{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:52:25Z","timestamp":1782276745023,"version":"3.54.5"},"reference-count":213,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006668","name":"Fund for Scientific and Technological Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010442","name":"Universidad Nacional de C\u00f3rdoba","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010442","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 11220200100830CO"],"award-info":[{"award-number":["PIP 11220200100830CO"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012478","name":"Secretaria de Ciencia y Tecnolog\u00eda - Universidad Nacional de C\u00f3rdoba","doi-asserted-by":"publisher","award":["2024-21-E-UNC-SECYT#ACTIP"],"award-info":[{"award-number":["2024-21-E-UNC-SECYT#ACTIP"]}],"id":[{"id":"10.13039\/100012478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Eye Research"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.exer.2025.110796","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:04:56Z","timestamp":1764979496000},"page":"110796","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Glial fibrillary acidic protein, an early and sustained indicator of retinopathy progression"],"prefix":"10.1016","volume":"263","author":[{"given":"Yamila","family":"Fern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Virginia","family":"Subirada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Victoria","family":"Vaglienti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albana","family":"Tovo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Constanza","family":"Paz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Federico","family":"Barcelona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4760-8518","authenticated-orcid":false,"given":"Mar\u00eda Cecilia","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.preteyeres.2011.11.002","article-title":"The molecular basis of retinal ganglion cell death in glaucoma","volume":"31","author":"Almasieh","year":"2012","journal-title":"Prog. Retin. Eye Res."},{"issue":"3","key":"10.1016\/j.exer.2025.110796_bib2","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1523\/JNEUROSCI.12-03-00840.1992","article-title":"Energy metabolism of rabbit retina as related to function: high cost of Na+ transport","volume":"12","author":"Ames","year":"1992","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.exer.2025.110796_bib3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0891-5849(91)90161-U","article-title":"Lipid peroxidation and retinopathy in streptozotocin-induced diabetes","volume":"11","author":"Armstrong","year":"1991","journal-title":"Free Radic. Biol. Med."},{"issue":"7","key":"10.1016\/j.exer.2025.110796_bib4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1167\/tvst.9.7.10","article-title":"Optical coherence tomography angiography projection artifact removal: impact on capillary density and interaction with diabetic retinopathy severity","volume":"9","author":"Ashraf","year":"2020","journal-title":"Transl. Vis. Sci. Technol."},{"issue":"6","key":"10.1016\/j.exer.2025.110796_bib5","doi-asserted-by":"crossref","first-page":"539","DOI":"10.7164\/antibiotics.31.539","article-title":"Rapamycin (AY-22,989), a new antifungal antibiotic. III. In vitro and in vivo evaluation","volume":"31","author":"Baker","year":"1978","journal-title":"J. Antibiot."},{"issue":"11","key":"10.1016\/j.exer.2025.110796_bib6","first-page":"3561","article-title":"Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. The penn state retina research group","volume":"41","author":"Barber","year":"2000","journal-title":"Invest Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.exer.2025.110796_bib7","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1167\/iovs.04-1340","article-title":"The Ins2 Akita mouse as a model of early retinal complications in diabetes","volume":"46","author":"Barber","year":"2005","journal-title":"Investig. Opthalmol. & Visual Sci."},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib8","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.exer.2010.05.017","article-title":"Immunohistochemical localization of low density lipoprotein receptor-related protein 1 and \u03b12-Macroglobulin in retinal and choroidal tissue of proliferative retinopathies","volume":"91","author":"Barcelona","year":"2010","journal-title":"Exp. Eye Res."},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib9","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1167\/iovs.10-5759","article-title":"\u03b12-Macroglobulin induces glial fibrillary acidic protein expression mediated by low-density lipoprotein receptor-related protein 1 in m\u00fcller cells","volume":"52","author":"Barcelona","year":"2011","journal-title":"Investig. Opthalmol. & Visual Sci."},{"issue":"34","key":"10.1016\/j.exer.2025.110796_bib10","doi-asserted-by":"crossref","first-page":"8826","DOI":"10.1523\/JNEUROSCI.4278-15.2016","article-title":"p75 NTR and its ligand ProNGF activate paracrine mechanisms etiological to the vascular, inflammatory, and neurodegenerative pathologies of diabetic retinopathy","volume":"36","author":"Barcelona","year":"2016","journal-title":"J. Neurosci."},{"issue":"1\u20133","key":"10.1016\/j.exer.2025.110796_bib11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0014-2999(03)01294-9","article-title":"Increase of glial fibrillary acidic protein and S-100B in hippocampus and cortex of diabetic rats: effects of vitamin E","volume":"462","author":"Baydas","year":"2003","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/ceo.12386","article-title":"Evaluation of the chorioretinal thickness changes in <scp>A<\/scp> lzheimer's disease using spectral\u2010domain optical coherence tomography","volume":"43","author":"Bayhan","year":"2015","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110796_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/0006-8993(92)90583-U","article-title":"GFAP expression of human schwann cells in tissue culture","volume":"570","author":"Bianchini","year":"1992","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.exer.2025.110796_bib14","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1023\/A:1023691628110","article-title":"Cyclosporin A-Sensitive decrease in the transmembrane potential across the inner membrane of liver mitochondria induced by low concentrations of fatty acids and Ca2+","volume":"68","author":"Bodrova","year":"2003","journal-title":"Biochemistry (Mosc.)"},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib15","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0006-8993(88)90699-3","article-title":"Expression of glial fibrillary acidic protein by differentiated astrocytes is regulated by serum antagonistic factors","volume":"457","author":"Bologa","year":"1988","journal-title":"Brain Res."},{"issue":"15","key":"10.1016\/j.exer.2025.110796_bib16","doi-asserted-by":"crossref","first-page":"8008","DOI":"10.3390\/ijms25158008","article-title":"Optimization of an ischemic retinopathy mouse model and the consequences of hypoxia in a time-dependent manner","volume":"25","author":"Bosnyak","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.exer.2025.110796_bib17","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1750-3639.1994.tb00840.x","article-title":"Structure and transcriptional regulation of the GFAP gene","volume":"4","author":"Brenner","year":"1994","journal-title":"Brain Pathol."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib18","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.2741\/Bringman","article-title":"Role of muller cells in retinal degenerations","volume":"6","author":"Bringmann","year":"2001","journal-title":"Front. Biosci."},{"issue":"6","key":"10.1016\/j.exer.2025.110796_bib19","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.preteyeres.2009.07.001","article-title":"Cellular signaling and factors involved in m\u00fcller cell gliosis: neuroprotective and detrimental effects","volume":"28","author":"Bringmann","year":"2009","journal-title":"Prog. Retin. Eye Res."