.exer.2025.110791_bib25","article-title":"A novel single domain bispecific antibody targeting VEGF and TNF-\u03b1 ameliorates rheumatoid arthritis","volume":"126","author":"Zhang","year":"2024","journal-title":"Int. Immunopharmacol."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525005640?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525005640?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:04:27Z","timestamp":1781323467000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483525005640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":25,"alternative-id":["S0014483525005640"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2025.110791","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual-target anti-vascular endothelial growth factor\/tumor necrosis factor-\u03b1 nanobody precisely intervenes in hypoxia-induced retinal neovascularization formation and inflammation activation","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2025.110791","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110791"}}