{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:55:50Z","timestamp":1781326550331,"version":"3.54.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100016305","name":"First Affiliated Hospital of Zhengzhou University","doi-asserted-by":"publisher","award":["YNQN2017160"],"award-info":[{"award-number":["YNQN2017160"]}],"id":[{"id":"10.13039\/501100016305","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018925","name":"Health Commission of Henan Province","doi-asserted-by":"publisher","award":["LHGJ20230217"],"award-info":[{"award-number":["LHGJ20230217"]}],"id":[{"id":"10.13039\/100018925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.exer.2025.110793","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T17:05:22Z","timestamp":1764867922000},"page":"110793","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Eye-brain structural alterations and associated neurotransmitter profiles in high myopia: Evidence from cross-modal correlation"],"prefix":"10.1016","volume":"263","author":[{"given":"Xiaopan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqiang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingzheng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingliang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4566-7565","authenticated-orcid":false,"given":"Baohong","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.exer.2025.110793_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s40101-024-00354-7","article-title":"The influence of the environment and lifestyle on myopia","volume":"43","author":"Biswas","year":"2024","journal-title":"J. Physiol. Anthropol."},{"issue":"7","key":"10.1016\/j.exer.2025.110793_bib2","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1093\/brain\/awp119","article-title":"Changes in cortical grey matter density associated with long-standing retinal visual field defects","volume":"132","author":"Boucard","year":"2009","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.exer.2025.110793_bib3","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cortex.2011.12.001","article-title":"Short frontal lobe connections of the human brain","volume":"48","author":"Catani","year":"2012","journal-title":"Cortex"},{"issue":"10","key":"10.1016\/j.exer.2025.110793_bib4","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1177\/0284185120902385","article-title":"Differences in network centrality between high and low myopia: a voxel-level degree centrality study","volume":"61","author":"Cheng","year":"2020","journal-title":"Acta Radiologica"},{"issue":"6972","key":"10.1016\/j.exer.2025.110793_bib5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/427311a","article-title":"Changes in grey matter induced by training","volume":"427","author":"Draganski","year":"2004","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.exer.2025.110793_bib6","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1001\/jamaophthalmol.2021.3303","article-title":"Continued increase of axial length and its risk factors in adults with high myopia","volume":"139","author":"Du","year":"2021","journal-title":"JAMA Ophthalmology"},{"issue":"3","key":"10.1016\/j.exer.2025.110793_bib7","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.aopr.2024.06.003","article-title":"Complications of high myopia: an update from clinical manifestations to underlying mechanisms","volume":"4","author":"Du","year":"2024","journal-title":"Adv. Ophthalmol. Pract. Res."},{"issue":"3","key":"10.1016\/j.exer.2025.110793_bib8","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/hbm.25244","article-title":"JuSpace: a tool for spatial correlation analyses of magnetic resonance imaging data with nuclear imaging derived neurotransmitter maps","volume":"42","author":"Dukart","year":"2021","journal-title":"Hum. Brain Mapp."},{"issue":"2","key":"10.1016\/j.exer.2025.110793_bib9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0014-2999(98)00286-6","article-title":"5-HT1A receptor-mediated inhibition of long-term potentiation in rat visual cortex","volume":"349","author":"Edagawa","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.exer.2025.110793_bib10","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1146\/annurev-neuro-071714-034002","article-title":"Plasticity of cortical excitatory-inhibitory balance","volume":"38","author":"Froemke","year":"2015","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.exer.2025.110793_bib11","doi-asserted-by":"crossref","first-page":"giae049","DOI":"10.1093\/gigascience\/giae049","article-title":"CAT: a computational anatomy toolbox for the analysis of structural MRI data","volume":"13","author":"Gaser","year":"2024","journal-title":"GigaScience"},{"issue":"4","key":"10.1016\/j.exer.2025.110793_bib12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1167\/iovs.61.4.49","article-title":"The complications of myopia: a review and meta-analysis","volume":"61","author":"Haarman","year":"2020","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"9","key":"10.1016\/j.exer.2025.110793_bib13","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1097\/WNR.0000000000001028","article-title":"Altered whole-brain gray matter volume in high myopia patients: a voxel-based morphometry study","volume":"29","author":"Huang","year":"2018","journal-title":"Neuroreport"},{"issue":"27","key":"10.1016\/j.exer.2025.110793_bib14","doi-asserted-by":"crossref","first-page":"9359","DOI":"10.1523\/JNEUROSCI.0711-12.2012","article-title":"Retinal dopamine mediates multiple dimensions of light-adapted vision","volume":"32","author":"Jackson","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.exer.2025.110793_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2022.959523","article-title":"Exploration of abnormal dynamic spontaneous brain activity in patients with high myopia via dynamic regional homogeneity analysis","volume":"16","author":"Ji","year":"2022","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.exer.2025.110793_bib16","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/141950","article-title":"Alterations of regional spontaneous brain activity and gray matter volume in the blind","volume":"2015","author":"Jiang","year":"2015","journal-title":"Neural Plast."