},{"issue":"4","key":"10.1016\/j.exer.2025.110796_bib20","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.preteyeres.2006.05.003","article-title":"M\u00fcller cells in the healthy and diseased retina","volume":"25","author":"Bringmann","year":"2006","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.exer.2025.110796_bib21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.preteyeres.2018.03.006","article-title":"The primate fovea: structure, function and development","volume":"66","author":"Bringmann","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"issue":"10","key":"10.1016\/j.exer.2025.110796_bib22","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.ophtha.2013.02.034","article-title":"Long-term outcomes of ranibizumab therapy for diabetic macular edema: the 36-Month results from two phase III trials","volume":"120","author":"Brown","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2025.110796_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2019.107903","article-title":"In vitro response and gene expression of human retinal m\u00fcller cells treated with different anti-VEGF drugs","volume":"191","author":"C\u00e1ceres-del-Carpio","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110796_bib24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.preteyeres.2015.06.002","article-title":"Molecular pathogenesis of retinal and choroidal vascular diseases","volume":"49","author":"Campochiaro","year":"2015","journal-title":"Prog. Retin. Eye Res."},{"issue":"6","key":"10.1016\/j.exer.2025.110796_bib25","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1002\/lt.21436","article-title":"Glial fibrillary acidic protein as an early marker of hepatic stellate cell activation in chronic and posttransplant recurrent hepatitis C","volume":"14","author":"Carotti","year":"2008","journal-title":"Liver Transplant."},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib26","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0197-0186(89)90103-4","article-title":"Expression of tubulin, GFAP and of their encoding mRNAs during the proliferation and differentiation of cultured astrocytes","volume":"15","author":"Charriere-Bertrand","year":"1989","journal-title":"Neurochem. Int."},{"issue":"8","key":"10.1016\/j.exer.2025.110796_bib27","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1242\/jcs.107.8.2299","article-title":"The endless story of the glial fibrillary acidic protein","volume":"107","author":"Chen","year":"1994","journal-title":"J. Cell Sci."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib28","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3233\/JAD-141659","article-title":"Retinal ganglion cell analysis using high-definition optical coherence tomography in patients with mild cognitive impairment and alzheimer's disease","volume":"45","author":"Cheung","year":"2015","journal-title":"J. Alzheim. Dis."},{"issue":"6","key":"10.1016\/j.exer.2025.110796_bib29","doi-asserted-by":"crossref","first-page":"374","DOI":"10.4161\/oxim.3.6.14787","article-title":"Mammalian target of rapamycin: hitting the bull\u2032s\u2010eye for neurological disorders","volume":"3","author":"Chong","year":"2010","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"3","key":"10.1016\/j.exer.2025.110796_bib30","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1444-0938.2012.00741.x","article-title":"The role of glia in retinal vascular disease","volume":"95","author":"Coorey","year":"2012","journal-title":"Clin. Exp. Optom."},{"issue":"10","key":"10.1016\/j.exer.2025.110796_bib31","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S0962-8924(00)01828-6","article-title":"The \u2018ins\u2019 and \u2018outs\u2019 of intermediate filament organization","volume":"10","author":"Coulombe","year":"2000","journal-title":"Trends Cell Biol."},{"issue":"9","key":"10.1016\/j.exer.2025.110796_bib32","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1007\/s00417-017-3715-9","article-title":"In Alzheimer's disease: thinning of the RNFL and superior hemiretina","volume":"255","author":"Cunha","year":"2017","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"issue":"4","key":"10.1016\/j.exer.2025.110796_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153830","article-title":"Macular thickness measurements with frequency Domain-OCT for quantification of retinal neural loss and its correlation with cognitive impairment in alzheimer\u02bcs disease","volume":"11","author":"Cunha","year":"2016","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.exer.2025.110796_bib34","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/eye.2009.108","article-title":"Microvascular lesions of diabetic retinopathy: clues towards understanding pathogenesis?","volume":"23","author":"Curtis","year":"2009","journal-title":"Eye"},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib35","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1167\/iovs.17-22920","article-title":"Nrf2 activation is a potential therapeutic approach to attenuate diabetic retinopathy","volume":"59","author":"Deliyanti","year":"2018","journal-title":"Investig. Opthalmol. & Visual Sci."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib36","first-page":"49","article-title":"Retinal thickness correlates with parietal cortical atrophy in early\u2010onset Alzheimer's disease and controls","volume":"10","author":"den Haan","year":"2018","journal-title":"Alzheimer's Dement.: Diagn. Assess. & Dis. Monitor."},{"key":"10.1016\/j.exer.2025.110796_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.visres.2023.108268","article-title":"Microglial and macroglial dynamics in a model of retinitis pigmentosa","volume":"210","author":"D\u00edaz-Lezama","year":"2023","journal-title":"Vis. Res."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/cne.902010103","article-title":"Glial fibrillary acidic protein in the optic nerve of the developing albino rat: an immunoperoxidase study of paraffin\u2010embedded tissue","volume":"201","author":"Dixon","year":"1981","journal-title":"J. Comp. Neurol."},{"issue":"6","key":"10.1016\/j.exer.2025.110796_bib39","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.ophtha.2010.02.031","article-title":"Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema","volume":"117","author":"Elman","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2025.110796_bib40","series-title":"Glial Fibrillary Acidic Protein: Gfap-Thirtyone Years (1969-2000)","author":"Eng","year":"2000"},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib41","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1159\/000445649","article-title":"Transcription of inflammatory cytokine TNF\u03b1 is upregulated in retinal angiogenesis under hyperoxia","volume":"39","author":"Feng","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"issue":"5","key":"10.1016\/j.exer.2025.110796_bib42","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1016\/j.ajpath.2011.01.040","article-title":"Induction of ischemic tolerance protects the retina from diabetic retinopathy","volume":"178","author":"Fernandez","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exer.2025.110796_bib43","first-page":"622","article-title":"Anti- \u03b12-Macroglobulin treatment in oxygen-induced retinopathy mouse model [poster abstract]","author":"Fern\u00e1ndez","year":"2024","journal-title":"ISER 2024 PROGRAM ABSTRACTS XXVI Biennial Meet. Int. Soc. Eye Res. (ISER) October 20 -24, 2024"},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.20406","article-title":"Transitin, a nestin\u2010related intermediate filament, is expressed by neural progenitors and can be induced in m\u00fcller glia in the chicken retina","volume":"484","author":"Fischer","year":"2005","journal-title":"J. Comp. Neurol."},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib45","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1001\/jama.2023.26074","article-title":"Age-related macular degeneration","volume":"331","author":"Fleckenstein","year":"2024","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib46","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s10633-009-9193-6","article-title":"The significance of neuronal and glial cell changes in the rat retina during oxygen-induced retinopathy","volume":"120","author":"Fletcher","year":"2010","journal-title":"Doc. Ophthalmol."},{"issue":"21","key":"10.1016\/j.exer.2025.110796_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232113324","article-title":"Vertebrate animal models of RP59: current status and future prospects","volume":"23","author":"Fliesler","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib48","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1056\/NEJMra021678","article-title":"Diabetic retinopathy","volume":"350","author":"Frank","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.exer.2025.110796_bib49","author":"Garcia-Ferrer"},{"issue":"6","key":"10.1016\/j.exer.2025.110796_bib50","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1159\/000524942","article-title":"Pathophysiology of age-related macular degeneration: implications for treatment","volume":"65","author":"Garcia-Garcia","year":"2022","journal-title":"Ophthalmic Res."