},{"issue":"4","key":"10.1016\/j.exer.2025.110793_bib17","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.3390\/jcm12041317","article-title":"Anatomic peculiarities associated with axial elongation of the myopic eye","volume":"12","author":"Jonas","year":"2023","journal-title":"J. Clin. Med."},{"issue":"2","key":"10.1016\/j.exer.2025.110793_bib18","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/IJG.0000000000000574","article-title":"Optic nerve head histopathology in high axial myopia","volume":"26","author":"Jonas","year":"2017","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.exer.2025.110793_bib19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s40662-020-00210-6","article-title":"Advances in myopia research anatomical findings in highly myopic eyes","volume":"7","author":"Jonas","year":"2020","journal-title":"Eye Vision"},{"issue":"1","key":"10.1016\/j.exer.2025.110793_bib20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41386-021-01137-9","article-title":"Development of prefrontal cortex","volume":"47","author":"Kolk","year":"2022","journal-title":"Neuropsychopharmacology"},{"issue":"6","key":"10.1016\/j.exer.2025.110793_bib21","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0149-7634(02)00021-0","article-title":"Contributions of the prefrontal cortex to the neural basis of human decision making","volume":"26","author":"Krawczyk","year":"2002","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.exer.2025.110793_bib22","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1167\/iovs.62.1.28","article-title":"Ambient light regulates retinal dopamine signaling and myopia susceptibility","volume":"62","author":"Landis","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.exer.2025.110793_bib23","article-title":"Cognitive dysfunctions in high myopia: an overview of potential neural morpho-functional mechanisms","volume":"13","author":"Li","year":"2022","journal-title":"Front. Neurol."},{"issue":"8","key":"10.1016\/j.exer.2025.110793_bib24","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1001\/jamaophthalmol.2023.2869","article-title":"Assessment of ocular deformation in pathologic myopia using 3-Dimensional magnetic resonance imaging","volume":"141","author":"Luo","year":"2023","journal-title":"JAMA Ophthalmology"},{"issue":"8","key":"10.1016\/j.exer.2025.110793_bib25","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.neubiorev.2007.04.017","article-title":"Activity- and use-dependent plasticity of the developing corticospinal system","volume":"31","author":"Martin","year":"2007","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"4","key":"10.1016\/j.exer.2025.110793_bib26","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/joa.12364","article-title":"Analysis of the volumetric relationship among human ocular, orbital and fronto-occipital cortical morphology","volume":"227","author":"Masters","year":"2015","journal-title":"J. Anat."},{"issue":"5","key":"10.1016\/j.exer.2025.110793_bib27","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.mehy.2012.02.002","article-title":"Relative size of the eye and orbit: an evolutionary and craniofacial constraint model for examining the etiology and disparate incidence of juvenile-onset myopia in humans","volume":"78","author":"Masters","year":"2012","journal-title":"Med. Hypotheses"},{"issue":"25","key":"10.1016\/j.exer.2025.110793_bib28","doi-asserted-by":"crossref","first-page":"10544","DOI":"10.1523\/JNEUROSCI.3007-12.2013","article-title":"Activation of serotonin 2A receptors underlies the psilocybin-induced effects on \u03b1 oscillations, N170 visual-evoked potentials, and visual hallucinations","volume":"33","author":"Michael","year":"2013","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.exer.2025.110793_bib29","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.tics.2018.12.006","article-title":"Dopamine and cognitive control in prefrontal cortex","volume":"23","author":"Ott","year":"2019","journal-title":"Trends Cognit. Sci."},{"issue":"9","key":"10.1016\/j.exer.2025.110793_bib30","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.1364\/BOE.10.004462","article-title":"Development of an in vivo magnetic resonance imaging and computer modelling platform to investigate the physiological optics of the crystalline lens","volume":"10","author":"Pan","year":"2019","journal-title":"Biomed. Opt. Express"},{"issue":"10","key":"10.1016\/j.exer.2025.110793_bib31","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1523\/JNEUROSCI.19-10-04034.1999","article-title":"5-HT1B receptor-mediated presynaptic inhibition of retinal input to the suprachiasmatic nucleus","volume":"19","author":"Pickard","year":"1999","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.exer.2025.110793_bib32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/aos.12825","article-title":"Structural brain MRI studies in eye diseases: are they clinically relevant? A review of current findings","volume":"94","author":"Prins","year":"2016","journal-title":"Acta Ophthalmol."},{"issue":"5","key":"10.1016\/j.exer.2025.110793_bib33","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1523\/JNEUROSCI.4928-07.2008","article-title":"Metabotropic glutamate receptor type 5-Dependent long-term potentiation of excitatory synapses on fast-spiking GABAergic neurons in mouse visual cortex","volume":"28","author":"Sarihi","year":"2008","journal-title":"J. Neurosci."},{"issue":"48","key":"10.1016\/j.exer.2025.110793_bib34","doi-asserted-by":"crossref","first-page":"8231","DOI":"10.1523\/JNEUROSCI.1196-23.2023","article-title":"The role of retinal dopamine D1 receptors in ocular growth and myopia development in mice","volume":"43","author":"Shu","year":"2023","journal-title":"J. Neurosci."},{"issue":"41","key":"10.1016\/j.exer.2025.110793_bib35","doi-asserted-by":"crossref","first-page":"12852","DOI":"10.1073\/pnas.1512878112","article-title":"Metabotropic glutamate receptor signaling is required for NMDA receptor-dependent ocular dominance plasticity and LTD in visual cortex","volume":"112","author":"Sidorov","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"6","key":"10.1016\/j.exer.2025.110793_bib36","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1167\/iovs.05-0856","article-title":"Three-dimensional modeling of the human eye based on magnetic resonance imaging","volume":"47","author":"Singh","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"1515","key":"10.1016\/j.exer.2025.110793_bib37","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1098\/rstb.2008.0269","article-title":"Molecular mechanisms of experience-dependent plasticity in visual cortex","volume":"364","author":"Tropea","year":"2008","journal-title":"Phil. Trans. Biol. Sci."},{"issue":"4","key":"10.1016\/j.exer.2025.110793_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014801","article-title":"Quantifying the link between anatomical connectivity, gray matter volume and regional cerebral blood flow: an integrative MRI study","volume":"6","author":"V\u00e1rkuti","year":"2011","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.exer.2025.110793_bib39","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1093\/brain\/awu030","article-title":"Evidence for both compensatory plastic and disuse atrophy-related neuroanatomical changes in the blind","volume":"137","author":"Voss","year":"2014","journal-title":"Brain"},{"issue":"12","key":"10.1016\/j.exer.2025.110793_bib40","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nrn2741","article-title":"Plasticity and stability of visual field maps in adult primary visual cortex","volume":"10","author":"Wandell","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"issue":"7","key":"10.1016\/j.exer.2025.110793_bib41","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.3348\/kjr.2020.0178","article-title":"Characterization of brain microstructural abnormalities in high myopia patients: a preliminary diffusion kurtosis imaging study","volume":"22","author":"Wang","year":"2021","journal-title":"Korean Soc. Radiol."},{"issue":"3","key":"10.1016\/j.exer.2025.110793_bib42","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1159\/000477466","article-title":"Using high-resolution 3D magnetic resonance imaging to quantitatively analyze the shape of eyeballs with high myopia and provide assistance for posterior scleral reinforcement","volume":"238","author":"Wen","year":"2017","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.exer.2025.110793_bib43","article-title":"Evidence of cortical thickness reduction and disconnection in high myopia","volume":"10","author":"Wu","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.exer.2025.110793_bib44","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ophtha.2006.05.071","article-title":"Characteristics of highly myopic eyes: the beijing eye study","volume":"114","author":"Xu","year":"2007","journal-title":"Ophthalmology"},{"issue":"8006","key":"10.1016\/j.exer.2025.110793_bib45","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41586-024-07130-8","article-title":"Compartmentalized ocular lymphatic system mediates eye\u2013brain immunity","volume":"628","author":"Yin","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.exer.2025.110793_bib46","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bbr.2016.01.046","article-title":"Altered functional connectivity density in high myopia","volume":"303","author":"Zhai","year":"2016","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.exer.2025.110793_bib47","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00234-022-03033-5","article-title":"Altered time-varying local spontaneous brain activity pattern in patients with high myopia: a dynamic amplitude of low-frequency fluctuations study","volume":"65","author":"Zhang","year":"2023","journal-title":"Neuroradiology"},{"key":"10.1016\/j.exer.2025.110793_bib48","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neuroscience.2025.02.047","article-title":"Structure\/Function alterations and related neurotransmitter activity maps in high myopia patients","volume":"570","author":"Zhang","year":"2025","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.exer.2025.110793_bib49","doi-asserted-by":"crossref","first-page":"6064","DOI":"10.1038\/s41467-024-50309-w","article-title":"Eye-brain connections revealed by multimodal retinal and brain imaging genetics","volume":"15","author":"Zhao","year":"2024","journal-title":"Nat. Commun."}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525005664?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014483525005664?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:05:01Z","timestamp":1781323501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014483525005664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":49,"alternative-id":["S0014483525005664"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2025.110793","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Eye-brain structural alterations and associated neurotransmitter profiles in high myopia: Evidence from cross-modal correlation","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2025.110793","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110793"}}