},{"issue":"6","key":"10.1016\/j.exer.2025.110796_bib51","doi-asserted-by":"crossref","DOI":"10.1111\/aos.12977","article-title":"Ganglion cell layer measurements correlate with disease severity in patients with <scp>A<\/scp> lzheimer's disease","volume":"94","author":"Garcia\u2010Martin","year":"2016","journal-title":"Acta Ophthalmol."},{"issue":"5","key":"10.1016\/j.exer.2025.110796_bib52","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.ophtha.2013.12.023","article-title":"Macular thickness as a potential biomarker of mild alzheimer's disease","volume":"121","author":"Garcia-Martin","year":"2014","journal-title":"Ophthalmology"},{"issue":"6","key":"10.1016\/j.exer.2025.110796_bib53","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1001\/archopht.117.6.821","article-title":"M\u00fcller cell cone, an overlooked part of the anatomy of the fovea centralis","volume":"117","author":"Gass","year":"1999","journal-title":"Arch. Ophthalmol."},{"issue":"4","key":"10.1016\/j.exer.2025.110796_bib54","doi-asserted-by":"crossref","first-page":"907","DOI":"10.3233\/JAD-132039","article-title":"Choroidal thinning as a new finding in alzheimer's disease: evidence from enhanced depth imaging spectral domain optical coherence tomography","volume":"40","author":"Gharbiya","year":"2014","journal-title":"J. Alzheim. Dis."},{"issue":"5","key":"10.1016\/j.exer.2025.110796_bib55","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1083\/jcb.111.5.2005","article-title":"Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunit","volume":"111","author":"Gill","year":"1990","journal-title":"J. Cell Biol."},{"issue":"9","key":"10.1016\/j.exer.2025.110796_bib56","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.ophtha.2020.03.021","article-title":"Five-year outcomes after initial aflibercept, bevacizumab, or ranibizumab treatment for diabetic macular edema (Protocol T extension study)","volume":"127","author":"Glassman","year":"2020","journal-title":"Ophthalmology"},{"key":"10.1016\/j.exer.2025.110796_bib57","first-page":"263","article-title":"Impact of obesity with impaired glucose tolerance on retinal degeneration in a rat model of metabolic syndrome","author":"Godisela","year":"2017","journal-title":"Mol. Vis."},{"issue":"9","key":"10.1016\/j.exer.2025.110796_bib58","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.3390\/jcm9092711","article-title":"Oxidative stress markers and the retinopathy of prematurity","volume":"9","author":"Graziosi","year":"2020","journal-title":"J. Clin. Med."},{"issue":"Issue 5","key":"10.1016\/j.exer.2025.110796_bib59","article-title":"Fibroblasts can express glial fibrillary acidic protein (GFAP) in vivo","volume":"60","author":"Hainfellner","year":"2001","journal-title":"JNEN (J. Neuropathol. Exp. Neurol.)"},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib60","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1007\/s12035-024-04382-3","article-title":"AQP4- and Kir4.1-Mediated m\u00fcller cell oedema is involved in retinal injury induced by hypobaric hypoxia","volume":"62","author":"Han","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"8","key":"10.1016\/j.exer.2025.110796_bib61","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.3390\/ph16081140","article-title":"Intravitreal anti-vascular endothelial growth factor therapies for retinal disorders","volume":"16","author":"Hang","year":"2023","journal-title":"Pharmaceuticals"},{"issue":"5","key":"10.1016\/j.exer.2025.110796_bib62","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/jnc.14271","article-title":"White matter degeneration in vascular and other ageing\u2010related dementias","volume":"144","author":"Hase","year":"2018","journal-title":"J. Neurochem."},{"issue":"6627","key":"10.1016\/j.exer.2025.110796_bib63","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1126\/science.abj8894","article-title":"Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation","volume":"379","author":"Hata","year":"2023","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.exer.2025.110796_bib64","doi-asserted-by":"crossref","DOI":"10.1172\/JCI159757","article-title":"Early-life peripheral infections reprogram retinal microglia and aggravate neovascular age-related macular degeneration in later life","volume":"133","author":"Hata","year":"2023","journal-title":"J. Clin. Investig."},{"issue":"11","key":"10.1016\/j.exer.2025.110796_bib65","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1016\/j.ophtha.2016.07.032","article-title":"Intravitreal aflibercept for diabetic macular edema","volume":"123","author":"Heier","year":"2016","journal-title":"Ophthalmology"},{"issue":"6","key":"10.1016\/j.exer.2025.110796_bib66","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1159\/000480007","article-title":"Nitrosative stress in the rat retina at the onset of streptozotocin-induced diabetes","volume":"42","author":"Hern\u00e1ndez-Ram\u00edrez","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.exer.2025.110796_bib67","author":"Hippert"},{"issue":"6","key":"10.1016\/j.exer.2025.110796_bib68","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1167\/iovs.62.6.25","article-title":"Nattokinase attenuates retinal neovascularization via modulation of Nrf2\/HO-1 and glial activation","volume":"62","author":"Huang","year":"2021","journal-title":"Investig. Opthalmol. & Visual Sci."},{"issue":"3","key":"10.1016\/j.exer.2025.110796_bib69","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1006\/exer.1996.0219","article-title":"Retinal GFAP and bFGF expression after multiple argon laser photocoagulation injuries assessed by both immunoreactivity and mRNA levels","volume":"64","author":"Humphrey","year":"1997","journal-title":"Exp. Eye Res."},{"issue":"8","key":"10.1016\/j.exer.2025.110796_bib70","doi-asserted-by":"crossref","first-page":"4722","DOI":"10.1016\/S0021-9258(19)39622-X","article-title":"Phosphorylation sites linked to glial filament disassembly in vitro locate in a non-alpha-helical head domain","volume":"265","author":"Inagaki","year":"1990","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.exer.2025.110796_bib71","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1002\/glia.20516","article-title":"Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma","volume":"55","author":"Inman","year":"2007","journal-title":"Glia"},{"issue":"9","key":"10.1016\/j.exer.2025.110796_bib72","doi-asserted-by":"crossref","first-page":"6089","DOI":"10.1167\/iovs.10-5189","article-title":"Establishment of a new animal model of focal subretinal fibrosis that resembles disciform lesion in advanced age-related macular degeneration","volume":"52","author":"Jo","year":"2011","journal-title":"Investig. Opthalmol. & Visual Sci."},{"issue":"12","key":"10.1016\/j.exer.2025.110796_bib213","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1007\/s00417-015-3127-7","article-title":"Elevated vitreous body glial fibrillary acidic protein in retinal diseases","volume":"253","author":"J\u00fcnemann","year":"2015","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110796_bib73","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.bbrc.2021.08.002","article-title":"Recombinant sulfated CCR2 peptide trap reduces retinal degeneration in mice","volume":"572","author":"Jung","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib74","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1001\/jama.2022.10233","article-title":"Sickle cell disease","volume":"328","author":"Kavanagh","year":"2022","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.exer.2025.110796_bib75","first-page":"471","article-title":"The role of astrocytes in the formation of cartilage in gliomas. An immunohistochemical study of four cases","volume":"117","author":"Kepes","year":"1984","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib76","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1038\/s41598-021-81482-3","article-title":"Hyperglycemia-induced VEGF and ROS production in retinal cells is inhibited by the mTOR inhibitor, rapamycin","volume":"11","author":"Kida","year":"2021","journal-title":"Sci. Rep."},{"issue":"s2","key":"10.1016\/j.exer.2025.110796_bib77","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1464-5491.2008.02505.x","article-title":"Microvascular disease: what does the UKPDS tell us about diabetic retinopathy?","volume":"25","author":"Kohner","year":"2008","journal-title":"Diabet. Med."},{"key":"10.1016\/j.exer.2025.110796_bib78","series-title":"2010 Annual International Conference of the IEEE Engineering in Medicine and Biology","first-page":"3049","article-title":"In vivo imaging of retinal gliosis: a platform for diagnosis of PD and screening of anti-PD compounds","author":"Kumar","year":"2010"},{"issue":"10","key":"10.1016\/j.exer.2025.110796_bib79","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1167\/iovs.64.10.8","article-title":"The role of m\u00fcller cells in diabetic macular edema","volume":"64","author":"Lai","year":"2023","journal-title":"Investig. Opthalmol. & Visual Sci."},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib80","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/jnr.490250207","article-title":"Developmental expression of glial fibrillary acidic protein mRNA in the rat brain analyzed by in situ hybridization","volume":"25","author":"Landry","year":"1990","journal-title":"J. Neurosci. Res."},{"issue":"12","key":"10.1016\/j.exer.2025.110796_bib81","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1136\/bjo.2005.079491","article-title":"Advanced glycation end products can induce glial reaction and neuronal degeneration in retinal explants","volume":"89","author":"Lecleire-Collet","year":"2005","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110796_bib82","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ajo.2020.04.040","article-title":"Retinal biomarkers of alzheimer disease","volume":"218","author":"Lee","year":"2020","journal-title":"Am. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib84","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0014-4835(89)90079-1","article-title":"Changes in the expression of specific m\u00fcller cell proteins during long-term retinal detachment","volume":"49","author":"Lewis","year":"1989","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.exer.2025.110796_bib85","author":"Lewis"},{"key":"10.1016\/j.exer.2025.110796_bib83","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1046\/j.1471-4159.2001.00595.x","article-title":"Intermediate filaments regulate astrocyte motility","author":"Lepekhin","year":"2001","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.exer.2025.110796_bib86","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1471-4159.1985.tb04080.x","article-title":"Temporal expression of mouse glial fibrillary acidic protein mRNA studied by a rapid in situ hybridization procedure","volume":"45","author":"Lewis","year":"1985","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.exer.2025.110796_bib87","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.cmet.2014.01.001","article-title":"Rapamycin: one drug, many effects","volume":"19","author":"Li","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.exer.2025.110796_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2019.107743","article-title":"Anti-apoptotic effect of interleukin-17 in a mouse model of oxygen-induced retinopathy","volume":"187","author":"Li","year":"2019","journal-title":"Exp. Eye Res."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib89","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0165-3806(88)90119-8","article-title":"The development of astrocytes in the cat retina: evidence of migration from the optic nerve","volume":"44","author":"Ling","year":"1988","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.exer.2025.110796_bib90","first-page":"1","article-title":"Hypoxia-induced oxidative stress in ischemic retinopathy","volume":"2012","author":"Li","year":"2012","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"49","key":"10.1016\/j.exer.2025.110796_bib91","doi-asserted-by":"crossref","first-page":"46212","DOI":"10.1074\/jbc.M105177200","article-title":"Identification of the high affinity binding site in transforming growth Factor-\u03b2 involved in complex formation with \u03b12-Macroglobulin","volume":"276","author":"Liu","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.exer.2025.110796_bib92","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.18240\/ijo.2020.09.04","article-title":"Acetylcholinesterase inhibition ameliorates retinal neovascularization and glial activation in oxygen-induced retinopathy","volume":"13","author":"Liu","year":"2020","journal-title":"Int. J. Ophthalmol."},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib93","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3233\/JAD-160067","article-title":"The association between retinal neuronal layer and brain structure is disrupted in patients with cognitive impairment and alzheimer's disease","volume":"54","author":"Liu","year":"2016","journal-title":"J. Alzheim. Dis."},{"key":"10.1016\/j.exer.2025.110796_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114219","article-title":"Parthenolide ameliorates diabetic retinopathy by suppressing microglia-induced m\u00fcller cell gliosis and inflammation via the NF-\u03baB signalling","volume":"151","author":"Li","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"7","key":"10.1016\/j.exer.2025.110796_bib95","doi-asserted-by":"crossref","first-page":"712","DOI":"10.3390\/life11070712","article-title":"The value of OCT and OCTA as potential biomarkers for preclinical alzheimer's disease: a review study","volume":"11","author":"L\u00f3pez-Cuenca","year":"2021","journal-title":"Life"},{"issue":"13","key":"10.1016\/j.exer.2025.110796_bib96","doi-asserted-by":"crossref","first-page":"9316","DOI":"10.1167\/iovs.11-7879","article-title":"Early inner retinal astrocyte dysfunction during diabetes and development of hypoxia, retinal stress, and neuronal functional loss","volume":"52","author":"Ly","year":"2011","journal-title":"Investig. Opthalmol. & Visual Sci."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib97","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1471-4159.1987.tb13162.x","article-title":"Glial fibrillary acidic protein in the cytoskeletal and soluble protein fractions of the developing rat brain","volume":"48","author":"Malloch","year":"1987","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib98","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1139\/y77-007","article-title":"Inhibition of the immune response by rapamycin, a new antifungal antibiotic","volume":"55","author":"Martel","year":"1977","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"11","key":"10.1016\/j.exer.2025.110796_bib99","doi-asserted-by":"crossref","first-page":"9607","DOI":"10.3390\/ijms24119607","article-title":"The disorganization of retinal inner layers is correlated to m\u00fcller cells impairment in diabetic macular edema: an imaging and omics study","volume":"24","author":"Midena","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exer.2025.110796_bib100","article-title":"Effect of hypoxia on m\u00fcller glia cultures","author":"Miguel-L\u00f3pez","year":"2025","journal-title":"Cells (MDPI)"},{"key":"10.1016\/j.exer.2025.110796_bib101","first-page":"280","article-title":"Nestin contributes to laser choroidal and retinal neovascularization","volume":"28","author":"Miloudi","year":"2022","journal-title":"Mol. Vis."},{"issue":"4","key":"10.1016\/j.exer.2025.110796_bib102","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/jnr.490230405","article-title":"Neuronal modulation of schwann cell glial fibrillary acidic protein (GFAP)","volume":"23","author":"Mokuno","year":"1989","journal-title":"J. Neurosci. Res."},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib103","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/jnr.490140202","article-title":"Hormones and growth factors induce the synthesis of glial fibrillary acidic protein in rat brain astrocytes","volume":"14","author":"Morrison","year":"1985","journal-title":"J. Neurosci. Res."},{"issue":"6","key":"10.1016\/j.exer.2025.110796_bib104","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1167\/iovs.18-25745","article-title":"Nrf2 activator RS9 suppresses pathological ocular angiogenesis and hyperpermeability","volume":"60","author":"Nakamura","year":"2019","journal-title":"Investig. Opthalmol. & Visual Sci."},{"issue":"32","key":"10.1016\/j.exer.2025.110796_bib105","doi-asserted-by":"crossref","first-page":"23269","DOI":"10.1016\/S0021-9258(18)50086-7","article-title":"Assembly regulatory domain of glial fibrillary acidic protein. A single phosphorylation diminishes its assembly-accelerating property","volume":"267","author":"Nakamura","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.exer.2025.110796_bib106","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1167\/iovs.06-1398","article-title":"Attenuated glial reactions and photoreceptor degeneration after retinal detachment in mice deficient in glial fibrillary acidic protein and vimentin","volume":"48","author":"Nakazawa","year":"2007","journal-title":"Investig. Opthalmol. & Visual Sci."},{"key":"10.1016\/j.exer.2025.110796_bib107","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0378-1119(03)00526-2","article-title":"Structural and functional characterization of the zebrafish gene for glial fibrillary acidic protein, GFAP","volume":"310","author":"Nielsen","year":"2003","journal-title":"Gene"},{"key":"10.1016\/j.exer.2025.110796_bib108","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108700","article-title":"Protective effect of rapamycin in models of retinal degeneration","volume":"210","author":"Niu","year":"2021","journal-title":"Exp. Eye Res."},{"issue":"11","key":"10.1016\/j.exer.2025.110796_bib109","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1001\/jamaophthalmol.2018.3556","article-title":"Association of preclinical alzheimer disease with optical coherence tomographic angiography findings","volume":"136","author":"O'Bryhim","year":"2018","journal-title":"JAMA Ophthalmol."},{"key":"10.1016\/j.exer.2025.110796_bib110","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.freeradbiomed.2021.11.037","article-title":"Vitamin E and preterm infants","volume":"180","author":"Ogihara","year":"2022","journal-title":"Free Radic. Biol. Med."},{"issue":"7","key":"10.1016\/j.exer.2025.110796_bib111","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/s10072-014-2055-3","article-title":"The relationship between the degree of cognitive impairment and retinal nerve fiber layer thickness","volume":"36","author":"Oktem","year":"2015","journal-title":"Neurol. Sci."},{"issue":"4","key":"10.1016\/j.exer.2025.110796_bib112","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/jnr.25158","article-title":"Peptidyl arginine deiminase 4 deficiency protects against subretinal fibrosis by inhibiting m\u00fcller glial hypercitrullination","volume":"101","author":"Palko","year":"2023","journal-title":"J. Neurosci. Res."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib113","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/0955-0674(92)90064-J","article-title":"Intermediate filament structure","volume":"4","author":"Parry","year":"1992","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.exer.2025.110796_bib114","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.573987","article-title":"Metabolic syndrome triggered by fructose diet impairs neuronal function and vascular integrity in ApoE-KO mouse retinas: implications of autophagy deficient activation","volume":"8","author":"Paz","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"11","key":"10.1016\/j.exer.2025.110796_bib115","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1023\/A:1022572304626","article-title":"The impact of genetic removal of GFAP and\/or vimentin on glutamine levels and transport of glucose and ascorbate in astrocytes","volume":"24","author":"Pekny","year":"1999","journal-title":"Neurochem"},{"issue":"3","key":"10.1016\/j.exer.2025.110796_bib116","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.ophtha.2009.07.045","article-title":"Retinopathy in persons without diabetes","volume":"117","author":"Peng","year":"2010","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.exer.2025.110796_bib117","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s12020-019-02017-5","article-title":"Activation of retinal m\u00fcller cells in response to glucose variability","volume":"65","author":"Picconi","year":"2019","journal-title":"Endocrine"},{"issue":"8","key":"10.1016\/j.exer.2025.110796_bib118","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.2337\/db20-1268","article-title":"Tribbles homolog 3 mediates the development and progression of diabetic retinopathy","volume":"70","author":"Pitale","year":"2021","journal-title":"Diabetes"},{"key":"10.1016\/j.exer.2025.110796_bib119","article-title":"Transition between immature radial glia and mature astrocytes studied with a monoclonal antibody to vimentin","volume":"vol. 15","author":"Pixley","year":"1984"},{"issue":"6","key":"10.1016\/j.exer.2025.110796_bib120","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.3390\/cells10061398","article-title":"Modeling retinal ganglion cell dysfunction in optic neuropathies","volume":"10","author":"Porciatti","year":"2021","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.exer.2025.110796_bib121","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.3390\/ijms21072351","article-title":"Mechanisms behind retinal ganglion cell loss in diabetes and therapeutic approach","volume":"21","author":"Potilinski","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib122","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/glia.20597","article-title":"Stimulation inhibits the mobility of recycling peptidergic vesicles in astrocytes","volume":"56","author":"Potokar","year":"2008","journal-title":"Glia"},{"issue":"12","key":"10.1016\/j.exer.2025.110796_bib123","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2016.117","article-title":"IL-17A exacerbates diabetic retinopathy by impairing m\u00fcller cell function via Act1 signaling","volume":"48","author":"Qiu","year":"2016","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib124","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41598-018-37271-6","article-title":"Functional and morphological changes of the retinal vessels in Alzheimer's disease and mild cognitive impairment","volume":"9","author":"Querques","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib125","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1242\/jcs.93.1.71","article-title":"Expression in Escherichia coli of fragments of glial fibrillary acidic protein: characterization, assembly properties and paracrystal formation","volume":"93","author":"Quinlan","year":"1989","journal-title":"J. Cell Sci."},{"issue":"5","key":"10.1016\/j.exer.2025.110796_bib126","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1006\/exer.2001.1061","article-title":"Changes of astrocytes in retinal ageing and age-related macular degeneration","volume":"73","author":"Ram\u00edrez","year":"2001","journal-title":"Exp. Eye Res."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib127","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cmet.2012.11.012","article-title":"Vascular complications of diabetes: mechanisms of injury and protective factors","volume":"17","author":"Rask-Madsen","year":"2013","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.exer.2025.110796_bib128","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1464-5491.2005.01499.x","article-title":"Animal models of diabetes mellitus","volume":"22","author":"Rees","year":"2005","journal-title":"Diabet. Med."},{"issue":"13","key":"10.1016\/j.exer.2025.110796_bib129","doi-asserted-by":"crossref","first-page":"5178","DOI":"10.1073\/pnas.86.13.5178","article-title":"Molecular cloning and primary structure of human glial fibrillary acidic protein","volume":"86","author":"Reeves","year":"1989","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.exer.2025.110796_bib130","series-title":"M\u00fcller Cells in the Healthy and Diseased Retina","author":"Reichenbach","year":"2010"},{"issue":"5","key":"10.1016\/j.exer.2025.110796_bib131","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/glia.22477","article-title":"New functions of m\u00fcller cells","volume":"61","author":"Reichenbach","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.exer.2025.110796_bib132","series-title":"Colloquium Series on Neuroglia in Biology and Medicine: from Physiology to Disease","article-title":"Retinal glia","author":"Reichenbach","year":"2015"},{"issue":"20","key":"10.1016\/j.exer.2025.110796_bib133","doi-asserted-by":"crossref","first-page":"32505","DOI":"10.18632\/oncotarget.17129","article-title":"Galectin-1 expression imprints a neurovascular phenotype in proliferative retinopathies and delineates responses to anti-VEGF","volume":"8","author":"Ridano","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib134","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/(SICI)1097-4547(19970401)48:1<53::AID-JNR5>3.0.CO;2-D","article-title":"Detection of the peripheral nervous system (PNS)-type glial fibrillary acidic protein (GFAP) and its mRNA in human lymphocytes","volume":"48","author":"Riol","year":"1997","journal-title":"J. Neurosci. Res."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib135","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12974-017-0943-1","article-title":"Retinopathy of prematurity: inflammation, choroidal degeneration, and novel promising therapeutic strategies","volume":"14","author":"Rivera","year":"2017","journal-title":"J. Neuroinflammation"},{"issue":"15","key":"10.1016\/j.exer.2025.110796_bib136","doi-asserted-by":"crossref","first-page":"6739","DOI":"10.1167\/iovs.16-19513","article-title":"Expression pattern of HIF-1\u03b1 and VEGF supports circumferential application of scatter laser for proliferative sickle retinopathy","volume":"57","author":"Rodrigues","year":"2016","journal-title":"Investig. Opthalmol. & Visual Sci."},{"issue":"11","key":"10.1016\/j.exer.2025.110796_bib137","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.2337\/db13-0014","article-title":"VEGF secreted by hypoxic m\u00fcller cells induces MMP-2 expression and activity in endothelial cells to promote retinal neovascularization in proliferative diabetic retinopathy","volume":"62","author":"Rodrigues","year":"2013","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib138","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3390\/antiox6020043","article-title":"NOX2-Induced activation of arginase and diabetes-induced retinal endothelial cell senescence","volume":"6","author":"Rojas","year":"2017","journal-title":"Antioxidants"},{"issue":"7","key":"10.1016\/j.exer.2025.110796_bib139","first-page":"1971","article-title":"Glial reactivity, an early feature of diabetic retinopathy","volume":"41","author":"Rungger-Br\u00e4ndle","year":"2000","journal-title":"IOVS"},{"issue":"12","key":"10.1016\/j.exer.2025.110796_bib140","doi-asserted-by":"crossref","first-page":"8993","DOI":"10.1167\/iovs.11-8423","article-title":"The sand rat, Psammomys obesus , develops type 2 diabetic retinopathy similar to humans","volume":"52","author":"Sa\u00efdi","year":"2011","journal-title":"Investig. Opthalmol. & Visual Sci."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib141","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s40478-025-02066-0","article-title":"Glial and immune dysregulation in glaucoma independent of retinal ganglion cell loss: a human post-mortem histopathology study","volume":"13","author":"Salkar","year":"2025","journal-title":"Acta Neuropathol. Commun."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib142","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s13195-024-01556-y","article-title":"Neurodegenerative biomarkers in different chambers of the eye relative to plasma: an agreement validation study","volume":"16","author":"Sampani","year":"2024","journal-title":"Alzheimers Res. Ther."},{"issue":"6","key":"10.1016\/j.exer.2025.110796_bib143","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.exer.2006.07.016","article-title":"Low-density lipoprotein receptor-related protein-1 (LRP-1) expression in a rat model of oxygen-induced retinal neovascularization","volume":"83","author":"S\u00e1nchez","year":"2006","journal-title":"Exp. Eye Res."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib144","doi-asserted-by":"crossref","DOI":"10.1177\/17590914221136365","article-title":"Multitarget activities of m\u00fcller glial cells and low-density lipoprotein receptor-related protein 1 in proliferative retinopathies","volume":"14","author":"Sanchez","year":"2022","journal-title":"ASN Neuro"},{"issue":"9","key":"10.1016\/j.exer.2025.110796_bib145","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1172\/JCI42142","article-title":"Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life","volume":"120","author":"Sapieha","year":"2010","journal-title":"J. Clin. Investig."},{"issue":"3","key":"10.1016\/j.exer.2025.110796_bib146","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009532","article-title":"Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitro","volume":"5","author":"Sarafian","year":"2010","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.exer.2025.110796_bib147","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1089\/dna.1995.14.313","article-title":"Transient induction of the glial intermediate filament protein gene in m\u00fcller cells in the mouse retina","volume":"14","author":"Sarthy","year":"1995","journal-title":"DNA Cell Biol."},{"issue":"6","key":"10.1016\/j.exer.2025.110796_bib148","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/BF00741450","article-title":"Developmental expression of the glial fibrillary acidic protein (GFAP) gene in the mouse retina","volume":"11","author":"Sarthy","year":"1991","journal-title":"Cell. Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.exer.2025.110796_bib149","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.exer.2005.12.014","article-title":"Focus on molecules: glial fibrillary acidic protein (GFAP)","volume":"84","author":"Sarthy","year":"2007","journal-title":"Exp. Eye Res."},{"issue":"3607","key":"10.1016\/j.exer.2025.110796_bib150","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1126\/science.143.3607.689","article-title":"Diabetes mellitus in the sand rat induced by standard laboratory diets","volume":"143","author":"Schmidt-Nielsen","year":"1964","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib151","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/glia.440010109","article-title":"Astrocytes in the Guinea pig, horse, and monkey retina: their occurrence coincides with the presence of blood vessels","volume":"1","author":"Schnitzer","year":"1988","journal-title":"Glia"},{"issue":"4","key":"10.1016\/j.exer.2025.110796_bib152","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1083\/jcb.132.4.635","article-title":"Detection of protein kinase activity specifically activated at metaphase-anaphase transition","volume":"132","author":"Sekimata","year":"1996","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib153","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0006-8993(99)01552-8","article-title":"Degeneration and gliosis in rat retina and central nervous system following 3,3\u2032-iminodipropionitrile exposure","volume":"833","author":"Seoane","year":"1999","journal-title":"Brain Res."},{"issue":"6","key":"10.1016\/j.exer.2025.110796_bib154","doi-asserted-by":"crossref","first-page":"E1450","DOI":"10.1152\/ajpendo.00113.2009","article-title":"A useful list of spontaneously arising animal models of obesity and diabetes","volume":"296","author":"Shafrir","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metabol."},{"key":"10.1016\/j.exer.2025.110796_bib155","article-title":"A mouse model for laser-induced choroidal neovascularization","volume":"106","author":"Shah","year":"2015","journal-title":"JoVE J."},{"issue":"3","key":"10.1016\/j.exer.2025.110796_bib156","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41433-019-0590-0","article-title":"Evolving role of anti-VEGF for diabetic macular oedema: from clinical trials to real life","volume":"34","author":"Sharma","year":"2020","journal-title":"Eye"},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib157","first-page":"219","article-title":"The structure and development of the rat retina: an immunofluorescence microscopical study using antibodies specific for intermediate filament proteins","volume":"30","author":"Shaw","year":"1983","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.exer.2025.110796_bib158","first-page":"5276","article-title":"The association of vitreous biomarker levels and optical coherence tomography markers to cognitive status","volume":"64","author":"Sheikh","year":"2023","journal-title":"IOVS [Abstract presented at ARVO 2023]"},{"issue":"10","key":"10.1016\/j.exer.2025.110796_bib159","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1016\/j.yexcr.2007.04.010","article-title":"Role of phosphorylation on the structural dynamics and function of types III and IV intermediate filaments","volume":"313","author":"Sihag","year":"2007","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib160","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1186\/s13054-021-03815-y","article-title":"Dangers of hyperoxia","volume":"25","author":"Singer","year":"2021","journal-title":"Crit. Care"},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib161","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/s12916-024-03475-z","article-title":"Circulating small extracellular vesicles in Alzheimer's disease: a case\u2013control study of neuro-inflammation and synaptic dysfunction","volume":"22","author":"Singh","year":"2024","journal-title":"BMC Med."},{"issue":"18","key":"10.1016\/j.exer.2025.110796_bib162","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1016\/j.yexcr.2007.08.020","article-title":"Ca2+-dependent mobility of vesicles capturing anti-VGLUT1 antibodies","volume":"313","author":"Stenovec","year":"2007","journal-title":"Exp. Cell Res."},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib163","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3390\/cells12020297","article-title":"Etiological roles of p75NTR in a mouse model of wet age-related macular degeneration","volume":"12","author":"Subirada","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.exer.2025.110796_bib164","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2019.00279","article-title":"Effect of autophagy modulators on vascular, glial, and neuronal alterations in the oxygen-induced retinopathy mouse model","volume":"13","author":"Subirada","year":"2019","journal-title":"Front. Cell. Neurosci."},{"issue":"12","key":"10.1016\/j.exer.2025.110796_bib165","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1111\/ejn.13965","article-title":"A journey into the retina: m\u00fcller glia commanding survival and death","volume":"47","author":"Subirada","year":"2018","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.exer.2025.110796_bib166","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.855178","article-title":"Rapamycin and resveratrol modulate the gliotic and pro-angiogenic response in m\u00fcller glial cells under hypoxia","volume":"10","author":"Subirada","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"6","key":"10.1016\/j.exer.2025.110796_bib167","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1167\/iovs.17-23678","article-title":"Proteomic analysis of early diabetic retinopathy reveals mediators of neurodegenerative brain diseases","volume":"59","author":"Sundstrom","year":"2018","journal-title":"Investig. Opthalmol. & Visual Sci."},{"key":"10.1016\/j.exer.2025.110796_bib168","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exer.2015.04.015","article-title":"Ebselen by modulating oxidative stress improves hypoxia-induced macroglial m\u00fcller cell and vascular injury in the retina","volume":"136","author":"Tan","year":"2015","journal-title":"Exp. Eye Res."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib169","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1471-4159.1989.tb10911.x","article-title":"Developmental expression of the glial fibrillary acidic protein mRNA in the central nervous system and in cultured astrocytes","volume":"52","author":"Tardy","year":"1989","journal-title":"J. Neurochem."},{"issue":"8","key":"10.1016\/j.exer.2025.110796_bib170","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1111\/j.1464-5491.2005.01562.x","article-title":"Increased plasma markers of inflammation and endothelial dysfunction and their association with microvascular complications in type 1 diabetic patients without clinically manifest macroangiopathy","volume":"22","author":"Targher","year":"2005","journal-title":"Diabet. Med."},{"issue":"7","key":"10.1016\/j.exer.2025.110796_bib171","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1167\/iovs.02-1136","article-title":"Immunohistochemical assessment of the glial mitogen-activated protein kinase activation in glaucoma","volume":"44","author":"Tezel","year":"2003","journal-title":"Investig. Opthalmol. & Visual Sci."},{"key":"10.1016\/j.exer.2025.110796_bib172","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.exer.2015.04.012","article-title":"Early adaptive response of the retina to a pro-diabetogenic diet: impairment of cone response and gene expression changes in high-fructose fed rats","volume":"135","author":"Thierry","year":"2015","journal-title":"Exp. Eye Res."},{"issue":"3","key":"10.1016\/j.exer.2025.110796_bib173","first-page":"473","article-title":"Age-related macular degeneration","volume":"105","author":"Thomas","year":"2021","journal-title":"Med. Clin."},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib174","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/WAD.0000000000000176","article-title":"Attenuation of choroidal thickness in patients with alzheimer disease","volume":"31","author":"Trebbastoni","year":"2017","journal-title":"Alzheimer Dis. Assoc. Disord."},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib175","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/oxfordjournals.jbchem.a124542","article-title":"Identification of phosphorylation sites on glial fibrillary acidic protein for cdc2 kinase and Ca2+-Calmodulin-Dependent protein kinase II1","volume":"116","author":"Tsujimura","year":"1994","journal-title":"J. Biochem."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib176","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0006-8993(72)90347-2","article-title":"Immunological study of the glial fibrillary acidic protein","volume":"37","author":"Uyeda","year":"1972","journal-title":"Brain Res."},{"key":"10.1016\/j.exer.2025.110796_bib177","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103725","article-title":"Corrigendum to \u201cNitro-Oleic acid protects from neovascularization, oxidative stress, gliosis and neurodegeneration in oxygen-induced retinopathy\u201d","author":"Vaglienti","year":"2025","journal-title":"Redox Biol."},{"issue":"3","key":"10.1016\/j.exer.2025.110796_bib178","doi-asserted-by":"crossref","first-page":"494","DOI":"10.3390\/cells12030494","article-title":"Protective effect of NO2-OA on oxidative stress, gliosis, and pro-angiogenic response in m\u00fcller glial cells","volume":"12","author":"Vaglienti","year":"2023","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib179","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1136\/bjophthalmol-2019-314127","article-title":"Optical coherence tomography angiography in preclinical Alzheimer's disease","volume":"104","author":"van de Kreeke","year":"2020","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exer.2025.110796_bib180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.06.003","article-title":"Glia\u2013neuron interactions in the mammalian retina","volume":"51","author":"Vecino","year":"2016","journal-title":"Prog. Retin. Eye Res."},{"issue":"8","key":"10.1016\/j.exer.2025.110796_bib181","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1167\/iovs.07-1474","article-title":"Abnormal reactivity of m\u00fcller cells after retinal detachment in mice deficient in GFAP and vimentin","volume":"49","author":"Verardo","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.exer.2025.110796_bib182","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/cne.22530","article-title":"Characterization of retinal function and glial cell response in a mouse model of oxygen\u2010induced retinopathy","volume":"519","author":"Vessey","year":"2011","journal-title":"J. Comp. Neurol."},{"issue":"9","key":"10.1016\/j.exer.2025.110796_bib183","doi-asserted-by":"crossref","first-page":"7919","DOI":"10.3390\/ijms24097919","article-title":"Large-scale protein analysis of experimental retinal artery occlusion","volume":"24","author":"Vestergaard","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.exer.2025.110796_bib184","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/BF01600164","article-title":"Glial fibrillary acidic protein immunoreactivity in normal and diseased human breast","volume":"418","author":"Viale","year":"1991","journal-title":"Virchows Arch. A Pathol. Anat. Histopathol."},{"issue":"3","key":"10.1016\/j.exer.2025.110796_bib185","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.3233\/JAD-230167","article-title":"Vitreous humor biomarkers reflect pathological changes in the brain for alzheimer's disease and chronic traumatic encephalopathy","volume":"93","author":"Vig","year":"2023","journal-title":"J. Alzheim. Dis."},{"issue":"6","key":"10.1016\/j.exer.2025.110796_bib186","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1167\/iovs.15-16554","article-title":"Aqueous humor biomarkers of m\u00fcller cell activation in diabetic eyes","volume":"56","author":"Vujosevic","year":"2015","journal-title":"Investig. Opthalmol. & Visual Sci."},{"issue":"3","key":"10.1016\/j.exer.2025.110796_bib187","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1046\/j.1442-9071.2003.00638.x","article-title":"M\u00fcller cells express the neuronal progenitor cell marker nestin in both differentiated and undifferentiated human foetal retina","volume":"31","author":"Walcott","year":"2003","journal-title":"Clin. Exp. Ophthalmol."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib188","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1001\/jamaophthalmol.2013.986","article-title":"Signaling pathways triggered by oxidative stress that mediate features of severe retinopathy of prematurity","volume":"131","author":"Wang","year":"2013","journal-title":"JAMA Ophthalmol."},{"key":"10.1016\/j.exer.2025.110796_bib189","first-page":"126","article-title":"Intermediate filaments: structural conservation and divergence","volume":"455","author":"Weber","year":"1985","journal-title":"ANNALS"},{"issue":"41","key":"10.1016\/j.exer.2025.110796_bib190","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1309276110","article-title":"Nrf2 acts cell-autonomously in endothelium to regulate tip cell formation and vascular branching","volume":"110","author":"Wei","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.exer.2025.110796_bib191","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.freeradbiomed.2016.08.013","article-title":"Nrf2 promotes reparative angiogenesis through regulation of NADPH oxidase-2 in oxygen-induced retinopathy","volume":"99","author":"Wei","year":"2016","journal-title":"Free Radic. Biol. Med."},{"issue":"8","key":"10.1016\/j.exer.2025.110796_bib192","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1242\/dev.01732","article-title":"Stabilization of the retinal vascular network by reciprocal feedback between blood vessels and astrocytes","volume":"132","author":"West","year":"2005","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib193","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0165-3806(94)00208-H","article-title":"Age-dependent changes in the regulation by external calcium ions of the phosphorylation of glial fibrillary acidic protein in slices of rat hippocampus","volume":"85","author":"Wofchuk","year":"1995","journal-title":"Dev. Brain Res."},{"issue":"9","key":"10.1016\/j.exer.2025.110796_bib194","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1167\/iovs.04-0069","article-title":"Associations between the metabolic syndrome and retinal microvascular signs: the atherosclerosis risk in communities study","volume":"45","author":"Wong","year":"2004","journal-title":"Investig. Opthalmol. & Visual Sci."},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib195","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis","volume":"2","author":"Wong","year":"2014","journal-title":"Lancet Global Health"},{"issue":"6","key":"10.1016\/j.exer.2025.110796_bib196","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1167\/iovs.10-6901","article-title":"Effects of ischemia\u2013reperfusion on physiological properties of m\u00fcller glial cells in the porcine retina","volume":"52","author":"Wurm","year":"2011","journal-title":"Investig. Opthalmol. & Visual Sci."},{"issue":"36","key":"10.1016\/j.exer.2025.110796_bib197","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1217091110","article-title":"Hypoxic retinal m\u00fcller cells promote vascular permeability by HIF-1\u2013dependent up-regulation of angiopoietin-like 4","volume":"110","author":"Xin","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib198","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.yexcr.2004.04.023","article-title":"The mouse synemin gene encodes three intermediate filament proteins generated by alternative exon usage and different open reading frames","volume":"298","author":"Xue","year":"2004","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib199","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s00125-013-3093-8","article-title":"NRF2 plays a protective role in diabetic retinopathy in mice","volume":"57","author":"Xu","year":"2014","journal-title":"Diabetologia"},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib200","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1001\/archopht.1969.00990020153002","article-title":"Some structural features of the fovea centralis in the human retina","volume":"82","author":"Yamada","year":"1969","journal-title":"Arch. Ophthalmol."},{"issue":"6","key":"10.1016\/j.exer.2025.110796_bib201","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.tins.2015.04.003","article-title":"Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker","volume":"38","author":"Yang","year":"2015","journal-title":"Trends Neurosci."},{"issue":"4","key":"10.1016\/j.exer.2025.110796_bib202","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1167\/iovs.61.4.15","article-title":"PPAR\u03b1-Dependent effects of palmitoylethanolamide against retinal neovascularization and fibrosis","volume":"61","author":"Ye","year":"2020","journal-title":"Investig. Opthalmol. & Visual Sci."},{"issue":"6","key":"10.1016\/j.exer.2025.110796_bib203","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.oret.2019.02.002","article-title":"Retinal microvascular and neurodegenerative changes in alzheimer's disease and mild cognitive impairment compared with control participants","volume":"3","author":"Yoon","year":"2019","journal-title":"Ophthalmol. Retina"},{"issue":"7","key":"10.1016\/j.exer.2025.110796_bib204","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/dmrr.1007","article-title":"Protective role of pigment epithelium\u2010derived factor (PEDF) in early phase of experimental diabetic retinopathy","volume":"25","author":"Yoshida","year":"2009","journal-title":"Diabetes Metabol. Res. Rev."},{"issue":"2","key":"10.1016\/j.exer.2025.110796_bib205","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.347","article-title":"Angiopoietin 2 induces astrocyte apoptosis via \u03b1v\u03b25-integrin signaling in diabetic retinopathy","volume":"7","author":"Yun","year":"2016","journal-title":"Cell Death Dis."},{"issue":"8","key":"10.1016\/j.exer.2025.110796_bib206","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1111\/dme.13369","article-title":"Retinal nerve fibre layer thickness is reduced in metabolic syndrome","volume":"34","author":"Zarei","year":"2017","journal-title":"Diabet. Med."},{"issue":"1","key":"10.1016\/j.exer.2025.110796_bib207","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1186\/s13287-022-03100-x","article-title":"Mesenchymal stem cell-derived extracellular vesicles protect retina in a mouse model of retinitis pigmentosa by anti-inflammation through miR-146a-Nr4a3 axis","volume":"13","author":"Zhang","year":"2022","journal-title":"Stem Cell Res. Ther."},{"issue":"12","key":"10.1016\/j.exer.2025.110796_bib208","doi-asserted-by":"crossref","first-page":"15822","DOI":"10.1096\/fj.202001295R","article-title":"Protective effects of rapamycin on the retinal vascular bed during the vaso\u2010obliteration phase in mouse oxygen\u2010induced retinopathy model","volume":"34","author":"Zhang","year":"2020","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.exer.2025.110796_bib209","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1002\/jcb.26473","article-title":"Retracted : effects of apelin on retinal microglial cells in a rat model of oxygen\u2010induced retinopathy of prematurity","volume":"119","author":"Zhang","year":"2018","journal-title":"J. Cell. Biochem."},{"issue":"4","key":"10.1016\/j.exer.2025.110796_bib210","article-title":"Parafoveal vessel loss and correlation between peripapillary vessel density and cognitive performance in amnestic mild cognitive impairment and early Alzheimer's disease on optical coherence tomography angiography","volume":"14","author":"Zhang","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.exer.2025.110796_bib211","article-title":"Rapamycin improved retinal function and morphology in a mouse model of retinal degeneration","volume":"16","author":"Zhao","year":"2022","journal-title":"Front. Neurosci."},{"issue":"12","key":"10.1016\/j.exer.2025.110796_bib212","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1007\/s00125-010-1900-z","article-title":"Hyperglycaemia-induced pro-inflammatory responses by retinal m\u00fcller glia are regulated by the receptor for advanced glycation end-products (RAGE)","volume":"53","author":"Zong","year":"2010","journal-title":"Diabetologia"}],"container-title":["Experimental Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448352500569X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448352500569X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:05:41Z","timestamp":1781323541000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001448352500569X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":213,"alternative-id":["S001448352500569X"],"URL":"https:\/\/doi.org\/10.1016\/j.exer.2025.110796","relation":{},"ISSN":["0014-4835"],"issn-type":[{"value":"0014-4835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glial fibrillary acidic protein, an early and sustained indicator of retinopathy progression","name":"articletitle","label":"Article Title"},{"value":"Experimental Eye Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exer.2025.110796","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110796"}}